Skip to content



Section edited by Montserrat Sanchez Cespedes

This section concerns all aspects of lung cancer including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

Page 1 of 2

  1. Content type: Research article

    Candidates for preoperative or intraoperative nodal assessment among patients with non-small cell lung cancer (NSCLC) manifesting as a subsolid tumor are not established. The present study was conducted to dem...

    Authors: Jun Yeun Cho, Cho Sun Leem, Youlim Kim, Eun Sun Kim, Sang Hoon Lee, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Jae Ho Lee, Choon-Taek Lee and Ho Il Yoon

    Citation: BMC Pulmonary Medicine 2018 18:151

    Published on:

  2. Content type: Research article

    Convenient approaches for accurate biopsy are extremely important to the diagnosis of lung cancer. We aimed to systematically review the clinical updates and development trends of approaches for biopsy, i.e., ...

    Authors: Chuan-Jiang Deng, Fu-Qiang Dai, Kai Qian, Qun-You Tan, Ru-Wen Wang, Bo Deng and Jing-Hai Zhou

    Citation: BMC Pulmonary Medicine 2018 18:146

    Published on:

  3. Content type: Research article

    As reported in Surveillance, Epidemiology, and End Results (SEER) data, US incidence and prevalence of neuroendocrine tumors (NET) has increased over recent years. The study objective was to update incidence a...

    Authors: Michael S. Broder, Beilei Cai, Eunice Chang and Maureen P. Neary

    Citation: BMC Pulmonary Medicine 2018 18:135

    Published on:

  4. Content type: Research article

    The diagnostic yields and safety profiles of transbronchial lung biopsy have not been evaluated in inexperienced physicians using the combined modality of radial probe endobronchial ultrasound and a guide shea...

    Authors: Jung Seop Eom, Jeong Ha Mok, Insu Kim, Min Ki Lee, Geewon Lee, Hyemi Park, Ji Won Lee, Yeon Joo Jeong, Won-Young Kim, Eun Jung Jo, Mi Hyun Kim, Kwangha Lee, Ki Uk Kim and Hye-Kyung Park

    Citation: BMC Pulmonary Medicine 2018 18:137

    Published on:

  5. Content type: Research article

    Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of developing lung cancer, but few studies have investigated the long-term outcomes of repeated surgery in such patients. The purpose of this ...

    Authors: Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Hiroyuki Ishikawa, Takehiro Watanabe and Masanori Tsuchida

    Citation: BMC Pulmonary Medicine 2018 18:134

    Published on:

  6. Content type: Research article

    Screening mutations in epidermal growth factor receptor (EGFR) to analyze non-small-cell lung cancer (NSCLC) profile is the criterion to choose the best therapeutic strategy.

    Authors: Zohra Mraihi, Jihen Ben Amar, Hend Bouacha, Soumaya Rammeh and Lamia Hila

    Citation: BMC Pulmonary Medicine 2018 18:132

    Published on:

  7. Content type: Research article

    To determine the association of lymphatic vessel density (LVD) with the prognosis of Asian non-small cell lung cancer (NSCLC) patients via a meta-analysis.

    Authors: Shuanglan Xu, Jiao Yang, Shuangyan Xu, Yun Zhu, Chunfang Zhang, Liqiong Liu, Hao Liu, Yunlong Dong, Zhaowei Teng and Xiqian Xing

    Citation: BMC Pulmonary Medicine 2018 18:128

    Published on:

  8. Content type: Research article

    Old age is an important factor that could affect the treatment of early-stage lung cancer. In this study, we evaluated the treatment patterns and outcomes of patients over the age of 80 years who had been diag...

    Authors: Kyungjong Lee, Hye Ok Kim, Hee Kyoung Choi and Gi Hyeon Seo

    Citation: BMC Pulmonary Medicine 2018 18:127

    Published on:

  9. Content type: Case report

    Crizotinib is a multi-target inhibitor approved for the treatment of advanced non-small-cell lung cancer patients with a ROS1 rearrangement. However, interstitial lung disease is a rare but severe and fatal si...

