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Asthma and allergic disorders

Section edited by Joerg Mattes

This section concerns all aspects of asthma and allergic disorders including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Benralizumab is a monoclonal antibody that binds to the human interleukin-5 (IL-5) receptor (IL-5R), thereby preventing IL-5 from binding to its receptor and inhibiting differentiation and maturation of eosino...

    Authors: A. Padilla-Galo, RCh Levy-Abitbol, C. Olveira, B. Valencia Azcona, M. Pérez Morales, F. Rivas-Ruiz, B. Tortajada-Goitia, I. Moya-Carmona and A. Levy-Naon

    Citation: BMC Pulmonary Medicine 2020 20:184

    Content type: Research article

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  2. Asthma patients experience impairments in health-related quality of life (HRQL). Interventions are available to improve HRQL. EQ-5D-5L is a common generic tool used to evaluate health interventions. However, t...

    Authors: Boglárka L. Szentes, Konrad Schultz, Dennis Nowak, Michael Schuler and Larissa Schwarzkopf

    Citation: BMC Pulmonary Medicine 2020 20:168

    Content type: Research article

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  3. Asthma is a complex syndrome with multiple domains including symptoms, lung function, asthma control, and airway inflammation. A study of Fenom PRO™, a novel monitor for exhaled nitric oxide (FeNO), provided a...

    Authors: Philip E. Silkoff, Mark Sarno, Solomon Ssenyange, Vivek Balasubramanyam, Brian Awabdy and Ryan Leard

    Citation: BMC Pulmonary Medicine 2020 20:139

    Content type: Research article

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  4. Surprisingly little is known about asthma control among asthmatics who smoke. The aim of this cross-sectional study was to investigate asthma symptom control according to the GINA guidelines among asthmatics w...

    Authors: Toni Kiljander, Tuija Poussa, Timo Helin, Antero Jaakkola, Kari Venho and Lauri Lehtimäki

    Citation: BMC Pulmonary Medicine 2020 20:88

    Content type: Research article

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  5. The 12-week, multicentre, observational INITIAL study (NCT02143739) assessed asthma severity in newly diagnosed Chinese patients.

    Authors: Jiangtao Lin, Xiuhua Fu, Ping Jiang, Weidong Song, Xiaoyun Hu, Zhijun Jie, Chuntao Liu, Zhengguang He, Xiangdong Zhou and Huaping Tang

    Citation: BMC Pulmonary Medicine 2020 20:87

    Content type: Research article

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  6. The Asthma Control Test (ACT) has been used to assess asthma control in both clinical trials and clinical practice. However, the relationships between ACT score and other measures of asthma impact are not full...

    Authors: Bas C. P. van Dijk, Henrik Svedsater, Andreas Heddini, Linda Nelsen, Janita S. Balradj and Cathelijne Alleman

    Citation: BMC Pulmonary Medicine 2020 20:79

    Content type: Research article

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  7. Paracetamol and ibuprofen are the most commonly used medications for fever and pain management in children. While the efficacy appears similar with both drugs, there are contradictory findings related to adver...

    Authors: Mohamed Sherbash, Luis Furuya-Kanamori, Joanne Daghfal Nader and Lukman Thalib

    Citation: BMC Pulmonary Medicine 2020 20:72

    Content type: Research article

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  8. Chronic cough has an important impact on physical, social and psychological aspects. A simple and effective method to assess different aspects of chronic cough severity is required. We aimed to develop a simpl...

    Authors: Wenzhi Zhan, Liting Zhang, Mei Jiang, Meihua Chen, Xiaoling Yuan, Jianxin Sun, Pusheng Xu, Feng Wu, Chunlai Zhang, Wei Luo, Xiaomei Chen, Hu Li and Kefang Lai

    Citation: BMC Pulmonary Medicine 2020 20:68

    Content type: Research article

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  9. Uncontrolled severe asthma in children is burdensome and challenging to manage. This study aims to describe outcomes in children with uncontrolled severe asthma managed in a nurse-led severe asthma clinic (SAC).

