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Asthma and allergic disorders

Section edited by Joerg Mattes

This section concerns all aspects of asthma and allergic disorders including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Content type: Technical advance

    Tralokinumab is an anti–interleukin (IL)-13 monoclonal antibody investigated for the treatment of severe, uncontrolled asthma in two Phase III clinical trials, STRATOS 1 and 2. The STRATOS 1 biomarker analysis...

    Authors: Mattis Gottlow, David J. Svensson, Ilya Lipkovich, Monika Huhn, Karin Bowen, Peter Wessman and Gene Colice

    Citation: BMC Pulmonary Medicine 2019 19:129

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  2. Content type: Research article

    In Latin America, there is scarce information about severe asthma (SA) according to the ERS/ATS 2014 criteria. This study aimed to compare the demographic, socio, clinical characteristics, treatment, and use o...

    Authors: Hugo Neffen, Felipe Moraes, Karynna Viana, Valentina Di Boscio, Gur Levy, Claudia Vieira, Gabriela Abreu and Claudia Soares

    Citation: BMC Pulmonary Medicine 2019 19:123

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  3. Content type: Research article

    Asthma is a chronic disease affecting 30 million people in Europe under 45y. Poor control of Asthma is the main cause of emergency-department (ED) access, becoming the strongest determinant of the economic bur...

    Authors: Laura Losappio, Enrico Heffler, Rossella Carpentiere, Monica Fornero, Cosimo Damiano Cannito, Francesco Guerrera, Francesca Puggioni, Riccardo Monti, Stefania Nicola, Giovanni Rolla and Luisa Brussino

    Citation: BMC Pulmonary Medicine 2019 19:107

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  4. Content type: Study protocol

    Asthma is now widely recognised to be a heterogeneous disease. The last two decades have seen the identification of a number of biological targets and development of various novel therapies. Despite this, asth...

    Authors: Adnan Azim, Heena Mistry, Anna Freeman, Clair Barber, Colin Newell, Kerry Gove, Yvette Thirlwall, Matt Harvey, Kimberley Bentley, Deborah Knight, Karen Long, Frances Mitchell, Yueqing Cheng, Judit Varkonyi-Sepp, Wolfgang Grabau, Paddy Dennison…

    Citation: BMC Pulmonary Medicine 2019 19:99

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  5. Content type: Research article

    Physical activity is an important part of life, and hence exercise-induced bronchoconstriction (EIB) can reduce the quality of life. A standardized test is needed to diagnose EIB. The American Thoracic Society...

    Authors: Melanie Dreßler, Theresa Friedrich, Natali Lasowski, Eva Herrmann, Stefan Zielen and Johannes Schulze

    Citation: BMC Pulmonary Medicine 2019 19:94

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  6. Content type: Study protocol

    Asthma is a syndrome composed of heterogeneous disease entities. Although it is agreed that proper asthma endo-typing and appropriate type-specific interventions are crucial in the management of asthma, little...

    Authors: Dong In Suh, Dae Jin Song, Hey-Sung Baek, Meeyong Shin, Young Yoo, Ji-Won Kwon, Gwang Cheon Jang, Hyeon-Jong Yang, Eun Lee, Hwan Soo Kim, Ju-Hee Seo, Sung-Il Woo, Hyung Young Kim, Youn Ho Shin, Ju Suk Lee, Jisun Yoon…

    Citation: BMC Pulmonary Medicine 2019 19:64

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  7. Content type: Research article

    Although there are theoretical reasons for believing that asthma and atopy may be negatively correlated with tuberculosis, epidemiological studies have had conflicting findings.

    Authors: Anthony L. Byrne, Ben J. Marais, Carole D. Mitnick, Frances L. Garden, Leonid Lecca, Carmen Contreras, Yaninna Yauri, Fanny Garcia and Guy B. Marks

    Citation: BMC Pulmonary Medicine 2019 19:40

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  8. Content type: Research article

    Bronchial provocation is often used to confirm asthma. Dyspnea sensation, however, associates poorly with the evoked drop in FEV1. Provocation tests only use the large airways parameter FEV1, although dyspnea is ...

