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Asthma and allergic disorders

Section edited by Joerg Mattes

This section concerns all aspects of asthma and allergic disorders including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

Page 1 of 3

  1. Content type: Research article

    In randomized controlled trials, bronchial thermoplasty (BT) has been proven to reduce symptoms in severe asthma, but the mechanisms by which this is achieved are uncertain as most studies have shown no improv...

    Authors: David Langton, Alvin Ing, Kim Bennetts, Wei Wang, Claude Farah, Matthew Peters, Virginia Plummer and Francis Thien

    Citation: BMC Pulmonary Medicine 2018 18:155

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  2. Content type: Research article

    The aim of this investigation was to study change in adults over a 20 year period in the prevalence of respiratory symptoms and disorders and its association to year of birth, life style and sleep related vari...

    Authors: Christer Janson, Ane Johannessen, Karl Franklin, Cecilie Svanes, Linus Schiöler, Andrei Malinovschi, Thorarinn Gislason, Bryndis Benediktsdottir, Vivi Schlünssen, Rain Jõgi, Deborah Jarvis and Eva Lindberg

    Citation: BMC Pulmonary Medicine 2018 18:152

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  3. Content type: Study protocol

    Asthma and wheezing disorders in childhood and adulthood are clinically heterogeneous regarding disease presentation, natural course, and response to treatment. Deciphering common disease mechanisms in distinc...

    Authors: Oliver Fuchs, Thomas Bahmer, Markus Weckmann, Anna-Maria Dittrich, Bianca Schaub, Barbara Rösler, Christine Happle, Folke Brinkmann, Isabell Ricklefs, Inke R. König, Henrik Watz, Klaus F. Rabe, Matthias V. Kopp, Gesine Hansen and Erika von Mutius

    Citation: BMC Pulmonary Medicine 2018 18:140

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  4. Content type: Research article

    Vitamin D deficiency has been linked to an increased risk of asthma. This study aimed to quantify the effect of early life vitamin D status on asthma and wheeze later in life.

    Authors: Song-Ying Shen, Wan-Qing Xiao, Jin-Hua Lu, Ming-Yang Yuan, Jian-Rong He, Hui-Min Xia, Xiu Qiu, Kar Keung Cheng and Kin Bong Hubert Lam

    Citation: BMC Pulmonary Medicine 2018 18:120

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  5. Content type: Research article

    Interleukin-5 (IL-5) antibodies represent a promising therapeutic option for patients with severe eosinophilic asthma. To date, no official treatment response criteria exist. In this study, simple criteria for...

    Authors: Nora Drick, Benjamin Seeliger, Tobias Welte, Jan Fuge and Hendrik Suhling

    Citation: BMC Pulmonary Medicine 2018 18:119

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  6. Content type: Research article

    Sputum induction is an important noninvasive method for analyzing bronchial inflammation in patients with asthma and other respiratory diseases. Most frequently, ultrasonic nebulizers are used for sputum induc...

    Authors: Sinem Koc-Günel, Ralf Schubert, Stefan Zielen and Martin Rosewich

    Citation: BMC Pulmonary Medicine 2018 18:115

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  7. Content type: Research article

    The natural history of airway inflammation and symptoms in occupations at risk of asthma is still not fully understood. We aimed to study the evolution during apprenticeship of inflammation markers, bronchial ...

    Authors: Valérie Demange, Denis Zmirou-Navier, Abraham Bohadana and Pascal Wild

    Citation: BMC Pulmonary Medicine 2018 18:113

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  8. Content type: Research article

    Multiple factors are involved in asthma exacerbations, including environmental exposure and viral infections. We aimed to assess the association between severe asthma exacerbations, acute respiratory viral inf...

    Authors: Lusmaia Damaceno Camargo Costa, Paulo Augusto Moreira Camargos, Paul L. P. Brand, Fabíola Souza Fiaccadori, Menira Borges de Lima Dias e Souza, Divina das Dôres de Paula Cardoso, Ítalo de Araújo Castro, Ruth Minamisava and Paulo Sérgio Sucasas da Costa

    Citation: BMC Pulmonary Medicine 2018 18:109

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  9. Content type: Research article

    Incorrect inhaler technique is a common cause of poor asthma control. This two-phase pragmatic study evaluated inhaler technique mastery and maintenance of mastery with DuoResp® (budesonide-formoterol [BF]) Sp...

