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Cancer

This section concerns all aspects of lung cancer including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Endobronchial lipoma is an extremely rare benign tumor, which is generally located in the first three subdivisions of the tracheobronchial tree. According to the existing literature, all endobronchial lipomas ...

    Authors: Shunjin Zhao, Yuexiang Shui and Zhong Dai

    Citation: BMC Pulmonary Medicine 2020 20:251

    Content type: Case report

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  2. Myospherulosis develops as the result of a reaction between exogenous lipids and red blood cells (RBC) of the patient, being the latter injured when perceived as a foreign body by the immune system, triggering...

    Authors: Liliana Fernández-Trujillo, Santiago Sanchez, Saveria Sangiovanni-Gonzalez, Eliana I. Morales, Mauricio Velásquez and Luz F. Sua

    Citation: BMC Pulmonary Medicine 2020 20:246

    Content type: Case report

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  3. Lung cancer is a frequent comorbidity of chronic obstructive pulmonary disease (COPD). However, the local risk of developing lung cancer related to regional emphysema distribution and clinical outcome has not ...

    Authors: Jung Won Heo, Hye Seon Kang, Chan Kwon Park, Sung Kyoung Kim, Ju Sang Kim, Jin Woo Kim, Seung Joon Kim, Sang Haak Lee and Chang Dong Yeo

    Citation: BMC Pulmonary Medicine 2020 20:242

    Content type: Research article

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  4. As part of the multinational I-O Optimise research initiative, this retrospective cohort study of patients with advanced non-small cell lung cancer (NSCLC) evaluated real-world treatment patterns and survival ...

    Authors: Marta Soares, Luís Antunes, Patrícia Redondo, Marina Borges, Ruben Hermans, Dony Patel, Fiona Grimson, Robin Munro, Carlos Chaib, Laure Lacoin, Melinda Daumont, John R. Penrod, John C. O’Donnell, Maria José Bento and Francisco Rocha Gonçalves

    Citation: BMC Pulmonary Medicine 2020 20:240

    Content type: Research article

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  5. Patients treated for non-squamous (non-Sq) non-small cell lung cancer (NSCLC) often require repeat biopsies to determine the optimal subsequent treatment. However, the differences between rebiopsy and initial ...

    Authors: Akiko Tateishi, Yuji Matsumoto, Midori Tanaka, Toshiyuki Nakai, Shinji Sasada, Masahiro Aoshima and Takaaki Tsuchida

    Citation: BMC Pulmonary Medicine 2020 20:238

    Content type: Research article

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  6. We explain to Dr. Benjamin (corresponding author) about why low-dose computed tomography reduce lung cancer mortality without significantly reducing all-cause mortality. We also conduct an up-to-date meta-anal...

    Authors: Kai-Lin Huang, Shih-Yuan Wang, Wan-Chen Lu, Ya-Hui Chang, Jian Su and Yen-Ta Lu

    Citation: BMC Pulmonary Medicine 2020 20:226

    Content type: Correspondence

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    The original article was published in BMC Pulmonary Medicine 2020 20:225

  7. The article by Huang K-L et al. Effects of low-dose computed tomography (LDCT) screening on lung cancer contains a conclusion that is not consistent with the data presented. With reference to the National Lung...

    Authors: Don Benjamin

    Citation: BMC Pulmonary Medicine 2020 20:225

    Content type: Correspondence

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    The original article was published in BMC Pulmonary Medicine 2019 19:126

    The Correspondence to this article has been published in BMC Pulmonary Medicine 2020 20:226

  8. miRNAs regulate a multitude of cellular processes and their aberrant regulation is linked to human cancer. However, the role of miR-425-5p in lung cancer (LCa) is still largely unclear. Here, we explored the r...

    Authors: Jin-shan Zhou, Ze-shan Yang, Si-yang Cheng, Jiang-hao Yu, Chao-Jun Huang and Qiang Feng

    Citation: BMC Pulmonary Medicine 2020 20:223

    Content type: Research article

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  9. Lung adenocarcinoma (LAD) is a prevalent type of bronchogenic malignant tumor and one of the most critical factors related to human death. Long noncoding RNAs (lncRNAs) are involved in many complex biological ...