    Authors: Shibo Wu, Kaitai Liu, Feng Ren, Dawei Zheng and Deng Pan

    Citation: BMC Pulmonary Medicine 2018 18:121

    Published on:

  10. Content type: Research article

    There are currently no data on the prevalence of sleep-disordered breathing (SDB) in patients with newly-diagnosed lung cancer. This might be of interest given that SDB is associated with increased cancer inci...

    Authors: Michael Dreher, Stefan Krüger, Susanne Schulze-Olden, András Keszei, Jan Hendrik Storre, Holger Woehrle, Michael Arzt and Tobias Müller

    Citation: BMC Pulmonary Medicine 2018 18:72

    Published on:

  11. Content type: Research article

    Malignant pleural mesothelioma (MPM) is marked by its difficult diagnosis and poor prognosis. Medical thoracoscopy (MT) is an effective and safe procedure for the diagnosis of exudative pleural effusions and m...

    Authors: Li-Li Xu, Yuan Yang, Zhen Wang, Xiao-Juan Wang, Zhao-Hui Tong and Huan-Zhong Shi

    Citation: BMC Pulmonary Medicine 2018 18:56

    Published on:

  12. Content type: Research article

    Interventional bronchoscopy is considered an effective treatment option for malignant central airway obstruction (MCAO). However, there are few reports of interventional bronchoscopy in patients with MCAOs due...

    Authors: Beomsu Shin, Boksoon Chang, Hojoong Kim and Byeong-Ho Jeong

    Citation: BMC Pulmonary Medicine 2018 18:46

    Published on:

  13. Content type: Research article

    Although the impact of therapeutic thoracentesis on lung function and blood gases has been evaluated in several studies, some physiological aspects of pleural fluid withdrawal remain unknown. The aim of the st...

    Authors: Monika Zielinska-Krawczyk, Elzbieta M. Grabczak, Marcin Michnikowski, Krzysztof Zielinski, Piotr Korczynski, Anna Stecka, Tomasz Golczewski and Rafal Krenke

    Citation: BMC Pulmonary Medicine 2018 18:36

    Published on:

  14. Content type: Case report

    Nivolumab, an anti-programmed cell death-1 (PD-1) monoclonal antibody used as an immune checkpoint inhibitor, is commonly employed for its anti-tumor effects against various types of malignant tumors. However,...

    Authors: N. Koyama, O. Iwase, E. Nakashima, K. Kishida, T. Kondo, Y. Watanabe, H. Takahashi, Y. Umebayashi, Y. Ogawa and H. Miura

    Citation: BMC Pulmonary Medicine 2018 18:23

    Published on:

  15. Content type: Case report

    Crizotinib is recommended as first-line therapy in ROS1-driven lung adenocarcinoma. However, the optimal first-line therapy for this subgroup of lung cancer is controversial according to the available clinical...

    Authors: Liang Dong, Jingwen Xia, Jing Zhang, Yuanyuan Zhang, Ning Zhu, Peng Zhang, Youzhi Zhang, Xiujuan Zhang and Shengqing Li

    Citation: BMC Pulmonary Medicine 2018 18:13

    Published on:

  16. Content type: Research article

    Previous studies show that overexpression of EMMPRIN involved in the malignant biological behavior of tumors. This investigation was to disclose the expression status of EMMPRIN in non-small cell lung cancer (...

    Authors: Bing Liu, Zhaohui Wan, Baowei Sheng, Yong Lin, Tian Fu, Qingdi Zeng and Congcong Qi

    Citation: BMC Pulmonary Medicine 2017 17:214

    Published on:

  17. Content type: Research article

    Previous studies have suggested that DNA double-strand break (DSB) repair is an important protective pathway after damage. The ataxia telangiectasia mutated (ATM) gene plays an important role in the DNA DSB re...