    Authors: Claire A. Cox, Ilse M. Boudewijn, Sebastiaan J. Vroegop, Siebrig Schokker, Anne J. Lexmond, Henderik W. Frijlink, Paul Hagedoorn, Judith M. Vonk, Martijn P. Farenhorst, Nick H. T. ten Hacken, Huib A. M. Kerstjens and Maarten van den Berge

    Citation: BMC Pulmonary Medicine 2019 19:23

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  9. Content type: Research article

    Inhibition of interleukin (IL)-13, a Type 2 inflammatory mediator in asthma, improves lung function and reduces exacerbations; however, more effective therapies are needed. A subset of asthma patients also exh...

    Authors: Tracy L. Staton, Kun Peng, Ryan Owen, David F. Choy, Christopher R. Cabanski, Alice Fong, Flavia Brunstein, Kathila R. Alatsis and Hubert Chen

    Citation: BMC Pulmonary Medicine 2019 19:5

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  10. Content type: Research article

    In randomized controlled trials, bronchial thermoplasty (BT) has been proven to reduce symptoms in severe asthma, but the mechanisms by which this is achieved are uncertain as most studies have shown no improv...

    Authors: David Langton, Alvin Ing, Kim Bennetts, Wei Wang, Claude Farah, Matthew Peters, Virginia Plummer and Francis Thien

    Citation: BMC Pulmonary Medicine 2018 18:155

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  11. Content type: Research article

    The aim of this investigation was to study change in adults over a 20 year period in the prevalence of respiratory symptoms and disorders and its association to year of birth, life style and sleep related vari...

    Authors: Christer Janson, Ane Johannessen, Karl Franklin, Cecilie Svanes, Linus Schiöler, Andrei Malinovschi, Thorarinn Gislason, Bryndis Benediktsdottir, Vivi Schlünssen, Rain Jõgi, Deborah Jarvis and Eva Lindberg

    Citation: BMC Pulmonary Medicine 2018 18:152

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  12. Content type: Study protocol

    Asthma and wheezing disorders in childhood and adulthood are clinically heterogeneous regarding disease presentation, natural course, and response to treatment. Deciphering common disease mechanisms in distinc...

    Authors: Oliver Fuchs, Thomas Bahmer, Markus Weckmann, Anna-Maria Dittrich, Bianca Schaub, Barbara Rösler, Christine Happle, Folke Brinkmann, Isabell Ricklefs, Inke R. König, Henrik Watz, Klaus F. Rabe, Matthias V. Kopp, Gesine Hansen and Erika von Mutius

    Citation: BMC Pulmonary Medicine 2018 18:140

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    The Correction to this article has been published in BMC Pulmonary Medicine 2018 18:165

  13. Content type: Research article

    Vitamin D deficiency has been linked to an increased risk of asthma. This study aimed to quantify the effect of early life vitamin D status on asthma and wheeze later in life.

    Authors: Song-Ying Shen, Wan-Qing Xiao, Jin-Hua Lu, Ming-Yang Yuan, Jian-Rong He, Hui-Min Xia, Xiu Qiu, Kar Keung Cheng and Kin Bong Hubert Lam

    Citation: BMC Pulmonary Medicine 2018 18:120

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  14. Content type: Research article

    Interleukin-5 (IL-5) antibodies represent a promising therapeutic option for patients with severe eosinophilic asthma. To date, no official treatment response criteria exist. In this study, simple criteria for...

    Authors: Nora Drick, Benjamin Seeliger, Tobias Welte, Jan Fuge and Hendrik Suhling

    Citation: BMC Pulmonary Medicine 2018 18:119

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  15. Content type: Research article

    Sputum induction is an important noninvasive method for analyzing bronchial inflammation in patients with asthma and other respiratory diseases. Most frequently, ultrasonic nebulizers are used for sputum induc...