    Authors: Tao Wang, Ruiren Zhai, Xiuhua Lv, Ke Wang and Junqing Xu

    Citation: BMC Pulmonary Medicine 2020 20:217

    Content type: Research article

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  10. Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors all over the world. In recent years, long non-coding RNAs (lncRNAs) have been proven to participate in the development of different...

    Authors: Lei Weng, Kejie Qiu, Weijing Gao, Chunbo Shi and Fen Shu

    Citation: BMC Pulmonary Medicine 2020 20:213

    Content type: Research article

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  11. ALK-rearrangement is observed in < 5% non-small cell lung cancer (NSCLC) cases and prior to the advent of oral tyrosine kinase inhibitors, the natural history of oncogenic NSCLC was typically poor. Literature ...

    Authors: Maria Walls, Gerard M. Walls, Jacqueline A. James, Kyle T. Crawford, Hossam Abdulkhalek, Tom B. Lynch, Aaron J. Peace, Terry E. McManus and O. Rhun Evans

    Citation: BMC Pulmonary Medicine 2020 20:209

    Content type: Case report

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  12. Tracheal bifurcation resection remains the greatest challenge in airway reconstruction, especially with extensive lesions. Additionally, lung cancer and pulmonary tuberculosis comorbidity complicate the chemor...

    Authors: Dmitry Giller, Boris Giller, Galina Scherbakova, Elizaveta V. Mikhaylenko, Liudmila M. Mikhaleva, Vladimir N. Nikolenko, Liliya V. Gavryushova, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev

    Citation: BMC Pulmonary Medicine 2020 20:197

    Content type: Case report

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  13. Conventional CTCS images the mid/lower chest for coronary artery disease (CAD). Because many CAD patients are also at risk for lung malignancy, CTCS often discovers incidental pulmonary nodules (IPN). CTCS exc...

    Authors: Boxiang Jiang, Philip A. Linden, Amit Gupta, Craig Jarrett, Stephanie G. Worrell, Vanessa P. Ho, Yaron Perry and Christopher W. Towe

    Citation: BMC Pulmonary Medicine 2020 20:187

    Content type: Research article

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  14. Long noncoding RNA POU class 3 homeobox 3 (POU3F3) is upregulated in esophageal squamous-cell carcinomas. The present study aimed to investigate the role of POU3F3 in non-small cell lung cancer (NSCLC).

    Authors: Qigang Zeng, Yong Dai, Chenxia Duan, Rong Zeng, Qingxiang Zeng and Chengong Wei

    Citation: BMC Pulmonary Medicine 2020 20:185

    Content type: Research article

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  15. Tumor necrosis factor (TNF) has been investigated to be correlated with the occurrence and progression of lung cancer. This investigation was to assess the efficacy and safety of recombinant mutant human tumor...

    Authors: Tian Fu, Yong Lin, Qingdi Zeng, Wei Yao and Liping Han

    Citation: BMC Pulmonary Medicine 2020 20:175

    Content type: Research article

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  16. Lung cancer is frequently situated peripherally in the upper lobes of the lung. Acquiring adequate tissue from this difficult-to-reach area remains a challenge. Transbronchial cryobiopsy (TBCB) has the ability...

    Authors: Sze Shyang Kho, Chan Sin Chai, Larry Ellee Nyanti, Adam Malik bin Ismail and Siew Teck Tie

    Citation: BMC Pulmonary Medicine 2020 20:158

    Content type: Case report

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  17. Long non-coding RNA (lncRNA) Wilms Tumor 1 Associated Protein Pseudogene 1 (WTAPP1) has been reported to be a critical player in the angiogenesis and migration of endothelial progenitor cells, while its involv...

    Authors: Li Zhang, Chengyan Jin, Guiyun Yang, Bin Wang, Peiyan Hua and Yan Zhang

    Citation: BMC Pulmonary Medicine 2020 20:153

    Content type: Research article

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  18. Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) has been become an important procedure for the diagnosis and staging of lung cancer. Our research identified the effects of differen...

