Cancer

LncRNA MAGI2-AS3 is downregulated in non-small cell lung cancer and may be a sponge of miR-25

This study aimed to investigate the role of lncRNA MAGI2-AS3 in non-small cell lung cancer (NSCLC).

Authors: Yutong Sui, Wencheng Chi, Li Feng and Jiakang Jiang

Prognostic factors for survival after bronchoscopic intervention in patients with airway obstruction due to primary pulmonary malignancy

Malignant central airway obstruction (MCAO) occurs in 20–30% of patients with primary pulmonary malignancy. Although bronchoscopic intervention is widely performed to treat MCAO, little data exist on the progn...

Authors: Bo-Guen Kim, Beomsu Shin, Boksoon Chang, Hojoong Kim and Byeong-Ho Jeong

A case report of an unusual non-mucinous papillary variant of CPAM type 1 with KRAS mutations

congenital pulmonary airway malformation (CPAM) is the most frequent congenital lung disorder. CPAM type 1 is the most common subtype, typically having a cystic radiological and histological appearance. Mucino...

Authors: Timco Koopman, Bart L. Rottier, Arja ter Elst and Wim Timens

Does a pulmonary rehabilitation based ERAS program (PREP) affect pulmonary complication incidence, pulmonary function and quality of life after lung cancer surgery? Study protocol for a multicenter randomized controlled trial

Lung cancer surgery is associated with a high incidence of postoperative pulmonary complications (PPCs). Preliminary evidence suggests that ERAS processes can reduce overall incidence of PPCs as short- and lon...

Authors: Yu Zheng, Mao Mao, Meifang Ji, Qiugang Zheng, Liang Liu, Zhigang Zhao, Haiming Wang, Xiangyang Wei, Yulong Wang, Jiamin Chen, Huiqing Zhou, Qiaoqiao Liang, Ying Chen, Xintong Zhang, Lu Wang, Yihui Cheng…

Lung carcinoma with diffuse cystic lesions misdiagnosed as pulmonary langerhans cell histocytosis: a case report

Cystic airspace is an uncommon imaging manifestation involved in non-small lung cancer (NSCLC). Diffuse cystic lesion is even rarer as pulmonary manifestation of NSCLC. In the present study, we reported a rare...

Authors: Xianhua Gui, Jingjing Ding, Yan Li, Min Yu, Tingting Chen, Mei Huang and Yonglong Xiao

Does this lung nodule need urgent review? A discrete choice experiment of Australian general practitioners

Lung cancer is the leading cause of cancer mortality in Australia. Guidelines suggest that patients with suspected lung cancer on thoracic imaging be referred for urgent specialist review. However, the term “s...

Authors: P. Brownell, F. Piccolo, F. Brims, R. Norman and D. Manners

Knockdown of circ-ABCB10 promotes sensitivity of lung cancer cells to cisplatin via miR-556-3p/AK4 axis

Due to the acquired drug resistance, the potency of cisplatin-based chemotherapy is limited in lung cancer, which is a big obstacle in clinical treatment of lung cancer. Abundant evidence has revealed that cir...

Authors: Zhihui Wu, Qiang Gong, Yan Yu, Jialin Zhu and Wencan Li

Circulating tumor cells prior to initial treatment is an important prognostic factor of survival in non-small cell lung cancer: a meta-analysis and system review

Our study aimed to verify the prognostic value of circulating tumor cells (CTCs) prior to initial treatment on survival of non-small cell lung cancer (NSCLC) by using meta-analysis and system review of publish...

Authors: Sha-Sha Jiang, Bo Deng, Yong-Geng Feng, Kai Qian, Qun-You Tan and Ru-Wen Wang

LncRNA LUADT1 sponges miR-15a-3p to upregulate Twist1 in small cell lung cancer

Lung adenocarcinoma associated transcript 1 (LUADT1) has been reported as an oncogenic long non-coding RNA (lncRNA) in lung adenocarcinoma, while its roles in small cell lung cancer (SCLC) are unknown. Our RNA...

Authors: Dingxue Wang, Wenyu Wu, Wenqi Huang, Jinghui Wang, Li Luo and Dongxin Tang

Robot-assisted bronchoscopy for pulmonary lesion diagnosis: results from the initial multicenter experience

The Robotic Endoscopic System (Auris Health, Inc., Redwood City, CA) has the potential to overcome several limitations of contemporary guided-bronchoscopic technologies for the diagnosis of lung lesions. Our o...

Authors: Udit Chaddha, Stephen P. Kovacs, Christopher Manley, D. Kyle Hogarth, Gustavo Cumbo-Nacheli, Sivasubramanium V. Bhavani, Rohit Kumar, Manisha Shende, John P. Egan III and Septimiu Murgu

Indwelling pleural catheters for malignancy-associated pleural effusion: report on a single centre’s ten years of experience

Recurrent pleural effusion is a common cause of dyspnoea, cough and chest pain during the course of malignant diseases. Chemical pleurodesis had been the only definitive treatment option until two decades ago....

