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Table 3 PROs of COPD patients according to the severity of airflow limitation based on PB-FEV1

From: COPD exacerbations and patient-reported outcomes according to post-bronchodilator FEV1 – a post-hoc analysis of pooled data

PROs

All COPD patients,

N = 374

Severity of airflow limitation based on PB-FEV1 (% predicted)

p-value

< 30%

30–49%

50–79%

≥ 80%

Number of COPD patients (% of total COPD patients)

85 (22.7)

142 (38.0)

111 (29.7)

36 (9.6)

mMRC, score (mean ± SD, 95% CI)

1.7 ± 1.3;

1.6–1.9

2.0 ± 1.4;

1.7–2.3

1.8 ± 1.3;

1.6–2.1

1.6 ± 1.1;

1.4–1.8

1.4 ± 1.1;

1.1–1.8

0.053

CAT, total score (mean ± SD, 95% CI)

14.8 ± 10.1;

13.8–15.8

15.7 ± 11.1;

13.3–18.1

14.9 ± 10.1;

13.2–16.5

15.1 ± 9.9;

13.2–17.0

11.6 ± 8.1;

8.9–14.4

0.230

SGRQ-c, % (mean ± SD, 95% CI)

Total

Symptoms

Activities

Impact

40.4 ± 26.0; 37.8–43.1

42.7 ± 26.4; 40.0–45.3

48.6 ± 30.4; 45.5–51.7

34.8 ± 29.4; 31.8–37.8

43.6 ± 29.2; 37.3–49.9

47.0 ± 29.2; 40.7–53.3

53.8 ± 32.5; 46.8–60.8

36.5 ± 32.9; 29.4–43.6

41.3 ± 27.1; 36.8–45.8

44.1 ± 27.8; 39.5–48.8

50.4 ± 32.1; 45.0–55.7

34.9 ± 29.2; 30.1–39.8

39.8 ± 23.7; 35.4–44.3

41.1 ± 22.7; 36.8–45.4

44.5 ± 27.2; 39.4–49.7

36.6 ± 28.8; 31.2–42.0

31.4 ± 18.5; 25.1–37.7

31.8 ± 21.4; 24.6–39.1

42.2 ± 26.1; 33.3–51.0

25.0 ± 21.5; 17.7–32.2

0.121

0.026

0.087

0.192

  1. Abbreviations: PROs, patient-reported outcomes; COPD, chronic obstructive pulmonary disease; PB-FEV1, post-bronchodilator forced expiratory volume in one second; mMRC, modified Medical Research Council; COPD Assessment Tool; SGRQ-c, St George’s Respiratory Questionnaire for COPD; SD, standard deviation; CI, confidence interval