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Table 2 Exacerbation frequency of COPD patients according to the severity of airflow limitation based on PB-FEV1

From: COPD exacerbations and patient-reported outcomes according to post-bronchodilator FEV1 – a post-hoc analysis of pooled data

Exacerbation frequency

All COPD patients,

N = 374

Severity of airflow limitation based on PB-FEV1 (% predicted)

p-value

< 30%

30–49%

50–79%

≥ 80%

Number of COPD patients (% of total COPD patients)

85 (22.7)

142 (38.0)

111 (29.7)

36 (9.6)

Total, episodes (mean ± SD, 95% CI)

Moderate, episodes (mean ± SD, 95% CI)

Severe, episodes (mean ± SD, 95% CI)

2.2 ± 4.2;

1.7–2.6

1.4 ± 3.1;

1.1–1.7

0.8 ± 1.5;

0.6–0.9

4.0 ± 7.0;

2.5–5.5

3.0 ± 5.5;

1.8–4.2

1.1 ± 2.0;

0.6–1.5

1.8 ± 2.9;

1.3–2.2

1.0 ± 1.8;

0.7–1.3

0.8 ± 1.4;

0.6–1.0

1.6 ± 2.7;

1.1–2.1

1.0 ± 1.8;

0.6–1.3

0.6 ± 1.3;

0.4–0.9

1.1 ± 1.8;

0.5–1.8

0.7 ± 1.1;

0.3–1.1

0.5 ± 0.8;

0.2–0.8

< 0.001

< 0.001

0.106

  1. Abbreviations: COPD, chronic obstructive pulmonary disease; PB-FEV1, post-bronchodilator forced expiratory volume in one second;
  2. SD, standard deviation; CI, confidence interval