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Cancer

Section edited by Montserrat Sanchez Cespedes

This section concerns all aspects of lung cancer including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Flexible bronchoscopy enables visualization of the respiratory airway mucosa from the oropharynx to third generation branching of the tracheobronchial tree. Bronchoscopic diagnoses vary from one locality to th...

    Authors: Deus A. Ndilanha, Grace A. Shayo, Ramadhan Hassan, Moses Byomuganyizi and Leonard E. K. Lema

    Citation: BMC Pulmonary Medicine 2019 19:214

    Content type: Research article

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  2. Spontaneous remission (SR) of cancer is a very rare phenomenon of unknown mechanism. In particular, SR of non-small cell lung cancer (NSCLC) has been scarcely reported. We present the case of a 74-year-old wom...

    Authors: Hee-Young Yoon, Heae Surng Park, Min Sun Cho, Sung Shin Shim, Yookyung Kim and Jin Hwa Lee

    Citation: BMC Pulmonary Medicine 2019 19:210

    Content type: Case report

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  3. Lung cancer is one of the most incident neoplastic diseases, and a leading cause of death for cancer worldwide. Knowledge of the incidence of druggable genetic alterations, their correlation with clinical and ...

    Authors: Maria Colombino, Panagiotis Paliogiannis, Antonio Cossu, Davide Adriano Santeufemia, Maria Cristina Sini, Milena Casula, Grazia Palomba, Antonella Manca, Marina Pisano, Valentina Doneddu and Giuseppe Palmieri

    Citation: BMC Pulmonary Medicine 2019 19:209

    Content type: Research article

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  4. The critical management of advanced non-small-cell lung carcinoma (NSCLC), especially when complicated by severe airway stenosis, is difficult and often leads to high clinical risks and medical costs.

    Authors: Ai-Gui Jiang, Hui-Yu Lu and Zhong-Qi Ding

    Citation: BMC Pulmonary Medicine 2019 19:205

    Content type: Case report

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  5. Dose intensity and dose density of first line Platinum and Etoposide (PE) do not influence Overall Survival (OS) of Small Cell Lung Cancer (SCLC) patients. The effect of treatment length, however, remains uncl...

    Authors: Mostafa Sallam, Helen Wong and Carles Escriu

    Citation: BMC Pulmonary Medicine 2019 19:195

    Content type: Research article

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  6. Radial endobronchial ultrasound (R-EBUS)-guided transbronchial biopsy (TBB) is a common diagnostic modality for peripheral pulmonary lesions; however, there is uncertainty about the optimal sequence of TBB and...

    Authors: Chun-Ta Huang, Yi-Ju Tsai, Chao-Chi Ho and Chong-Jen Yu

    Citation: BMC Pulmonary Medicine 2019 19:193

    Content type: Research article

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  7. In non-small cell lung cancer (NSCLC) patients, concomitant idiopathic pulmonary fibrosis (IPF) and emphysema (CPFE) are independently related to poor survival. CPFE is a condition with features of both pulmon...

    Authors: Sung Woo Moon, Moo Suk Park, Young Sam Kim, Joon Jang, Jae Ho Lee, Choon-Taek Lee, Jin-Haeng Chung, Hyo Sup Shim, Kyung Won Lee, Seung-Seob Kim, Sang Hoon Lee and Ho Il Yoon

    Citation: BMC Pulmonary Medicine 2019 19:177

    Content type: Research article

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  8. Emphysema and chronic obstructive pulmonary disease (COPD) are well known independent risk factors for lung cancer. However, the developmental mechanisms between emphysema/COPD and lung cancer remain unknown. ...

    Authors: Ken Arimura, Yasuo Sekine, Kenzo Hiroshima, Satoru Shimizu, Noriyuki Shibata, Mitsuko Kondo, Kiyoshi Takeyama and Etsuko Tagaya

    Citation: BMC Pulmonary Medicine 2019 19:169

    Content type: Research article

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  9. The diagnosis of lung typical carcinoid tumors results challenging when limited size and unfavorable sampling location is associated. It has been reported that bronchoscopy with endobronchial ultrasound (EBUS)...

    Authors: Roberto Piro, Roberto Tonelli, Sofia Taddei, Alessandro Marchioni, Giovanni Musci, Enrico Clini and Nicola Facciolongo

    Citation: BMC Pulmonary Medicine 2019 19:168

    Content type: Case report

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  10. Endobronchial ultrasound-guided trans-bronchial needle aspiration (EBUS-TBNA) is minimally invasive technique used for diagnosis and/or staging of benign and malignant pulmonary and non-pulmonary disease. Prev...

