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Table 6 Receiver operator characteristics (ROC) analysis for predicting obstructive sleep apnea and nocturnal hypoxemia

From: Obstructive sleep apnea and nocturnal hypoxemia in adult patients with cystic fibrosis

 

OSA

Nocturnal hypoxemia

 

AUC

p

Cut-off value

Sensitivity (95% CI)

Specificity (95% CI)

AUC

p

Cut-off value

Sensitivity (95% CI)

Specificity (95% CI)

BMI, kg/m2

0.53

0.737

> 21

47.6 (28.3–67.6)

51.6 (34.8–68.0)

0.50

0.983

> 21

46.2 (23.2–70.9)

51.3 (36.2–66.1)

FEV1, % predicted

0.59

0.225

< 49.5

57.1 (36.6–75.5)

64.5 (47.0-79.9)

0.74

0.009

< 49.5

76.9 (49.7–91.8)

66.7 (51.0-79.4)

Awake pO2, mmHg

0.66

0.048

< 78.5

66.7 (45.4–82.8)

71.0 (53.4–84.0)

0.76

0.006

< 78.5

76.9 (49.7–91.8)

66.7 (51.0-79.4)

Age, years

0.58

0.318

> 28.5

66.7 (45.4–82.1)

48.4 (32.0-65.2)

0.65

0.120

> 30.5

61.5 (35.5–82.3)

61.5 (46.0-75.1)

ESS score

0.51

0.888

< 5.5

52.4 (32.4–71.7)

54.8 (37.8–70.9)

0.58

0.404

< 6.5

61.5 (35.5–82.3)

41.0 (27.1–56.6)

Awake SpO2, %

0.62

0.148

< 96.5

66.7 (45.4–82.8)

45.2 (29.2–62.2)

0.71

0.025

< 95.5

61.5 (35.5–82.3)

79.5 (64.5–89.2)

  1. AUC, area under the ROC curve; BMI, body mass index; CI, confidence interval; ESS, Epworth Sleepiness Scale; FEV1, forced expiratory volume in 1 s; OSA, obstructive sleep apnea; pO2, partial pressure of oxygen; SpO2, oxygen saturation
  2. Bold values denote statistical significance at the p < 0.05 level