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Section edited by Montserrat Sanchez Cespedes

This section concerns all aspects of lung cancer including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Content type: Research article

    Endobronchial ultrasound-guided trans-bronchial needle aspiration (EBUS-TBNA) is minimally invasive technique used for diagnosis and/or staging of benign and malignant pulmonary and non-pulmonary disease. Prev...

    Authors: Nicola Bailey, Zoe Krisnadi, Raena Kaur, Siobhain Mulrennan, Martin Phillips and Neli Slavova-Azmanova

    Citation: BMC Pulmonary Medicine 2019 19:155

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  2. Content type: Research article

    The effectiveness of Incentive spirometry (IS) in patients undergoing video-assisted thoracic surgery (VATS) remains lacking. We conducted a population-based study to investigate the effectiveness of IS on pat...

    Authors: Chin-Jung Liu, Wen-Chen Tsai, Chia-Chen Chu, Chih-Hsin Muo and Wei-Sheng Chung

    Citation: BMC Pulmonary Medicine 2019 19:121

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  3. Content type: Research article

    Malignant endobronchial mass (MEM) has poor prognosis, cryotherapy is reportedly to diagnose MEM, however, the therapeutic role of cryotherapy impacts on survival has not be well addressed.

    Authors: Fu-Tsai Chung, Chun-Liang Chou, Yu-Lun Lo, Chih-Hsi Kuo, Tsai-Yu Wang, Chun-Hwa Wang, Hung-Yu Huang, Horng-Chyuan Lin, Chih-Hao Chang, Chung-Shu Lee, Hao-Cheng Chen and Shu-Min Lin

    Citation: BMC Pulmonary Medicine 2019 19:101

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  4. Content type: Research article

    Lobectomy is the standard treatment for patients with stage I non-small cell lung cancer (NSCLC). Recent studies have shown promising results of stereotactic body radiation therapy (SBRT) in these patients. We...

    Authors: Qingren Lin, Xiaojiang Sun, Ning Zhou, Zhun Wang, Yaping Xu and Yuezhen Wang

    Citation: BMC Pulmonary Medicine 2019 19:98

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  5. Content type: Research article

    The presence of emphysema on computed tomography (CT) is associated with an increased frequency of lung cancer, but the postoperative outcomes of patients with pulmonary emphysema are not well known. The objec...

    Authors: Seijiro Sato, Masaya Nakamura, Yuki Shimizu, Tatsuya Goto, Terumoto Koike, Hiroyuki Ishikawa and Masanori Tsuchida

    Citation: BMC Pulmonary Medicine 2019 19:73

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  6. Content type: Research article

    Acute exacerbation of interstitial lung disease (AE-ILD) is the most serious complication in lung cancer patients with pre-existing ILD receiving chemotherapy. The role of vascular endothelial growth factor (V...

    Authors: Shohei Hamada, Hidenori Ichiyasu, Tokunori Ikeda, Megumi Inaba, Kosuke Kashiwabara, Tomoki Sadamatsu, Nahoko Sato, Kimitaka Akaike, Hiroko Okabayashi, Koichi Saruwatari, Yusuke Tomita, Sho Saeki, Naomi Hirata, Takeshi Yoshinaga and Kazuhiko Fujii

    Citation: BMC Pulmonary Medicine 2019 19:72

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  7. Content type: Study protocol

    Lung cancer is the leading cause of cancer-related death due in large part to our inability to diagnose it at an early and potentially curable stage. Screening for lung cancer via low dose computed tomographic...

    Authors: Ehab Billatos, Fenghai Duan, Elizabeth Moses, Helga Marques, Irene Mahon, Lindsey Dymond, Charles Apgar, Denise Aberle, George Washko and Avrum Spira

    Citation: BMC Pulmonary Medicine 2019 19:59

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  8. Content type: Research article

    HOTTIP, a long non-coding RNA located in the HOXA cluster, plays a role in the patterning of tissues with mesodermal components, including the lung. Overexpression of HOXA genes, including HOTTIP, has been associ...