    Authors: Nicola Bailey, Zoe Krisnadi, Raena Kaur, Siobhain Mulrennan, Martin Phillips and Neli Slavova-Azmanova

    Citation: BMC Pulmonary Medicine 2019 19:155

    Content type: Research article

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  11. The effectiveness of Incentive spirometry (IS) in patients undergoing video-assisted thoracic surgery (VATS) remains lacking. We conducted a population-based study to investigate the effectiveness of IS on pat...

    Authors: Chin-Jung Liu, Wen-Chen Tsai, Chia-Chen Chu, Chih-Hsin Muo and Wei-Sheng Chung

    Citation: BMC Pulmonary Medicine 2019 19:121

    Content type: Research article

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  12. Malignant endobronchial mass (MEM) has poor prognosis, cryotherapy is reportedly to diagnose MEM, however, the therapeutic role of cryotherapy impacts on survival has not be well addressed.

    Authors: Fu-Tsai Chung, Chun-Liang Chou, Yu-Lun Lo, Chih-Hsi Kuo, Tsai-Yu Wang, Chun-Hwa Wang, Hung-Yu Huang, Horng-Chyuan Lin, Chih-Hao Chang, Chung-Shu Lee, Hao-Cheng Chen and Shu-Min Lin

    Citation: BMC Pulmonary Medicine 2019 19:101

    Content type: Research article

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  13. Lobectomy is the standard treatment for patients with stage I non-small cell lung cancer (NSCLC). Recent studies have shown promising results of stereotactic body radiation therapy (SBRT) in these patients. We...

    Authors: Qingren Lin, Xiaojiang Sun, Ning Zhou, Zhun Wang, Yaping Xu and Yuezhen Wang

    Citation: BMC Pulmonary Medicine 2019 19:98

    Content type: Research article

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  14. The presence of emphysema on computed tomography (CT) is associated with an increased frequency of lung cancer, but the postoperative outcomes of patients with pulmonary emphysema are not well known. The objec...

    Authors: Seijiro Sato, Masaya Nakamura, Yuki Shimizu, Tatsuya Goto, Terumoto Koike, Hiroyuki Ishikawa and Masanori Tsuchida

    Citation: BMC Pulmonary Medicine 2019 19:73

    Content type: Research article

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  15. Acute exacerbation of interstitial lung disease (AE-ILD) is the most serious complication in lung cancer patients with pre-existing ILD receiving chemotherapy. The role of vascular endothelial growth factor (V...

    Authors: Shohei Hamada, Hidenori Ichiyasu, Tokunori Ikeda, Megumi Inaba, Kosuke Kashiwabara, Tomoki Sadamatsu, Nahoko Sato, Kimitaka Akaike, Hiroko Okabayashi, Koichi Saruwatari, Yusuke Tomita, Sho Saeki, Naomi Hirata, Takeshi Yoshinaga and Kazuhiko Fujii

    Citation: BMC Pulmonary Medicine 2019 19:72

    Content type: Research article

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  16. Lung cancer is the leading cause of cancer-related death due in large part to our inability to diagnose it at an early and potentially curable stage. Screening for lung cancer via low dose computed tomographic...

    Authors: Ehab Billatos, Fenghai Duan, Elizabeth Moses, Helga Marques, Irene Mahon, Lindsey Dymond, Charles Apgar, Denise Aberle, George Washko and Avrum Spira

    Citation: BMC Pulmonary Medicine 2019 19:59

    Content type: Study protocol

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  17. HOTTIP, a long non-coding RNA located in the HOXA cluster, plays a role in the patterning of tissues with mesodermal components, including the lung. Overexpression of HOXA genes, including HOTTIP, has been associ...

    Authors: Alfons Navarro, Jorge Moises, Sandra Santasusagna, Ramon M. Marrades, Nuria Viñolas, Joan J. Castellano, Jordi Canals, Carmen Muñoz, José Ramírez, Laureano Molins and Mariano Monzo

    Citation: BMC Pulmonary Medicine 2019 19:55

    Content type: Research article

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  18. Pulmonary non-Hodgkin lymphoma (NHL) is rare. The most frequent subtype of pulmonary NHL is low-grade B-cell lymphoma, such as lymphoma of mucosa-associated lymphoma tissue. Extranodal natural killer cell/T-ce...