    Authors: Sinem Koc-Günel, Ralf Schubert, Stefan Zielen and Martin Rosewich

    Citation: BMC Pulmonary Medicine 2018 18:115

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  16. Content type: Research article

    The natural history of airway inflammation and symptoms in occupations at risk of asthma is still not fully understood. We aimed to study the evolution during apprenticeship of inflammation markers, bronchial ...

    Authors: Valérie Demange, Denis Zmirou-Navier, Abraham Bohadana and Pascal Wild

    Citation: BMC Pulmonary Medicine 2018 18:113

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  17. Content type: Research article

    Multiple factors are involved in asthma exacerbations, including environmental exposure and viral infections. We aimed to assess the association between severe asthma exacerbations, acute respiratory viral inf...

    Authors: Lusmaia Damaceno Camargo Costa, Paulo Augusto Moreira Camargos, Paul L. P. Brand, Fabíola Souza Fiaccadori, Menira Borges de Lima Dias e Souza, Divina das Dôres de Paula Cardoso, Ítalo de Araújo Castro, Ruth Minamisava and Paulo Sérgio Sucasas da Costa

    Citation: BMC Pulmonary Medicine 2018 18:109

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  18. Content type: Research article

    Incorrect inhaler technique is a common cause of poor asthma control. This two-phase pragmatic study evaluated inhaler technique mastery and maintenance of mastery with DuoResp® (budesonide-formoterol [BF]) Sp...

    Authors: David B. Price, Vicky Thomas, P. N. Richard Dekhuijzen, Sinthia Bosnic-Anticevich, Nicolas Roche, Federico Lavorini, Priyanka Raju, Daryl Freeman, Carole Nicholls, Iain R. Small, Erika Sims, Guilherme Safioti, Janice Canvin and Henry Chrystyn

    Citation: BMC Pulmonary Medicine 2018 18:107

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  19. Content type: Research article

    An increasing number of studies using primary human bronchial epithelial cells (BECs) have reported intrinsic differences in the expression of several genes between cells from asthmatic and non-asthmatic donor...

    Authors: Stephen R. Reeves, Kaitlyn A. Barrow, Maria P. White, Lucille M. Rich, Maryam Naushab and Jason S. Debley

    Citation: BMC Pulmonary Medicine 2018 18:91

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  20. Content type: Research article

    Asthma is a common chronic respiratory disease leading to morbidity, mortality and impaired quality of life worldwide. Information on asthma prevalence in the Middle East is fragmented and relatively out-dated...

    Authors: Hesham Tarraf, Omur Aydin, Dilsad Mungan, Mohammad Albader, Bassam Mahboub, Adam Doble, Aaicha Lahlou, Luqman Tariq, Fayaz Aziz and Abdelkader El Hasnaoui

    Citation: BMC Pulmonary Medicine 2018 18:68

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  21. Content type: Research article

    Although pre-puberty asthma is more prevalent in males, after puberty through middle-age, asthma is more prevalent in females. The surge of sex hormones with puberty might explain this gender switch.

    Authors: Mark D. DeBoer, Brenda R. Phillips, David T. Mauger, Joe Zein, Serpil C. Erzurum, Anne M. Fitzpatrick, Benjamin M. Gaston, Ross Myers, Kristie R. Ross, James Chmiel, Min Jie Lee, John V. Fahy, Michael Peters, Ngoc P. Ly, Sally E. Wenzel, Merritt L. Fajt…

    Citation: BMC Pulmonary Medicine 2018 18:58

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  22. Content type: Case report

    Allergic bronchopulmonary aspergillosis (ABPA) is an allergic pulmonary disease comprising a complex hypersensitivity reaction to Aspergillus fumigatus. Clinical features of ABPA are wheezing, mucoid impaction, a...

