Fig. 1

Verification of asthma model establishment and analysis of differentially expressed lncRNAs and mRNAs in lung tissues. Asthma model was established in mice (n = 11). A Asthma model establishment was assessed by HE staining and Masson staining. Scale bar = 50 μm. Black arrows indicate inflammatory cell infiltration and collagen deposition. Stars indicate smooth muscle layer, and triangles indicate subepithelial basement membrane, respectively. B Asthma model establishment was evaluated by measuring cytokine levels of IL-4, IL-5, IL-13 and IFN-γ in BALF (bronchoalveolar lavage fluid). C Hierarchical clustering was performed for differentially expressed lncRNAs and mRNAs in lung tissues (n = 3). Red indicates the up-regulated lncRNAs or mRNAs and blue indicates down-regulated lncRNAs or mRNAs. lncRNA = long noncoding RNA. M indicates model group, Z indicates control group. D Scatter plot showing the correlation of mRNAs and lncRNAs between asthma model and control mice