Authors: Nikolaj Frost, Martin Brünger, Christoph Ruwwe-Glösenkamp, Matthias Raspe, Antje Tessmer, Bettina Temmesfeld-Wollbrück, Dirk Schürmann, Norbert Suttorp and Martin Witzenrath

Diagnoses from lung specimen collected through flexible bronchoscopy from patients in a tertiary hospital in Dar es Salaam Tanzania: a retrospective cross-sectional study

Flexible bronchoscopy enables visualization of the respiratory airway mucosa from the oropharynx to third generation branching of the tracheobronchial tree. Bronchoscopic diagnoses vary from one locality to th...

Authors: Deus A. Ndilanha, Grace A. Shayo, Ramadhan Hassan, Moses Byomuganyizi and Leonard E. K. Lema

Spontaneous remission of advanced progressive poorly differentiated non-small cell lung cancer: a case report and review of literature

Spontaneous remission (SR) of cancer is a very rare phenomenon of unknown mechanism. In particular, SR of non-small cell lung cancer (NSCLC) has been scarcely reported. We present the case of a 74-year-old wom...

Authors: Hee-Young Yoon, Heae Surng Park, Min Sun Cho, Sung Shin Shim, Yookyung Kim and Jin Hwa Lee

EGFR, KRAS, BRAF, ALK, and cMET genetic alterations in 1440 Sardinian patients with lung adenocarcinoma

Lung cancer is one of the most incident neoplastic diseases, and a leading cause of death for cancer worldwide. Knowledge of the incidence of druggable genetic alterations, their correlation with clinical and ...

Authors: Maria Colombino, Panagiotis Paliogiannis, Antonio Cossu, Davide Adriano Santeufemia, Maria Cristina Sini, Milena Casula, Grazia Palomba, Antonella Manca, Marina Pisano, Valentina Doneddu and Giuseppe Palmieri

Implantation of ¹²⁵I radioactive seeds via c-TBNA combined with chemotherapy in an advanced non-small-cell lung carcinoma patient

The critical management of advanced non-small-cell lung carcinoma (NSCLC), especially when complicated by severe airway stenosis, is difficult and often leads to high clinical risks and medical costs.

Authors: Ai-Gui Jiang, Hui-Yu Lu and Zhong-Qi Ding

Primary bronchial myeloid sarcoma mimicking bronchogenic carcinoma: a case report

Myeloid sarcoma (MS) rarely involves the bronchus, and primary bronchial MS has almost never been reported in mainland China.

Authors: Wang Wang, Hesheng He, Xingwu Chen and Chenhong Zhang

Treatment beyond four cycles of first line Platinum and Etoposide chemotherapy in real-life patients with stage IV Small Cell Lung Cancer: a retrospective study of the Merseyside and Cheshire Cancer network

Dose intensity and dose density of first line Platinum and Etoposide (PE) do not influence Overall Survival (OS) of Small Cell Lung Cancer (SCLC) patients. The effect of treatment length, however, remains uncl...

Authors: Mostafa Sallam, Helen Wong and Carles Escriu

Radial endobronchial ultrasound-guided transbronchial biopsy for peripheral pulmonary malignancy: biopsy- or brushing-first?

Radial endobronchial ultrasound (R-EBUS)-guided transbronchial biopsy (TBB) is a common diagnostic modality for peripheral pulmonary lesions; however, there is uncertainty about the optimal sequence of TBB and...

Authors: Chun-Ta Huang, Yi-Ju Tsai, Chao-Chi Ho and Chong-Jen Yu

Combined pulmonary fibrosis and emphysema and idiopathic pulmonary fibrosis in non-small cell lung cancer: impact on survival and acute exacerbation

In non-small cell lung cancer (NSCLC) patients, concomitant idiopathic pulmonary fibrosis (IPF) and emphysema (CPFE) are independently related to poor survival. CPFE is a condition with features of both pulmon...

Authors: Sung Woo Moon, Moo Suk Park, Young Sam Kim, Joon Jang, Jae Ho Lee, Choon-Taek Lee, Jin-Haeng Chung, Hyo Sup Shim, Kyung Won Lee, Seung-Seob Kim, Sang Hoon Lee and Ho Il Yoon

LncRNA PLAC 2 downregulated miR-21 in non-small cell lung cancer and predicted survival

LncRNA PLAC2 has been characterized as a tumor suppressive lncRNA in glioma. We investigated the role of PLAC2 in non-small cell lung cancer (NSCLC).

Authors: Huan Xia, Ming Xiu, Jinying Gao and Hongyu Jing

PD-L1, FGFR1, PIK3CA, PTEN, and p16 expression in pulmonary emphysema and chronic obstructive pulmonary disease with resected lung squamous cell carcinoma

Emphysema and chronic obstructive pulmonary disease (COPD) are well known independent risk factors for lung cancer. However, the developmental mechanisms between emphysema/COPD and lung cancer remain unknown. ...

