Section edited by Montserrat Sanchez Cespedes

This section concerns all aspects of lung cancer including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Research article

    Propensity score analysis of lung cancer risk in a population with high prevalence of non-smoking related lung cancer

    Lung cancer has been the leading cause of cancer-related mortality worldwide among both men and women in recent years. There is an increase in the incidence of nonsmoking-related lung cancer in recent years. T...

    Kuei-Feng Lin, Hsiu-Fu Wu, Wei-Chun Huang, Pei-Ling Tang, Ming-Ting Wu and Fu-Zong Wu

    BMC Pulmonary Medicine 2017 17:120

    Published on: 6 September 2017

  2. Research article

    Association between Charlson comorbidity index score and outcome in patients with stage IIIB-IV non-small cell lung cancer

    This retrospective study investigated the association between the Charlson comorbidity index (CCI) score and the survival of patients with stage IIIB-IV (advanced, non-resectable) non-small cell lung cancer (N...

    Lei Zhao, Lai-Han Leung, Jing Wang, Huihui Li, Juanjuan Che, Lian Liu, Xiaojun Yao and Bangwei Cao

    BMC Pulmonary Medicine 2017 17:112

    Published on: 15 August 2017

  3. Research article

    Cathepsin-S degraded decorin are elevated in fibrotic lung disorders – development and biological validation of a new serum biomarker

    Decorin is one of the most abundant proteoglycans of the extracellular matrix and is mainly secreted and deposited in the interstitial matrix by fibroblasts where it plays an important role in collagen turnove...

    S.N. Kehlet, C.L. Bager, N. Willumsen, B. Dasgupta, C. Brodmerkel, M. Curran, S. Brix, D.J. Leeming and M. A. Karsdal

    BMC Pulmonary Medicine 2017 17:110

    Published on: 9 August 2017

  4. Research article

    Diagnostic value of medical thoracoscopy in malignant pleural effusion

    Medical thoracoscopy has been shown to be an efficacious procedure in diagnosing unexplained exudative pleural effusions with excellent safety. This study aimed to assess the diagnostic significance of thoraco...

    Yan-Bing Wu, Li-Li Xu, Xiao-Juan Wang, Zhen Wang, Jun Zhang, Zhao-Hui Tong and Huan-Zhong Shi

    BMC Pulmonary Medicine 2017 17:109

    Published on: 4 August 2017

  5. Research article

    Detection of ALK fusion transcripts in FFPE lung cancer samples by NanoString technology

    ALK-rearranged lung cancers exhibit specific pathologic and clinical features and are responsive to anti-ALK therapies. Therefore, the detection of ALK-rearrangement is fundamental for...

    Adriane F. Evangelista, Maicon F. Zanon, Adriana Cruvinel Carloni, Flávia E. de Paula, Mariana Andozia Morini, Maressa Ferreira-Neto, Iberê Cauduro Soares, Jose Elias Miziara, Pedro de Marchi, Cristovam Scapulatempo-Neto and Rui M. Reis

    BMC Pulmonary Medicine 2017 17:86

    Published on: 26 May 2017

  6. Research article

    Electromagnetic navigation bronchoscopy to access lung lesions in 1,000 subjects: first results of the prospective, multicenter NAVIGATE study

    Electromagnetic navigation bronchoscopy (ENB) is an image-guided, minimally invasive approach that uses a flexible catheter to access pulmonary lesions.

    Sandeep J. Khandhar, Mark R. Bowling, Javier Flandes, Thomas R. Gildea, Kristin L. Hood, William S. Krimsky, Douglas J. Minnich, Septimiu D. Murgu, Michael Pritchett, Eric M. Toloza, Momen M. Wahidi, Jennifer J. Wolvers and Erik E. Folch

    BMC Pulmonary Medicine 2017 17:59

    Published on: 11 April 2017

  7. Research article

    Transbronchial and transesophageal fine-needle aspiration using a single ultrasound bronchoscope in the diagnosis of locoregional recurrence of surgically-treated lung cancer

    The present study sought to evaluate the usefulness of EBUS-TBNA in the diagnosis of locoregional recurrence of lung cancer in a cohort of lung cancer patients who were previously treated surgically, and descr...

