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Table 4 Univariate regression and multivariate regression for all-cause mortality of hospitalized NCFB patients using Cox proportional hazard model

From: Risk factors and prognostic value of osteoporosis in hospitalized patients with bronchiectasis

Basic clinical characteristics

Survivors (n = 158)

Non-survivors (n = 21)

Unadjusted

Adjusteda

HR (95% CI)

P value

HR (95% CI)

P value

BSI

11 (8, 14)

17 (15, 19)

1.34 (1.20–1.50)

0.001

1.22 (1.05–1.41)

0.008

Sex (male%) (male-ref)

83 (53.53%)

12 (57.14%)

0.82 (0.34–1.94)

0.647

–

–

Current or ex-smokers (%) (non smokers-ref)

62 (39.24%)

9 (42.86%)

1.19 (0.50–2.82)

0.698

–

–

Comorbidities

    

–

–

COPD (%)

49 (31.01%)

7 (33.33%)

1.12 (0.45–2.79)

0.801

–

–

Asthma (%)

16 (10.13%)

1 (4.76%)

0.47 (0.06–3.47)

0.802

–

–

PAH (%)

31 (19.62%)

15 (71.42%)

5.13 (2.13–12.39)

 < 0.001

3.19 (1.18–8.65)

0.022

HT (%)

39 (24.68%)

11 (52.38%)

3.03 (1.28–7.14)

0.011

–

–

Diabetes (%)

19 (12.02%)

5 (23.81%)

2.24 (0.82–6.11)

0.117

–

–

Sinusitis (%)

29 (18.35%)

1 (4.76%)

0.25 (0.03–1.86)

0.175

–

–

GERD (%)

30 (19.00%)

3 (14.29%)

0.70 (0.21–2.36)

0.560

–

–

CVD (%)

28 (17.72%)

13 (61.90%)

6.29 (2.60–15.19)

 < 0.001

2.77 (1.03–7.44)

0.043

Cerebrovascular disease (%)

5 (3.16%)

4 (19.05%)

6.13 (2.05–18.27)

0.001

5.36 (1.62–17.65)

0.006

PVD (%)

9 (5.70%)

0 (0%)

0.05 (0.00–219.42)

0.476

–

–

Kidney disease (%)

9 (5.70%)

2 (9.52%)

1.51 (0.35–6.49)

0.579

–

–

Liver disease (%)

20 (12.66%)

2 (9.52%)

0.79 (0.18–3.39)

0.750

–

–

Anemia (%)

28 (17.72%)

8 (38.10%)

2.71 (1.12–6.54)

0.027

–

–

CTD (%)

13 (8.23%)

2 (9.52%)

1.26 (0.29–5.43)

0.753

–

–

Osteoporosis (%)

27 (17.09%)

11 (52.38%)

5.34 (2.26–12.67)

 < 0.001

4.29 (1.75–10.49)

0.001

Post–infection (non post-infection-ref)

36 (22.78%)

8 (38.10%)

2.06 (0.85–4.97)

0.108

–

–

Macrolides treatment (%)

14 (8.86%)

9 (42.86%)

6.08 (2.56–14.45)

 < 0.001

–

–

  1. Data are presented as frequency (%), mean ± standard deviation, or as median (interquartile range), unless otherwise stated. a: BSI, PAH, HT, CVD, cerebrovascular disease, anemia, osteoporosis, and macrolides treatment showed a significant association with survival (P < 0.05) in the univariate survival analysis and were entered in the multivariate analysis model. Cox proportional hazard regression (method: Forward LR) showed that BSI, PAH, CVD, cerebrovascular disease, and osteoporosis were independently associated with the all-cause mortality of hospitalized NCFB patients
  2. NCFB non-cystic fibrosis bronchiectasis, BSI Bronchiectasis Severity Index, COPD chronic obstructive pulmonary disease, PAH, pulmonary artery hypertension, HT, hypertension, GERD, gastroesophageal reflux disease, CVD, cardiovascular diseases, PVD, peripheral vascular disease, CTD, connective tissue disease, ICS, inhaled corticosteroid, HR, hazard ratio, 95% CI 95% confidence interval
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BMC Pulmonary Medicine

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