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Asthma and allergic disorders

This section concerns all aspects of asthma and allergic disorders including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. A high strength of beclomethasone/formoterol fumarate (BDP/FF) in a pressurised metered dose inhaler (pMDI), which contains extrafine BDP (200 μg/actuation) and FF (6 μg/actuation) has been developed to treat tho...

    Authors: Pierluigi Paggiaro, Massimo Corradi, Manuela Latorre, Helene Raptis, Annamaria Muraro, Christian Gessner, Zenon Siergiejko, Mario Scuri and Stefano Petruzzelli

    Citation: BMC Pulmonary Medicine 2016 16:180

    Content type: Research article

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  2. Despite advances in asthma treatment, severe asthma (SA) still results in high morbidity and use of health resources. Our hypothesis was that SA patients would achieve adequate control with a systematic protoc...

    Authors: Rodrigo Athanazio, Regina Carvalho-Pinto, Frederico Leon Arrabal Fernandes, Samia Rached, Klaus Rabe, Alberto Cukier and Rafael Stelmach

    Citation: BMC Pulmonary Medicine 2016 16:153

    Content type: Research article

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  3. Asthma is a prevalent chronic disease and occupation contributes to approximately 15 % of cases among adults. However, there are still few studies on risk factors for work-exacerbated asthma. The current study...

    Authors: Jeong-Lim Kim, Paul K. Henneberger, Susanna Lohman, Anna-Carin Olin, Anna Dahlman-Höglund, Eva Andersson, Kjell Torén and Mathias Holm

    Citation: BMC Pulmonary Medicine 2016 16:148

    Content type: Research article

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  4. The structural changes of the respiratory system related to ageing determine lung function decline in healthy subjects after 25 years of age. An annual reduction of 25 ml in Forced Expiratory Volume in 1 s (FE...

    Authors: P. C. A. Almeida, E. V. Ponte, A. Souza-Machado and A. A. Cruz

    Citation: BMC Pulmonary Medicine 2016 16:141

    Content type: Research article

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  5. In patients with asthma, particularly severe asthma, poor adherence to inhaled drugs negatively affects the achievement of disease control. A better adherence rate is expected in the case of injected drugs, su...

    Authors: M. Caminati, G. Senna, G. Stefanizzi, R. Bellamoli, S. Longhi, F. Chieco-Bianchi, G. Guarnieri, S. Tognella, M. Olivieri, C. Micheletto, G. Festi, E. Bertocco, M. Mazza, A. Rossi and A. Vianello

    Citation: BMC Pulmonary Medicine 2016 16:128

    Content type: Research article

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  6. We investigated the net changes in prevalence of symptoms of asthma and rhinitis over 10 years in a cohort of young by baseline sensitization status.

    Authors: Vanessa Garcia-Larsen, James F. Potts, Stefano Del Giacco, Patricia Bustos, Patricia V. Diaz, Hugo Amigo, Manuel Oyarzun and Roberto J. Rona

    Citation: BMC Pulmonary Medicine 2016 16:116

    Content type: Research article

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  7. For many years, African Dust Storms (ADE) has been thought to be associated with high prevalence of asthma in Puerto Rico (PR). Endotoxins (ENX) have been associated with ADE particulate matter (PM) and are kn...

    Authors: Mario G. Ortiz-Martínez, Orquídea Frías-Belén, Sylvette Nazario-Jiménez, María López-Quintero, Rosa I. Rodríguez-Cotto and Braulio D. Jiménez-Vélez

    Citation: BMC Pulmonary Medicine 2016 16:112

    Content type: Research article

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  8. Asthma represents a significant clinical and economic burden to the US healthcare system. Along with other clinical manifestations of the disease, elevated sputum and blood eosinophil levels are observed in pa...

    Authors: Julian Casciano, Jerry A. Krishnan, Mary Buatti Small, Philip O. Buck, Gokul Gopalan, Chenghui Li, Robert Kemp and Zenobia Dotiwala

    Citation: BMC Pulmonary Medicine 2016 16:109

    Content type: Research article

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  9. Asthma is a common chronic condition with an economic burden of almost $56 billion annually in the US. Biologic markers like blood eosinophils, that help predict the risk of exacerbation could help guide more ...

