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Cancer

This section concerns all aspects of lung cancer including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. The identification of NTRK fusions in tumours has become critically important due to the actionable events predictive of response to TRK inhibitor. It is not clear whether the NTRK breakpoint location is diffe...

    Authors: Lei Zhang, Huanhuan Liu, Ye Tian, Huina Wang and Xueying Yang

    Citation: BMC Pulmonary Medicine 2021 21:125

    Content type: Case report

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  2. Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease with unclear pathogenesis. IPF is considered as a risk factor for lung cancer. Compared to other lung cancers, small-cell lung cancer ...

    Authors: Xiyue Zhang, Wei Li, Chunyan Li, Jie Zhang and Zhenzhong Su

    Citation: BMC Pulmonary Medicine 2021 21:122

    Content type: Case report

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  3. SMAD4 has been found to be inactivated to varying degrees in many types of cancer; the purpose of this study was to investigate the correlation between SMAD4 expression in non-small cell lung cancer (NSCLC) a...

    Authors: Xiangjun Guo, Mengmeng Li, Xin Wang, Yun Pan and Jiashu Li

    Citation: BMC Pulmonary Medicine 2021 21:111

    Content type: Research article

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  4. Although repeat pulmonary resection (RPR) for multiple lung cancer has been performed for non-small cell lung cancer and metastatic lung tumor, with the prognostic benefit detailed in several reports, the risk...

    Authors: Nozomu Motono, Shun Iwai, Yoshihito Iijima, Katsuo Usuda and Hidetaka Uramoto

    Citation: BMC Pulmonary Medicine 2021 21:109

    Content type: Research article

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  5. Indium is a metal used as a compound called indium-tin oxide for liquid crystal display. Its inhalation causes lung toxicity, resulting in a new occupational lung disease called indium lung. Although the carci...

    Authors: Yasuharu Sekine, Hideo Ichimura, Sho Ueda, Keisuke Kobayashi, Takeshi Nawa, Atsuko Amata, Tatsuya Chonan, Akiko Sakata, Yoji Komatsu and Yukio Sato

    Citation: BMC Pulmonary Medicine 2021 21:107

    Content type: Case report

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  7. LINC01116 is a recently identified oncogenic lncRNA in glioma. Differential expression analysis using the public gene expression analysis tool GEPIA revealed the upregulation of LINC01116 in lung cancer. We st...

    Authors: Wenzhou Liu, Feihai Liang, Guangyu Yang and Lei Xian

    Citation: BMC Pulmonary Medicine 2021 21:50

    Content type: Research article

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  8. Besides the clinical benefit of crizotinib in ALK-rearranged metastatic non-small cell lung cancer (NSCLC), concerns about its hepatotoxicity have arisen. It is not clear whether this is a drug class side effe...

    Authors: Flávia Amaral Duarte, Leonardo Brand Rodrigues, Flávia Rocha Paes, Paulo Henrique Costa Diniz and Helena Flávia Cuba de Almada Lima

    Citation: BMC Pulmonary Medicine 2021 21:43

    Content type: Case report

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  9. Zosteriform skin metastasis (ZSM) is rare, and its etiology is not well understood. ZSM is possibly derived from the retrograde movement of cancer cells through the lymphatic vessels during disease development...

    Authors: Yohei Maki, Yoshifumi Kimizuka, Koji Murakami, Kimiya Sato, Hisashi Sasaki, Takayuki Yamamoto, Chie Watanabe, Tomoya Sano, Jun Miyata, Yuji Fujikura and Akihiko Kawana

    Citation: BMC Pulmonary Medicine 2021 21:41

    Content type: Case report

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  10. To evaluate the feasibility and safety of microcoil in simultaneous localization for multiple pulmonary nodules before video-assisted thoracic surgery (VATS).

    Authors: Yanyan Xu, Lingchuan Ma, Hongliang Sun, Zhenguo Huang, Zhenrong Zhang, Fei Xiao, Qianli Ma, Jie Lin and Sheng Xie

    Citation: BMC Pulmonary Medicine 2021 21:39

    Content type: Research article

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  11. Extranodal natural killer/T cell lymphoma (ENKL) is a rare subtype of non-Hodgkin lymphoma, and lung involvement is extremely rare. The patients with pulmonary ENKL always presented unspecific symptoms of the ...

    Authors: Wei Wang, Zhi-Tao Li, Nan-Nan Cui, Guo-Bin Wang and Shui-Qiao Fu

    Citation: BMC Pulmonary Medicine 2021 21:27

    Content type: Case report

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  13. Chemo-radiotherapy and systemic therapies have proven satisfactory outcomes as standard treatments for various thoracic malignancies; however, adverse pulmonary effects, like pneumonitis, can be life-threateni...