    Authors: Tomohiro Yabushita, Satoshi Yoshioka, Takeru Furumiya, Momoko Nakamura, Daisuke Yamashita, Yukihiro Imai and Takayuki Ishikawa

    Citation: BMC Pulmonary Medicine 2019 19:48

    Content type: Case report

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  19. Postpneumonectomy-like syndrome is a rare condition resulting from unilateral lung disease with severe lung volume loss leading to excessive mediastinal shift and herniation of the healthy lung into the contra...

    Authors: Athanasios K. Konstantinidis, Vlasios V. Vitsas, Konstantinos Tatsis, Thomas Vadivoulis, Apostolos Kittas, Christos Chronis, Vanesa Bellou, Ioannis N. Vamvakaris, Rodoula Tringidou and Grigoris K. Stratakos

    Citation: BMC Pulmonary Medicine 2019 19:44

    Content type: Case report

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  20. Pulmonary carcinoids are included in the group of neuroendocrine tumors (NET) and derive from pulmonary neuroendocrine cells. The incidence of these tumors is increasing, but disease awareness remains low amon...

    Authors: Abdulrahman Hakami, Evita Zwartkruis, Teodora Radonic and Johannes M. A. Daniels

    Citation: BMC Pulmonary Medicine 2019 19:41

    Content type: Case report

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  21. Endosonography with needle aspiration (EBUS/EUS-NA) is recommended as the first choice for mediastinal nodal assessment in non-small cell lung cancer (NSCLC). It is important to maintain adequate negative pred...

    Authors: Sukyeon Kim, Beomsu Shin, Hyun Lee, Jick Hwan Ha, Kyungjong Lee, Sang-Won Um, Hojoong Kim and Byeong-Ho Jeong

    Citation: BMC Pulmonary Medicine 2019 19:14

    Content type: Research article

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    The Correction to this article has been published in BMC Pulmonary Medicine 2019 19:69

  22. Sporadic lymphangioleiomyomatosis (LAM) is a rare form of diffuse parenchymal lung disease. PD-1 blocking antibodies constitute an essential treatment option for advanced non-small-cell lung cancer (NSCLC). Th...

    Authors: Johan Pluvy, Solenn Brosseau, Sandrine Stelianides, Claire Danel, Marina Nguenang, Antoine Khalil, Bruno Crestani, Gérard Zalcman and Valérie Gounant

    Citation: BMC Pulmonary Medicine 2019 19:12

    Content type: Case report

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  23. Cystic lung lesions involving both lungs include a variety of diseases, such as pulmonary Langerhans cell histiocytosis, lymphangioleiomyomatosis and pulmonary metastasis. Primary pulmonary meningioma accompan...

    Authors: Xin Wang, Pengfei Li, Ping Zhou, Yiyun Fu, Yutian Lai and Guowei Che

    Citation: BMC Pulmonary Medicine 2019 19:8

    Content type: Case report

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  24. EGFR mutations are routinely explored in lung adenocarcinoma by sequencing tumoral DNA. The aim of this study was to evaluate a fluorescent-labelled erlotinib based theranostic agent for the molecular imaging of ...

    Authors: Maxime Patout, Florian Guisier, Xavier Brune, Pierre Bohn, Anthony Romieu, Nasrin Sarafan-Vasseur, Richard Sesboüé, Pierre-Yves Renard, Luc Thiberville and Mathieu Salaün

    Citation: BMC Pulmonary Medicine 2019 19:3

    Content type: Research article

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  25. Pulmonary carcinosarcoma (PCS) is a rare primary lung malignancy and has a poor prognosis among lung tumor histological subtypes. However, an appropriate treatment strategy has not been developed for unresecta...

    Authors: Azusa Tanimoto, Shinji Takeuchi, Hiroshi Kotani, Kaname Yamashita, Tadaaki Yamada, Koushiro Ohtsubo, Hiromichi Ebi, Hiroko Ikeda and Seiji Yano

    Citation: BMC Pulmonary Medicine 2018 18:193

    Content type: Case report

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  26. The optimal procedure for maximizing the diagnostic yield and minimizing the procedural complexity of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is controversial. We conducted...