    Authors: Zhipeng Yan, Xiang Tong, Yao Ma, Sitong Liu, Lingjing Yang, Xin Yang, Xue Yang, Min Bai and Hong Fan

    Citation: BMC Pulmonary Medicine 2017 17:205

    Published on:

  18. Content type: Research article

    NKX2–1, a key molecule in lung development, is highly expressed in non-small cell lung cancer (NSCLC), particularly in lung adenocarcinoma (ADK), where it is a diagnostic marker. Studies of the prognostic role...

    Authors: Jorge Moisés, Alfons Navarro, Sandra Santasusagna, Nuria Viñolas, Laureano Molins, José Ramirez, Jeisson Osorio, Adela Saco, Joan Josep Castellano, Carmen Muñoz, Sara Morales, Mariano Monzó and Ramón María Marrades

    Citation: BMC Pulmonary Medicine 2017 17:197

    Published on:

  19. Content type: Research article

    It is crucial to develop novel diagnostic approaches for determining if peripheral lung nodules are malignant, as such nodules are frequently detected due to the increased use of chest computed tomography scan...

    Authors: Akifumi Uchida, Takuya Samukawa, Tomohiro Kumamoto, Masahiro Ohshige, Kazuhito Hatanaka, Yoshihiro Nakamura, Keiko Mizuno, Ikkou Higashimoto, Masami Sato and Hiromasa Inoue

    Citation: BMC Pulmonary Medicine 2017 17:195

    Published on:

  20. Content type: Research article

    Transbronchial biopsy for peripheral pulmonary lesions is generally performed under X-ray fluoroscopy. Virtual bronchoscopic navigation (VBN) is a method in which virtual images of the bronchial route to the l...

    Authors: Fumihiro Asano, Takashi Ishida, Naofumi Shinagawa, Noriaki Sukoh, Masaki Anzai, Kenya Kanazawa, Akifumi Tsuzuku and Satoshi Morita

    Citation: BMC Pulmonary Medicine 2017 17:184

    Published on:

  21. Content type: Research article

    Guidelines recommend timely evaluation of patients with suspected lung cancer. We evaluated the impact of a Rapid Investigation Clinic (RIC) on timeliness of lung cancer diagnosis and treatment between Februar...

    Authors: Nicole Ezer, Asma Navasakulpong, Kevin Schwartzman, Linda Ofiara and Anne V. Gonzalez

    Citation: BMC Pulmonary Medicine 2017 17:178

    Published on:

  22. Content type: Research article

    When epidermal growth factor receptor (EGFR) gene mutation-positive non-small cell lung cancer (NSCLC) acquires resistance to the initial tyrosine kinase inhibitor (TKI) treatment, reassessing the tumor DNA by...

    Authors: Sakurako Uozu, Kazuyoshi Imaizumi, Teppei Yamaguchi, Yasuhiro Goto, Kenji Kawada, Tomoyuki Minezawa, Takuya Okamura, Ken Akao, Masamichi Hayashi, Sumito Isogai, Mitsushi Okazawa, Naozumi Hashimoto and Yoshinori Hasegawa

    Citation: BMC Pulmonary Medicine 2017 17:175

    Published on:

  23. Content type: Case report

    Alectinib, a second-generation anaplastic lymphoma kinase (ALK) inhibitor, is a key drug for ALK rearranged lung adenocarcinoma. Interstitial lung disease (ILD) is an important adverse effect of alectinib, whi...

    Authors: Tatsuya Nitawaki, Yoshihiko Sakata, Kodai Kawamura and Kazuya Ichikado

    Citation: BMC Pulmonary Medicine 2017 17:173

    Published on:

  24. Content type: Research article

    Previously reported prognostic tools for patients with resected non-small cell lung cancer (NSCLC) include factors found postoperatively, but not preoperatively. However, it would be important to predict patie...

    Authors: Shogo Kumagai, Satoshi Marumo, Machiko Arita, Keiji Yamanashi, Ryota Sumitomo, Yosuke Otake, Tsuyoshi Shoji, Motonari Fukui, Toshiro Katayama, Norihito Okumura and Cheng-Long Huang

    Citation: BMC Pulmonary Medicine 2017 17:166

    Published on:

  25. Content type: Research article

    To report the prevalence of pleural plaques in a lung cancer screening trial by low-dose computed tomography (LDCT) and to test the association with incidence of lung cancer and mortality.