    Authors: Marisol Arroyo-Hernández, Federico Maldonado, Francisco Lozano-Ruiz, Wendy Muñoz-Montaño, Mónica Nuñez-Baez and Oscar Arrieta

    Citation: BMC Pulmonary Medicine 2021 21:9

    Content type: Review

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  14. Immune checkpoint inhibitors have potential applications in treating various cancers but are associated with immune-related adverse events, such as inflammation, in a wide range of organs; however, allergic in...

    Authors: Masanori Harada, Hyogo Naoi, Kazuyo Yasuda, Yutaro Ito, Namio Kagoo, Tsutomu Kubota, Koshiro Ichijo, Eisuke Mochizuki, Masahiro Uehara, Shun Matsuura, Masaru Tsukui and Naoki Koshimizu

    Citation: BMC Pulmonary Medicine 2021 21:6

    Content type: Case report

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  15. Matrix metalloproteinase 2 (MMP2) has been found to be related to malignant tumors; the aim of this study was to investigate the correlation between MMP2 expression in lung cancer tissues and clinical paramete...

    Authors: Liping Han, Baowei Sheng, Qingdi Zeng, Wei Yao and Qiufang Jiang

    Citation: BMC Pulmonary Medicine 2020 20:283

    Content type: Research article

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  16. The early diagnosis of non-small cell lung cancer is of great significance to the prognosis of patients. However, traditional histopathology and imaging screening have certain limitations. Therefore, new diagn...

    Authors: Jingyao Li, Yi Liao, Yaling Ran, Guiyu Wang, Wei Wu, Yang Qiu, Jie Liu, Ningyu Wen, Tao Jing, Haidong Wang and Shixin Zhang

    Citation: BMC Pulmonary Medicine 2020 20:274

    Content type: Research article

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  18. Recently, long non-coding RNAs (lncRNAs) have been reported to be involved in regulating chemo-resistance of NSCLC, however, the role of lncRNA SNHG14 in the DDP-resistance of NSCLC remains unexplored.

    Authors: Li Xu, Yan Xu, Min Yang, Jia Li, Fang Xu and Bo-Lin Chen

    Citation: BMC Pulmonary Medicine 2020 20:266

    Content type: Research article

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  20. Endobronchial lipoma is an extremely rare benign tumor, which is generally located in the first three subdivisions of the tracheobronchial tree. According to the existing literature, all endobronchial lipomas ...

    Authors: Shunjin Zhao, Yuexiang Shui and Zhong Dai

    Citation: BMC Pulmonary Medicine 2020 20:251

    Content type: Case report

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  21. Myospherulosis develops as the result of a reaction between exogenous lipids and red blood cells (RBC) of the patient, being the latter injured when perceived as a foreign body by the immune system, triggering...

    Authors: Liliana Fernández-Trujillo, Santiago Sanchez, Saveria Sangiovanni-Gonzalez, Eliana I. Morales, Mauricio Velásquez and Luz F. Sua

    Citation: BMC Pulmonary Medicine 2020 20:246

    Content type: Case report

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  22. Lung cancer is a frequent comorbidity of chronic obstructive pulmonary disease (COPD). However, the local risk of developing lung cancer related to regional emphysema distribution and clinical outcome has not ...

    Authors: Jung Won Heo, Hye Seon Kang, Chan Kwon Park, Sung Kyoung Kim, Ju Sang Kim, Jin Woo Kim, Seung Joon Kim, Sang Haak Lee and Chang Dong Yeo

    Citation: BMC Pulmonary Medicine 2020 20:242

    Content type: Research article

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  23. As part of the multinational I-O Optimise research initiative, this retrospective cohort study of patients with advanced non-small cell lung cancer (NSCLC) evaluated real-world treatment patterns and survival ...

    Authors: Marta Soares, Luís Antunes, Patrícia Redondo, Marina Borges, Ruben Hermans, Dony Patel, Fiona Grimson, Robin Munro, Carlos Chaib, Laure Lacoin, Melinda Daumont, John R. Penrod, John C. O’Donnell, Maria José Bento and Francisco Rocha Gonçalves

    Citation: BMC Pulmonary Medicine 2020 20:240

    Content type: Research article

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  24. Patients treated for non-squamous (non-Sq) non-small cell lung cancer (NSCLC) often require repeat biopsies to determine the optimal subsequent treatment. However, the differences between rebiopsy and initial ...

    Authors: Akiko Tateishi, Yuji Matsumoto, Midori Tanaka, Toshiyuki Nakai, Shinji Sasada, Masahiro Aoshima and Takaaki Tsuchida

    Citation: BMC Pulmonary Medicine 2020 20:238

    Content type: Research article

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  26. We explain to Dr. Benjamin (corresponding author) about why low-dose computed tomography reduce lung cancer mortality without significantly reducing all-cause mortality. We also conduct an up-to-date meta-anal...

