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Asthma and allergic disorders

This section concerns all aspects of asthma and allergic disorders including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Nonpharmacologic interventions for asthma management rely on identification and mitigation of important asthma triggers. Cockroach exposure is strongly associated with asthma morbidity. It is also associated w...

    Authors: Felicia A. Rabito, Derek Werthmann, Hua He, Aubrey S. Madkour, Whitney D. Arroyave, Michelle L. Sever and Thomas A. LaVeist

    Citation: BMC Pulmonary Medicine 2021 21:83

    Content type: Research article

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  2. Inflammation caused by chronic lung disease in childhood may lead to delayed heart rate recovery (HRR) however, there is lack of evidence on HRR in this population. The aim was to assess HRR after functional ...

    Authors: Élida Pereira Silva, Bruno Alvarenga Soares, Mariana M. Reimberg, Raphael Ritti-Dias, Karina Silva Nascimento, Fabiana Silvia Anjos, Gustavo Falbo Wandalsen, Dirceu Solé, Simone Dal Corso and Fernanda Cordoba Lanza

    Citation: BMC Pulmonary Medicine 2021 21:61

    Content type: Research article

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  3. Asthma and osteoarthritis (OA) are medical conditions that inhibit physical activity and adversely affect quality of life. Despite the high prevalence, there are limited studies focusing on the comorbid condit...

    Authors: Hyeon-Kyoung Koo, Pamela Song and Joo-Hyun Lee

    Citation: BMC Pulmonary Medicine 2021 21:59

    Content type: Research article

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  5. Persistent allergic airway diseases cause a great burden worldwide. Their pathogenesis is not clear enough. There is evidence that one of the recently described cytokine interleukin (IL) 22 may be involved in ...

    Authors: Laura Tamasauskiene, Vilte Marija Gintauskiene, Daina Bastyte and Brigita Sitkauskiene

    Citation: BMC Pulmonary Medicine 2021 21:36

    Content type: Research article

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  6. Eosinophilic granulomatosis with polyangiitis (EGPA) is a disease that is associated with severe uncontrolled eosinophilic asthma. Eosinophils play an important pathogenic role in the development of both disea...

    Authors: Carlos Martínez-Rivera, Ignasi Garcia-Olivé, Blanca Urrutia-Royo, Maria Basagaña-Torrento, Antoni Rosell and Jorge Abad

    Citation: BMC Pulmonary Medicine 2021 21:35

    Content type: Case report

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  7. Salbutamol-induced lactic acidosis is a rare presentation that could manifest in specific clinical context as acute asthmatic attack treatment. An increase of glycolysis pathway leading to pyruvate escalation ...

    Authors: Vorakamol Phoophiboon, Parima Singhagowinta, Sangdao Boonkaya and Thitiwat Sriprasart

    Citation: BMC Pulmonary Medicine 2021 21:23

    Content type: Case report

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  8. Spontaneous pneumothorax is a common problem globally. Bullas and blebs have been implicated in this problem, but the etiology of their formation is unknown. We aim to show the relation between a novel clinica...

    Authors: Akira Iyoda, Yoko Azuma, Takashi Sakai, Satoshi Koezuka, Hajime Otsuka and Atsushi Sano

    Citation: BMC Pulmonary Medicine 2021 21:20

    Content type: Research article

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  9. A once-daily (o.d.) fixed-dose combination of indacaterol acetate (IND), glycopyrronium bromide (GLY), and mometasone furoate (MF) delivered via the Breezhaler® device (IND/GLY/MF) is being developed for treatmen...

    Authors: Satoru Inoue, Soniya Vaidya, Hanns-Christian Tillmann, Yohei Sakita, Surendra Machineni, Olivier Heudi and Kenichi Furihata

    Citation: BMC Pulmonary Medicine 2021 21:18

    Content type: Research article

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  10. Fungal infections are rarely reported as a complication of bronchial thermoplasty (BT) in patients without immunosuppressive comorbidity.

    Authors: Shinji Sasada, Kenshiro Ohmura, Tomoyo Oguri, Yutaro Fujimoto, Saori Murata, Yumi Tsuchiya, Kota Ishioka, Saeko Takahashi, Morio Nakamura and Masahiro Kaji

    Citation: BMC Pulmonary Medicine 2020 20:312

    Content type: Case report

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  11. As a main line of defense of the respiratory tract, the airway epithelium plays an important role in the pathogenesis of asthma. CDHR3 and EMSY were reported to be expressed in the human airway epithelium. Althou...