    Authors: Youzu Xu, Jian Lin, Meifang Chen, Haihong Zheng and Jiaxi Feng

    Citation: BMC Pulmonary Medicine 2020 20:140

    Content type: Research article

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  19. Various host factors can promote pneumonia susceptibility of lung cancer patients. However, data about risk factors for pneumonia in lung cancer patients receiving active treatments such as chemotherapy, radio...

    Authors: Jung Won Heo, Chang Dong Yeo, Chan Kwon Park, Sung Kyoung Kim, Ju Sang Kim, Jin Woo Kim, Seung Joon Kim, Sang Haak Lee and Hye Seon Kang

    Citation: BMC Pulmonary Medicine 2020 20:117

    Content type: Research article

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  20. Appropriate management of lung nodules detected incidentally or through lung cancer screening can increase the rate of early-stage diagnoses and potentially improve treatment outcomes. However, the implementat...

    Authors: Gregory P. LeMense, Ernest A. Waller, Cheryl Campbell and Tyler Bowen

    Citation: BMC Pulmonary Medicine 2020 20:115

    Content type: Research article

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  21. The involvement of lncRNA FEZF1-AS1 has been analyzed in many types of cancers, while its roles in non-small cell lung cancer (NSCLC) remains unclear. We then explored the role of FEZF1-AS1 in NSCLC.

    Authors: Shangxiao Huang, Chunjun Li, Jianfeng Huang, Penghui Luo, Dunchang Mo and Hanlei Wang

    Citation: BMC Pulmonary Medicine 2020 20:110

    Content type: Research article

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  22. Immune checkpoint inhibitors (ICIs) are the standard treatment for non-small cell lung cancer. The unique adverse events that can arise after treatment with ICIs are known as immune-related adverse events (irA...

    Authors: Takeshi Terashima, Eri Iwami, Takashi Shimada, Aoi Kuroda, Tatsu Matsuzaki, Takahiro Nakajima, Aya Sasaki and Keisuke Eguchi

    Citation: BMC Pulmonary Medicine 2020 20:104

    Content type: Case report

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  23. The prognostic value of elevated pretreatment platelet counts remains controversial in lung cancer patients. We performed the present meta-analysis to determine its precise role in these patients.

    Authors: Yuan Yuan, Hai Zhong, Liang Ye, Qian Li, Surong Fang, Wei Gu and Yingying Qian

    Citation: BMC Pulmonary Medicine 2020 20:96

    Content type: Research article

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  24. Malignant melanoma (MM) generally presents as a primary neoplasm of the skin, and most MM cases of the respiratory system are metastatic. Primary MM of the lung (PMML) is quite rare, and its diagnosis is relat...

    Authors: Shuangshuang Deng, Xiaobo Sun, Zhen Zhu, Jingjing Lu, Guanghua Wen, Xuejiao Chang, Hui Gao, Yanfei Hua, Lumei Wang and Jinli Gao

    Citation: BMC Pulmonary Medicine 2020 20:94

    Content type: Case report

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  25. Kartagener syndrome, an autosomal recessive disorder with a triad of chronic sinusitis, bronchiectasis, and situs inversus, is characterized by recurrent respiratory tract infections and chronic inflammation o...

    Authors: Yoshiaki Nagai, Nobuyuki Koyama, Yuki Iwai, Hiroyoshi Tsubochi, Masahiro Hiruta, Yoshiko Mizushina, Shinichiro Koyama, Yuichi Ishikawa and Koichi Hagiwara

    Citation: BMC Pulmonary Medicine 2020 20:93

    Content type: Case report

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  26. The most prevalent complication of percutaneous lung biopsy is pneumothorax (PNX). A routine immediate post-procedure CT scan (ICT) to spot PNX is done in many centers. However, the diagnostic yield of this pr...

