Table 4 Models with the best performance among all tested models
Models | Number (death/total) | AUC (95%CI) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) | HL P-value | |
|---|---|---|---|---|---|---|---|---|---|
Overall | Balanced | ||||||||
Basic and biomarkers’ models | |||||||||
Basic Model | 972/3663 | 0.832 (0.816–0.847) | 55.0 | 90.6 | 67.8 | 84.8 | 81.1 | 72.8 | 0.010 |
INR | 272/668 | 0.842 (0.812–0.873) | 75.7 | 79.8 | 72.0 | 82.7 | 78.1 | 77.8 | 0.982 |
Creatinine | 658/1980 | 0.814 (0.794–0.834) | 56.2 | 87.8 | 69.7 | 80.1 | 77.3 | 72.0 | 0.583 |
TLC | 745/2429 | 0.818 (0.800–0.837) | 54.1 | 88.8 | 68.2 | 81.4 | 78.2 | 71.5 | 0.597 |
PLT | 724/2340 | 0.820 (0.801–0.838) | 53.2 | 88.6 | 67.7 | 80.9 | 77.6 | 70.9 | 0.549 |
HB | 615/1813 | 0.803 (0.782–0.825) | 53.7 | 87.9 | 69.5 | 78.7 | 76.3 | 70.8 | 0.093 |
LDH | 326/1026 | 0.815 (0.787–0.843) | 50.6 | 89.4 | 69.0 | 79.5 | 77.1 | 70.0 | 0.783 |
Troponin | 112/285 | 0.747 (0.689–0.805) | 54.5 | 84.4 | 69.3 | 74.1 | 72.6 | 69.5 | 0.671 |
CRP | 538/1872 | 0.799 (0.777–0.821) | 47.6 | 90.8 | 67.5 | 81.1 | 78.4 | 69.2 | 0.575 |
CK-Total | 205/615 | 0.739 (0.697–0.781) | 42.0 | 87.6 | 62.8 | 75.1 | 72.4 | 64.8 | 0.597 |
CK-MB | 157/435 | 0.729 (0.680–0.777) | 45.2 | 84.2 | 61.7 | 73.1 | 70.1 | 64.7 | 0.975 |
Extra models | |||||||||
Smoking | 972/3663 | 0.832 (0.817–0.847 | 55.0 | 90.6 | 67.9 | 84.8 | 81.2 | 72.8 | 0.029 |
Obesity | 972/3663 | 0.830 (0.814–0.845) | 55.3 | 90.5 | 67.8 | 84.9 | 81.2 | 72.9 | 0.005 |
Haematological disease | 972/3663 | 0.829 (0.814–0.845) | 55.3 | 90.4 | 67.5 | 84.8 | 81.1 | 72.9 | 0.0004 |
Malignancy | 972/3663 | 0.831 (0.816–0.846) | 56.3 | 90.3 | 67.7 | 85.1 | 81.3 | 73.3 | 0.004 |