Asthma and allergic disorders

Section edited by Joerg Mattes

This section concerns all aspects of asthma and allergic disorders including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Research article

    Patient preferences for dry powder inhaler attributes in asthma and chronic obstructive pulmonary disease in France: a discrete choice experiment

    Dry powder inhalers (DPIs) are often used in asthma and chronic obstructive pulmonary disease (COPD) therapies. Using the discrete choice experiment (DCE) methodology, this study conducted in France was design...

    Natalia Hawken, Saku Torvinen, Mohamed-Elmoctar Neine, Ikbel Amri, Mondher Toumi, Samuel Aballéa, Adam Plich and Nicolas Roche

    BMC Pulmonary Medicine 2017 17:99

    Published on: 6 July 2017

  2. Research article

    Epithelial ciliated beating cells essential for ex vivo ALI culture growth

    Bronchial epithelium plays a key role in orchestrating innate and adaptive immunity. The fate of ex vivo airway epithelial cultures growing at the air liquid interface (ALI) derived from human endobronchial bi...

    Delphine Gras, Aurélie Petit, Jérémy Charriot, Lucie Knabe, Khuder Alagha, Anne Sophie Gamez, Céline Garulli, Arnaud Bourdin, Pascal Chanez, Nicolas Molinari and Isabelle Vachier

    BMC Pulmonary Medicine 2017 17:80

    Published on: 3 May 2017

  3. Research article

    Predictive factors for moderate or severe exacerbations in asthma patients receiving outpatient care

    Asthma exacerbations are important events that affect disease control, but predictive factors for severe or moderate exacerbations are not known. The objective was to study the predictive factors for moderate ...

    Francisco Javier Álvarez Gutiérrez, Marta Ferrer Galván, Juan Francisco Medina Gallardo, Marta Barrera Mancera, Beatriz Romero Romero and Auxiliadora Romero Falcón

    BMC Pulmonary Medicine 2017 17:77

    Published on: 2 May 2017

  4. Research article

    Asthma control using fluticasone propionate/salmeterol in Asian and non-Asian populations: a post hoc analysis of the GOAL study

    To analyse the efficacy of fluticasone propionate (FP) alone and combined with salmeterol (SAL) in achieving guideline-defined asthma control in Asian patients.

    Jean Bousquet, Neil Barnes, Michael Gibbs, Nadeem Gul, Susan A Tomkins, Xin Zhou, Young-Joo Cho, Hae-Sim Park, William Busse and Nanshan Zhong

    BMC Pulmonary Medicine 2017 17:75

    Published on: 28 April 2017

  5. Research article

    Efficacy of budesonide/formoterol maintenance and reliever therapy compared with higher-dose budesonide as step-up from low-dose inhaled corticosteroid treatment

    Asthma management may involve a step up in treatment when symptoms are not well controlled. We examined whether budesonide/formoterol maintenance and reliever therapy (MRT) is as effective as higher, fixed-dos...

    Christine R. Jenkins, Göran Eriksson, Eric D. Bateman, Helen K. Reddel, Malcolm R. Sears, Magnus Lindberg and Paul M. O’Byrne

    BMC Pulmonary Medicine 2017 17:65

    Published on: 20 April 2017

  6. Research article

    Obstructive sleep apnoea accelerates FEV1 decline in asthmatic patients

    Although the prevalence of both obstructive sleep apnoea (OSA) and asthma are both increasing, little is known about the impact of OSA on the natural history of lung function in asthmatic patients.

    Tsai-Yu Wang, Yu-Lun Lo, Shu-Min Lin, Chien-Da Huang, Fu-Tasi Chung, Horng-Chyuan Lin, Chun-Hua Wang and Han-Pin Kuo

    BMC Pulmonary Medicine 2017 17:55

    Published on: 21 March 2017

  7. Study protocol

    Effectiveness of pulmonary rehabilitation for patients with asthma: study protocol of a randomized controlled trial (EPRA)

    Asthma patients are enrolled in multimodal pulmonary rehabilitation (PR) programs. However, available data for the effectiveness of PR in asthma are sparse. Therefore, the primary aim of this randomized contro...

    Konrad Schultz, Hildegard Seidl, Danijel Jelusic, Rupert Wagner, Michael Wittmann, Hermann Faller, Dennis Nowak and Michael Schuler

    BMC Pulmonary Medicine 2017 17:49

    Published on: 9 March 2017

  8. Research article

    Predictors of correct technique in patients using pressurized metered dose inhalers

    Correct inhaler technique is recommended by guidelines for optimum asthma care. The objective of the study is to determine real life predictors of correct pressurized metered dose inhaler (pMDI) technique in A...

    Kyra Bartolo, Martin Balzan, Emma Louise Schembri, Rachelle Asciak, Darlene Mercieca Balbi, Michael Pace Bardon and Stephen Montefort

    BMC Pulmonary Medicine 2017 17:47

    Published on: 28 February 2017

  9. Research article

    Persistent asthma phenotype related with late-onset, high atopy, and low socioeconomic status in school-aged Korean children

    Treatment guidelines for asthma have been established based on asthma severity; there are limitations in the identification of underlying pathophysiology and prediction of prognosis in heterogeneous phenotypes...