    Authors: Rafael Y. Brzezinski, Ifat Vigiser, Irina Fomin, Lilach Israeli, Shani Shenhar-Tsarfaty and Amir Bar-Shai

    Citation: BMC Pulmonary Medicine 2020 20:91

    Content type: Research article

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  27. Synchronous multiple primary lung cancers (sMPLC) are rare forms of lung cancer, and their diagnosis remains as a significant challenge. Distinguishing sMPLC from advanced disease is important as their prognos...

    Authors: Yang Song, Ziqi Jia, Pancheng Wu, Weiwei Wang, Qiuxiang Ou, Hua Bao, Man Yu, Xue Wu, Peng Liu, Naixin Liang, Shuyang Zhang and Shanqing Li

    Citation: BMC Pulmonary Medicine 2020 20:80

    Content type: Case report

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  28. Malignant tumors are risk factors for a pulmonary embolism (PE), and a PE caused by a tumor is not uncommon. Primary pleural squamous cell carcinoma (PPSCC) is a rare malignancy; thus, a related PE is extremel...

    Authors: Zhongzhong Chen, Tingting Feng, Meng Wang, Xingxiang Xu, Yuxiu Wang, Yiran Li and Lingfeng Min

    Citation: BMC Pulmonary Medicine 2020 20:75

    Content type: Case report

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  29. Lung cancer is one of the most common co-morbid conditions in patients with idiopathic pulmonary fibrosis (IPF) and negatively affects the prognosis of IPF; Current guidelines for the management of IPF do not ...

    Authors: Weirong Ma, Hui Li, Zhigang Tian, Shaojin Wang, Xiwei Zheng and Jia Hou

    Citation: BMC Pulmonary Medicine 2020 20:69

    Content type: Case report

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  30. Malignant central airway obstruction (MCAO) occurs in 20–30% of patients with primary pulmonary malignancy. Although bronchoscopic intervention is widely performed to treat MCAO, little data exist on the progn...

    Authors: Bo-Guen Kim, Beomsu Shin, Boksoon Chang, Hojoong Kim and Byeong-Ho Jeong

    Citation: BMC Pulmonary Medicine 2020 20:54

    Content type: Research article

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  31. congenital pulmonary airway malformation (CPAM) is the most frequent congenital lung disorder. CPAM type 1 is the most common subtype, typically having a cystic radiological and histological appearance. Mucino...

    Authors: Timco Koopman, Bart L. Rottier, Arja ter Elst and Wim Timens

    Citation: BMC Pulmonary Medicine 2020 20:52

    Content type: Case report

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  32. Lung cancer surgery is associated with a high incidence of postoperative pulmonary complications (PPCs). Preliminary evidence suggests that ERAS processes can reduce overall incidence of PPCs as short- and lon...

    Authors: Yu Zheng, Mao Mao, Meifang Ji, Qiugang Zheng, Liang Liu, Zhigang Zhao, Haiming Wang, Xiangyang Wei, Yulong Wang, Jiamin Chen, Huiqing Zhou, Qiaoqiao Liang, Ying Chen, Xintong Zhang, Lu Wang, Yihui Cheng…

    Citation: BMC Pulmonary Medicine 2020 20:44

    Content type: Study protocol

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  33. Cystic airspace is an uncommon imaging manifestation involved in non-small lung cancer (NSCLC). Diffuse cystic lesion is even rarer as pulmonary manifestation of NSCLC. In the present study, we reported a rare...

    Authors: Xianhua Gui, Jingjing Ding, Yan Li, Min Yu, Tingting Chen, Mei Huang and Yonglong Xiao

    Citation: BMC Pulmonary Medicine 2020 20:30

    Content type: Case report

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  34. Lung cancer is the leading cause of cancer mortality in Australia. Guidelines suggest that patients with suspected lung cancer on thoracic imaging be referred for urgent specialist review. However, the term “s...

