Performance of radiomics models derived from different CT reconstruction parameters for lung cancer risk prediction

Table 2 The predictive performance of 15 radiomics models

Models	Training set				Test set				P value*
Models	Accuracy	AUC (95% CI)	Sensitivity	Specificity	Accuracy	AUC (95% CI)	Sensitivity	Specificity	P value*
5SLC + 1	0.767	0.825 (0.756, 0.888)	0.784	0.75	0.644	0.743 (0.607, 0.862)	0.682	0.609	0.1443
5SL + 1	0.757	0.819 (0.745, 0.883)	0.765	0.75	0.644	0.741 (0.611, 0.858)	0.682	0.609	0.3137
5SLC	0.777	0.813 (0.736, 0.883)	0.843	0.712	0.711	0.737 (0.601, 0.859)	0.773	0.652	0.0578
5SC	0.757	0.806 (0.732, 0.874)	0.863	0.654	0.711	0.737 (0.599, 0.860)	0.864	0.565	0.1213
5SL	0.767	0.805 (0.729, 0.873)	0.686	0.846	0.644	0.729 (0.597, 0.852)	0.591	0.696	0.1547
5SC + 1	0.728	0.792 (0.718, 0.862)	0.902	0.558	0.733	0.725 (0.584, 0.849)	0.955	0.522	0.0705
5 L	0.757	0.771 (0.690, 0.847)	0.745	0.769	0.689	0.711 (0.570, 0.840)	0.727	0.652	0.3912
5 L + 1	0.777	0.797 (0.719, 0.867)	0.824	0.731	0.667	0.709 (0.564, 0.840)	0.773	0.565	0.0233
5 S	0.757	0.808 (0.735, 0.877)	0.784	0.731	0.644	0.709 (0.567, 0.830)	0.636	0.652	0.0554
5 S + 1	0.738	0.804 (0.731, 0.871)	0.804	0.673	0.6	0.702 (0.558, 0.826)	0.636	0.565	0.0058
5LC	0.757	0.764 (0.683, 0.840)	0.784	0.731	0.622	0.700 (0.556, 0.830)	0.591	0.652	0.1426
5 C + 1	0.728	0.756 (0.673, 0.831)	0.824	0.635	0.622	0.694 (0.543, 0.828)	0.773	0.478	0.0776
5LC + 1	0.728	0.771 (0.693, 0.845)	0.843	0.615	0.644	0.688 (0.542, 0.819)	0.818	0.478	0.1569
5 C	0.689	0.750 (0.670, 0.827)	0.863	0.519	0.622	0.684 (0.540, 0.814)	0.955	0.304	0.4862
1 mm	0.748	0.771 (0.682, 0.846)	0.804	0.692	0.644	0.674 (0.528, 0.802)	0.682	0.609	0.0389

* The P value was calculated using Hosmer-Lemeshow Test from the test set. When P > 0.05, the model had a high goodness of fit
Abbreviations: AUC, area under the curve; 5 L, 5 mm unenhanced lung window; 5 S, 5 mm unenhanced mediastinal window, 5 C, 5 mm contrast-enhanced mediastinal window; 1 mm, 1 mm unenhanced lung window. Other model symbols were combinations of single-window abbreviations, for example, 5SLC + 1 = 5 mm unenhanced mediastinal window + 5 mm unenhanced lung window + 5 mm contrast-enhanced mediastinal window + 1 mm unenhanced lung window

ISSN: 1471-2466