    Authors: Alfons Navarro, Jorge Moises, Sandra Santasusagna, Ramon M. Marrades, Nuria Viñolas, Joan J. Castellano, Jordi Canals, Carmen Muñoz, José Ramírez, Laureano Molins and Mariano Monzo

    Citation: BMC Pulmonary Medicine 2019 19:55

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  9. Content type: Case report

    Pulmonary non-Hodgkin lymphoma (NHL) is rare. The most frequent subtype of pulmonary NHL is low-grade B-cell lymphoma, such as lymphoma of mucosa-associated lymphoma tissue. Extranodal natural killer cell/T-ce...

    Authors: Tomohiro Yabushita, Satoshi Yoshioka, Takeru Furumiya, Momoko Nakamura, Daisuke Yamashita, Yukihiro Imai and Takayuki Ishikawa

    Citation: BMC Pulmonary Medicine 2019 19:48

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  10. Content type: Case report

    Postpneumonectomy-like syndrome is a rare condition resulting from unilateral lung disease with severe lung volume loss leading to excessive mediastinal shift and herniation of the healthy lung into the contra...

    Authors: Athanasios K. Konstantinidis, Vlasios V. Vitsas, Konstantinos Tatsis, Thomas Vadivoulis, Apostolos Kittas, Christos Chronis, Vanesa Bellou, Ioannis N. Vamvakaris, Rodoula Tringidou and Grigoris K. Stratakos

    Citation: BMC Pulmonary Medicine 2019 19:44

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  11. Content type: Case report

    Pulmonary carcinoids are included in the group of neuroendocrine tumors (NET) and derive from pulmonary neuroendocrine cells. The incidence of these tumors is increasing, but disease awareness remains low amon...

    Authors: Abdulrahman Hakami, Evita Zwartkruis, Teodora Radonic and Johannes M. A. Daniels

    Citation: BMC Pulmonary Medicine 2019 19:41

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  12. Content type: Research article

    Endosonography with needle aspiration (EBUS/EUS-NA) is recommended as the first choice for mediastinal nodal assessment in non-small cell lung cancer (NSCLC). It is important to maintain adequate negative pred...

    Authors: Sukyeon Kim, Beomsu Shin, Hyun Lee, Jick Hwan Ha, Kyungjong Lee, Sang-Won Um, Hojoong Kim and Byeong-Ho Jeong

    Citation: BMC Pulmonary Medicine 2019 19:14

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    The Correction to this article has been published in BMC Pulmonary Medicine 2019 19:69

  13. Content type: Case report

    Sporadic lymphangioleiomyomatosis (LAM) is a rare form of diffuse parenchymal lung disease. PD-1 blocking antibodies constitute an essential treatment option for advanced non-small-cell lung cancer (NSCLC). Th...

    Authors: Johan Pluvy, Solenn Brosseau, Sandrine Stelianides, Claire Danel, Marina Nguenang, Antoine Khalil, Bruno Crestani, Gérard Zalcman and Valérie Gounant

    Citation: BMC Pulmonary Medicine 2019 19:12

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  14. Content type: Case report

    Cystic lung lesions involving both lungs include a variety of diseases, such as pulmonary Langerhans cell histiocytosis, lymphangioleiomyomatosis and pulmonary metastasis. Primary pulmonary meningioma accompan...

    Authors: Xin Wang, Pengfei Li, Ping Zhou, Yiyun Fu, Yutian Lai and Guowei Che

    Citation: BMC Pulmonary Medicine 2019 19:8

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  15. Content type: Research article

    EGFR mutations are routinely explored in lung adenocarcinoma by sequencing tumoral DNA. The aim of this study was to evaluate a fluorescent-labelled erlotinib based theranostic agent for the molecular imaging of ...