    Authors: Takeshi Terashima, Taro Shinozaki, Eri Iwami, Takahiro Nakajima and Tatsu Matsuzaki

    Citation: BMC Pulmonary Medicine 2018 18:53

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  23. Content type: Case report

    Mortality related to asthma has decreased worldwide since the introduction of inhaled corticosteroid therapy in the past decades. However, there are still some asthma fatalities identified mainly in population...

    Authors: Thais Mauad, Felipe B. P. do Nascimento, Marisa Dolhnikoff, Milena C. M. Picka and Paulo H. N. Saldiva

    Citation: BMC Pulmonary Medicine 2018 18:50

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  24. Content type: Research article

    Thus far, no algorithms have been developed to automatically extract patients who meet Asthma Predictive Index (API) criteria from the Electronic health records (EHR) yet. Our objective is to develop and valid...

    Authors: Harsheen Kaur, Sunghwan Sohn, Chung-Il Wi, Euijung Ryu, Miguel A. Park, Kay Bachman, Hirohito Kita, Ivana Croghan, Jose A. Castro-Rodriguez, Gretchen A. Voge, Hongfang Liu and Young J. Juhn

    Citation: BMC Pulmonary Medicine 2018 18:34

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  25. Content type: Research article

    Bronchial thermoplasty (BT) is a non-pharmacological intervention for severe asthma whose mechanism of action is not completely explained by a reduction of airway smooth muscle (ASM). In this study we analyzed...

    Authors: N. Facciolongo, A. Di Stefano, V. Pietrini, C. Galeone, F. Bellanova, F. Menzella, N. Scichilone, R. Piro, G. L. Bajocchi, B. Balbi, L. Agostini, P. P. Salsi, D. Formisano and M. Lusuardi

    Citation: BMC Pulmonary Medicine 2018 18:29

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  26. Content type: Research article

    Postoperative pulmonary complications (PPC) in patients with pulmonary diseases remain to be resolved clinical issue. However, most evidence regarding PPC has been established more than 10 years ago. Therefore...

    Authors: Takanori Numata, Katsutoshi Nakayama, Satoko Fujii, Yoko Yumino, Nayuta Saito, Masahiro Yoshida, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hiroshi Wakui, Shunsuke Minagawa, Takeo Ishikawa, Hiromichi Hara…

    Citation: BMC Pulmonary Medicine 2018 18:4

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  27. Content type: Research article

    Annexin-A1 (ANXA1) is a glucocorticoid-induced protein with multiple actions in the regulation of inflammatory cell activation. The anti-inflammatory protein ANXA1 and its N-formyl peptide receptor 2 (FPR2) ha...

    Authors: Sun-Hye Lee, Pureun-Haneul Lee, Byeong-Gon Kim, Hyun-Jeong Seo, Ae-Rin Baek, Jong-Sook Park, June-Hyuk Lee, Sung-Woo Park, Do-Jin Kim, Choon-Sik Park and An-Soo Jang

    Citation: BMC Pulmonary Medicine 2018 18:1

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  28. Content type: Research article

    We previously reported that the ILVBL gene on chromosome 19p13.1 was associated with the risk for aspirin-exacerbated respiratory disease (AERD) and the percent decline of forced expired volume in one second (FEV...

    Authors: Hun Soo Chang, Jong Sook Park, Ho Sung Lee, Jiwon Lyu, Ji-Hye Son, Inseon S. Choi, Hyoung Doo Shin and Choon-Sik Park

    Citation: BMC Pulmonary Medicine 2017 17:210

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  29. Content type: Research article

    Previous studies have indicated that chitinase 3-like 1 (CHI3L1) gene rs4950928 polymorphism and acidic mammalian chitinase (AMCase or CHIA) gene rs10494132 polymorphism are associated with the risk of asthma....