    Authors: Julian Casciano, Jerry A. Krishnan, Mary Buatti Small, Philip O. Buck, Gokul Gopalan, Chenghui Li, Robert Kemp and Zenobia Dotiwala

    Citation: BMC Pulmonary Medicine 2016 16:100

    Content type: Research article

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  10. House dust mite (HDM) allergens constitute the leading trigger for the symptoms of persistent respiratory allergies (such as allergic rhinitis and asthma). However, the fluctuating, pernicious nature of the sy...

    Authors: Pascal Demoly, Andrea Matucci, Oliviero Rossi and Carmen Vidal

    Citation: BMC Pulmonary Medicine 2016 16:85

    Content type: Research article

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  11. Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are characterized by acute lung inflammation. Intercellular adhesion molecule-1 (ICAM-1) and interleukin-8 (IL-8) play an important role i...

    Authors: Ting Wu, Jia-Xin Shi, Shen Geng, Wei Zhou, Yi Shi and Xin Su

    Citation: BMC Pulmonary Medicine 2016 16:84

    Content type: Research article

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  12. To identify, summarise and synthesise the evidence for using interactive digital interventions to support patient self-management of asthma, and determine their impact.

    Authors: Gary McLean, Elizabeth Murray, Rebecca Band, Keith R. Moffat, Peter Hanlon, Anne Bruton, Mike Thomas, Lucy Yardley and Frances S. Mair

    Citation: BMC Pulmonary Medicine 2016 16:83

    Content type: Research article

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  13. Single nucleotide polymorphisms (SNPs) in chitinase 3-like 1 (CHI3L1), the gene encoding YKL-40, and increased serum YKL-40 levels are associated with severe forms of asthma. It has never been addressed whether S...

    Authors: Jakob Usemann, Urs Frey, Ines Mack, Anne Schmidt, Olga Gorlanova, Martin Röösli, Dominik Hartl and Philipp Latzin

    Citation: BMC Pulmonary Medicine 2016 16:81

    Content type: Research article

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  14. Most randomised clinical trials typically exclude a significant proportion of asthma patients, including those at higher risk of adverse events, with comorbidities, obesity, poor inhaler technique and adherenc...

    Authors: Thys van der Molen, Dirkje S. Postma, Richard J. Martin, Ron M. C. Herings, Jetty A. Overbeek, Victoria Thomas, Cristiana Miglio, Richard Dekhuijzen, Nicolas Roche, Theresa Guilbert, Elliot Israel, Wim van Aalderen, Elizabeth V. Hillyer, Simon van Rysewyk and David B. Price

    Citation: BMC Pulmonary Medicine 2016 16:80

    Content type: Research article

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    The Erratum to this article has been published in BMC Pulmonary Medicine 2016 16:105

  15. Although the heterogeneous nature of asthma has prompted asthma phenotyping with physiological or biomarker data, these studies have been mostly cross-sectional. Longitudinal studies that assess the stability ...

    Authors: T. Zaihra, C. J. Walsh, S. Ahmed, C. Fugère, Q. A. Hamid, R. Olivenstein, J. G. Martin and A. Benedetti

    Citation: BMC Pulmonary Medicine 2016 16:74

    Content type: Research article

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  16. Periostin levels are associated with airway eosinophilia and are suppressed by corticosteroid treatment in asthma. This study sought to determine the relationship between serum and sputum periostin, airway inf...

    Authors: Jodie L. Simpson, Ian A. Yang, John W. Upham, Paul N. Reynolds, Sandra Hodge, Alan L. James, Christine Jenkins, Matthew J. Peters, Guiquan Jia, Cecile T. J. Holweg and Peter G. Gibson

    Citation: BMC Pulmonary Medicine 2016 16:67

    Content type: Research article

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  17. Many patients with asthma require frequent rescue medication for acute symptoms despite appropriate controller therapies. Thus, determining the most effective relief regimen is important in the management of m...

    Authors: James F. Donohue, Robert Wise, William W. Busse, Sandra Garfinkel, Valentina B. Zubek, Mo Ghafouri, Raymond C. Manuel, Rozsa Schlenker-Herceg and Eugene R. Bleecker

    Citation: BMC Pulmonary Medicine 2016 16:65

    Content type: Research article

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  18. A national program for the treatment of severe allergic (IgE-dependent) asthma with omalizumab (OMA) was implemented in Poland in 2013. This observational study evaluated the effectiveness of the Polish OMA pr...

    Authors: Izabela Kupryś-Lipińska, Paweł Majak, Joanna Molinska and Piotr Kuna

    Citation: BMC Pulmonary Medicine 2016 16:61

    Content type: Research article

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  19. Asthma is among the most common chronic diseases in adults. International guidelines have emphasized the importance of regular spirometry for asthma control evaluation. However, spirometry use in primary care ...

