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Table 3 Outcome of IPFT and surgical intervention in pleural infection

From: Retrospective review comparing intrapleural fibrinolytic therapy (alteplase) and surgical intervention in complex pleural effusion

Outcome

IPFT (n = 30)

Surgical intervention (n = 18)

p-value

Baseline chest radiograph(cm2)—mean

112.27 ± 56.31

78.19 ± 55.6

0.087

Duration from baseline chest radiograph to intervention (days)—median (IQR)

2.5 (1–11)

3.5 (1–32)

0.213

Week 1a

Chest radiograph changes (%)–mean

32.33 ± 42.84

32.05 ± 33.24

0.985

Success rate (n)

8 (38.1%)

2 (20%)

0.428

Week 4–8b

Chest radiograph changes (%)—median (IQR)

62 (− 123.48–100)

73.46 (45.79–100)

0.164

Success rate (n)

11 (57.9%)

8 (80%)

0.414

Pre-intervention total white cells (× 109/L)—median (IQR)

9.7 (4.1–31.3)

9.75 (6.9–18.8)

0.881

48 h post-intervention total white cells (× 109/L)—mean

11.59 ± 4.27

12.34 ± 4.97

0.631

Pre-intervention CRP(mg/dL)—median (IQR)

10.03 (0.89–33.2)

9.48 (0.48–43.59)

0.641

48 h post-intervention CRP (mg/dL)—median (IQR)

9.66 (0.77–25.45)

6.41 (2.58–31.84)

0.867

Duration of chest tube in situ (days) median (IQR)

11 (8–23.75)

13.5 (8.5–19.75)

0.983

Length of stay (days)—median (IQR)

20.5 (15–34.75)

26.5 (21.25–40.75)

0.141

Mortality at 30 days(n)

1 (3%)

0 (0%)

0.376

Immediate post-intervention complications (n)c

6 (20%)

17 (94%)

 < 0.0005

Hypotension

0

16

 Bleeding

0

1

 Fever

5

0

 Chest pain

1

0

  1. aMissing data: 9 from intrapleural alteplase and 8 from surgical intervention at week 1 (4 pneumonectomies, 1 lobectomy)
  2. bMissing data: 11 from intrapleural alteplase and 8 from surgical intervention at weeks 4–8 (4 pneumonectomies, 1 lobectomy)
  3. cImmediate post-intervention complications: fever, chest pain, bleeding, hypotension