    Authors: Mario Silva, Nicola Sverzellati, Davide Colombi, Gianluca Milanese, Carlo La Vecchia, Carlotta Galeone, Alfonso Marchianò and Ugo Pastorino

    Citation: BMC Pulmonary Medicine 2017 17:155

    Published on:

  26. Content type: Research article

    Radial-probe endobronchial ultrasound (rEBUS)-guided transbronchial biopsy (TBB) is invaluable in the diagnosis of peripheral pulmonary lesions (PPLs); however, in certain instances, the procedure has to be re...

    Authors: Chun-Ta Huang, Yi-Ju Tsai, Chao-Chi Ho and Chong-Jen Yu

    Citation: BMC Pulmonary Medicine 2017 17:132

    Published on:

  27. Content type: Research article

    Lung cancer has been the leading cause of cancer-related mortality worldwide among both men and women in recent years. There is an increase in the incidence of nonsmoking-related lung cancer in recent years. T...

    Authors: Kuei-Feng Lin, Hsiu-Fu Wu, Wei-Chun Huang, Pei-Ling Tang, Ming-Ting Wu and Fu-Zong Wu

    Citation: BMC Pulmonary Medicine 2017 17:120

    Published on:

  28. Content type: Research article

    This retrospective study investigated the association between the Charlson comorbidity index (CCI) score and the survival of patients with stage IIIB-IV (advanced, non-resectable) non-small cell lung cancer (N...

    Authors: Lei Zhao, Lai-Han Leung, Jing Wang, Huihui Li, Juanjuan Che, Lian Liu, Xiaojun Yao and Bangwei Cao

    Citation: BMC Pulmonary Medicine 2017 17:112

    Published on:

  29. Content type: Research article

    Decorin is one of the most abundant proteoglycans of the extracellular matrix and is mainly secreted and deposited in the interstitial matrix by fibroblasts where it plays an important role in collagen turnove...

    Authors: S.N. Kehlet, C.L. Bager, N. Willumsen, B. Dasgupta, C. Brodmerkel, M. Curran, S. Brix, D.J. Leeming and M. A. Karsdal

    Citation: BMC Pulmonary Medicine 2017 17:110

    Published on:

  30. Content type: Research article

    Medical thoracoscopy has been shown to be an efficacious procedure in diagnosing unexplained exudative pleural effusions with excellent safety. This study aimed to assess the diagnostic significance of thoraco...

    Authors: Yan-Bing Wu, Li-Li Xu, Xiao-Juan Wang, Zhen Wang, Jun Zhang, Zhao-Hui Tong and Huan-Zhong Shi

    Citation: BMC Pulmonary Medicine 2017 17:109

    Published on:

  31. Content type: Research article

    We analyzed the differences between maximum and peak computed tomography (CT) numbers (M-P), respectively representing the densities of the solid center and the main periphery of ground-glass nodules (GGNs), a...

    Authors: Mingzheng Peng, Gang Yu, Chengzhong Zhang, Cuidi Li and Jinwu Wang

    Citation: BMC Pulmonary Medicine 2017 17:93

    Published on:

  32. Content type: Research article

    ALK-rearranged lung cancers exhibit specific pathologic and clinical features and are responsive to anti-ALK therapies. Therefore, the detection of ALK-rearrangement is fundamental for...

    Authors: Adriane F. Evangelista, Maicon F. Zanon, Adriana Cruvinel Carloni, Flávia E. de Paula, Mariana Andozia Morini, Maressa Ferreira-Neto, Iberê Cauduro Soares, Jose Elias Miziara, Pedro de Marchi, Cristovam Scapulatempo-Neto and Rui M. Reis

    Citation: BMC Pulmonary Medicine 2017 17:86

    Published on:

  33. Content type: Research article

    Electromagnetic navigation bronchoscopy (ENB) is an image-guided, minimally invasive approach that uses a flexible catheter to access pulmonary lesions.