    Authors: Maxime Patout, Florian Guisier, Xavier Brune, Pierre Bohn, Anthony Romieu, Nasrin Sarafan-Vasseur, Richard Sesboüé, Pierre-Yves Renard, Luc Thiberville and Mathieu Salaün

    Citation: BMC Pulmonary Medicine 2019 19:3

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  16. Content type: Case report

    Pulmonary carcinosarcoma (PCS) is a rare primary lung malignancy and has a poor prognosis among lung tumor histological subtypes. However, an appropriate treatment strategy has not been developed for unresecta...

    Authors: Azusa Tanimoto, Shinji Takeuchi, Hiroshi Kotani, Kaname Yamashita, Tadaaki Yamada, Koushiro Ohtsubo, Hiromichi Ebi, Hiroko Ikeda and Seiji Yano

    Citation: BMC Pulmonary Medicine 2018 18:193

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  17. Content type: Research article

    The optimal procedure for maximizing the diagnostic yield and minimizing the procedural complexity of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is controversial. We conducted...

    Authors: Xiaoxiao Lin, Min Ye, Yuping Li, Jing Ren, Qiyan Lou, Yangyang Li, Xiaohui Jin, Ko-Pen Wang and Chengshui Chen

    Citation: BMC Pulmonary Medicine 2018 18:192

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  18. Content type: Research article

    Hsp90-beta has been investigated to be correlated with the occurrence and development of tumor. The intention of this research was to test the level of Hsp90-beta in malignant pleural effusion (MPE) of patient...

    Authors: Rong Biaoxue, Li Min, Fu Tian, Gao Wenlong and Liu Hua

    Citation: BMC Pulmonary Medicine 2018 18:188

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  19. Content type: Research article

    The purpose of this study was to compare clinical outcomes of Erlotinib versus Gefitinib in the treatment of Asian patients with exon 19 EGFR-mutant lung adenocarcinoma and newly diagnosed brain metastases.

    Authors: Ye Jiang, Jing Zhang, Juanjuan Huang, Bo Xu, Ning Li, Lei Cao and Mingdong Zhao

    Citation: BMC Pulmonary Medicine 2018 18:171

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  20. Content type: Research article

    Candidates for preoperative or intraoperative nodal assessment among patients with non-small cell lung cancer (NSCLC) manifesting as a subsolid tumor are not established. The present study was conducted to dem...

    Authors: Jun Yeun Cho, Cho Sun Leem, Youlim Kim, Eun Sun Kim, Sang Hoon Lee, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Jae Ho Lee, Choon-Taek Lee and Ho Il Yoon

    Citation: BMC Pulmonary Medicine 2018 18:151

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  21. Content type: Research article

    Convenient approaches for accurate biopsy are extremely important to the diagnosis of lung cancer. We aimed to systematically review the clinical updates and development trends of approaches for biopsy, i.e., ...

    Authors: Chuan-Jiang Deng, Fu-Qiang Dai, Kai Qian, Qun-You Tan, Ru-Wen Wang, Bo Deng and Jing-Hai Zhou

    Citation: BMC Pulmonary Medicine 2018 18:146

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  22. Content type: Research article

    The diagnostic yields and safety profiles of transbronchial lung biopsy have not been evaluated in inexperienced physicians using the combined modality of radial probe endobronchial ultrasound and a guide shea...

    Authors: Jung Seop Eom, Jeong Ha Mok, Insu Kim, Min Ki Lee, Geewon Lee, Hyemi Park, Ji Won Lee, Yeon Joo Jeong, Won-Young Kim, Eun Jung Jo, Mi Hyun Kim, Kwangha Lee, Ki Uk Kim and Hye-Kyung Park

    Citation: BMC Pulmonary Medicine 2018 18:137

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  23. Content type: Research article

    As reported in Surveillance, Epidemiology, and End Results (SEER) data, US incidence and prevalence of neuroendocrine tumors (NET) has increased over recent years. The study objective was to update incidence a...

    Authors: Michael S. Broder, Beilei Cai, Eunice Chang and Maureen P. Neary

    Citation: BMC Pulmonary Medicine 2018 18:135

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  24. Content type: Research article

    Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of developing lung cancer, but few studies have investigated the long-term outcomes of repeated surgery in such patients. The purpose of this ...

