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Table 4 Risk factors for 30 days ICU mortality of patients admitted for SARS with or without COVID-19

From: Dysglycemias in patients admitted to ICUs with severe acute respiratory syndrome due to COVID-19 versus other causes - a cohort study

Factors

Mortality in the overall cohort

OR (95% CI)

p value§

n †

Results #

Diagnosis

Non-COVID-19

30

30 (21.7)

Ref.

 

COVID-19

290

290 (41.3)

2.528 (1.642–3.892)*

< 0.001

Sex

Female

371

144 (38.8)

Ref.

 

Male

470

176 (37.4)

0.911 (0.686–1.211)**

0.522

History of diabetes

No

582

207 (35.6)

Ref.

 

Yes

259

113 (43.6)

1.377 (1.018–1.861)**

0.038

Presumed obesity

No

591

232 (39.3)

Ref.

 

Yes

250

88 (35.2)

0.770 (0.563–1.052)**

0.101

Charlson Comorbidity Index

No death

521

1 (0–1)

  

Death

320

1 (0–2)

1.300 (1.167–1.447)

< 0.001

Age

No death

521

57.6 ± 16.7

  

Death

320

66.7 ± 14.7

1.041 (1.030–1.051)**

< 0.001

APACHE II in the first 24 h

No death

521

10 (6–15)

  

Death

320

19 (12–27)

1.123 (1.101–1.146)**

< 0.001

SOFA scores in the first 24 h

No death

521

3 (2–4)

  

Death

320

6 (3–8)

1.524 (1.423–1.633)**

< 0.001

CRP levels in the first 24 h

No death

518

91.6 (39–156)

  

Death

319

142 (88–219)

1.006 (1.004–1.008)**

< 0.001

Highest glucose level at admission(mg/dL)

No death

520

150.5 (118–199.5)

  

Death

317

180 (136–290)

1.005 (1.004–1.007)**

< 0.001

Highest glucose level during ICU stay (mg/dL)

No death

521

196 (156–294)

  

Death

320

335 (209.5–453.5)

1.006 (1.005–1.007)**

< 0.001

Mean glucose level during ICU stay (mg/dL)

No death

521

133.6 (115.5–166.3)

  

Death

320

178.7 (138.5–226.9)

1.012 (1.009–1.015)**

< 0.001

Mean glucose variability (CV %) during ICU stay

No death

469

23.9 (18.2–33.1)

  

Death

296

35.5 (25.0–46.8)

1.041 (1.030–1.052)

< 0.001

% of days with hyperglycemia

No death

521

17.6 (0–60)

  

Death

320

66.7 (28.6–93.3)

1.018 (1.014–1.022)**

< 0.001

Occurrence of hypoglycemia (< 70 mg/dL) during ICU stay

No

623

197 (31.6)

Ref.

 

Yes

218

123 (56.4)

2.848 (2.065–3.927)

< 0.001

Nosocomial infection

No

672

211 (31.4)

Ref.

 

Yes

169

109 (64.5)

3.841 (2.685–5.493)**

< 0.001

Mean SOFA score during ICU stay

No death

521

2.8 (2–4.1)

  

Death

320

7.6 (6–9.2)

2.786 (2.432–3.192)**

< 0.001

Mean CRP level during ICU stay

No death

518

83.2 (43.9–135.9)

  

Death

319

175.7 (126.9–224.9)

1.018 (1.015–1.020)**

< 0.001

Use of corticosteroids during ICU stay

No

290

95 (32.8)

Ref.

 

Yes

551

225 (40.8)

1.215 (0.891–1.655)**

0.218

  1. Abbreviations: APACHE II, Acute Physiology and Chronic Health Evaluation II; SOFA, Sequential Organ Failure Assessment; CRP, C-reactive protein (mg/L)
  2. †Total number of cases in the row
  3. #Data are expressed as number (percent), mean ± standard deviation, or median (first quartile - third quartile)
  4. *Odds ratio and 95% confidence interval of the generalized linear model with univariate binary logistic distribution for mortality during ICU stay up to 30 days
  5. **Odds ratio and 95% confidence interval of the generalized linear model with binary logistic distribution for mortality during ICU stay up to 30 days, adjusted for the presence of COVID-19 (crude model)
  6. §Wald test p value, p < 0.05 indicates statistical significance
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BMC Pulmonary Medicine

ISSN: 1471-2466

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