    Authors: Miaomiao Zhang, Guo Chen, Yu Wang, Shou-Quan Wu, Andrew J. Sandford and Jian-Qing He

    Citation: BMC Pulmonary Medicine 2020 20:305

    Content type: Research article

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  12. Asthma is a common chronic lung disease in children. We aimed to determine the associations between stress-induced phosphoprotein 1 (STIP1) and glucocorticoid-induced transcript 1 (GLCCI1) polymorphisms and susce...

    Authors: Juan Huang, Xiaolei Hu, Xiangrong Zheng, Jian Kuang, Chentao Liu, Xia Wang and Yongjun Tang

    Citation: BMC Pulmonary Medicine 2020 20:303

    Content type: Research article

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  13. Severe asthma is a chronic disease contributing to disproportionate disease morbidity and mortality. From the year of 2007, many genome-wide association studies (GWAS) have documented a large number of asthma-...

    Authors: Zhouzhou Dong, Yunlong Ma, Hua Zhou, Linhui Shi, Gongjie Ye, Lei Yang, Panpan Liu and Li Zhou

    Citation: BMC Pulmonary Medicine 2020 20:270

    Content type: Research article

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  14. Pulmonary rehabilitation offers potential benefits to people with asthma. It is however unknown if rehabilitation favourably affects patients’ health care needs. We therefore examined if rehabilitation reduced...

    Authors: Julia Salandi, Andrea Icks, Jalal Gholami, Stefan Hummel, Konrad Schultz, Christian Apfelbacher, Aziz Sheikh and Adrian Loerbroks

    Citation: BMC Pulmonary Medicine 2020 20:267

    Content type: Research article

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  15. Severe asthma is a complex heterogeneous disease typically requiring advanced therapies. Underlying the treatment of all asthma, however, is the consistent recommendation across international guidelines to ens...

    Authors: J. Michael Ramsahai, Emily King, Robert Niven, Gael Tavernier, Peter A. B. Wark and Jodie L. Simpson

    Citation: BMC Pulmonary Medicine 2020 20:228

    Content type: Research article

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  16. Inhalation therapy is the backbone of asthma and COPD control. However, inhaler adherence and device mishandling continue to be a problem in real life. Some studies have shown that using a patient-preferred in...

    Authors: Jens Schreiber, Tina Sonnenburg and Eva Luecke

    Citation: BMC Pulmonary Medicine 2020 20:222

    Content type: Research article

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  18. Benralizumab, an anti-interleukin-5 (IL-5) receptor α monoclonal antibody, significantly reduces the number of annual exacerbations and oral corticosteroid (OCS) maintenance doses for patients with severe eosi...

    Authors: Takanori Numata, Hanae Miyagawa, Saiko Nishioka, Keitaro Okuda, Hirofumi Utsumi, Mitsuo Hashimoto, Shunsuke Minagawa, Takeo Ishikawa, Hiromichi Hara, Jun Araya and Kazuyoshi Kuwano

    Citation: BMC Pulmonary Medicine 2020 20:207

    Content type: Research article

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  19. Benralizumab is a monoclonal antibody that binds to the human interleukin-5 (IL-5) receptor (IL-5R), thereby preventing IL-5 from binding to its receptor and inhibiting differentiation and maturation of eosino...

    Authors: A. Padilla-Galo, RCh Levy-Abitbol, C. Olveira, B. Valencia Azcona, M. Pérez Morales, F. Rivas-Ruiz, B. Tortajada-Goitia, I. Moya-Carmona and A. Levy-Naon

    Citation: BMC Pulmonary Medicine 2020 20:184

    Content type: Research article

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  20. Asthma patients experience impairments in health-related quality of life (HRQL). Interventions are available to improve HRQL. EQ-5D-5L is a common generic tool used to evaluate health interventions. However, t...

    Authors: Boglárka L. Szentes, Konrad Schultz, Dennis Nowak, Michael Schuler and Larissa Schwarzkopf

    Citation: BMC Pulmonary Medicine 2020 20:168

    Content type: Research article

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  21. Asthma is a complex syndrome with multiple domains including symptoms, lung function, asthma control, and airway inflammation. A study of Fenom PRO™, a novel monitor for exhaled nitric oxide (FeNO), provided a...