    Authors: Xiaoxiao Lin, Min Ye, Yuping Li, Jing Ren, Qiyan Lou, Yangyang Li, Xiaohui Jin, Ko-Pen Wang and Chengshui Chen

    Citation: BMC Pulmonary Medicine 2018 18:192

    Content type: Research article

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  27. Hsp90-beta has been investigated to be correlated with the occurrence and development of tumor. The intention of this research was to test the level of Hsp90-beta in malignant pleural effusion (MPE) of patient...

    Authors: Rong Biaoxue, Li Min, Fu Tian, Gao Wenlong and Liu Hua

    Citation: BMC Pulmonary Medicine 2018 18:188

    Content type: Research article

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  28. The purpose of this study was to compare clinical outcomes of Erlotinib versus Gefitinib in the treatment of Asian patients with exon 19 EGFR-mutant lung adenocarcinoma and newly diagnosed brain metastases.

    Authors: Ye Jiang, Jing Zhang, Juanjuan Huang, Bo Xu, Ning Li, Lei Cao and Mingdong Zhao

    Citation: BMC Pulmonary Medicine 2018 18:171

    Content type: Research article

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  29. Candidates for preoperative or intraoperative nodal assessment among patients with non-small cell lung cancer (NSCLC) manifesting as a subsolid tumor are not established. The present study was conducted to dem...

    Authors: Jun Yeun Cho, Cho Sun Leem, Youlim Kim, Eun Sun Kim, Sang Hoon Lee, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Jae Ho Lee, Choon-Taek Lee and Ho Il Yoon

    Citation: BMC Pulmonary Medicine 2018 18:151

    Content type: Research article

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  30. Convenient approaches for accurate biopsy are extremely important to the diagnosis of lung cancer. We aimed to systematically review the clinical updates and development trends of approaches for biopsy, i.e., ...

    Authors: Chuan-Jiang Deng, Fu-Qiang Dai, Kai Qian, Qun-You Tan, Ru-Wen Wang, Bo Deng and Jing-Hai Zhou

    Citation: BMC Pulmonary Medicine 2018 18:146

    Content type: Research article

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  31. The diagnostic yields and safety profiles of transbronchial lung biopsy have not been evaluated in inexperienced physicians using the combined modality of radial probe endobronchial ultrasound and a guide shea...

    Authors: Jung Seop Eom, Jeong Ha Mok, Insu Kim, Min Ki Lee, Geewon Lee, Hyemi Park, Ji Won Lee, Yeon Joo Jeong, Won-Young Kim, Eun Jung Jo, Mi Hyun Kim, Kwangha Lee, Ki Uk Kim and Hye-Kyung Park

    Citation: BMC Pulmonary Medicine 2018 18:137

    Content type: Research article

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  32. As reported in Surveillance, Epidemiology, and End Results (SEER) data, US incidence and prevalence of neuroendocrine tumors (NET) has increased over recent years. The study objective was to update incidence a...

    Authors: Michael S. Broder, Beilei Cai, Eunice Chang and Maureen P. Neary

    Citation: BMC Pulmonary Medicine 2018 18:135

    Content type: Research article

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  33. Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of developing lung cancer, but few studies have investigated the long-term outcomes of repeated surgery in such patients. The purpose of this ...

    Authors: Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Hiroyuki Ishikawa, Takehiro Watanabe and Masanori Tsuchida

    Citation: BMC Pulmonary Medicine 2018 18:134

    Content type: Research article

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  34. Screening mutations in epidermal growth factor receptor (EGFR) to analyze non-small-cell lung cancer (NSCLC) profile is the criterion to choose the best therapeutic strategy.

    Authors: Zohra Mraihi, Jihen Ben Amar, Hend Bouacha, Soumaya Rammeh and Lamia Hila

    Citation: BMC Pulmonary Medicine 2018 18:132

    Content type: Research article

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  35. To determine the association of lymphatic vessel density (LVD) with the prognosis of Asian non-small cell lung cancer (NSCLC) patients via a meta-analysis.

    Authors: Shuanglan Xu, Jiao Yang, Shuangyan Xu, Yun Zhu, Chunfang Zhang, Liqiong Liu, Hao Liu, Yunlong Dong, Zhaowei Teng and Xiqian Xing

    Citation: BMC Pulmonary Medicine 2018 18:128

    Content type: Research article

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  36. Old age is an important factor that could affect the treatment of early-stage lung cancer. In this study, we evaluated the treatment patterns and outcomes of patients over the age of 80 years who had been diag...

