The adjusted impact of different severities of acute exacerbations and medications on the risk of developing dementia in COPD patients

Table 4 The adjusted effect of dementia development for different severities of COPD

	Patients who suffered AEs of COPD and were admitted to the ED in the study group (n = 3,451)
Development of dementia during the study period	ED treatment only (n = 2,003)		Hospital admission (n = 1,284)		ICU admission (n = 164)		Controls (n = 51,318)
Development of dementia during the study period	No.	%	No.	%	No.	%	No.	%
Yes	80	4.0	173	13.5	32	19.5	423	0.8
No	1,923	96.0	1,111	86.5	132	80.5	50,895	99.2
Crude hazard ratio^ab (95% CI)	2.11*(1.68–2.65)		8.52*(7.23–10.03)		11.05*(7.77–15.71)		-

^a The crude hazard ratio was calculated by a stratified Cox proportional hazards model (stratified by age, sex, and the year of index hospitalization)
^b Compared with the control group
*p < 0.001

ISSN: 1471-2466