    Eun Lee, Si Hyeon Lee, Ji-Won Kwon, Young-Ho Kim, Jisun Yoon, Hyun-Ju Cho, Song-I Yang, Young-Ho Jung, Hyung Young Kim, Ju-Hee Seo, Hyo Bin Kim, So Yeon Lee, Ho-Jang Kwon and Soo-Jong Hong

    BMC Pulmonary Medicine 2017 17:45

    Published on: 23 February 2017

  10. Research article

    Effect of inhaled corticosteroid particle size on asthma efficacy and safety outcomes: a systematic literature review and meta-analysis

    Inhaled corticosteroids (ICS) are the primary treatment for persistent asthma. Currently available ICS have differing particle size due to both formulation and propellant, and it has been postulated that this ...

    Céline El Baou, Rachael L. Di Santostefano, Rafael Alfonso-Cristancho, Elizabeth A Suarez, David Stempel, Mark L Everard and Neil Barnes

    BMC Pulmonary Medicine 2017 17:31

    Published on: 7 February 2017

  11. Research article

    Epigenetic modifying enzyme expression in asthmatic airway epithelial cells and fibroblasts

    Recognition of the airway epithelium as a central mediator in the pathogenesis of asthma has necessitated greater understanding of the aberrant cellular mechanisms of the epithelium in asthma. The architecture...

    Dorota Stefanowicz, Jari Ullah, Kevin Lee, Furquan Shaheen, Ekiomoado Olumese, Nick Fishbane, Hyun-Kyoung Koo, Teal S. Hallstrand, Darryl A. Knight and Tillie-Louise Hackett

    BMC Pulmonary Medicine 2017 17:24

    Published on: 31 January 2017

  12. Research article

    What patients really think about asthma guidelines: barriers to guideline implementation from the patients’ perspective

    Treatment of asthma does not always comply with asthma guidelines (AG). This may be rooted in direct or indirect resistance on the doctors’ and/or patients’ side or be caused by the healthcare system. To asses...

    H. Lingner, B. Burger, P. Kardos, C. P. Criée, H. Worth and E. Hummers-Pradier

    BMC Pulmonary Medicine 2017 17:13

    Published on: 11 January 2017

  13. Research article

    High strength extrafine pMDI beclometasone/formoterol (200/6 μg) is effective in asthma patients not adequately controlled on medium-high dose of inhaled corticosteroids

    A high strength of beclomethasone/formoterol fumarate (BDP/FF) in a pressurised metered dose inhaler (pMDI), which contains extrafine BDP (200 μg/actuation) and FF (6 μg/actuation) has been developed to treat tho...

    Pierluigi Paggiaro, Massimo Corradi, Manuela Latorre, Helene Raptis, Annamaria Muraro, Christian Gessner, Zenon Siergiejko, Mario Scuri and Stefano Petruzzelli

    BMC Pulmonary Medicine 2016 16:180

    Published on: 9 December 2016

  14. Research article

    Can severe asthmatic patients achieve asthma control? A systematic approach in patients with difficult to control asthma followed in a specialized clinic

    Despite advances in asthma treatment, severe asthma (SA) still results in high morbidity and use of health resources. Our hypothesis was that SA patients would achieve adequate control with a systematic protoc...

    Rodrigo Athanazio, Regina Carvalho-Pinto, Frederico Leon Arrabal Fernandes, Samia Rached, Klaus Rabe, Alberto Cukier and Rafael Stelmach

    BMC Pulmonary Medicine 2016 16:153

    Published on: 16 November 2016

  15. Research article

    Impact of occupational exposures on exacerbation of asthma: a population-based asthma cohort study

    Asthma is a prevalent chronic disease and occupation contributes to approximately 15 % of cases among adults. However, there are still few studies on risk factors for work-exacerbated asthma. The current study...

    Jeong-Lim Kim, Paul K. Henneberger, Susanna Lohman, Anna-Carin Olin, Anna Dahlman-Höglund, Eva Andersson, Kjell Torén and Mathias Holm

    BMC Pulmonary Medicine 2016 16:148

    Published on: 15 November 2016

  16. Research article

    Drop-out rate among patients treated with omalizumab for severe asthma: Literature review and real-life experience

    In patients with asthma, particularly severe asthma, poor adherence to inhaled drugs negatively affects the achievement of disease control. A better adherence rate is expected in the case of injected drugs, su...

    M. Caminati, G. Senna, G. Stefanizzi, R. Bellamoli, S. Longhi, F. Chieco-Bianchi, G. Guarnieri, S. Tognella, M. Olivieri, C. Micheletto, G. Festi, E. Bertocco, M. Mazza, A. Rossi and A. Vianello

    BMC Pulmonary Medicine 2016 16:128

    Published on: 25 August 2016

  17. Research article

    Changes in symptoms of asthma and rhinitis by sensitization status over ten years in a cohort of young Chilean adults

    We investigated the net changes in prevalence of symptoms of asthma and rhinitis over 10 years in a cohort of young by baseline sensitization status.

    Vanessa Garcia-Larsen, James F. Potts, Stefano Del Giacco, Patricia Bustos, Patricia V. Diaz, Hugo Amigo, Manuel Oyarzun and Roberto J. Rona

    BMC Pulmonary Medicine 2016 16:116

    Published on: 8 August 2016

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