| R5 | R20 | R5-R20 | X5 | AX | Fres | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Value |  ≤ ULN |  > ULN |  ≤ ULN |  > ULN |  ≤ ULN |  > ULN |  ≤ ULN |  > ULN |  ≤ ULN |  > ULN |  ≤ ULN |  > ULN |
Spirometry | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 FEV1, L | 2.30 (0.51) | 1.72 (0.56)* | 2.01 (0.62) | 1.82 (0.56)* | 2.31 (0.51) | 1.74 (0.56)* | 2.28 (0.54) | 1.66 (0.52)* | 2.34 (0.49) | 1.70 (0.55)* | 2.38 (0.49) | 1.74 (0.55)* |
 FEV1, %pred | 83.20 (14.33) | 63.72 (17.47)* | 73.30 (19.34) | 67.43 (17.04)* | 84.21(13.36) | 63.96 (17.58)* | 81.60 (15.12) | 62.61 (17.33)* | 84.23 (13.52) | 63.43 (17.28)* | 85.63(13.19) | 64.73 (17.38)* |
 FVC, L | 3.69 (0.73) | 3.14 (0.73)* | 3.43 (0.78) | 3.21 (0.73)* | 3.69 (0.74) | 3.17 (0.73)* | 3.71 (0.73) | 3.06 (0.67)* | 3.76 (0.70) | 3.11 (0.71)* | 3.77 (0.71) | 3.17 (0.72)* |
 FVC, %pred | 105.11(15.81) | 91.66 (16.40)* | 98.40 (17.77) | 93.94 (16.27) †| 106.15 (15.12) | 91.63 (16.47)* | 104.80 (15.43) | 90.19 (16.23)* | 106.57(15.14) | 90.99 (16.07)* | 107.25 (14.97) | 92.14 (16.41)* |
 FEV1/FVC, L | 62.24 (6.10) | 54.19 (10.42)* | 57.92 (9.64) | 56.26 (10.00) †| 62.72 (5.90) | 54.25 (10.25)* | 61.27 (6.84) | 54.00 (10.67)* | 62.38 (5.93) | 54.25 (10.41)* | 63.18 (5.42) | 54.64 (10.18)* |
 FEF50, %pred | 44.26 (14.45) | 28.69 (13.93)* | 36.10 (16.56) | 32.20 (14.47) †| 45.25 (14.30) | 28.78 (13.73)* | 42.67 (15.20) | 28.04 (13.46)* | 45.08 (14.17) | 28.47 (13.68)* | 46.81 (13.91) | 29.21 (13.72)* |
 FEF75, %pred | 37.09 (14.27) | 28.89 (12.28)* | 32.47 (13.95) | 31.49 (13.15) | 37.61 (14.43) | 28.94 (12.18)* | 36.18 (14.39) | 28.60 (12.02)* | 37.65 (14.65) | 28.69 (11.84)* | 37.95 (14.09) | 29.39 (12.63)* |
 MMEF, %pred | 41.61 (12.79) | 29.04 (12.63)* | 34.85 (14.34) | 32.28 (13.39) †| 42.63 (12.99) | 28.98 (12.15)* | 40.35 (13.41) | 28.49 (12.26)* | 42.46 (12.95) | 28.74 (12.08)* | 43.70 (12.58) | 29.44 (12.36)* |
IOS | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 R5, kPa/L/s | 0.26 (0.23–0.29) | 0.42 (0.37–0.51)* | 0.31 (0.26–0.40) | 0.45 (0.38–0.54)* | 0.27 (0.24–0.32) | 0.41 (0.34–0.50)* | 0.28 (0.24–0.34) | 0.42 (0.36–0.52)* | 0.27 (0.23–0.32) | 0.42 (0.35–0.51)* | 0.27 (0.23–0.32) | 0.40 (0.33–0.49)* |
 R20, kPa/L/s | 0.23 (0.20–0.25) | 0.30 (0.26–0.34)* | 0.25 (0.22–0.27) | 0.33 (0.31–0.38) | 0.25 (0.22–0.30) | 0.27 (0.24–0.32)* | 0.25 (0.22–0.30) | 0.28 (0.25–0.33)* | 0.24 (0.21–0.29) | 0.28 (0.25–0.32)* | 0.25 (0.22–0.30) | 0.27 (0.24–0.32)* |
 R5–R20, kPa/L/s | 0.03 (0.01–0.05) | 0.13 (0.08–0.19)* | 0.06 (0.03–0.13) | 0.10 (0.05–0.18)* | 0.02 (0.01–0.04) | 0.12 (0.08–0.19)* | 0.04 (0.02–0.06) | 0.14 (0.09–0.20)* | 0.03 (0.01–0.04) | 0.13 (0.08–0.19)* | 0.02 (0.01–0.04) | 0.11 (0.07–0.18)* |
 X5, kPa/L/s |  − 0.09 ( − 0.11–0.07) |  − 0.17 ( − 0.24–0.12)* |  − 0.11 ( − 0.17–0.08) |  − 0.16 ( − 0.24–0.10)* |  − 0.09 ( − 0.11–0.07) |  − 0.16 ( − 0.24–0.11)* |  − 0.09 ( − 0.10–0.07) |  − 0.18 ( − 0.25–0.14)* |  − 0.08( − 0.10–0.07) |  − 0.17 ( − 0.24–0.12)* |  − 0.08 ( − 0.10–0.07) |  − 0.15 ( − 0.23–0.11)* |
 AX, kPa/L | 0.24 (0.15–0.40) | 1.27 (0.65–2.27)* | 0.49 (0.22–1.21) | 1.09 (0.42–2.35)* | 0.22 (0.13–0.33) | 1.21 (0.64–2.21)* | 0.25 (0.15–0.41) | 1.48 (0.81–2.37)* | 0.22 (0.14–0.30) | 1.23 (0.70–2.24)* | 0.19 (0.12–0.27) | 1.09 (0.58–2.07)* |
 Fres, HZ | 12.33 (9.63–15.24) | 21.53 (17.62–25.27)* | 16.00 (11.64–21.40) | 20.47 (14.96–26.44)* | 11.39 (9.32–13.74) | 21.43 (17.50–25.03)* | 12.86 (9.80–15.90) | 21.75 (17.96–25.65)* | 11.44 (9.37–13.47) | 21.60 (18.05–25.24)* | 10.66 (9.17–12.81) | 20.91 (16.85–24.75)* |