Table 2 Characteristics of patients with IPF or CTD-ILD

Male, n (%)

25 (64.1)

12 (37.5)

Age (years)

66 ± 9

62 ± 11

Current smoker, n (%)

8 (20.5)

5 (15.6)

Smoking index

60 (0 ~ 450)

0 (0 ~ 438)

Underlying diseases, n (%)

 Hypertension

18 (46.2)

8 (25.0)

 Diabetes

15 (38.5)

7 (21.9)

 Cardiovascular disease

13 (33.3)

8 (25.0)

 Cerebrovascular disease

4 (10.3)

2 (6.3)

Subtypes of CTD, n (%)

 Rheumatoid arthritis

N/A

10 (31.2)

 Sjogren's syndrome

N/A

9 (28.1)

 Systemic lupus erythematosus

N/A

5 (15.6)

 Dermatomyositis

N/A

2 (6.3)

 Systemic Sclerosis

N/A

2 (6.3)

 Mixed connective tissue disease

N/A

4 (12.5)

Radiologic patterns of ILD, n(%)

 UIP

36 (92.3)

25 (78.1)

 Probable UIP

3 (7.7)

7 (21.9)

Onset of symptoms to hospital admission (days)

60 (30 ~ 120)

63 (19 ~ 321)

Laboratory data at admission

 Lactate (mmol/L)

1.20 (0.90 ~ 1.50)

0.95 (0.80 ~ 1.35)

 White blood cell(× 10⁹/L)

6.8 (6.0 ~ 8.0)

6.9 (5.3 ~ 9.5)

 Neutrophil granulocyte (× 10⁹/L)

3.8 (3.2 ~ 4.8)

4.2 (3.0 ~ 6.5)

 Lymphocyte (× 10⁹/L)

1.9 (1.4 ~ 2.4)

1.6 (1.3 ~ 2.2)

 Haemoglobin (g/L)

135.3 ± 14.7

130.5 ± 17.7

 Platelet (× 10⁹/L)

208 ± 43

227 ± 62

 C-reactive protein (mg/L)

5.0 (1.0 ~ 8.0)

6.0 (5.0 ~ 14.9)

 Procalcitonin (ng/ml)

0.05 (0.05 ~ 0.05)

0.05 (0.05 ~ 0.05)

 ESR (mm/h)

15.0 (6.0 ~ 35.0)

32.5 (10.0 ~ 50.0)

 ALT (U/L)

17.6 (13.0 ~ 23.6)

16.2 (10.6 ~ 20.0)

 AST (U/L)

20.2 (17.0 ~ 26.0)

19.9 (16.5 ~ 23.9)

 Creatinine (umol/L)

72.2 ± 14.0

67.0 ± 12.1

 D-Dimer (mg/L)

0.11 (0.07 ~ 0.23)

0.16 (0.11 ~ 0.39)

Pulmonary function test

 TLC% pred

76.0 (67.2 ~ 82.0)

75.4 (63.8 ~ 80.0)

 FVC% pred

72.1 ± 10.7

72.5 ± 11.2

 DLCO% pred

67.0 ± 12.3

63.2 ± 10.8

Rcn3 level in serum (ng/ml)

2.48 (1.85 ~ 3.65)

3.63 (2.49 ~ 4.84)