    Authors: Sandeep J. Khandhar, Mark R. Bowling, Javier Flandes, Thomas R. Gildea, Kristin L. Hood, William S. Krimsky, Douglas J. Minnich, Septimiu D. Murgu, Michael Pritchett, Eric M. Toloza, Momen M. Wahidi, Jennifer J. Wolvers and Erik E. Folch

    Citation: BMC Pulmonary Medicine 2017 17:59

    Published on:

  34. Content type: Research article

    The present study sought to evaluate the usefulness of EBUS-TBNA in the diagnosis of locoregional recurrence of lung cancer in a cohort of lung cancer patients who were previously treated surgically, and descr...

    Authors: José Sanz-Santos, Pere Serra, Felipe Andreo, Mohamed Torky, Carmen Centeno, Teresa Morán, Enric Carcereny, Esther Fernández, Samuel García-Reina and Juan Ruiz-Manzano

    Citation: BMC Pulmonary Medicine 2017 17:46

    Published on:

  35. Content type: Research article

    Cumulative sum (CUSUM) analysis can be used to continuously monitor the performance of an individual or process and detect deviations from a preset or standard level of achievement. However, no previous study ...

    Authors: Yasuhiro Norisue, Yasuharu Tokuda, Mayrol Juarez, Ryo Uchimido, Shigeki Fujitani and David A. Stoeckel

    Citation: BMC Pulmonary Medicine 2017 17:32

    Published on:

  36. Content type: Research article

    Staging of mediastinal lymph nodes in non-small cell lung cancer (NSCLC) is mandatory. The maximum Standard Uptake Value (SUVmax) obtained using F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) i...

    Authors: M. Serra Fortuny, M. Gallego, Ll Berna, C. Montón, L. Vigil, M. J. Masdeu, A. Fernández-Villar, M. I. Botana, R. Cordovilla, R. García-Luján, E. Cases and E. Monsó

    Citation: BMC Pulmonary Medicine 2016 16:177

    Published on:

  37. Content type: Technical advance

    Nowadays, small peripheral pulmonary lesions (PPLs) are frequently detected and the prognosis of lung cancer depends on the early diagnosis. Because of the high fee and requiring specialized training, many adv...

    Authors: Chaosheng Deng, Xiaoming Cao, Dawen Wu, Haibo Ding, Ruixiong You, Qunlin Chen, Linying Chen, Xin Zhang, Qiaoxian Zhang and Yongquan Wu

    Citation: BMC Pulmonary Medicine 2016 16:166

    Published on:

  38. Content type: Research article

    The most efficient approach to diagnose malignant pleural effusions (MPEs) is still controversial and uncertain. This study aimed to evaluate the utility of a combined approach using ultrasound (US)-guided cut...

    Authors: Jinlin Wang, Xinghua Zhou, Xiaohong Xie, Qing Tang, Panxiao Shen and Yunxiang Zeng

    Citation: BMC Pulmonary Medicine 2016 16:155

    Published on:

  39. Content type: Research article

    Limited studies have examined the association between lung cancer and bronchiectasis (BE). This study evaluated the regional association between BE and lung cancer by analyzing the lobar location of lung cance...

    Authors: Yeon Wook Kim, Chang-Hoon Lee, Kwang-Nam Jin, Jung-Kyu Lee, Eun Young Heo, Sung Soo Park, Hee Soon Chung and Deog Kyeom Kim

    Citation: BMC Pulmonary Medicine 2016 16:151

    Published on:

  40. Content type: Research article

    Re-biopsy for resistant non-small cell lung cancer (NSCLC) after treatment with epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) is important for selection of better therapy, but there h...

    Authors: Takehiro Izumo, Yuji Matsumoto, Christine Chavez and Takaaki Tsuchida

    Citation: BMC Pulmonary Medicine 2016 16:106

    Published on:

  41. Content type: Research article

    Since the first articles published for over 10 years ago, endobronchial ultrasound (EBUS) has gained a strong scientific backing and has been incorporated into routine medical practice in pulmonology and thora...