    Authors: Kyungjong Lee, Hye Ok Kim, Hee Kyoung Choi and Gi Hyeon Seo

    Citation: BMC Pulmonary Medicine 2018 18:127

    Content type: Research article

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  37. Crizotinib is a multi-target inhibitor approved for the treatment of advanced non-small-cell lung cancer patients with a ROS1 rearrangement. However, interstitial lung disease is a rare but severe and fatal si...

    Authors: Shibo Wu, Kaitai Liu, Feng Ren, Dawei Zheng and Deng Pan

    Citation: BMC Pulmonary Medicine 2018 18:121

    Content type: Case report

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  38. There are currently no data on the prevalence of sleep-disordered breathing (SDB) in patients with newly-diagnosed lung cancer. This might be of interest given that SDB is associated with increased cancer inci...

    Authors: Michael Dreher, Stefan Krüger, Susanne Schulze-Olden, András Keszei, Jan Hendrik Storre, Holger Woehrle, Michael Arzt and Tobias Müller

    Citation: BMC Pulmonary Medicine 2018 18:72

    Content type: Research article

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  39. Malignant pleural mesothelioma (MPM) is marked by its difficult diagnosis and poor prognosis. Medical thoracoscopy (MT) is an effective and safe procedure for the diagnosis of exudative pleural effusions and m...

    Authors: Li-Li Xu, Yuan Yang, Zhen Wang, Xiao-Juan Wang, Zhao-Hui Tong and Huan-Zhong Shi

    Citation: BMC Pulmonary Medicine 2018 18:56

    Content type: Research article

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  40. Interventional bronchoscopy is considered an effective treatment option for malignant central airway obstruction (MCAO). However, there are few reports of interventional bronchoscopy in patients with MCAOs due...

    Authors: Beomsu Shin, Boksoon Chang, Hojoong Kim and Byeong-Ho Jeong

    Citation: BMC Pulmonary Medicine 2018 18:46

    Content type: Research article

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  41. Although the impact of therapeutic thoracentesis on lung function and blood gases has been evaluated in several studies, some physiological aspects of pleural fluid withdrawal remain unknown. The aim of the st...

    Authors: Monika Zielinska-Krawczyk, Elzbieta M. Grabczak, Marcin Michnikowski, Krzysztof Zielinski, Piotr Korczynski, Anna Stecka, Tomasz Golczewski and Rafal Krenke

    Citation: BMC Pulmonary Medicine 2018 18:36

    Content type: Research article

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  42. Nivolumab, an anti-programmed cell death-1 (PD-1) monoclonal antibody used as an immune checkpoint inhibitor, is commonly employed for its anti-tumor effects against various types of malignant tumors. However,...

    Authors: N. Koyama, O. Iwase, E. Nakashima, K. Kishida, T. Kondo, Y. Watanabe, H. Takahashi, Y. Umebayashi, Y. Ogawa and H. Miura

    Citation: BMC Pulmonary Medicine 2018 18:23

    Content type: Case report

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  43. Crizotinib is recommended as first-line therapy in ROS1-driven lung adenocarcinoma. However, the optimal first-line therapy for this subgroup of lung cancer is controversial according to the available clinical...

    Authors: Liang Dong, Jingwen Xia, Jing Zhang, Yuanyuan Zhang, Ning Zhu, Peng Zhang, Youzhi Zhang, Xiujuan Zhang and Shengqing Li

    Citation: BMC Pulmonary Medicine 2018 18:13

    Content type: Case report

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  44. Previous studies show that overexpression of EMMPRIN involved in the malignant biological behavior of tumors. This investigation was to disclose the expression status of EMMPRIN in non-small cell lung cancer (...

    Authors: Bing Liu, Zhaohui Wan, Baowei Sheng, Yong Lin, Tian Fu, Qingdi Zeng and Congcong Qi

    Citation: BMC Pulmonary Medicine 2017 17:214

    Content type: Research article

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  45. Previous studies have suggested that DNA double-strand break (DSB) repair is an important protective pathway after damage. The ataxia telangiectasia mutated (ATM) gene plays an important role in the DNA DSB re...

    Authors: Zhipeng Yan, Xiang Tong, Yao Ma, Sitong Liu, Lingjing Yang, Xin Yang, Xue Yang, Min Bai and Hong Fan

    Citation: BMC Pulmonary Medicine 2017 17:205

    Content type: Research article

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