    Authors: Patricia de Gouveia Belinelo, Aleisha Nielsen, Bernadette Goddard, Lauren Platt, Carla Rebeca Da Silva Sena, Paul D. Robinson, Bruce Whitehead, Jodi Hilton, Tanya Gulliver, Laurence Roddick, Kasey Pearce, Vanessa E. Murphy, Peter G. Gibson, Adam Collison and Joerg Mattes

    Citation: BMC Pulmonary Medicine 2020 20:66

    Content type: Research article

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  10. Asthma is one of the conditions that contributes to the global burden of respiratory diseases and has been previously associated with diet intake. The goal of this study was to determine the relationship betwe...

    Authors: Carla E. Tarazona-Meza, Corrine Hanson, Suzanne L. Pollard, Karina M. Romero Rivero, Rocio M. Galvez Davila, Sameera Talegawkar, Carlos Rojas, Jessica L. Rice, William Checkley and Nadia N. Hansel

    Citation: BMC Pulmonary Medicine 2020 20:63

    Content type: Research article

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  11. Asthma is one of the chronic diseases which affects the airway, and inhalers are the preferred medications to treat this problem. Improper inhalational technique leads to decreased efficacy of the medication b...

    Authors: Tadesse Melaku Abegaz, Efrata Ashuro Shegena, Natnael Fentie Gessie, Eyob Alemayehu Gebreyohannes and Mohammed Assen Seid

    Citation: BMC Pulmonary Medicine 2020 20:48

    Content type: Research article

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    The Correction to this article has been published in BMC Pulmonary Medicine 2020 20:95

  12. Onset of allergic asthma has a strong association with childhood but only a few studies have analyzed incidence of asthma from childhood to late adulthood in relation to allergy. The purpose of the study was t...

    Authors: Johanna Pakkasela, Pinja Ilmarinen, Jasmin Honkamäki, Leena E. Tuomisto, Heidi Andersén, Päivi Piirilä, Hanna Hisinger-Mölkänen, Anssi Sovijärvi, Helena Backman, Bo Lundbäck, Eva Rönmark, Hannu Kankaanranta and Lauri Lehtimäki

    Citation: BMC Pulmonary Medicine 2020 20:9

    Content type: Research article

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  13. The dose-response relationship of inhaled corticosteroid (ICS)/fast-onset long acting beta agonist (LABA) reliever therapy has not been formally addressed. The objective of this retrospective analysis is to as...

    Authors: Richard Beasley, James Harper, Grace Bird, Harriette Dunphy, Alex Semprini, Ian D. Pavord, Alberto Papi and Mark Weatherall

    Citation: BMC Pulmonary Medicine 2019 19:264

    Content type: Research article

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  14. Although the impact of asthma education on important outcomes (e.g. emergency visits) has been well established, only an estimated quarter of asthma patients in Germany have received patient education yet. The...

    Authors: Oxana Atmann, Klaus Linde, Christoph Werner, Ulrike Dorn and Antonius Schneider

    Citation: BMC Pulmonary Medicine 2019 19:256

    Content type: Research article

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  15. Pneumonia is an important cause of morbidity and mortality. COPD patients using inhaled corticosteroids (ICS) have an increased risk of pneumonia, but less is known about whether ICS treatment in asthma also i...

    Authors: Emil Ekbom, Jennifer Quint, Linus Schöler, Andrei Malinovschi, Karl Franklin, Mathias Holm, Kjell Torén, Eva Lindberg, Deborah Jarvis and Christer Janson

    Citation: BMC Pulmonary Medicine 2019 19:254

    Content type: Research article

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  16. The diagnostic criteria for asthma-chronic obstructive pulmonary disease overlap have not been unified. Different studies have used different criteria, and this has led to diagnostic inconsistencies.

    Authors: Wenjing Ye, Xiaoming Li, Wen Gu, Xuejun Guo, Fengfeng Han and Song Liu

    Citation: BMC Pulmonary Medicine 2019 19:249

    Content type: Research article

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  17. Quantifying the effects of personal health behaviors and environmental exposure on asthma flare-ups is a challenge. Most studies have focused on monitoring the symptoms and drug usage for relieving symptoms. I...

    Authors: Ta-Chien Chan, Tsuey-Hwa Hu, Yen-Hua Chu and Jing-Shiang Hwang

    Citation: BMC Pulmonary Medicine 2019 19:231

    Content type: Research article

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  18. The dysfunction of airway epithelial barrier is closely related to the pathogenesis of asthma. Secreted Hsp90α participates in inflammation and Hsp90 inhibitor protects endothelial dysfunction. In the current ...