    Authors: João Pedro Steinhauser Motta, Axel Tobias Kempa, Alexandre Pinto Cardoso, Marcos Eduardo Paschoal, Ronir Raggio Luiz, José Roberto Lapa e Silva and Franz Stanzel

    Citation: BMC Pulmonary Medicine 2016 16:101

    Published on:

  42. Content type: Research article

    The epidermal growth factor receptor (EGFR) mutation status assessment has become increasingly important given the significant impact of tyrosine kinase inhibitors in lung cancer management.

    Authors: Andrei-Tudor Cernomaz, Ina Iuliana Macovei, Ionut Pavel, Carmen Grigoriu, Mihai Marinca, Florent Baty, Simona Peter, Radu Zonda, Martin Brutsche and Bogdan- Dragos Grigoriu

    Citation: BMC Pulmonary Medicine 2016 16:88

    Published on:

  43. Content type: Research article

    Bronchoscopy is frequently used for the evaluation of suspicious pulmonary lesions found on computed tomography, but its sensitivity for detecting lung cancer is limited. Recently, a bronchial genomic classifi...

    Authors: J. Scott Ferguson, Ryan Van Wert, Yoonha Choi, Michael J. Rosenbluth, Kate Porta Smith, Jing Huang and Avrum Spira

    Citation: BMC Pulmonary Medicine 2016 16:66

    Published on:

  44. Content type: Research article

    Radial endobronchial ultrasound with a guide sheath (EBUS-GS) has improved the diagnostic outcomes of peripheral lung lesions. However, to our knowledge, reports on the use of EBUS-GS for diagnosis of cavitary...

    Authors: Manabu Hayama, Norio Okamoto, Hidekazu Suzuki, Motohiro Tamiya, Takayuki Shiroyama, Ayako Tanaka, Takuji Nishida, Takashi Nishihara, Nobuko Uehara, Naoko Morishita, Kunimitsu Kawahara and Tomonori Hirashima

    Citation: BMC Pulmonary Medicine 2016 16:76

    Published on:

  45. Content type: Research article

    The evaluation of solitary pulmonary lesions (SPL) requires a balance between procedure-related morbidity and diagnostic yield, particularly in areas where tuberculosis (TB) is endemic. Data on ultrathin bronc...

    Authors: Daniel Franzen, Andreas H. Diacon, Lutz Freitag, Pawel T. Schubert, Colleen A. Wright and Macé M. Schuurmans

    Citation: BMC Pulmonary Medicine 2016 16:62

    Published on:

  46. Content type: Study protocol

    Electromagnetic navigation bronchoscopy (ENB) procedures allow physicians to access peripheral lung lesions beyond the reach of conventional bronchoscopy. However, published research is primarily limited to sm...

    Authors: Erik E. Folch, Mark R. Bowling, Thomas R. Gildea, Kristin L. Hood, Septimiu D. Murgu, Eric M. Toloza, Momen M. Wahidi, Terence Williams and Sandeep J. Khandhar

    Citation: BMC Pulmonary Medicine 2016 16:60

    Published on:

  47. Content type: Research article

    Insulinoma associated-1 (INSM1) gene is expressed exclusively in early embryonic neuroendocrine tissues, but has been found highly re-activated in most of the neuroendocrine tumors including small cell lung carci...

    Authors: Chiachen Chen, Mary B. Breslin and Michael S. Lan

    Citation: BMC Pulmonary Medicine 2016 16:49

    Published on:

  48. Content type: Research article

    Indwelling pleural catheters (IPC) are increasingly becoming a first-line treatment in the management of malignant pleural effusions. Ambulatory management using IPC are increasingly used in this patient group...

    Authors: Charleen Chan Wah Hak, Parthipan Sivakumar and Liju Ahmed

    Citation: BMC Pulmonary Medicine 2016 16:41

    Published on:

2016 Journal Metrics