    Authors: Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Hiroyuki Ishikawa, Takehiro Watanabe and Masanori Tsuchida

    Citation: BMC Pulmonary Medicine 2018 18:134

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  25. Content type: Research article

    Screening mutations in epidermal growth factor receptor (EGFR) to analyze non-small-cell lung cancer (NSCLC) profile is the criterion to choose the best therapeutic strategy.

    Authors: Zohra Mraihi, Jihen Ben Amar, Hend Bouacha, Soumaya Rammeh and Lamia Hila

    Citation: BMC Pulmonary Medicine 2018 18:132

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  26. Content type: Research article

    To determine the association of lymphatic vessel density (LVD) with the prognosis of Asian non-small cell lung cancer (NSCLC) patients via a meta-analysis.

    Authors: Shuanglan Xu, Jiao Yang, Shuangyan Xu, Yun Zhu, Chunfang Zhang, Liqiong Liu, Hao Liu, Yunlong Dong, Zhaowei Teng and Xiqian Xing

    Citation: BMC Pulmonary Medicine 2018 18:128

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  27. Content type: Research article

    Old age is an important factor that could affect the treatment of early-stage lung cancer. In this study, we evaluated the treatment patterns and outcomes of patients over the age of 80 years who had been diag...

    Authors: Kyungjong Lee, Hye Ok Kim, Hee Kyoung Choi and Gi Hyeon Seo

    Citation: BMC Pulmonary Medicine 2018 18:127

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  28. Content type: Case report

    Crizotinib is a multi-target inhibitor approved for the treatment of advanced non-small-cell lung cancer patients with a ROS1 rearrangement. However, interstitial lung disease is a rare but severe and fatal si...

    Authors: Shibo Wu, Kaitai Liu, Feng Ren, Dawei Zheng and Deng Pan

    Citation: BMC Pulmonary Medicine 2018 18:121

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  29. Content type: Research article

    There are currently no data on the prevalence of sleep-disordered breathing (SDB) in patients with newly-diagnosed lung cancer. This might be of interest given that SDB is associated with increased cancer inci...

    Authors: Michael Dreher, Stefan Krüger, Susanne Schulze-Olden, András Keszei, Jan Hendrik Storre, Holger Woehrle, Michael Arzt and Tobias Müller

    Citation: BMC Pulmonary Medicine 2018 18:72

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  30. Content type: Research article

    Malignant pleural mesothelioma (MPM) is marked by its difficult diagnosis and poor prognosis. Medical thoracoscopy (MT) is an effective and safe procedure for the diagnosis of exudative pleural effusions and m...

    Authors: Li-Li Xu, Yuan Yang, Zhen Wang, Xiao-Juan Wang, Zhao-Hui Tong and Huan-Zhong Shi

    Citation: BMC Pulmonary Medicine 2018 18:56

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  31. Content type: Research article

    Interventional bronchoscopy is considered an effective treatment option for malignant central airway obstruction (MCAO). However, there are few reports of interventional bronchoscopy in patients with MCAOs due...

    Authors: Beomsu Shin, Boksoon Chang, Hojoong Kim and Byeong-Ho Jeong

    Citation: BMC Pulmonary Medicine 2018 18:46

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  32. Content type: Research article

    Although the impact of therapeutic thoracentesis on lung function and blood gases has been evaluated in several studies, some physiological aspects of pleural fluid withdrawal remain unknown. The aim of the st...

    Authors: Monika Zielinska-Krawczyk, Elzbieta M. Grabczak, Marcin Michnikowski, Krzysztof Zielinski, Piotr Korczynski, Anna Stecka, Tomasz Golczewski and Rafal Krenke

    Citation: BMC Pulmonary Medicine 2018 18:36

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  33. Content type: Case report

    Nivolumab, an anti-programmed cell death-1 (PD-1) monoclonal antibody used as an immune checkpoint inhibitor, is commonly employed for its anti-tumor effects against various types of malignant tumors. However,...