    Authors: Cuiping Ye, Chaowen Huang, Mengchen Zou, Yahui Hu, Lishan Luo, Yilan Wei, Xuan Wan, Haijin Zhao, Wei Li, Shaoxi Cai and Hangming Dong

    Citation: BMC Pulmonary Medicine 2019 19:218

    Content type: Research article

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  19. The published data on the association between β2-adrenergic receptor gene polymorphisms and asthma susceptibility are inconclusive. To derive a more precise estimation of this association, a meta-analysis was ...

    Authors: Songlin Zhao, Wei Zhang and Xiuhong Nie

    Citation: BMC Pulmonary Medicine 2019 19:202

    Content type: Research article

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  20. Patient awareness of asthma severity is important for optimal asthma management. However, there is often a discrepancy between physician assessment of asthma control based on guidelines and patient discernment...

    Authors: Tewodros H. Gebremariam, Charles B. Sherman and Neil W. Schluger

    Citation: BMC Pulmonary Medicine 2019 19:187

    Content type: Research article

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  21. Several major randomized control studies have demonstrated that mepolizumab, an anti-IL-5 monoclonal antibody, is effective for patients with severe eosinophilic asthma who show exacerbation or require systemi...

    Authors: Takanori Numata, Katsutoshi Nakayama, Hirofumi Utsumi, Kenji Kobayashi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Shunsuke Minagawa, Takeo Ishikawa, Hiromichi Hara, Jun Araya and Kazuyoshi Kuwano

    Citation: BMC Pulmonary Medicine 2019 19:176

    Content type: Research article

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  22. Asthma is an extensive public health problem and inadequate disease control is not uncommon. Individuals’ self-perceived barriers to medical treatment for the entire treatment chain (from seeking care for symp...

    Authors: Tove Hedenrud, Annika Jakobsson, Hanan El Malla and Helle Håkonsen

    Citation: BMC Pulmonary Medicine 2019 19:175

    Content type: Research article

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  23. Severe non-allergic eosinophilic asthma (SNEA) is a rare asthma phenotype associated with severe clinical course, frequent exacerbations, and resistance to therapy, including high steroid doses. The key featur...

    Authors: Virginija Kalinauskaite-Zukauske, Andrius Januskevicius, Ieva Janulaityte, Skaidrius Miliauskas and Kestutis Malakauskas

    Citation: BMC Pulmonary Medicine 2019 19:158

    Content type: Research article

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  24. Asthma is a heterogeneous disease and understanding this heterogeneity will enable the realisation of precision medicine. We sought to compare the sputum and serum inflammatory profiles in moderate-to-severe a...

    Authors: Michael A. Ghebre, Pee Hwee Pang, Dhananjay Desai, Beverley Hargadon, Chris Newby, Joanne Woods, Laura Rapley, Suzanne E. Cohen, Athula Herath, Erol A. Gaillard, Richard D. May and Chris E. Brightling

    Citation: BMC Pulmonary Medicine 2019 19:144

    Content type: Research article

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  25. Chest computed tomography (CT) scans have a recognised role in investigating adults with severe asthma to exclude alternative diagnoses, but its role in children is less clear. The objective of this study was ...

    Authors: David Lo, Amit Maniyar, Sumit Gupta and Erol Gaillard

    Citation: BMC Pulmonary Medicine 2019 19:136

    Content type: Research article

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  26. To investigate the effect of asthma rehabilitation at high altitude (3100 m, HA) compared to low altitude (760 m, LA).

    Authors: Stéphanie Saxer, Simon R. Schneider, Paula Appenzeller, Patrick R. Bader, Mona Lichtblau, Michael Furian, Ulan Sheraliev, Bermet Estebesova, Berik Emilov, Talant Sooronbaev, Konrad E. Bloch and Silvia Ulrich

    Citation: BMC Pulmonary Medicine 2019 19:134

    Content type: Research article

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  27. Tralokinumab is an anti–interleukin (IL)-13 monoclonal antibody investigated for the treatment of severe, uncontrolled asthma in two Phase III clinical trials, STRATOS 1 and 2. The STRATOS 1 biomarker analysis...