    Authors: David B. Price, Vicky Thomas, P. N. Richard Dekhuijzen, Sinthia Bosnic-Anticevich, Nicolas Roche, Federico Lavorini, Priyanka Raju, Daryl Freeman, Carole Nicholls, Iain R. Small, Erika Sims, Guilherme Safioti, Janice Canvin and Henry Chrystyn

    Citation: BMC Pulmonary Medicine 2018 18:107

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  10. Content type: Research article

    An increasing number of studies using primary human bronchial epithelial cells (BECs) have reported intrinsic differences in the expression of several genes between cells from asthmatic and non-asthmatic donor...

    Authors: Stephen R. Reeves, Kaitlyn A. Barrow, Maria P. White, Lucille M. Rich, Maryam Naushab and Jason S. Debley

    Citation: BMC Pulmonary Medicine 2018 18:91

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  11. Content type: Research article

    Asthma is a common chronic respiratory disease leading to morbidity, mortality and impaired quality of life worldwide. Information on asthma prevalence in the Middle East is fragmented and relatively out-dated...

    Authors: Hesham Tarraf, Omur Aydin, Dilsad Mungan, Mohammad Albader, Bassam Mahboub, Adam Doble, Aaicha Lahlou, Luqman Tariq, Fayaz Aziz and Abdelkader El Hasnaoui

    Citation: BMC Pulmonary Medicine 2018 18:68

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  12. Content type: Research article

    Although pre-puberty asthma is more prevalent in males, after puberty through middle-age, asthma is more prevalent in females. The surge of sex hormones with puberty might explain this gender switch.

    Authors: Mark D. DeBoer, Brenda R. Phillips, David T. Mauger, Joe Zein, Serpil C. Erzurum, Anne M. Fitzpatrick, Benjamin M. Gaston, Ross Myers, Kristie R. Ross, James Chmiel, Min Jie Lee, John V. Fahy, Michael Peters, Ngoc P. Ly, Sally E. Wenzel, Merritt L. Fajt…

    Citation: BMC Pulmonary Medicine 2018 18:58

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  13. Content type: Case report

    Allergic bronchopulmonary aspergillosis (ABPA) is an allergic pulmonary disease comprising a complex hypersensitivity reaction to Aspergillus fumigatus. Clinical features of ABPA are wheezing, mucoid impaction, a...

    Authors: Takeshi Terashima, Taro Shinozaki, Eri Iwami, Takahiro Nakajima and Tatsu Matsuzaki

    Citation: BMC Pulmonary Medicine 2018 18:53

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  14. Content type: Case report

    Mortality related to asthma has decreased worldwide since the introduction of inhaled corticosteroid therapy in the past decades. However, there are still some asthma fatalities identified mainly in population...

    Authors: Thais Mauad, Felipe B. P. do Nascimento, Marisa Dolhnikoff, Milena C. M. Picka and Paulo H. N. Saldiva

    Citation: BMC Pulmonary Medicine 2018 18:50

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  15. Content type: Research article

    Thus far, no algorithms have been developed to automatically extract patients who meet Asthma Predictive Index (API) criteria from the Electronic health records (EHR) yet. Our objective is to develop and valid...

    Authors: Harsheen Kaur, Sunghwan Sohn, Chung-Il Wi, Euijung Ryu, Miguel A. Park, Kay Bachman, Hirohito Kita, Ivana Croghan, Jose A. Castro-Rodriguez, Gretchen A. Voge, Hongfang Liu and Young J. Juhn

    Citation: BMC Pulmonary Medicine 2018 18:34

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  16. Content type: Research article

    Bronchial thermoplasty (BT) is a non-pharmacological intervention for severe asthma whose mechanism of action is not completely explained by a reduction of airway smooth muscle (ASM). In this study we analyzed...