    Authors: N. Koyama, O. Iwase, E. Nakashima, K. Kishida, T. Kondo, Y. Watanabe, H. Takahashi, Y. Umebayashi, Y. Ogawa and H. Miura

    Citation: BMC Pulmonary Medicine 2018 18:23

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  34. Content type: Case report

    Crizotinib is recommended as first-line therapy in ROS1-driven lung adenocarcinoma. However, the optimal first-line therapy for this subgroup of lung cancer is controversial according to the available clinical...

    Authors: Liang Dong, Jingwen Xia, Jing Zhang, Yuanyuan Zhang, Ning Zhu, Peng Zhang, Youzhi Zhang, Xiujuan Zhang and Shengqing Li

    Citation: BMC Pulmonary Medicine 2018 18:13

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  35. Content type: Research article

    Previous studies show that overexpression of EMMPRIN involved in the malignant biological behavior of tumors. This investigation was to disclose the expression status of EMMPRIN in non-small cell lung cancer (...

    Authors: Bing Liu, Zhaohui Wan, Baowei Sheng, Yong Lin, Tian Fu, Qingdi Zeng and Congcong Qi

    Citation: BMC Pulmonary Medicine 2017 17:214

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  36. Content type: Research article

    Previous studies have suggested that DNA double-strand break (DSB) repair is an important protective pathway after damage. The ataxia telangiectasia mutated (ATM) gene plays an important role in the DNA DSB re...

    Authors: Zhipeng Yan, Xiang Tong, Yao Ma, Sitong Liu, Lingjing Yang, Xin Yang, Xue Yang, Min Bai and Hong Fan

    Citation: BMC Pulmonary Medicine 2017 17:205

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  37. Content type: Research article

    NKX2–1, a key molecule in lung development, is highly expressed in non-small cell lung cancer (NSCLC), particularly in lung adenocarcinoma (ADK), where it is a diagnostic marker. Studies of the prognostic role...

    Authors: Jorge Moisés, Alfons Navarro, Sandra Santasusagna, Nuria Viñolas, Laureano Molins, José Ramirez, Jeisson Osorio, Adela Saco, Joan Josep Castellano, Carmen Muñoz, Sara Morales, Mariano Monzó and Ramón María Marrades

    Citation: BMC Pulmonary Medicine 2017 17:197

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  38. Content type: Research article

    It is crucial to develop novel diagnostic approaches for determining if peripheral lung nodules are malignant, as such nodules are frequently detected due to the increased use of chest computed tomography scan...

    Authors: Akifumi Uchida, Takuya Samukawa, Tomohiro Kumamoto, Masahiro Ohshige, Kazuhito Hatanaka, Yoshihiro Nakamura, Keiko Mizuno, Ikkou Higashimoto, Masami Sato and Hiromasa Inoue

    Citation: BMC Pulmonary Medicine 2017 17:195

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  39. Content type: Research article

    Transbronchial biopsy for peripheral pulmonary lesions is generally performed under X-ray fluoroscopy. Virtual bronchoscopic navigation (VBN) is a method in which virtual images of the bronchial route to the l...

    Authors: Fumihiro Asano, Takashi Ishida, Naofumi Shinagawa, Noriaki Sukoh, Masaki Anzai, Kenya Kanazawa, Akifumi Tsuzuku and Satoshi Morita

    Citation: BMC Pulmonary Medicine 2017 17:184

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  40. Content type: Research article

    Guidelines recommend timely evaluation of patients with suspected lung cancer. We evaluated the impact of a Rapid Investigation Clinic (RIC) on timeliness of lung cancer diagnosis and treatment between Februar...

    Authors: Nicole Ezer, Asma Navasakulpong, Kevin Schwartzman, Linda Ofiara and Anne V. Gonzalez

    Citation: BMC Pulmonary Medicine 2017 17:178

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  41. Content type: Research article

    When epidermal growth factor receptor (EGFR) gene mutation-positive non-small cell lung cancer (NSCLC) acquires resistance to the initial tyrosine kinase inhibitor (TKI) treatment, reassessing the tumor DNA by...