    Authors: Samir Gupta, Dilshad Moosa, Ana MacPherson, Christopher Allen and Itamar E. Tamari

    Citation: BMC Pulmonary Medicine 2016 16:56

    Content type: Research article

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  20. Late-onset asthma (onset > 12 years) is pathologically distinct from early-onset asthma. The mechanism of air pollution is not a classic allergic inflammation and could have differential effect on late-onset a...

    Authors: Tsung-Ju Wu, Chang-Fu Wu, Bing-Yu Chen, Yungling Leo Lee and Yue Leon Guo

    Citation: BMC Pulmonary Medicine 2016 16:54

    Content type: Research article

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  21. This study aims to find out whether extracellular miRNAs is implicated in recurrent childhood wheezing with asthmatic risk.

    Authors: Congshan Jiang, Hongchuan Yu, Qingzhu Sun, Wenhua Zhu, Jing Xu, Ning Gao, Rui Zhang, Li Liu, Xiaoying Wu, Xudong Yang, Liesu Meng and Shemin Lu

    Citation: BMC Pulmonary Medicine 2016 16:50

    Content type: Research article

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  22. There is very little information available on a national level as to the number of people exposed to specific asthmagens in workplaces.

    Authors: Lin Fritschi, Julie Crewe, Ellie Darcey, Alison Reid, Deborah C. Glass, Geza P. Benke, Tim Driscoll, Susan Peters, Si Si, Michael J. Abramson and Renee N. Carey

    Citation: BMC Pulmonary Medicine 2016 16:48

    Content type: Research article

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  23. The technique of induced sputum has allowed to subdivide asthma patients into inflammatory phenotypes according to their level of granulocyte airway infiltration. There are very few studies which looked at det...

    Authors: Sophie Demarche, Florence Schleich, Monique Henket, Virginie Paulus, Thierry Van Hees and Renaud Louis

    Citation: BMC Pulmonary Medicine 2016 16:46

    Content type: Research article

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  24. Budesonide and formoterol (BF) Spiromax® is a dry powder inhaler designed to deliver BF with maximum ease of use for patients with asthma or chronic obstructive pulmonary disease.

    Authors: J. Christian Virchow, Roberto Rodriguez-Roisin, Alberto Papi, Tushar P. Shah and Gokul Gopalan

    Citation: BMC Pulmonary Medicine 2016 16:42

    Content type: Research article

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  25. Serious inhaler technique errors can impair drug delivery to the lungs. This randomised, crossover, open-label study evaluated the proportion of patients making predefined serious errors with Pulmojet compared...

    Authors: Henry Chrystyn, David B. Price, Mathieu Molimard, John Haughney, Sinthia Bosnic-Anticevich, Federico Lavorini, John Efthimiou, Dawn Shan, Erika Sims, Anne Burden, Catherine Hutton and Nicolas Roche

    Citation: BMC Pulmonary Medicine 2016 16:12

    Content type: Research article

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  26. Idiopathic pulmonary fibrosis (IPF) is a chronic, fibrotic interstitial lung disease of unknown origin. It has a median survival of three years but a wide range in survival rate which is difficult to predict a...

    Authors: Cathy Sampson, Ben Hope Gill, Nicholas Kim Harrison, Annmarie Nelson and Anthony Byrne

    Citation: BMC Pulmonary Medicine 2015 15:155

    Content type: Research article

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  27. The preferences of parents and children with asthma influence their ability to manage a child’s asthma and achieve good control. Potential differences between parents and adolescents with respect to specific p...

    Authors: Wendy J. Ungar, Anahita Hadioonzadeh, Mehdi Najafzadeh, Nicole W. Tsao, Sharon Dell and Larry D. Lynd

    Citation: BMC Pulmonary Medicine 2015 15:146

    Content type: Research article

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  28. Physical training has been shown to improve exercise capabilities in patients with asthma. Most studies focused on children and younger adults. Previously, the maximum program duration was six months. It is no...

    Authors: Andreas Meyer, Sabine Günther, Timm Volmer, Karin Taube and Hans J Baumann

    Citation: BMC Pulmonary Medicine 2015 15:56

    Content type: Research article

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  29. After the SMART trial evaluating the safety of salmeterol (long-acting beta-2-agonist (LABA)) in asthma patients, regulatory actions were taken to promote a guideline-adherent prescribing of LABA only to patie...