    Authors: N. Facciolongo, A. Di Stefano, V. Pietrini, C. Galeone, F. Bellanova, F. Menzella, N. Scichilone, R. Piro, G. L. Bajocchi, B. Balbi, L. Agostini, P. P. Salsi, D. Formisano and M. Lusuardi

    Citation: BMC Pulmonary Medicine 2018 18:29

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  17. Content type: Research article

    Postoperative pulmonary complications (PPC) in patients with pulmonary diseases remain to be resolved clinical issue. However, most evidence regarding PPC has been established more than 10 years ago. Therefore...

    Authors: Takanori Numata, Katsutoshi Nakayama, Satoko Fujii, Yoko Yumino, Nayuta Saito, Masahiro Yoshida, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hiroshi Wakui, Shunsuke Minagawa, Takeo Ishikawa, Hiromichi Hara…

    Citation: BMC Pulmonary Medicine 2018 18:4

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  18. Content type: Research article

    Annexin-A1 (ANXA1) is a glucocorticoid-induced protein with multiple actions in the regulation of inflammatory cell activation. The anti-inflammatory protein ANXA1 and its N-formyl peptide receptor 2 (FPR2) ha...

    Authors: Sun-Hye Lee, Pureun-Haneul Lee, Byeong-Gon Kim, Hyun-Jeong Seo, Ae-Rin Baek, Jong-Sook Park, June-Hyuk Lee, Sung-Woo Park, Do-Jin Kim, Choon-Sik Park and An-Soo Jang

    Citation: BMC Pulmonary Medicine 2018 18:1

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  19. Content type: Research article

    We previously reported that the ILVBL gene on chromosome 19p13.1 was associated with the risk for aspirin-exacerbated respiratory disease (AERD) and the percent decline of forced expired volume in one second (FEV...

    Authors: Hun Soo Chang, Jong Sook Park, Ho Sung Lee, Jiwon Lyu, Ji-Hye Son, Inseon S. Choi, Hyoung Doo Shin and Choon-Sik Park

    Citation: BMC Pulmonary Medicine 2017 17:210

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  20. Content type: Research article

    Previous studies have indicated that chitinase 3-like 1 (CHI3L1) gene rs4950928 polymorphism and acidic mammalian chitinase (AMCase or CHIA) gene rs10494132 polymorphism are associated with the risk of asthma....

    Authors: Yanting Zhu, Xin Yan, Cui Zhai, Lan Yang and Manxiang Li

    Citation: BMC Pulmonary Medicine 2017 17:193

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  21. Content type: Research article

    Gene expression changes in the structural cells of the airways are thought to play a role in the development of asthma and airway hyperresponsiveness. This includes changes to smooth muscle contractile machine...

    Authors: Christopher D. Pascoe, Ma’en Obeidat, Bryna A. Arsenault, Yunlong Nie, Stephanie Warner, Dorota Stefanowicz, Samuel J. Wadsworth, Jeremy A. Hirota, S. Jasemine Yang, Delbert R. Dorscheid, Chris Carlsten, Tillie L. Hackett, Chun Y. Seow and Peter D. Paré

    Citation: BMC Pulmonary Medicine 2017 17:189

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  22. Content type: Research article

    Inhaled corticosteroids are recommended as the first-line controller medication for childhood asthma owing to their multiple clinical benefits. However, heterogeneity in the response towards these drugs remain...

    Authors: Yi-Fan Wu, Ming-Wei Su, Bor-Luen Chiang, Yao-Hsu Yang, Ching-Hui Tsai and Yungling L. Lee

    Citation: BMC Pulmonary Medicine 2017 17:176

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  23. Content type: Research article

    Asthma inflammatory phenotypes are often defined by relative cell counts of airway eosinophils/neutrophils. However, the importance of neutrophilia remains unclear, as does the effect of ICS treatment on asthm...

    Authors: Collin R. Brooks, Christine J. Van Dalen, Elizabeth Harding, Ian F. Hermans and Jeroen Douwes

    Citation: BMC Pulmonary Medicine 2017 17:169

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  24. Content type: Research article

    Despite recognition of asthma as a growing global issue and development of global guidelines, asthma treatment practices vary between countries. Several studies have reported patients’ perspectives on asthma c...