    Authors: Philip E. Silkoff, Mark Sarno, Solomon Ssenyange, Vivek Balasubramanyam, Brian Awabdy and Ryan Leard

    Citation: BMC Pulmonary Medicine 2020 20:139

    Content type: Research article

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  23. Surprisingly little is known about asthma control among asthmatics who smoke. The aim of this cross-sectional study was to investigate asthma symptom control according to the GINA guidelines among asthmatics w...

    Authors: Toni Kiljander, Tuija Poussa, Timo Helin, Antero Jaakkola, Kari Venho and Lauri Lehtimäki

    Citation: BMC Pulmonary Medicine 2020 20:88

    Content type: Research article

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  24. The 12-week, multicentre, observational INITIAL study (NCT02143739) assessed asthma severity in newly diagnosed Chinese patients.

    Authors: Jiangtao Lin, Xiuhua Fu, Ping Jiang, Weidong Song, Xiaoyun Hu, Zhijun Jie, Chuntao Liu, Zhengguang He, Xiangdong Zhou and Huaping Tang

    Citation: BMC Pulmonary Medicine 2020 20:87

    Content type: Research article

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  25. The Asthma Control Test (ACT) has been used to assess asthma control in both clinical trials and clinical practice. However, the relationships between ACT score and other measures of asthma impact are not full...

    Authors: Bas C. P. van Dijk, Henrik Svedsater, Andreas Heddini, Linda Nelsen, Janita S. Balradj and Cathelijne Alleman

    Citation: BMC Pulmonary Medicine 2020 20:79

    Content type: Research article

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  26. Paracetamol and ibuprofen are the most commonly used medications for fever and pain management in children. While the efficacy appears similar with both drugs, there are contradictory findings related to adver...

    Authors: Mohamed Sherbash, Luis Furuya-Kanamori, Joanne Daghfal Nader and Lukman Thalib

    Citation: BMC Pulmonary Medicine 2020 20:72

    Content type: Research article

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  27. Chronic cough has an important impact on physical, social and psychological aspects. A simple and effective method to assess different aspects of chronic cough severity is required. We aimed to develop a simpl...

    Authors: Wenzhi Zhan, Liting Zhang, Mei Jiang, Meihua Chen, Xiaoling Yuan, Jianxin Sun, Pusheng Xu, Feng Wu, Chunlai Zhang, Wei Luo, Xiaomei Chen, Hu Li and Kefang Lai

    Citation: BMC Pulmonary Medicine 2020 20:68

    Content type: Research article

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  28. Uncontrolled severe asthma in children is burdensome and challenging to manage. This study aims to describe outcomes in children with uncontrolled severe asthma managed in a nurse-led severe asthma clinic (SAC).

    Authors: Patricia de Gouveia Belinelo, Aleisha Nielsen, Bernadette Goddard, Lauren Platt, Carla Rebeca Da Silva Sena, Paul D. Robinson, Bruce Whitehead, Jodi Hilton, Tanya Gulliver, Laurence Roddick, Kasey Pearce, Vanessa E. Murphy, Peter G. Gibson, Adam Collison and Joerg Mattes

    Citation: BMC Pulmonary Medicine 2020 20:66

    Content type: Research article

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  29. Asthma is one of the conditions that contributes to the global burden of respiratory diseases and has been previously associated with diet intake. The goal of this study was to determine the relationship betwe...

    Authors: Carla E. Tarazona-Meza, Corrine Hanson, Suzanne L. Pollard, Karina M. Romero Rivero, Rocio M. Galvez Davila, Sameera Talegawkar, Carlos Rojas, Jessica L. Rice, William Checkley and Nadia N. Hansel

    Citation: BMC Pulmonary Medicine 2020 20:63

    Content type: Research article

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  31. Asthma is one of the chronic diseases which affects the airway, and inhalers are the preferred medications to treat this problem. Improper inhalational technique leads to decreased efficacy of the medication b...