    Authors: Kai-Lin Huang, Shih-Yuan Wang, Wan-Chen Lu, Ya-Hui Chang, Jian Su and Yen-Ta Lu

    Citation: BMC Pulmonary Medicine 2020 20:226

    Content type: Correspondence

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    The original article was published in BMC Pulmonary Medicine 2020 20:225

  27. The article by Huang K-L et al. Effects of low-dose computed tomography (LDCT) screening on lung cancer contains a conclusion that is not consistent with the data presented. With reference to the National Lung...

    Authors: Don Benjamin

    Citation: BMC Pulmonary Medicine 2020 20:225

    Content type: Correspondence

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    The original article was published in BMC Pulmonary Medicine 2019 19:126

    The Correspondence to this article has been published in BMC Pulmonary Medicine 2020 20:226

  28. miRNAs regulate a multitude of cellular processes and their aberrant regulation is linked to human cancer. However, the role of miR-425-5p in lung cancer (LCa) is still largely unclear. Here, we explored the r...

    Authors: Jin-shan Zhou, Ze-shan Yang, Si-yang Cheng, Jiang-hao Yu, Chao-Jun Huang and Qiang Feng

    Citation: BMC Pulmonary Medicine 2020 20:223

    Content type: Research article

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  29. Lung adenocarcinoma (LAD) is a prevalent type of bronchogenic malignant tumor and one of the most critical factors related to human death. Long noncoding RNAs (lncRNAs) are involved in many complex biological ...

    Authors: Tao Wang, Ruiren Zhai, Xiuhua Lv, Ke Wang and Junqing Xu

    Citation: BMC Pulmonary Medicine 2020 20:217

    Content type: Research article

    Published on:

  30. Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors all over the world. In recent years, long non-coding RNAs (lncRNAs) have been proven to participate in the development of different...

    Authors: Lei Weng, Kejie Qiu, Weijing Gao, Chunbo Shi and Fen Shu

    Citation: BMC Pulmonary Medicine 2020 20:213

    Content type: Research article

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  31. ALK-rearrangement is observed in < 5% non-small cell lung cancer (NSCLC) cases and prior to the advent of oral tyrosine kinase inhibitors, the natural history of oncogenic NSCLC was typically poor. Literature ...

    Authors: Maria Walls, Gerard M. Walls, Jacqueline A. James, Kyle T. Crawford, Hossam Abdulkhalek, Tom B. Lynch, Aaron J. Peace, Terry E. McManus and O. Rhun Evans

    Citation: BMC Pulmonary Medicine 2020 20:209

    Content type: Case report

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  34. Tracheal bifurcation resection remains the greatest challenge in airway reconstruction, especially with extensive lesions. Additionally, lung cancer and pulmonary tuberculosis comorbidity complicate the chemor...

    Authors: Dmitry Giller, Boris Giller, Galina Scherbakova, Elizaveta V. Mikhaylenko, Liudmila M. Mikhaleva, Vladimir N. Nikolenko, Liliya V. Gavryushova, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev

    Citation: BMC Pulmonary Medicine 2020 20:197

    Content type: Case report

    Published on:

  35. Conventional CTCS images the mid/lower chest for coronary artery disease (CAD). Because many CAD patients are also at risk for lung malignancy, CTCS often discovers incidental pulmonary nodules (IPN). CTCS exc...

    Authors: Boxiang Jiang, Philip A. Linden, Amit Gupta, Craig Jarrett, Stephanie G. Worrell, Vanessa P. Ho, Yaron Perry and Christopher W. Towe

    Citation: BMC Pulmonary Medicine 2020 20:187

    Content type: Research article

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  36. Long noncoding RNA POU class 3 homeobox 3 (POU3F3) is upregulated in esophageal squamous-cell carcinomas. The present study aimed to investigate the role of POU3F3 in non-small cell lung cancer (NSCLC).

    Authors: Qigang Zeng, Yong Dai, Chenxia Duan, Rong Zeng, Qingxiang Zeng and Chengong Wei

    Citation: BMC Pulmonary Medicine 2020 20:185

    Content type: Research article

    Published on:

  37. Tumor necrosis factor (TNF) has been investigated to be correlated with the occurrence and progression of lung cancer. This investigation was to assess the efficacy and safety of recombinant mutant human tumor...