    Authors: Mattis Gottlow, David J. Svensson, Ilya Lipkovich, Monika Huhn, Karin Bowen, Peter Wessman and Gene Colice

    Citation: BMC Pulmonary Medicine 2019 19:129

    Content type: Technical advance

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  28. In Latin America, there is scarce information about severe asthma (SA) according to the ERS/ATS 2014 criteria. This study aimed to compare the demographic, socio, clinical characteristics, treatment, and use o...

    Authors: Hugo Neffen, Felipe Moraes, Karynna Viana, Valentina Di Boscio, Gur Levy, Claudia Vieira, Gabriela Abreu and Claudia Soares

    Citation: BMC Pulmonary Medicine 2019 19:123

    Content type: Research article

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  29. Asthma is a chronic disease affecting 30 million people in Europe under 45y. Poor control of Asthma is the main cause of emergency-department (ED) access, becoming the strongest determinant of the economic bur...

    Authors: Laura Losappio, Enrico Heffler, Rossella Carpentiere, Monica Fornero, Cosimo Damiano Cannito, Francesco Guerrera, Francesca Puggioni, Riccardo Monti, Stefania Nicola, Giovanni Rolla and Luisa Brussino

    Citation: BMC Pulmonary Medicine 2019 19:107

    Content type: Research article

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  30. Asthma is now widely recognised to be a heterogeneous disease. The last two decades have seen the identification of a number of biological targets and development of various novel therapies. Despite this, asth...

    Authors: Adnan Azim, Heena Mistry, Anna Freeman, Clair Barber, Colin Newell, Kerry Gove, Yvette Thirlwall, Matt Harvey, Kimberley Bentley, Deborah Knight, Karen Long, Frances Mitchell, Yueqing Cheng, Judit Varkonyi-Sepp, Wolfgang Grabau, Paddy Dennison…

    Citation: BMC Pulmonary Medicine 2019 19:99

    Content type: Study protocol

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  31. Physical activity is an important part of life, and hence exercise-induced bronchoconstriction (EIB) can reduce the quality of life. A standardized test is needed to diagnose EIB. The American Thoracic Society...

    Authors: Melanie Dreßler, Theresa Friedrich, Natali Lasowski, Eva Herrmann, Stefan Zielen and Johannes Schulze

    Citation: BMC Pulmonary Medicine 2019 19:94

    Content type: Research article

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  32. Asthma is a syndrome composed of heterogeneous disease entities. Although it is agreed that proper asthma endo-typing and appropriate type-specific interventions are crucial in the management of asthma, little...

    Authors: Dong In Suh, Dae Jin Song, Hey-Sung Baek, Meeyong Shin, Young Yoo, Ji-Won Kwon, Gwang Cheon Jang, Hyeon-Jong Yang, Eun Lee, Hwan Soo Kim, Ju-Hee Seo, Sung-Il Woo, Hyung Young Kim, Youn Ho Shin, Ju Suk Lee, Jisun Yoon…

    Citation: BMC Pulmonary Medicine 2019 19:64

    Content type: Study protocol

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  33. Although there are theoretical reasons for believing that asthma and atopy may be negatively correlated with tuberculosis, epidemiological studies have had conflicting findings.

    Authors: Anthony L. Byrne, Ben J. Marais, Carole D. Mitnick, Frances L. Garden, Leonid Lecca, Carmen Contreras, Yaninna Yauri, Fanny Garcia and Guy B. Marks

    Citation: BMC Pulmonary Medicine 2019 19:40

    Content type: Research article

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  34. Bronchial provocation is often used to confirm asthma. Dyspnea sensation, however, associates poorly with the evoked drop in FEV1. Provocation tests only use the large airways parameter FEV1, although dyspnea is ...

    Authors: Claire A. Cox, Ilse M. Boudewijn, Sebastiaan J. Vroegop, Siebrig Schokker, Anne J. Lexmond, Henderik W. Frijlink, Paul Hagedoorn, Judith M. Vonk, Martijn P. Farenhorst, Nick H. T. ten Hacken, Huib A. M. Kerstjens and Maarten van den Berge

    Citation: BMC Pulmonary Medicine 2019 19:23

    Content type: Research article

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  35. Inhibition of interleukin (IL)-13, a Type 2 inflammatory mediator in asthma, improves lung function and reduces exacerbations; however, more effective therapies are needed. A subset of asthma patients also exh...

