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Fig. 4 | BMC Pulmonary Medicine

Fig. 4

From: miR-125b-5p upregulation by TRIM28 induces cisplatin resistance in non-small cell lung cancer through CREB1 inhibition

Fig. 4

miR-125b-5p induces resistance to DDP by down-regulating CREB1 expression in NSCLC cells. A CCK8 assay was performed to detect DDP sensitivity in A549 cells upon stimulation with indicated concentrations of DDP (0 μg/mL, 6.25 μg/mL) under the following conditions: a. control mimic + control vector; b. control mimic + CREB1 vector; c. miR-125b-5p mimic + control vector; d. miR-125b-5p mimic + CREB1 vector. B, C Apoptosis analysis in A549 cells following transfection conditions described in A at indicated concentrations of DDP. D CREB1 protein expression was quantified by western blotting for A549/DDP cells following transfection described in A. E CCK8 assay was performed to detect DDP resistance in A549/DDP cells following transfection described in A. F, G Apoptosis analysis in A549/DDP cells following transfection described in A. *p < 0.05, **p < 0.01, ***p < 0.001

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