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Fig. 1 | BMC Pulmonary Medicine

Fig. 1

From: Single-cell sequencing analysis fibrosis provides insights into the pathobiological cell types and cytokines of radiation-induced pulmonary fibrosis

Fig. 1

Single-cell RNA-seq analysis of radiation-induced pulmonary fibrosis in rats. SNE of the 19,879 cells analyzed in this study, with each cell color-coded for the associated cell type and the number of transcripts detected in that cell. Canonical correlation analysis was performed in R4.0.3 environment and then visualized via the above-mentioned nearest-neighbor graph, constructed in conjunction with the tSNE method. Cells were clustered using a graph-based shared nearest-neighbor clustering method, using canonical cell markers to label clusters by cell identity as indicated in the graph. Cell types were classified as indicated: (A, B) A t-SNE plot of 19,879 cells isolated from lung tissue, exhibiting 11 identified clusters; (C, D) t-SNE of normal mouse lung tissue; (E, F) t-SNE in lung tissue of RIPF rats

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BMC Pulmonary Medicine

ISSN: 1471-2466

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