    Authors: Tian Fu, Yong Lin, Qingdi Zeng, Wei Yao and Liping Han

    Citation: BMC Pulmonary Medicine 2020 20:175

    Content type: Research article

    Published on:

  38. Lung cancer is frequently situated peripherally in the upper lobes of the lung. Acquiring adequate tissue from this difficult-to-reach area remains a challenge. Transbronchial cryobiopsy (TBCB) has the ability...

    Authors: Sze Shyang Kho, Chan Sin Chai, Larry Ellee Nyanti, Adam Malik bin Ismail and Siew Teck Tie

    Citation: BMC Pulmonary Medicine 2020 20:158

    Content type: Case report

    Published on:

  39. Long non-coding RNA (lncRNA) Wilms Tumor 1 Associated Protein Pseudogene 1 (WTAPP1) has been reported to be a critical player in the angiogenesis and migration of endothelial progenitor cells, while its involv...

    Authors: Li Zhang, Chengyan Jin, Guiyun Yang, Bin Wang, Peiyan Hua and Yan Zhang

    Citation: BMC Pulmonary Medicine 2020 20:153

    Content type: Research article

    Published on:

  41. Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) has been become an important procedure for the diagnosis and staging of lung cancer. Our research identified the effects of differen...

    Authors: Youzu Xu, Jian Lin, Meifang Chen, Haihong Zheng and Jiaxi Feng

    Citation: BMC Pulmonary Medicine 2020 20:140

    Content type: Research article

    Published on:

  43. Various host factors can promote pneumonia susceptibility of lung cancer patients. However, data about risk factors for pneumonia in lung cancer patients receiving active treatments such as chemotherapy, radio...

    Authors: Jung Won Heo, Chang Dong Yeo, Chan Kwon Park, Sung Kyoung Kim, Ju Sang Kim, Jin Woo Kim, Seung Joon Kim, Sang Haak Lee and Hye Seon Kang

    Citation: BMC Pulmonary Medicine 2020 20:117

    Content type: Research article

    Published on:

  44. Appropriate management of lung nodules detected incidentally or through lung cancer screening can increase the rate of early-stage diagnoses and potentially improve treatment outcomes. However, the implementat...

    Authors: Gregory P. LeMense, Ernest A. Waller, Cheryl Campbell and Tyler Bowen

    Citation: BMC Pulmonary Medicine 2020 20:115

    Content type: Research article

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  46. The involvement of lncRNA FEZF1-AS1 has been analyzed in many types of cancers, while its roles in non-small cell lung cancer (NSCLC) remains unclear. We then explored the role of FEZF1-AS1 in NSCLC.

    Authors: Shangxiao Huang, Chunjun Li, Jianfeng Huang, Penghui Luo, Dunchang Mo and Hanlei Wang

    Citation: BMC Pulmonary Medicine 2020 20:110

    Content type: Research article

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  47. Immune checkpoint inhibitors (ICIs) are the standard treatment for non-small cell lung cancer. The unique adverse events that can arise after treatment with ICIs are known as immune-related adverse events (irA...

    Authors: Takeshi Terashima, Eri Iwami, Takashi Shimada, Aoi Kuroda, Tatsu Matsuzaki, Takahiro Nakajima, Aya Sasaki and Keisuke Eguchi

    Citation: BMC Pulmonary Medicine 2020 20:104

    Content type: Case report

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  48. The prognostic value of elevated pretreatment platelet counts remains controversial in lung cancer patients. We performed the present meta-analysis to determine its precise role in these patients.

    Authors: Yuan Yuan, Hai Zhong, Liang Ye, Qian Li, Surong Fang, Wei Gu and Yingying Qian

    Citation: BMC Pulmonary Medicine 2020 20:96

    Content type: Research article

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  49. Malignant melanoma (MM) generally presents as a primary neoplasm of the skin, and most MM cases of the respiratory system are metastatic. Primary MM of the lung (PMML) is quite rare, and its diagnosis is relat...

    Authors: Shuangshuang Deng, Xiaobo Sun, Zhen Zhu, Jingjing Lu, Guanghua Wen, Xuejiao Chang, Hui Gao, Yanfei Hua, Lumei Wang and Jinli Gao

    Citation: BMC Pulmonary Medicine 2020 20:94

    Content type: Case report

    Published on:

  50. Kartagener syndrome, an autosomal recessive disorder with a triad of chronic sinusitis, bronchiectasis, and situs inversus, is characterized by recurrent respiratory tract infections and chronic inflammation o...

    Authors: Yoshiaki Nagai, Nobuyuki Koyama, Yuki Iwai, Hiroyoshi Tsubochi, Masahiro Hiruta, Yoshiko Mizushina, Shinichiro Koyama, Yuichi Ishikawa and Koichi Hagiwara

    Citation: BMC Pulmonary Medicine 2020 20:93

    Content type: Case report

    Published on:

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