    José Sanz-Santos, Pere Serra, Felipe Andreo, Mohamed Torky, Carmen Centeno, Teresa Morán, Enric Carcereny, Esther Fernández, Samuel García-Reina and Juan Ruiz-Manzano

    BMC Pulmonary Medicine 2017 17:46

    Published on: 28 February 2017

  8. Research article

    Combined cumulative sum (CUSUM) and chronological environmental analysis as a tool to improve the learning environment for linear-probe endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) trainees: a pilot study

    Cumulative sum (CUSUM) analysis can be used to continuously monitor the performance of an individual or process and detect deviations from a preset or standard level of achievement. However, no previous study ...

    Yasuhiro Norisue, Yasuharu Tokuda, Mayrol Juarez, Ryo Uchimido, Shigeki Fujitani and David A. Stoeckel

    BMC Pulmonary Medicine 2017 17:32

    Published on: 7 February 2017

  9. Research article

    FDG-PET parameters predicting mediastinal malignancy in lung cancer

    Staging of mediastinal lymph nodes in non-small cell lung cancer (NSCLC) is mandatory. The maximum Standard Uptake Value (SUVmax) obtained using F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) i...

    M. Serra Fortuny, M. Gallego, Ll Berna, C. Montón, L. Vigil, M. J. Masdeu, A. Fernández-Villar, M. I. Botana, R. Cordovilla, R. García-Luján, E. Cases and E. Monsó

    BMC Pulmonary Medicine 2016 16:177

    Published on: 8 December 2016

  10. Technical advance

    Small lung lesions invisible under fluoroscopy are located accurately by three-dimensional localization technique on chest wall surface and performed bronchoscopy procedures to increase diagnostic yields

    Nowadays, small peripheral pulmonary lesions (PPLs) are frequently detected and the prognosis of lung cancer depends on the early diagnosis. Because of the high fee and requiring specialized training, many adv...

    Chaosheng Deng, Xiaoming Cao, Dawen Wu, Haibo Ding, Ruixiong You, Qunlin Chen, Linying Chen, Xin Zhang, Qiaoxian Zhang and Yongquan Wu

    BMC Pulmonary Medicine 2016 16:166

    Published on: 29 November 2016

  11. Research article

    Combined ultrasound-guided cutting-needle biopsy and standard pleural biopsy for diagnosis of malignant pleural effusions

    The most efficient approach to diagnose malignant pleural effusions (MPEs) is still controversial and uncertain. This study aimed to evaluate the utility of a combined approach using ultrasound (US)-guided cut...

    Jinlin Wang, Xinghua Zhou, Xiaohong Xie, Qing Tang, Panxiao Shen and Yunxiang Zeng

    BMC Pulmonary Medicine 2016 16:155

    Published on: 17 November 2016

  12. Research article

    The regional association between bronchiectasis and lung cancer in chest CT

    Limited studies have examined the association between lung cancer and bronchiectasis (BE). This study evaluated the regional association between BE and lung cancer by analyzing the lobar location of lung cance...

    Yeon Wook Kim, Chang-Hoon Lee, Kwang-Nam Jin, Jung-Kyu Lee, Eun Young Heo, Sung Soo Park, Hee Soon Chung and Deog Kyeom Kim

    BMC Pulmonary Medicine 2016 16:151

    Published on: 15 November 2016

  13. Research article

    Re-biopsy by endobronchial ultrasound procedures for mutation analysis of non-small cell lung cancer after EGFR tyrosine kinase inhibitor treatment

    Re-biopsy for resistant non-small cell lung cancer (NSCLC) after treatment with epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) is important for selection of better therapy, but there h...