    Authors: Marietta Rottenkolber, Rainald Fischer, Luisa Ibáñez, Joan Fortuny, Robert Reynolds, Justyna Amelio, Roman Gerlach, Martin Tauscher, Petra Thürmann, Joerg Hasford and Sven Schmiedl

    Citation: BMC Pulmonary Medicine 2015 15:55

    Content type: Research article

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  30. Dampness and mould exposure have been repeatedly associated with respiratory health. However, less is known about the specific agents provoking or arresting health effects in adult populations. We aimed to ass...

    Authors: Christina Tischer, Jan-Paul Zock, Maria Valkonen, Gert Doekes, Stefano Guerra, Dick Heederik, Deborah Jarvis, Dan Norbäck, Mario Olivieri, Jordi Sunyer, Cecilie Svanes, Martin Täubel, Elisabeth Thiering, Giuseppe Verlato, Anne Hyvärinen and Joachim Heinrich

    Citation: BMC Pulmonary Medicine 2015 15:48

    Content type: Research article

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  31. Spiromax® is a novel dry-powder inhaler containing formulations of budesonide plus formoterol (BF). The device is intended to provide dose equivalence with enhanced user-friendliness compared to BF Turbuhaler®...

    Authors: Wahida Azouz, Philip Chetcuti, Harold Hosker, Dinesh Saralaya and Henry Chrystyn

    Citation: BMC Pulmonary Medicine 2015 15:47

    Content type: Research article

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  32. The morbidity associated with severe uncontrolled asthma is disproportionately higher in low- and middle-income countries than in high-income countries. The aim of this study was to describe the phenotypic cha...

    Authors: Wenderson Clay Correia de Andrade, Laura Maria de Lima Belizário Facury Lasmar, Cristiane de Abreu Tonelli Ricci, Paulo Augusto Moreira Camargos and Álvaro A Cruz

    Citation: BMC Pulmonary Medicine 2015 15:36

    Content type: Research article

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  33. Asthma is a common chronic disease among young adults, and several studies have reported increased mortality rates in patients with asthma. However, no study has described sudden unexpected death in a nationwi...

    Authors: Anders Juul Gullach, Bjarke Risgaard, Thomas Hadberg Lynge, Reza Jabbari, Charlotte Glinge, Stig Haunsø, Vibeke Backer, Bo Gregers Winkel and Jacob Tfelt-Hansen

    Citation: BMC Pulmonary Medicine 2015 15:35

    Content type: Research article

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  34. Skin prick tests (SPT) are widely used both in clinical diagnostics and in research. The standardization of allergen extracts is well documented to be crucial for the validity of SPT, whereas less emphasis has...

    Authors: Gert F Thomsen, Vivi Schlünssen, Lars R Skadhauge, Tine Halsen Malling, David L Sherson, Øyvind Omland and Torben Sigsgaard

    Citation: BMC Pulmonary Medicine 2015 15:33

    Content type: Research article

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  35. Patients with pulmonary arteriovenous malformations usually complain of dyspnoea upon exertion, fatigue or migraine, or may be asymptomatic. We describe a patient with an unreported manifestation of a pulmonar...

    Authors: Etienne-Marie Jutant, Philippe Puyo, Mostafa El Hajjam, Sandra Blivet, Emmanuel Houdart, Michel Aubier, Pascal Lacombe and Thierry Chinet

    Citation: BMC Pulmonary Medicine 2015 15:28

    Content type: Case report

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  36. Argan is now used worldwide in numerous cosmetic products. Nine workers from a cosmetic factory were examined in our occupational medicine department, following the diagnosis of a case of hypersensitivity pneu...

    Authors: Christophe Paris, Fabrice Herin, Gabriel Reboux, Emmanuelle Penven, Coralie Barrera, Cécile Guidat and Isabelle Thaon

    Citation: BMC Pulmonary Medicine 2015 15:18

    Content type: Research article

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  37. Asthma is the most common chronic condition of childhood and disproportionately affects inner-city minority children. Low rates of asthma preventer medication adherence is a major contributor to poor asthma co...

    Authors: John M Wiecha, William G Adams, Denis Rybin, Maria Rizzodepaoli, Jeremy Keller and Jayanti M Clay

    Citation: BMC Pulmonary Medicine 2015 15:17

    Content type: Research article

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  38. Asthma is characterized by airway hyper-responsiveness and variable airflow obstruction, in part as a consequence of hyper-contractile airway smooth muscle, which persists in primary cell culture. One potentia...

