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Basic science and experimental pulmonology

Section edited by Isis Fernandez

This section considers studies on molecular mechanisms and biological basis of non-cancer pulmonary disorders, including animal models of lung disease, in vitro studies, pulmonary physiology in health and disease, and experimental spirometry.

  1. Content type: Research article

    The respiratory microbiome is altered in COPD patients but its relationship with core components of the disease, such as the severity of airflow limitation, the frequency of exacerbations or the circulating le...

    Authors: Laura Millares, Sergi Pascual, Concepción Montón, Marian García-Núñez, Cristina Lalmolda, Rosa Faner, Carme Casadevall, Laia Setó, Silvia Capilla, Amàlia Moreno, Ady Angélica Castro-Acosta, Carlos José Alvarez-Martinez, Oriol Sibila, Germán Peces-Barba, Borja G. Cosio, Alvar Agustí…

    Citation: BMC Pulmonary Medicine 2019 19:112

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  2. Content type: Research article

    Acute respiratory distress syndrome (ARDS) is a life-threatening disease; however, its treatment has not yet been fully established. The progression of ARDS is considered to be mediated by altered intercellula...

    Authors: Sotaro Shikano, Yasuhiro Gon, Shuichiro Maruoka, Tetsuo Shimizu, Yutaka Kozu, Yuko Iida, Mari Hikichi, Mai Takahashi, Shinichi Okamoto, Kota Tsuya, Asami Fukuda, Kenji Mizumura and Shu Hashimoto

    Citation: BMC Pulmonary Medicine 2019 19:110

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  3. Content type: Research article

    Reactive oxygen species (ROS) levels largely determine pulmonary fibrosis. Antioxidants have been found to ameliorate lung fibrosis after long-term paraquat (PQ) exposure. The effects of antioxidants, however,...

    Authors: Ming-wei Liu, Mei-xian Su, Deng-yun Tang, Li Hao, Xiang-Han Xun and Yun-qiao Huang

    Citation: BMC Pulmonary Medicine 2019 19:35

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  4. Content type: Research article

    Impaired angiogenesis is assumed to be an important factor in the development of chronic thromboembolic pulmonary hypertension (CTEPH). However, the role of endothelial cells (ECs) in CTEPH remains unclear. Th...

    Authors: Akira Naito, Seiichiro Sakao, Irene M. Lang, Norbert F. Voelkel, Takayuki Jujo, Keiichi Ishida, Toshihiko Sugiura, Goro Matsumiya, Ichiro Yoshino, Nobuhiro Tanabe and Koichiro Tatsumi

    Citation: BMC Pulmonary Medicine 2018 18:197

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  5. Content type: Research article

    Hepatic ischemia-reperfusion injury (IRI) is a common pathological phenomenon, which causes hepatic injury as well as remote organ injuries such as the lung. Several mediators, such as oxidative stress, Ca2+ over...

    Authors: Yao Tong, Zhuang Yu, Renlingzi Zhang, Xibing Ding, Zhixia Chen and Quan Li

    Citation: BMC Pulmonary Medicine 2018 18:189

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  6. Content type: Research article

    The breakdown of alveolar barrier dysfunction contributes to Lipopolysaccharide stimulated pulmonary edema and acute lung injury. Actin cytoskeleton has been implicated to be critical in regulation of epitheli...

    Authors: Weiju Wang, Jie Weng, Lei Yu, Qiaobing Huang, Yong Jiang and Xiaohua Guo

    Citation: BMC Pulmonary Medicine 2018 18:178

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  7. Content type: Research article

    The acute respiratory distress syndrome (ARDS) is a serious disease in critically ill patients that is characterized by pulmonary dysfunctions, hypoxemia and significant mortality. Patients with immunodeficien...

    Authors: Eva Verjans, Stephanie Kanzler, Kim Ohl, Annette D. Rieg, Nadine Ruske, Angela Schippers, Norbert Wagner, Klaus Tenbrock, Stefan Uhlig and Christian Martin

    Citation: BMC Pulmonary Medicine 2018 18:174

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  8. Content type: Research article

    Interleukin (IL)-3 amplifies inflammation. However, the effect of IL-3 in acute lung injury (ALI), an acute inflammatory disease, is unclear. The aim of this study was to test the hypothesis that IL-3 plays an...

    Authors: Zhijian Huang, Wei Zhang, Jian Yang, Feiyu Sun and Hongwei Zhou

    Citation: BMC Pulmonary Medicine 2018 18:164

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  9. Content type: Research article

    Pulmonary function tests (PFTs) are routinely performed in the upright position due to measurement devices and patient comfort. This systematic review investigated the influence of body position on lung functi...