    Authors: Sakurako Uozu, Kazuyoshi Imaizumi, Teppei Yamaguchi, Yasuhiro Goto, Kenji Kawada, Tomoyuki Minezawa, Takuya Okamura, Ken Akao, Masamichi Hayashi, Sumito Isogai, Mitsushi Okazawa, Naozumi Hashimoto and Yoshinori Hasegawa

    Citation: BMC Pulmonary Medicine 2017 17:175

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  42. Content type: Case report

    Alectinib, a second-generation anaplastic lymphoma kinase (ALK) inhibitor, is a key drug for ALK rearranged lung adenocarcinoma. Interstitial lung disease (ILD) is an important adverse effect of alectinib, whi...

    Authors: Tatsuya Nitawaki, Yoshihiko Sakata, Kodai Kawamura and Kazuya Ichikado

    Citation: BMC Pulmonary Medicine 2017 17:173

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  43. Content type: Research article

    Previously reported prognostic tools for patients with resected non-small cell lung cancer (NSCLC) include factors found postoperatively, but not preoperatively. However, it would be important to predict patie...

    Authors: Shogo Kumagai, Satoshi Marumo, Machiko Arita, Keiji Yamanashi, Ryota Sumitomo, Yosuke Otake, Tsuyoshi Shoji, Motonari Fukui, Toshiro Katayama, Norihito Okumura and Cheng-Long Huang

    Citation: BMC Pulmonary Medicine 2017 17:166

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  44. Content type: Research article

    To report the prevalence of pleural plaques in a lung cancer screening trial by low-dose computed tomography (LDCT) and to test the association with incidence of lung cancer and mortality.

    Authors: Mario Silva, Nicola Sverzellati, Davide Colombi, Gianluca Milanese, Carlo La Vecchia, Carlotta Galeone, Alfonso Marchianò and Ugo Pastorino

    Citation: BMC Pulmonary Medicine 2017 17:155

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  45. Content type: Research article

    Radial-probe endobronchial ultrasound (rEBUS)-guided transbronchial biopsy (TBB) is invaluable in the diagnosis of peripheral pulmonary lesions (PPLs); however, in certain instances, the procedure has to be re...

    Authors: Chun-Ta Huang, Yi-Ju Tsai, Chao-Chi Ho and Chong-Jen Yu

    Citation: BMC Pulmonary Medicine 2017 17:132

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  46. Content type: Research article

    Lung cancer has been the leading cause of cancer-related mortality worldwide among both men and women in recent years. There is an increase in the incidence of nonsmoking-related lung cancer in recent years. T...

    Authors: Kuei-Feng Lin, Hsiu-Fu Wu, Wei-Chun Huang, Pei-Ling Tang, Ming-Ting Wu and Fu-Zong Wu

    Citation: BMC Pulmonary Medicine 2017 17:120

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  47. Content type: Research article

    This retrospective study investigated the association between the Charlson comorbidity index (CCI) score and the survival of patients with stage IIIB-IV (advanced, non-resectable) non-small cell lung cancer (N...

    Authors: Lei Zhao, Lai-Han Leung, Jing Wang, Huihui Li, Juanjuan Che, Lian Liu, Xiaojun Yao and Bangwei Cao

    Citation: BMC Pulmonary Medicine 2017 17:112

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  48. Content type: Research article

    Decorin is one of the most abundant proteoglycans of the extracellular matrix and is mainly secreted and deposited in the interstitial matrix by fibroblasts where it plays an important role in collagen turnove...

    Authors: S.N. Kehlet, C.L. Bager, N. Willumsen, B. Dasgupta, C. Brodmerkel, M. Curran, S. Brix, D.J. Leeming and M. A. Karsdal

    Citation: BMC Pulmonary Medicine 2017 17:110

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