    Takehiro Izumo, Yuji Matsumoto, Christine Chavez and Takaaki Tsuchida

    BMC Pulmonary Medicine 2016 16:106

    Published on: 26 July 2016

  14. Research article

    Endobronchial ultrasound in real life: primary diagnosis and mediastinal staging of lung cancer in patients submitted to thoracic surgery

    Since the first articles published for over 10 years ago, endobronchial ultrasound (EBUS) has gained a strong scientific backing and has been incorporated into routine medical practice in pulmonology and thora...

    João Pedro Steinhauser Motta, Axel Tobias Kempa, Alexandre Pinto Cardoso, Marcos Eduardo Paschoal, Ronir Raggio Luiz, José Roberto Lapa e Silva and Franz Stanzel

    BMC Pulmonary Medicine 2016 16:101

    Published on: 19 July 2016

  15. Research article

    Comparison of next generation sequencing, SNaPshot assay and real-time polymerase chain reaction for lung adenocarcinoma EGFR mutation assessment

    The epidermal growth factor receptor (EGFR) mutation status assessment has become increasingly important given the significant impact of tyrosine kinase inhibitors in lung cancer management.

    Andrei-Tudor Cernomaz, Ina Iuliana Macovei, Ionut Pavel, Carmen Grigoriu, Mihai Marinca, Florent Baty, Simona Peter, Radu Zonda, Martin Brutsche and Bogdan- Dragos Grigoriu

    BMC Pulmonary Medicine 2016 16:88

    Published on: 23 May 2016

  16. Research article

    Impact of a bronchial genomic classifier on clinical decision making in patients undergoing diagnostic evaluation for lung cancer

    Bronchoscopy is frequently used for the evaluation of suspicious pulmonary lesions found on computed tomography, but its sensitivity for detecting lung cancer is limited. Recently, a bronchial genomic classifi...

    J. Scott Ferguson, Ryan Van Wert, Yoonha Choi, Michael J. Rosenbluth, Kate Porta Smith, Jing Huang and Avrum Spira

    BMC Pulmonary Medicine 2016 16:66

    Published on: 17 May 2016

  17. Research article

    Radial endobronchial ultrasound with a guide sheath for diagnosis of peripheral cavitary lung lesions: a retrospective study

    Radial endobronchial ultrasound with a guide sheath (EBUS-GS) has improved the diagnostic outcomes of peripheral lung lesions. However, to our knowledge, reports on the use of EBUS-GS for diagnosis of cavitary...

    Manabu Hayama, Norio Okamoto, Hidekazu Suzuki, Motohiro Tamiya, Takayuki Shiroyama, Ayako Tanaka, Takuji Nishida, Takashi Nishihara, Nobuko Uehara, Naoko Morishita, Kunimitsu Kawahara and Tomonori Hirashima

    BMC Pulmonary Medicine 2016 16:76

    Published on: 11 May 2016

  18. Research article

    Ultrathin bronchoscopy for solitary pulmonary lesions in a region endemic for tuberculosis: a randomised pilot trial

    The evaluation of solitary pulmonary lesions (SPL) requires a balance between procedure-related morbidity and diagnostic yield, particularly in areas where tuberculosis (TB) is endemic. Data on ultrathin bronc...

    Daniel Franzen, Andreas H. Diacon, Lutz Freitag, Pawel T. Schubert, Colleen A. Wright and Macé M. Schuurmans

    BMC Pulmonary Medicine 2016 16:62

    Published on: 27 April 2016

  19. Study protocol

    Design of a prospective, multicenter, global, cohort study of electromagnetic navigation bronchoscopy

    Electromagnetic navigation bronchoscopy (ENB) procedures allow physicians to access peripheral lung lesions beyond the reach of conventional bronchoscopy. However, published research is primarily limited to sm...

    Erik E. Folch, Mark R. Bowling, Thomas R. Gildea, Kristin L. Hood, Septimiu D. Murgu, Eric M. Toloza, Momen M. Wahidi, Terence Williams and Sandeep J. Khandhar

    BMC Pulmonary Medicine 2016 16:60

    Published on: 26 April 2016

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