    Authors: Yanting Zhu, Xin Yan, Cui Zhai, Lan Yang and Manxiang Li

    Citation: BMC Pulmonary Medicine 2017 17:193

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  30. Content type: Research article

    Gene expression changes in the structural cells of the airways are thought to play a role in the development of asthma and airway hyperresponsiveness. This includes changes to smooth muscle contractile machine...

    Authors: Christopher D. Pascoe, Ma’en Obeidat, Bryna A. Arsenault, Yunlong Nie, Stephanie Warner, Dorota Stefanowicz, Samuel J. Wadsworth, Jeremy A. Hirota, S. Jasemine Yang, Delbert R. Dorscheid, Chris Carlsten, Tillie L. Hackett, Chun Y. Seow and Peter D. Paré

    Citation: BMC Pulmonary Medicine 2017 17:189

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  31. Content type: Research article

    Inhaled corticosteroids are recommended as the first-line controller medication for childhood asthma owing to their multiple clinical benefits. However, heterogeneity in the response towards these drugs remain...

    Authors: Yi-Fan Wu, Ming-Wei Su, Bor-Luen Chiang, Yao-Hsu Yang, Ching-Hui Tsai and Yungling L. Lee

    Citation: BMC Pulmonary Medicine 2017 17:176

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  32. Content type: Research article

    Asthma inflammatory phenotypes are often defined by relative cell counts of airway eosinophils/neutrophils. However, the importance of neutrophilia remains unclear, as does the effect of ICS treatment on asthm...

    Authors: Collin R. Brooks, Christine J. Van Dalen, Elizabeth Harding, Ian F. Hermans and Jeroen Douwes

    Citation: BMC Pulmonary Medicine 2017 17:169

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  33. Content type: Research article

    Despite recognition of asthma as a growing global issue and development of global guidelines, asthma treatment practices vary between countries. Several studies have reported patients’ perspectives on asthma c...

    Authors: Kenneth R. Chapman, David Hinds, Peter Piazza, Chantal Raherison, Michael Gibbs, Timm Greulich, Kenneth Gaalswyk, Jiangtao Lin, Mitsuru Adachi and Kourtney J. Davis

    Citation: BMC Pulmonary Medicine 2017 17:153

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  34. Content type: Research article

    Respiratory tract infection is a major cause of acute exacerbation of bronchial asthma (AEBA). Although recent findings suggest that common bacteria are causally associated with AEBA, a comprehensive epidemiol...

    Authors: Yutaka Yoshii, Kenichiro Shimizu, Miyuki Morozumi, Naoko Chiba, Kimiko Ubukata, Hironori Uruga, Shigeo Hanada, Hiroshi Wakui, Shunsuke Minagawa, Hiromichi Hara, Takanori Numata, Keisuke Saito, Jun Araya, Katsutoshi Nakayama, Kazuma Kishi and Kazuyoshi Kuwano

    Citation: BMC Pulmonary Medicine 2017 17:150

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  35. Content type: Research article

    Over one million children receive treatment for asthma in the UK. South Asian children experience excess morbidity and higher rates of hospitalization than the White population. This study aimed to explore per...

    Authors: Monica Lakhanpaul, Lorraine Culley, Noelle Robertson, Deborah Bird, Nicky Hudson, Narynder Johal, Melanie McFeeters, Emma Angell, Charlotte Hamlyn-Williams, Nadine Abbas, Logan Manikam and Mark Johnson

    Citation: BMC Pulmonary Medicine 2017 17:126

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  36. Content type: Research article

    Dry powder inhalers (DPIs) are often used in asthma and chronic obstructive pulmonary disease (COPD) therapies. Using the discrete choice experiment (DCE) methodology, this study conducted in France was design...

