Fig. 2

Images of lung parameters in two patients. Notes: The first column shows the distribution of emphysema (displayed in blue). The second and third columns illustrate the distribution of voxels corresponding to PRM class (PRM^fSAD voxels in yellow, PRM^Emph voxels in red, and normal voxels in green). The last column shows the tracheobronchial tree generated by three-dimensional reconstruction; a A 61-year old male with reduced MMEF (FEV₁/FVC = 0.84, FEV₁%pred = 91.6%, MMEF%pred = 67.0%). The emphysema index is 5%. PRM^fSAD, PRM^Emph and PRM^Normal are 16%, 4% and 78% respectively. The luminal area of the fifth- and sixth- bronchi are 10.4 mm² and 5.2 mm² respectively; b A 58-year old female with normal pulmonary function (FEV₁/FVC = 0.96, FEV₁%pred = 99.0%, MMEF%pred = 121.1%). The emphysema index is 3%. PRM^fSAD, PRM^Emph and PRM^Normal are 1%, 1% and 97% respectively. The luminal area of the fifth- and sixth- bronchi are 14.3 mm² and 6.6 mm² respectively. PRM, Parametric response mapping; PRM^Emph, emphysema by PRM; RPM^fSAD, functional small airway disease; PRM^Normal, normal lung parenchyma by PRM