    Authors: Tadesse Melaku Abegaz, Efrata Ashuro Shegena, Natnael Fentie Gessie, Eyob Alemayehu Gebreyohannes and Mohammed Assen Seid

    Citation: BMC Pulmonary Medicine 2020 20:48

    Content type: Research article

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    The Correction to this article has been published in BMC Pulmonary Medicine 2020 20:95

  32. Onset of allergic asthma has a strong association with childhood but only a few studies have analyzed incidence of asthma from childhood to late adulthood in relation to allergy. The purpose of the study was t...

    Authors: Johanna Pakkasela, Pinja Ilmarinen, Jasmin Honkamäki, Leena E. Tuomisto, Heidi Andersén, Päivi Piirilä, Hanna Hisinger-Mölkänen, Anssi Sovijärvi, Helena Backman, Bo Lundbäck, Eva Rönmark, Hannu Kankaanranta and Lauri Lehtimäki

    Citation: BMC Pulmonary Medicine 2020 20:9

    Content type: Research article

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  33. The dose-response relationship of inhaled corticosteroid (ICS)/fast-onset long acting beta agonist (LABA) reliever therapy has not been formally addressed. The objective of this retrospective analysis is to as...

    Authors: Richard Beasley, James Harper, Grace Bird, Harriette Dunphy, Alex Semprini, Ian D. Pavord, Alberto Papi and Mark Weatherall

    Citation: BMC Pulmonary Medicine 2019 19:264

    Content type: Research article

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  34. Although the impact of asthma education on important outcomes (e.g. emergency visits) has been well established, only an estimated quarter of asthma patients in Germany have received patient education yet. The...

    Authors: Oxana Atmann, Klaus Linde, Christoph Werner, Ulrike Dorn and Antonius Schneider

    Citation: BMC Pulmonary Medicine 2019 19:256

    Content type: Research article

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  35. Pneumonia is an important cause of morbidity and mortality. COPD patients using inhaled corticosteroids (ICS) have an increased risk of pneumonia, but less is known about whether ICS treatment in asthma also i...

    Authors: Emil Ekbom, Jennifer Quint, Linus Schöler, Andrei Malinovschi, Karl Franklin, Mathias Holm, Kjell Torén, Eva Lindberg, Deborah Jarvis and Christer Janson

    Citation: BMC Pulmonary Medicine 2019 19:254

    Content type: Research article

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  36. The diagnostic criteria for asthma-chronic obstructive pulmonary disease overlap have not been unified. Different studies have used different criteria, and this has led to diagnostic inconsistencies.

    Authors: Wenjing Ye, Xiaoming Li, Wen Gu, Xuejun Guo, Fengfeng Han and Song Liu

    Citation: BMC Pulmonary Medicine 2019 19:249

    Content type: Research article

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  38. Quantifying the effects of personal health behaviors and environmental exposure on asthma flare-ups is a challenge. Most studies have focused on monitoring the symptoms and drug usage for relieving symptoms. I...

    Authors: Ta-Chien Chan, Tsuey-Hwa Hu, Yen-Hua Chu and Jing-Shiang Hwang

    Citation: BMC Pulmonary Medicine 2019 19:231

    Content type: Research article

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  39. The dysfunction of airway epithelial barrier is closely related to the pathogenesis of asthma. Secreted Hsp90α participates in inflammation and Hsp90 inhibitor protects endothelial dysfunction. In the current ...

    Authors: Cuiping Ye, Chaowen Huang, Mengchen Zou, Yahui Hu, Lishan Luo, Yilan Wei, Xuan Wan, Haijin Zhao, Wei Li, Shaoxi Cai and Hangming Dong

    Citation: BMC Pulmonary Medicine 2019 19:218

    Content type: Research article

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  40. The published data on the association between β2-adrenergic receptor gene polymorphisms and asthma susceptibility are inconclusive. To derive a more precise estimation of this association, a meta-analysis was ...

    Authors: Songlin Zhao, Wei Zhang and Xiuhong Nie

    Citation: BMC Pulmonary Medicine 2019 19:202

    Content type: Research article

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  41. Patient awareness of asthma severity is important for optimal asthma management. However, there is often a discrepancy between physician assessment of asthma control based on guidelines and patient discernment...

    Authors: Tewodros H. Gebremariam, Charles B. Sherman and Neil W. Schluger

    Citation: BMC Pulmonary Medicine 2019 19:187

    Content type: Research article

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  42. Several major randomized control studies have demonstrated that mepolizumab, an anti-IL-5 monoclonal antibody, is effective for patients with severe eosinophilic asthma who show exacerbation or require systemi...