    Authors: Kenneth R. Chapman, David Hinds, Peter Piazza, Chantal Raherison, Michael Gibbs, Timm Greulich, Kenneth Gaalswyk, Jiangtao Lin, Mitsuru Adachi and Kourtney J. Davis

    Citation: BMC Pulmonary Medicine 2017 17:153

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  25. Content type: Research article

    Respiratory tract infection is a major cause of acute exacerbation of bronchial asthma (AEBA). Although recent findings suggest that common bacteria are causally associated with AEBA, a comprehensive epidemiol...

    Authors: Yutaka Yoshii, Kenichiro Shimizu, Miyuki Morozumi, Naoko Chiba, Kimiko Ubukata, Hironori Uruga, Shigeo Hanada, Hiroshi Wakui, Shunsuke Minagawa, Hiromichi Hara, Takanori Numata, Keisuke Saito, Jun Araya, Katsutoshi Nakayama, Kazuma Kishi and Kazuyoshi Kuwano

    Citation: BMC Pulmonary Medicine 2017 17:150

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  26. Content type: Research article

    Over one million children receive treatment for asthma in the UK. South Asian children experience excess morbidity and higher rates of hospitalization than the White population. This study aimed to explore per...

    Authors: Monica Lakhanpaul, Lorraine Culley, Noelle Robertson, Deborah Bird, Nicky Hudson, Narynder Johal, Melanie McFeeters, Emma Angell, Charlotte Hamlyn-Williams, Nadine Abbas, Logan Manikam and Mark Johnson

    Citation: BMC Pulmonary Medicine 2017 17:126

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  27. Content type: Research article

    Dry powder inhalers (DPIs) are often used in asthma and chronic obstructive pulmonary disease (COPD) therapies. Using the discrete choice experiment (DCE) methodology, this study conducted in France was design...

    Authors: Natalia Hawken, Saku Torvinen, Mohamed-Elmoctar Neine, Ikbel Amri, Mondher Toumi, Samuel Aballéa, Adam Plich and Nicolas Roche

    Citation: BMC Pulmonary Medicine 2017 17:99

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  28. Content type: Research article

    Bronchial epithelium plays a key role in orchestrating innate and adaptive immunity. The fate of ex vivo airway epithelial cultures growing at the air liquid interface (ALI) derived from human endobronchial bi...

    Authors: Delphine Gras, Aurélie Petit, Jérémy Charriot, Lucie Knabe, Khuder Alagha, Anne Sophie Gamez, Céline Garulli, Arnaud Bourdin, Pascal Chanez, Nicolas Molinari and Isabelle Vachier

    Citation: BMC Pulmonary Medicine 2017 17:80

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  29. Content type: Research article

    Asthma exacerbations are important events that affect disease control, but predictive factors for severe or moderate exacerbations are not known. The objective was to study the predictive factors for moderate ...

    Authors: Francisco Javier Álvarez Gutiérrez, Marta Ferrer Galván, Juan Francisco Medina Gallardo, Marta Barrera Mancera, Beatriz Romero Romero and Auxiliadora Romero Falcón

    Citation: BMC Pulmonary Medicine 2017 17:77

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  30. Content type: Research article

    To analyse the efficacy of fluticasone propionate (FP) alone and combined with salmeterol (SAL) in achieving guideline-defined asthma control in Asian patients.

    Authors: Jean Bousquet, Neil Barnes, Michael Gibbs, Nadeem Gul, Susan A Tomkins, Xin Zhou, Young-Joo Cho, Hae-Sim Park, William Busse and Nanshan Zhong

    Citation: BMC Pulmonary Medicine 2017 17:75

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  31. Content type: Research article

    Asthma exacerbations are frequent in patients with severe disease. This report describes results from two retrospective cohort studies describing exacerbation frequency and risk, emergency department (ED)/hosp...