    Authors: Tracy L. Staton, Kun Peng, Ryan Owen, David F. Choy, Christopher R. Cabanski, Alice Fong, Flavia Brunstein, Kathila R. Alatsis and Hubert Chen

    Citation: BMC Pulmonary Medicine 2019 19:5

    Content type: Research article

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  36. In randomized controlled trials, bronchial thermoplasty (BT) has been proven to reduce symptoms in severe asthma, but the mechanisms by which this is achieved are uncertain as most studies have shown no improv...

    Authors: David Langton, Alvin Ing, Kim Bennetts, Wei Wang, Claude Farah, Matthew Peters, Virginia Plummer and Francis Thien

    Citation: BMC Pulmonary Medicine 2018 18:155

    Content type: Research article

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  37. The aim of this investigation was to study change in adults over a 20 year period in the prevalence of respiratory symptoms and disorders and its association to year of birth, life style and sleep related vari...

    Authors: Christer Janson, Ane Johannessen, Karl Franklin, Cecilie Svanes, Linus Schiöler, Andrei Malinovschi, Thorarinn Gislason, Bryndis Benediktsdottir, Vivi Schlünssen, Rain Jõgi, Deborah Jarvis and Eva Lindberg

    Citation: BMC Pulmonary Medicine 2018 18:152

    Content type: Research article

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  38. Asthma and wheezing disorders in childhood and adulthood are clinically heterogeneous regarding disease presentation, natural course, and response to treatment. Deciphering common disease mechanisms in distinc...

    Authors: Oliver Fuchs, Thomas Bahmer, Markus Weckmann, Anna-Maria Dittrich, Bianca Schaub, Barbara Rösler, Christine Happle, Folke Brinkmann, Isabell Ricklefs, Inke R. König, Henrik Watz, Klaus F. Rabe, Matthias V. Kopp, Gesine Hansen and Erika von Mutius

    Citation: BMC Pulmonary Medicine 2018 18:140

    Content type: Study protocol

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    The Correction to this article has been published in BMC Pulmonary Medicine 2018 18:165

  39. Vitamin D deficiency has been linked to an increased risk of asthma. This study aimed to quantify the effect of early life vitamin D status on asthma and wheeze later in life.

    Authors: Song-Ying Shen, Wan-Qing Xiao, Jin-Hua Lu, Ming-Yang Yuan, Jian-Rong He, Hui-Min Xia, Xiu Qiu, Kar Keung Cheng and Kin Bong Hubert Lam

    Citation: BMC Pulmonary Medicine 2018 18:120

    Content type: Research article

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  40. Interleukin-5 (IL-5) antibodies represent a promising therapeutic option for patients with severe eosinophilic asthma. To date, no official treatment response criteria exist. In this study, simple criteria for...

    Authors: Nora Drick, Benjamin Seeliger, Tobias Welte, Jan Fuge and Hendrik Suhling

    Citation: BMC Pulmonary Medicine 2018 18:119

    Content type: Research article

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  41. Sputum induction is an important noninvasive method for analyzing bronchial inflammation in patients with asthma and other respiratory diseases. Most frequently, ultrasonic nebulizers are used for sputum induc...

    Authors: Sinem Koc-Günel, Ralf Schubert, Stefan Zielen and Martin Rosewich

    Citation: BMC Pulmonary Medicine 2018 18:115

    Content type: Research article

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  42. The natural history of airway inflammation and symptoms in occupations at risk of asthma is still not fully understood. We aimed to study the evolution during apprenticeship of inflammation markers, bronchial ...

    Authors: Valérie Demange, Denis Zmirou-Navier, Abraham Bohadana and Pascal Wild

    Citation: BMC Pulmonary Medicine 2018 18:113

    Content type: Research article

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  43. Multiple factors are involved in asthma exacerbations, including environmental exposure and viral infections. We aimed to assess the association between severe asthma exacerbations, acute respiratory viral inf...

    Authors: Lusmaia Damaceno Camargo Costa, Paulo Augusto Moreira Camargos, Paul L. P. Brand, Fabíola Souza Fiaccadori, Menira Borges de Lima Dias e Souza, Divina das Dôres de Paula Cardoso, Ítalo de Araújo Castro, Ruth Minamisava and Paulo Sérgio Sucasas da Costa

    Citation: BMC Pulmonary Medicine 2018 18:109

    Content type: Research article

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