    Authors: Takanori Numata, Katsutoshi Nakayama, Hirofumi Utsumi, Kenji Kobayashi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Shunsuke Minagawa, Takeo Ishikawa, Hiromichi Hara, Jun Araya and Kazuyoshi Kuwano

    Citation: BMC Pulmonary Medicine 2019 19:176

    Content type: Research article

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  43. Asthma is an extensive public health problem and inadequate disease control is not uncommon. Individuals’ self-perceived barriers to medical treatment for the entire treatment chain (from seeking care for symp...

    Authors: Tove Hedenrud, Annika Jakobsson, Hanan El Malla and Helle Håkonsen

    Citation: BMC Pulmonary Medicine 2019 19:175

    Content type: Research article

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  44. Severe non-allergic eosinophilic asthma (SNEA) is a rare asthma phenotype associated with severe clinical course, frequent exacerbations, and resistance to therapy, including high steroid doses. The key featur...

    Authors: Virginija Kalinauskaite-Zukauske, Andrius Januskevicius, Ieva Janulaityte, Skaidrius Miliauskas and Kestutis Malakauskas

    Citation: BMC Pulmonary Medicine 2019 19:158

    Content type: Research article

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  45. Asthma is a heterogeneous disease and understanding this heterogeneity will enable the realisation of precision medicine. We sought to compare the sputum and serum inflammatory profiles in moderate-to-severe a...

    Authors: Michael A. Ghebre, Pee Hwee Pang, Dhananjay Desai, Beverley Hargadon, Chris Newby, Joanne Woods, Laura Rapley, Suzanne E. Cohen, Athula Herath, Erol A. Gaillard, Richard D. May and Chris E. Brightling

    Citation: BMC Pulmonary Medicine 2019 19:144

    Content type: Research article

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  46. Chest computed tomography (CT) scans have a recognised role in investigating adults with severe asthma to exclude alternative diagnoses, but its role in children is less clear. The objective of this study was ...

    Authors: David Lo, Amit Maniyar, Sumit Gupta and Erol Gaillard

    Citation: BMC Pulmonary Medicine 2019 19:136

    Content type: Research article

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  47. To investigate the effect of asthma rehabilitation at high altitude (3100 m, HA) compared to low altitude (760 m, LA).

    Authors: Stéphanie Saxer, Simon R. Schneider, Paula Appenzeller, Patrick R. Bader, Mona Lichtblau, Michael Furian, Ulan Sheraliev, Bermet Estebesova, Berik Emilov, Talant Sooronbaev, Konrad E. Bloch and Silvia Ulrich

    Citation: BMC Pulmonary Medicine 2019 19:134

    Content type: Research article

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  48. Tralokinumab is an anti–interleukin (IL)-13 monoclonal antibody investigated for the treatment of severe, uncontrolled asthma in two Phase III clinical trials, STRATOS 1 and 2. The STRATOS 1 biomarker analysis...

    Authors: Mattis Gottlow, David J. Svensson, Ilya Lipkovich, Monika Huhn, Karin Bowen, Peter Wessman and Gene Colice

    Citation: BMC Pulmonary Medicine 2019 19:129

    Content type: Technical advance

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  49. In Latin America, there is scarce information about severe asthma (SA) according to the ERS/ATS 2014 criteria. This study aimed to compare the demographic, socio, clinical characteristics, treatment, and use o...

    Authors: Hugo Neffen, Felipe Moraes, Karynna Viana, Valentina Di Boscio, Gur Levy, Claudia Vieira, Gabriela Abreu and Claudia Soares

    Citation: BMC Pulmonary Medicine 2019 19:123

    Content type: Research article

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  50. Asthma is a chronic disease affecting 30 million people in Europe under 45y. Poor control of Asthma is the main cause of emergency-department (ED) access, becoming the strongest determinant of the economic bur...

    Authors: Laura Losappio, Enrico Heffler, Rossella Carpentiere, Monica Fornero, Cosimo Damiano Cannito, Francesco Guerrera, Francesca Puggioni, Riccardo Monti, Stefania Nicola, Giovanni Rolla and Luisa Brussino

    Citation: BMC Pulmonary Medicine 2019 19:107

    Content type: Research article

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