    Authors: David Sweeney, Fay Hollins, Edith Gomez, Rajendra Mistry, Ruth Saunders, Robert Alfred John Challiss and Christopher Edward Brightling

    Citation: BMC Pulmonary Medicine 2015 15:12

    Content type: Research article

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  39. YKL-40 is also called chitinase-3-like-1 (CHI3L1) protein and may be a marker for asthma. The aims of the present study were to investigate whether serum YKL-40 levels are stable or decreased in patients with ...

    Authors: Tianwen Lai, Min Chen, Zaichun Deng, Yingying Lǚ, Dong Wu, Dongming Li and Bin Wu

    Citation: BMC Pulmonary Medicine 2015 15:1

    Content type: Research article

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  40. Adiposity has been linked to both higher risk of asthma and reduced lung function. The effects of adiposity on asthma may depend on both atopic status and gender, while the relationship is less clear with resp...

    Authors: Runa V Fenger, Arturo Gonzalez-Quintela, Carmen Vidal, Lise-Lotte Husemoen, Tea Skaaby, Betina H Thuesen, Mette Aadahl, Flemming Madsen and Allan Linneberg

    Citation: BMC Pulmonary Medicine 2014 14:208

    Content type: Research article

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  41. A subset of severe asthma patients has fixed airways obstruction, which is characterized by incomplete reversibility to bronchodilator challenge. We aimed to elucidate the factors associated with fixed airways...

    Authors: Anthony Chau Ang Yii, Gan Liang Tan, Keng Leong Tan, Therese Sophie Lapperre and Mariko Siyue Koh

    Citation: BMC Pulmonary Medicine 2014 14:191

    Content type: Research article

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  42. The use of computerized clinical decision support systems may improve the diagnosis and ongoing management of chronic diseases, which requires recurrent visits to multiple health professionals, disease and med...

    Authors: Mariam Fathima, David Peiris, Pradnya Naik-Panvelkar, Bandana Saini and Carol Lyn Armour

    Citation: BMC Pulmonary Medicine 2014 14:189

    Content type: Research article

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  43. Long-acting β2-adrenergic agonists (LABAs) are recommended in combination with inhaled corticosteroids (ICSs) for asthma management. Abediterol is a novel, selective, potent, once-daily LABA in development for tr...

    Authors: Dave Singh, Helena Pujol, Anna Ribera, Beatriz Seoane, Eric Massana, Carol Astbury, Sandrine Ruiz and Gonzalo de Miquel

    Citation: BMC Pulmonary Medicine 2014 14:176

    Content type: Research article

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  44. Inhaled allergen challenge is a standard method to study airway responses to inflammatory provocation and evaluate the therapeutic potential of novel anti-inflammatory compounds in asthma. MEM 1414 is a novel ...

    Authors: Brian R Leaker, Dave Singh, Ferhana Y Ali, Peter J Barnes and Brian O’Connor

    Citation: BMC Pulmonary Medicine 2014 14:166

    Content type: Research article

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  45. Wheezing during early life is a very common disorder, but the reasons underlying the different wheezing phenotypes are still unclear. The aims of this study were to analyse the potential correlations between t...

    Authors: Susanna Esposito, Valentina Ierardi, Cristina Daleno, Alessia Scala, Leonardo Terranova, Claudia Tagliabue, Walter Peves Rios, Claudio Pelucchi and Nicola Principi

    Citation: BMC Pulmonary Medicine 2014 14:162

    Content type: Research article

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  46. In epidemiological studies of asthma, questionnaires to differentiate asthmatics from non-asthmatics have proven to be cost-effective and convenient. The aim of this study was to analyze the association betwee...

    Authors: So Yeon Lim, Young Joo Jo and Eun Mi Chun

    Citation: BMC Pulmonary Medicine 2014 14:161

    Content type: Research article

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  47. Asthma is a chronic inflammatory airway disease characterized by reversible obstruction, inflammation and hyperresponsiveness to different stimulus. Aerobic and breathing exercises have been demonstrated to be...

    Authors: Karen B Evaristo, Milene G Saccomani, Milton A Martins, Alberto Cukier, Rafael Stelmach, Marcos R Rodrigues, Danilo F Santaella and Celso RF Carvalho

    Citation: BMC Pulmonary Medicine 2014 14:160

    Content type: Study protocol

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