    Authors: P. Brownell, F. Piccolo, F. Brims, R. Norman and D. Manners

    Citation: BMC Pulmonary Medicine 2020 20:24

    Content type: Research article

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    The Correction to this article has been published in BMC Pulmonary Medicine 2020 20:53

  35. Due to the acquired drug resistance, the potency of cisplatin-based chemotherapy is limited in lung cancer, which is a big obstacle in clinical treatment of lung cancer. Abundant evidence has revealed that cir...

    Authors: Zhihui Wu, Qiang Gong, Yan Yu, Jialin Zhu and Wencan Li

    Citation: BMC Pulmonary Medicine 2020 20:10

    Content type: Research article

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  36. Our study aimed to verify the prognostic value of circulating tumor cells (CTCs) prior to initial treatment on survival of non-small cell lung cancer (NSCLC) by using meta-analysis and system review of publish...

    Authors: Sha-Sha Jiang, Bo Deng, Yong-Geng Feng, Kai Qian, Qun-You Tan and Ru-Wen Wang

    Citation: BMC Pulmonary Medicine 2019 19:262

    Content type: Research article

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  37. Lung adenocarcinoma associated transcript 1 (LUADT1) has been reported as an oncogenic long non-coding RNA (lncRNA) in lung adenocarcinoma, while its roles in small cell lung cancer (SCLC) are unknown. Our RNA...

    Authors: Dingxue Wang, Wenyu Wu, Wenqi Huang, Jinghui Wang, Li Luo and Dongxin Tang

    Citation: BMC Pulmonary Medicine 2019 19:246

    Content type: Research article

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  38. The Robotic Endoscopic System (Auris Health, Inc., Redwood City, CA) has the potential to overcome several limitations of contemporary guided-bronchoscopic technologies for the diagnosis of lung lesions. Our o...

    Authors: Udit Chaddha, Stephen P. Kovacs, Christopher Manley, D. Kyle Hogarth, Gustavo Cumbo-Nacheli, Sivasubramanium V. Bhavani, Rohit Kumar, Manisha Shende, John P. Egan III and Septimiu Murgu

    Citation: BMC Pulmonary Medicine 2019 19:243

    Content type: Research article

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  39. Recurrent pleural effusion is a common cause of dyspnoea, cough and chest pain during the course of malignant diseases. Chemical pleurodesis had been the only definitive treatment option until two decades ago....

    Authors: Nikolaj Frost, Martin Brünger, Christoph Ruwwe-Glösenkamp, Matthias Raspe, Antje Tessmer, Bettina Temmesfeld-Wollbrück, Dirk Schürmann, Norbert Suttorp and Martin Witzenrath

    Citation: BMC Pulmonary Medicine 2019 19:232

    Content type: Research article

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  40. Flexible bronchoscopy enables visualization of the respiratory airway mucosa from the oropharynx to third generation branching of the tracheobronchial tree. Bronchoscopic diagnoses vary from one locality to th...

    Authors: Deus A. Ndilanha, Grace A. Shayo, Ramadhan Hassan, Moses Byomuganyizi and Leonard E. K. Lema

    Citation: BMC Pulmonary Medicine 2019 19:214

    Content type: Research article

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  41. Spontaneous remission (SR) of cancer is a very rare phenomenon of unknown mechanism. In particular, SR of non-small cell lung cancer (NSCLC) has been scarcely reported. We present the case of a 74-year-old wom...

    Authors: Hee-Young Yoon, Heae Surng Park, Min Sun Cho, Sung Shin Shim, Yookyung Kim and Jin Hwa Lee

    Citation: BMC Pulmonary Medicine 2019 19:210

    Content type: Case report

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  42. Lung cancer is one of the most incident neoplastic diseases, and a leading cause of death for cancer worldwide. Knowledge of the incidence of druggable genetic alterations, their correlation with clinical and ...

    Authors: Maria Colombino, Panagiotis Paliogiannis, Antonio Cossu, Davide Adriano Santeufemia, Maria Cristina Sini, Milena Casula, Grazia Palomba, Antonella Manca, Marina Pisano, Valentina Doneddu and Giuseppe Palmieri

    Citation: BMC Pulmonary Medicine 2019 19:209

    Content type: Research article

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