    Authors: Robert Y. Suruki, Jonas B. Daugherty, Nada Boudiaf and Frank C. Albers

    Citation: BMC Pulmonary Medicine 2017 17:74

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  32. Content type: Research article

    Asthma management may involve a step up in treatment when symptoms are not well controlled. We examined whether budesonide/formoterol maintenance and reliever therapy (MRT) is as effective as higher, fixed-dos...

    Authors: Christine R. Jenkins, Göran Eriksson, Eric D. Bateman, Helen K. Reddel, Malcolm R. Sears, Magnus Lindberg and Paul M. O’Byrne

    Citation: BMC Pulmonary Medicine 2017 17:65

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  33. Content type: Research article

    Although the prevalence of both obstructive sleep apnoea (OSA) and asthma are both increasing, little is known about the impact of OSA on the natural history of lung function in asthmatic patients.

    Authors: Tsai-Yu Wang, Yu-Lun Lo, Shu-Min Lin, Chien-Da Huang, Fu-Tasi Chung, Horng-Chyuan Lin, Chun-Hua Wang and Han-Pin Kuo

    Citation: BMC Pulmonary Medicine 2017 17:55

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  34. Content type: Study protocol

    Asthma patients are enrolled in multimodal pulmonary rehabilitation (PR) programs. However, available data for the effectiveness of PR in asthma are sparse. Therefore, the primary aim of this randomized contro...

    Authors: Konrad Schultz, Hildegard Seidl, Danijel Jelusic, Rupert Wagner, Michael Wittmann, Hermann Faller, Dennis Nowak and Michael Schuler

    Citation: BMC Pulmonary Medicine 2017 17:49

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  35. Content type: Research article

    Correct inhaler technique is recommended by guidelines for optimum asthma care. The objective of the study is to determine real life predictors of correct pressurized metered dose inhaler (pMDI) technique in A...

    Authors: Kyra Bartolo, Martin Balzan, Emma Louise Schembri, Rachelle Asciak, Darlene Mercieca Balbi, Michael Pace Bardon and Stephen Montefort

    Citation: BMC Pulmonary Medicine 2017 17:47

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  36. Content type: Research article

    Treatment guidelines for asthma have been established based on asthma severity; there are limitations in the identification of underlying pathophysiology and prediction of prognosis in heterogeneous phenotypes...

    Authors: Eun Lee, Si Hyeon Lee, Ji-Won Kwon, Young-Ho Kim, Jisun Yoon, Hyun-Ju Cho, Song-I Yang, Young-Ho Jung, Hyung Young Kim, Ju-Hee Seo, Hyo Bin Kim, So Yeon Lee, Ho-Jang Kwon and Soo-Jong Hong

    Citation: BMC Pulmonary Medicine 2017 17:45

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  37. Content type: Research article

    Inhaled corticosteroids (ICS) are the primary treatment for persistent asthma. Currently available ICS have differing particle size due to both formulation and propellant, and it has been postulated that this ...

    Authors: Céline El Baou, Rachael L. Di Santostefano, Rafael Alfonso-Cristancho, Elizabeth A Suarez, David Stempel, Mark L Everard and Neil Barnes

    Citation: BMC Pulmonary Medicine 2017 17:31

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    The Correction to this article has been published in BMC Pulmonary Medicine 2017 17:172

  38. Content type: Research article

    Recognition of the airway epithelium as a central mediator in the pathogenesis of asthma has necessitated greater understanding of the aberrant cellular mechanisms of the epithelium in asthma. The architecture...

    Authors: Dorota Stefanowicz, Jari Ullah, Kevin Lee, Furquan Shaheen, Ekiomoado Olumese, Nick Fishbane, Hyun-Kyoung Koo, Teal S. Hallstrand, Darryl A. Knight and Tillie-Louise Hackett

    Citation: BMC Pulmonary Medicine 2017 17:24

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  39. Content type: Research article

    Treatment of asthma does not always comply with asthma guidelines (AG). This may be rooted in direct or indirect resistance on the doctors’ and/or patients’ side or be caused by the healthcare system. To asses...

