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Table 1 Clinical characteristics of asymptomatic,mild and severe patients with COVID-19 on admission

From: Circulating eosinophils associated with responsiveness to COVID-19 vaccine and the disease severity in patients with SARS-CoV-2 omicron variant infection

 

Asymptomatic

N = 705

Mild

N = 286

Severe

N = 166

P Value*Asymptomatic versus mild

P Value*mild

versus severe

Overall

N = 1157(% or IQR)

Clinical characteristics

      

Sex

   

0.292

0.736

 

 Male

365(51.77%)

159(55.59%)

95(57.22%)

  

619(53.50)

 Female

340(48.22%)

127(44.40%)

71(42.77%)

  

538(46.49)

Age

30(21.25, 46.00)

33(24,46)

62(44.50,72.50)

0.783

< 0.001

 

Disease onset time (day)

1.00(1.00,1.00)

1.00(1.00,1.00)

1.50(1.00,6.00)

0.753

< 0.001

 

COVID-19 vaccine

      

 0-dose

121(17.16%)

43(15.03%)

153(92.16%)

0.451

< 0.001

317(27.39)

 1-dose

15(2.12%)

7(2.44%)

1(0.60%)

0.813

0.194

23(1.98)

 2-doses

241(34.18%)

122(42.65%)

6(3.61%)

0.013

< 0.001

369(31.89)

 3-doses

328(46.52%)

114(39.86%)

6(3.61%)

0.057

< 0.001

448(38.72)

Time from last vaccine dose (day)

83(49.00,161.00)

130(56.00,175.00)

86(55.00,153.5.00)

0.06

0.06

 

Comorbidities

      

 Hypertension

64(9.07%)

23(8.04%)

87(52.40%)

0.624

< 0.001

174(15.03)

 Coronary artery disease

18(2.55%)

14(4.89%)

40(24.09%)

0.073

< 0.001

72(6.22)

 Diabetes

30(4.25%)

10(3.49%)

44(26.50%)

0.602

< 0.001

84(7.26)

 COPD

2(0.28%)

3(1.04%)

14(8.43%)

0.148

0.012

19(1.64)

 Cerebrovascular disease

11(1.56%)

3(1.04%)

43(25.90%)

0.58

< 0.001

57(4.92)

 Chronic renal disease

7(0.99%)

2(0.69%)

14(8.43%)

0.737

< 0.001

23(1.98)

 Malignant tumor

9(1.27%)

4(1.39%)

19(11.44%)

1

0.004

32(2.76)

 Rheumatic disease

4(0.56%)

1(0.34%)

2(1.20%)

1

0.39

7(0.60)

Symptoms

      

Fever

 

132(46.20%)

48(28.91%)

 

0.005

180(15.55)

Cough

 

168(58.70%)

62(37.34%)

 

0.002

230(19.87)

Shortness of breath

 

0

12(7.22%)

 

< 0.001

12(1.03)

Fatigue

 

29(10.10%)

12(7.22%)

 

0.299

41(3.54)

Nausea or vomiting

 

2(0.70%)

6(3.61%)

 

0.023

8(0.69)

Diarrhea

 

3(1.00%)

2(1.20%)

 

0.882

5(0.43)

Sore throat

 

91(31.80%)

5(3.01%)

 

< 0.001

96(8.29)

Laboratory findings

      

WBC (10^9/L)

4.80(3.92,6.31)

4.68(4.06,6.85)

6.71(4.72,9.60)

0.582

< 0.001

5.39 (4.23,7.59)

EOS (10^9/L)

0.06(0.02,0.13)

0.05(0.01,0.09)

0.01(0.00,0.03)

0.065

< 0.001

0.04 (0.01,0.08)

Neutrophils (10^9/L)

2.59(1.94, 3.66)

2.87(1.97,4.31)

4.74(3.03,7.76)

0.873

< 0.001

3.40 (2.31,5.24)

Lymphocytes (10^9/L)

1.47(1.00,1.47)

1.56(0.75,2.14)

0.84(0.53,1.29)

0.319

< 0.001

1.29 (0.76,1.63)

Monocytes (10^9/L)

0.51(0.39,0.66)

0.55(0.39, 0.7)

0.50(0.35,0.75)

0.042

0.772

0.52 (0.38,0.70)

CRP (mg/L)

1.96(0.40,3.92)

2.68(0.90,3.25)

30.85(6.21,76.53)

0.782

< 0.001

14.92(2.50,27.90)

D-Dimer(ug/ml)

0.23(0.18, 0.34)

0.49(0.30,0.71)

1.42(0.93,2.84)

0.096

< 0.001

0.71 (0.47,1.30)

NLR

1.82(1.18, 2.84)

2.16(1.24, 3.65)

5.23 (2.74,11.92)

0.231

< 0.001

3.07 (1.72,6.14)

CD4 (cell/ul)

 

720.50(553.59, 943.25)

292.52(178.60,482.76)

 

< 0.001

366.09(366.09,713.01)

CD8 (cell/ul)

 

458.50(360.75, 609.00)

156.00(87.88,342.32)

 

< 0.001

307.25(224.32,475.66)

CD4/CD8

 

720.50(553.59, 943.25)

292.52(178.60,482.76)

 

0.074

506.51(366.10,713.01)

Outcome

      

 HFNO

0

0

40(24.10%)

  

40(3.45)

 Mechanical ventilation

0

0

126(75.90%)

  

126(10.89)

 Death

0

0

69(41.57%)

  

69(5.96)

  1. Data are presented as median (IQR) or n (%). p values comparing the group of asymptomatic and mild patients are from χ² test or Mann-Whitney U test. EOS, Eosinophils. NLR, Neutrophil-to-Lymphocyte Ratio