    Authors: Natalia Hawken, Saku Torvinen, Mohamed-Elmoctar Neine, Ikbel Amri, Mondher Toumi, Samuel Aballéa, Adam Plich and Nicolas Roche

    Citation: BMC Pulmonary Medicine 2017 17:99

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  37. Content type: Research article

    Bronchial epithelium plays a key role in orchestrating innate and adaptive immunity. The fate of ex vivo airway epithelial cultures growing at the air liquid interface (ALI) derived from human endobronchial bi...

    Authors: Delphine Gras, Aurélie Petit, Jérémy Charriot, Lucie Knabe, Khuder Alagha, Anne Sophie Gamez, Céline Garulli, Arnaud Bourdin, Pascal Chanez, Nicolas Molinari and Isabelle Vachier

    Citation: BMC Pulmonary Medicine 2017 17:80

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  38. Content type: Research article

    Asthma exacerbations are important events that affect disease control, but predictive factors for severe or moderate exacerbations are not known. The objective was to study the predictive factors for moderate ...

    Authors: Francisco Javier Álvarez Gutiérrez, Marta Ferrer Galván, Juan Francisco Medina Gallardo, Marta Barrera Mancera, Beatriz Romero Romero and Auxiliadora Romero Falcón

    Citation: BMC Pulmonary Medicine 2017 17:77

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  39. Content type: Research article

    To analyse the efficacy of fluticasone propionate (FP) alone and combined with salmeterol (SAL) in achieving guideline-defined asthma control in Asian patients.

    Authors: Jean Bousquet, Neil Barnes, Michael Gibbs, Nadeem Gul, Susan A Tomkins, Xin Zhou, Young-Joo Cho, Hae-Sim Park, William Busse and Nanshan Zhong

    Citation: BMC Pulmonary Medicine 2017 17:75

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  40. Content type: Research article

    Asthma exacerbations are frequent in patients with severe disease. This report describes results from two retrospective cohort studies describing exacerbation frequency and risk, emergency department (ED)/hosp...

    Authors: Robert Y. Suruki, Jonas B. Daugherty, Nada Boudiaf and Frank C. Albers

    Citation: BMC Pulmonary Medicine 2017 17:74

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  41. Content type: Research article

    Asthma management may involve a step up in treatment when symptoms are not well controlled. We examined whether budesonide/formoterol maintenance and reliever therapy (MRT) is as effective as higher, fixed-dos...

    Authors: Christine R. Jenkins, Göran Eriksson, Eric D. Bateman, Helen K. Reddel, Malcolm R. Sears, Magnus Lindberg and Paul M. O’Byrne

    Citation: BMC Pulmonary Medicine 2017 17:65

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  42. Content type: Research article

    Although the prevalence of both obstructive sleep apnoea (OSA) and asthma are both increasing, little is known about the impact of OSA on the natural history of lung function in asthmatic patients.

    Authors: Tsai-Yu Wang, Yu-Lun Lo, Shu-Min Lin, Chien-Da Huang, Fu-Tasi Chung, Horng-Chyuan Lin, Chun-Hua Wang and Han-Pin Kuo

    Citation: BMC Pulmonary Medicine 2017 17:55

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  43. Content type: Study protocol

    Asthma patients are enrolled in multimodal pulmonary rehabilitation (PR) programs. However, available data for the effectiveness of PR in asthma are sparse. Therefore, the primary aim of this randomized contro...

    Authors: Konrad Schultz, Hildegard Seidl, Danijel Jelusic, Rupert Wagner, Michael Wittmann, Hermann Faller, Dennis Nowak and Michael Schuler

    Citation: BMC Pulmonary Medicine 2017 17:49

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  44. Content type: Research article

    Correct inhaler technique is recommended by guidelines for optimum asthma care. The objective of the study is to determine real life predictors of correct pressurized metered dose inhaler (pMDI) technique in A...

    Authors: Kyra Bartolo, Martin Balzan, Emma Louise Schembri, Rachelle Asciak, Darlene Mercieca Balbi, Michael Pace Bardon and Stephen Montefort

    Citation: BMC Pulmonary Medicine 2017 17:47

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