    Authors: H. Lingner, B. Burger, P. Kardos, C. P. Criée, H. Worth and E. Hummers-Pradier

    Citation: BMC Pulmonary Medicine 2017 17:13

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  40. Content type: Research article

    A high strength of beclomethasone/formoterol fumarate (BDP/FF) in a pressurised metered dose inhaler (pMDI), which contains extrafine BDP (200 μg/actuation) and FF (6 μg/actuation) has been developed to treat tho...

    Authors: Pierluigi Paggiaro, Massimo Corradi, Manuela Latorre, Helene Raptis, Annamaria Muraro, Christian Gessner, Zenon Siergiejko, Mario Scuri and Stefano Petruzzelli

    Citation: BMC Pulmonary Medicine 2016 16:180

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  41. Content type: Research article

    Despite advances in asthma treatment, severe asthma (SA) still results in high morbidity and use of health resources. Our hypothesis was that SA patients would achieve adequate control with a systematic protoc...

    Authors: Rodrigo Athanazio, Regina Carvalho-Pinto, Frederico Leon Arrabal Fernandes, Samia Rached, Klaus Rabe, Alberto Cukier and Rafael Stelmach

    Citation: BMC Pulmonary Medicine 2016 16:153

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  42. Content type: Research article

    Asthma is a prevalent chronic disease and occupation contributes to approximately 15 % of cases among adults. However, there are still few studies on risk factors for work-exacerbated asthma. The current study...

    Authors: Jeong-Lim Kim, Paul K. Henneberger, Susanna Lohman, Anna-Carin Olin, Anna Dahlman-Höglund, Eva Andersson, Kjell Torén and Mathias Holm

    Citation: BMC Pulmonary Medicine 2016 16:148

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  43. Content type: Research article

    The structural changes of the respiratory system related to ageing determine lung function decline in healthy subjects after 25 years of age. An annual reduction of 25 ml in Forced Expiratory Volume in 1 s (FE...

    Authors: P. C. A. Almeida, E. V. Ponte, A. Souza-Machado and A. A. Cruz

    Citation: BMC Pulmonary Medicine 2016 16:141

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  44. Content type: Research article

    In patients with asthma, particularly severe asthma, poor adherence to inhaled drugs negatively affects the achievement of disease control. A better adherence rate is expected in the case of injected drugs, su...

    Authors: M. Caminati, G. Senna, G. Stefanizzi, R. Bellamoli, S. Longhi, F. Chieco-Bianchi, G. Guarnieri, S. Tognella, M. Olivieri, C. Micheletto, G. Festi, E. Bertocco, M. Mazza, A. Rossi and A. Vianello

    Citation: BMC Pulmonary Medicine 2016 16:128

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  45. Content type: Research article

    We investigated the net changes in prevalence of symptoms of asthma and rhinitis over 10 years in a cohort of young by baseline sensitization status.

    Authors: Vanessa Garcia-Larsen, James F. Potts, Stefano Del Giacco, Patricia Bustos, Patricia V. Diaz, Hugo Amigo, Manuel Oyarzun and Roberto J. Rona

    Citation: BMC Pulmonary Medicine 2016 16:116

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  46. Content type: Research article

    For many years, African Dust Storms (ADE) has been thought to be associated with high prevalence of asthma in Puerto Rico (PR). Endotoxins (ENX) have been associated with ADE particulate matter (PM) and are kn...

    Authors: Mario G. Ortiz-Martínez, Orquídea Frías-Belén, Sylvette Nazario-Jiménez, María López-Quintero, Rosa I. Rodríguez-Cotto and Braulio D. Jiménez-Vélez

    Citation: BMC Pulmonary Medicine 2016 16:112

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  47. Content type: Research article

    Asthma represents a significant clinical and economic burden to the US healthcare system. Along with other clinical manifestations of the disease, elevated sputum and blood eosinophil levels are observed in pa...

    Authors: Julian Casciano, Jerry A. Krishnan, Mary Buatti Small, Philip O. Buck, Gokul Gopalan, Chenghui Li, Robert Kemp and Zenobia Dotiwala

    Citation: BMC Pulmonary Medicine 2016 16:109

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