    Authors: Shikma Katz, Nissim Arish, Ariel Rokach, Yacov Zaltzman and Esther-Lee Marcus

    Citation: BMC Pulmonary Medicine 2018 18:159

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  10. Content type: Research article

    Pulmonary hypertension (PH) is a rare disease characterized by proliferation and occlusion of small pulmonary arterioles, which has been associated with a high mortality rate. The pathogenesis of PH is complex...

    Authors: Caiyong Yin, Kai Li, Yanfang Yu, Huijie Huang, Youjia Yu, Zhongqun Wang, Jinchuan Yan, Yan Pu, Zheng Li, Ding Li, Peng Chen and Feng Chen

    Citation: BMC Pulmonary Medicine 2018 18:158

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  11. Content type: Research article

    Adipose-derived mesenchymal stem cell (ASCs) exerts immunomodulatory roles in asthma. However, the underlying mechanism remains unclear. The present study aimed to explore the effects and mechanisms of ASCs on...

    Authors: Ranran Dai, Youchao Yu, Guofeng Yan, Xiaoxia Hou, Yingmeng Ni and Guochao Shi

    Citation: BMC Pulmonary Medicine 2018 18:131

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  12. Content type: Research article

    Src homology 2 containing protein tyrosine phosphatase (PTP) 2 (Shp2) is a typical tyrosine phosphatase interacting with receptor tyrosine kinase to regulate multiple signaling pathways in diverse pathological...

    Authors: Yusheng Cheng, Min Yu, Jian Xu, Mengyu He, Hong Wang, Hui Kong and Weiping Xie

    Citation: BMC Pulmonary Medicine 2018 18:130

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  13. Content type: Research article

    The ability of circulating monocytes to develop into lung macrophages and promote lung tissue damage depends upon their phenotypic pattern of differentiation and activation. Whether this phenotypic pattern var...

    Authors: William D. Cornwell, Victor Kim, Xiaoxuan Fan, Marie Elena Vega, Frederick V. Ramsey, Gerard J. Criner and Thomas J. Rogers

    Citation: BMC Pulmonary Medicine 2018 18:101

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  14. Content type: Research article

    Compared to other pulmonary function tests, there is a lack of standardization regarding how a maximum voluntary ventilation (MVV) maneuver is performed. Specifically, little is known about the variation in br...

    Authors: Eric V. Neufeld, Brett A. Dolezal, William Speier and Christopher B. Cooper

    Citation: BMC Pulmonary Medicine 2018 18:89

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  15. Content type: Research article

    There is a need for more powerful methods to identify low-effect SNPs that contribute to hereditary COPD pathogenesis. We hypothesized that SNPs contributing to COPD risk through cis-regulatory effects are enrich...

    Authors: Jiyoun Yeo, Diego A. Morales, Tian Chen, Erin L. Crawford, Xiaolu Zhang, Thomas M. Blomquist, Albert M. Levin, Pierre P. Massion, Douglas A. Arenberg, David E. Midthun, Peter J. Mazzone, Steven D. Nathan, Ronald J. Wainz, Patrick Nana-Sinkam, Paige F. S. Willey, Taylor J. Arend…

    Citation: BMC Pulmonary Medicine 2018 18:42

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  16. Content type: Research article

    The relationship of spirometric values to other respiratory and functional parameters in advanced age is not well studied. We assessed this relationship in elderly subjects with either good or poor spirometric...

    Authors: Stefan Karrasch, Jürgen Behr, Rudolf M. Huber, Dennis Nowak, Annette Peters, Stefan Peters, Rolf Holle, Rudolf A. Jörres and Holger Schulz

    Citation: BMC Pulmonary Medicine 2018 18:27

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  17. Content type: Research article

    (Over-)expression of arginase may limit local availability of arginine for nitric oxide synthesis. We investigated the significance of arginase1 (ARG1) for the development of airway hyperresponsiveness (AHR) a...

    Authors: Roy H. E. Cloots, Selvakumari Sankaranarayanan, Matthew E. Poynter, Els Terwindt, Paul van Dijk, Wouter H. Lamers and S. Eleonore Köhler

    Citation: BMC Pulmonary Medicine 2017 17:158

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  18. Content type: Research article

    The six-minute walk test (6MWT) is a safe, simple, inexpensive tool for evaluating the functional exercise capacity. However, there is a lack of standard reference equations for the six-minute walk distance (6...

    Authors: He Zou, Jia Zhang, Xiaoshu Chen, Yi Wang, Wei Lin, Jianfeng Lin, Hao Chen and Jingye Pan

    Citation: BMC Pulmonary Medicine 2017 17:119

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