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Table 2 Percentage change in COPD and asthma prescriptions rates from 2004 to 2020 with 95% CI

From: Trends in hospital admissions and prescribing due to chronic obstructive pulmonary disease and asthma in England and Wales between 1999 and 2020: an ecological study

COPD and asthma medications

Prescriptions rate in 2004 prescriptions per 100,000 persons (95% CI)

Prescriptions rate in 2020 prescriptions per 100,000 persons (95% CI)

% change from 2004 to 2020 (%)

95% confidence interval

Bronchodilators

    

Total

50,132.91 (50,119.50–50,146.31)

56,217.53 (56,204.95–56,230.12)

12.1

11.31–12.96

Adrenoceptor agonists

    

 Total

40,059.54 (40,046.40–40,072.68)

42,624.80 (42,612.25–42,637.34)

6.4

5.78–7.02

 Selective β2 agonists

39,729.43 (39,716.31–39,742.55)

42,619.21 (42,606.67–42,631.75)

7.3

6.64–7.96

 Other adrenoceptor agonists

330.11 (328.57–331.65)

5.59 (5.40–5.78)

− 98.3

− 97.97 to − 98.63

Antimuscarinic bronchodilators

4884.60 (4878.82–4890.38)

9733.11 (9725.60–9740.63)

99.3

99.09–99.51

Theophylline

2098.36 (2094.51–2102.20)

1322.37 (1319.47–1325.26)

− 37.0

− 35.78 to − 38.22

Compound bronchodilator preparations

3090.41 (3085.77–3095.05)

2537.26 (2533.27–2541.24)

− 17.9

16.93–18.87

Inhaled corticosteroids

27,246.10 (27,234.16–27,258.04)

38,216.42 (38,204.09–38,228.74)

40.3

39.06–41.54

Cromoglycate, leukotriene and phosphodiesterase type-4 Inhibitors

    

Total

1366.51 (1363.39–1369.62)

5733.39 (5727.49–5739.29)

319.6

318.42–320.78

Cromoglycate and related therapy

147.11 (146.08–148.14)

16.93 (16.60–17.26)

− 88.5

87.69–89.31

Leukotriene receptor antagonists

1219.40 (1216.45–1222.34)

5707.33 (5701.45–5713.21)

368.0

366.78–369.22

Phosphodiesterase type-4 inhibitors

< 0.01 (0.00–0.01) *In 2011

9.13 (8.89–9.37)

516,325.1 *from 2011

516,323.73–516,326.27