Authors: Ken Arimura, Yasuo Sekine, Kenzo Hiroshima, Satoru Shimizu, Noriyuki Shibata, Mitsuko Kondo, Kiyoshi Takeyama and Etsuko Tagaya

Atypical diagnosis for typical lung carcinoid

The diagnosis of lung typical carcinoid tumors results challenging when limited size and unfavorable sampling location is associated. It has been reported that bronchoscopy with endobronchial ultrasound (EBUS)...

Authors: Roberto Piro, Roberto Tonelli, Sofia Taddei, Alessandro Marchioni, Giovanni Musci, Enrico Clini and Nicola Facciolongo

Bronchoscopic management of peripheral pulmonary lesions: robotic approach paves the way to the future

Authors: Michele Mondoni and Giovanni Sotgiu

A pragmatic application of endobronchial ultrasound-guided transbronchial needle aspiration: a single institution experience

Endobronchial ultrasound-guided trans-bronchial needle aspiration (EBUS-TBNA) is minimally invasive technique used for diagnosis and/or staging of benign and malignant pulmonary and non-pulmonary disease. Prev...

Authors: Nicola Bailey, Zoe Krisnadi, Raena Kaur, Siobhain Mulrennan, Martin Phillips and Neli Slavova-Azmanova

Is incentive spirometry beneficial for patients with lung cancer receiving video-assisted thoracic surgery?

The effectiveness of Incentive spirometry (IS) in patients undergoing video-assisted thoracic surgery (VATS) remains lacking. We conducted a population-based study to investigate the effectiveness of IS on pat...

Authors: Chin-Jung Liu, Wen-Chen Tsai, Chia-Chen Chu, Chih-Hsin Muo and Wei-Sheng Chung

Factors affecting survival in patients with endobronchial malignant mass after flexible Bronchoscopic cryotherapy: a cohort study

Malignant endobronchial mass (MEM) has poor prognosis, cryotherapy is reportedly to diagnose MEM, however, the therapeutic role of cryotherapy impacts on survival has not be well addressed.

Authors: Fu-Tsai Chung, Chun-Liang Chou, Yu-Lun Lo, Chih-Hsi Kuo, Tsai-Yu Wang, Chun-Hwa Wang, Hung-Yu Huang, Horng-Chyuan Lin, Chih-Hao Chang, Chung-Shu Lee, Hao-Cheng Chen and Shu-Min Lin

Outcomes of stereotactic body radiotherapy versus lobectomy for stage I non-small cell lung cancer: a propensity score matching analysis

Lobectomy is the standard treatment for patients with stage I non-small cell lung cancer (NSCLC). Recent studies have shown promising results of stereotactic body radiation therapy (SBRT) in these patients. We...

Authors: Qingren Lin, Xiaojiang Sun, Ning Zhou, Zhun Wang, Yaping Xu and Yuezhen Wang

Robotic assisted-bronchoscopy: technical tips and lessons learned from the initial experience with sampling peripheral lung lesions

Peripheral pulmonary nodules are increasingly detected in patients screened for lung cancer or during disease progression of thoracic or extrathoracic malignancies. Sampling these lesions requires surgery, com...

Authors: Septimiu Dan Murgu

The impact of emphysema on surgical outcomes of early-stage lung cancer: a retrospective study

The presence of emphysema on computed tomography (CT) is associated with an increased frequency of lung cancer, but the postoperative outcomes of patients with pulmonary emphysema are not well known. The objec...

Authors: Seijiro Sato, Masaya Nakamura, Yuki Shimizu, Tatsuya Goto, Terumoto Koike, Hiroyuki Ishikawa and Masanori Tsuchida

Protective effect of bevacizumab on chemotherapy-related acute exacerbation of interstitial lung disease in patients with advanced non-squamous non-small cell lung cancer

Acute exacerbation of interstitial lung disease (AE-ILD) is the most serious complication in lung cancer patients with pre-existing ILD receiving chemotherapy. The role of vascular endothelial growth factor (V...

Authors: Shohei Hamada, Hidenori Ichiyasu, Tokunori Ikeda, Megumi Inaba, Kosuke Kashiwabara, Tomoki Sadamatsu, Nahoko Sato, Kimitaka Akaike, Hiroko Okabayashi, Koichi Saruwatari, Yusuke Tomita, Sho Saeki, Naomi Hirata, Takeshi Yoshinaga and Kazuhiko Fujii

Detection of early lung cancer among military personnel (DECAMP) consortium: study protocols

Lung cancer is the leading cause of cancer-related death due in large part to our inability to diagnose it at an early and potentially curable stage. Screening for lung cancer via low dose computed tomographic...

Authors: Ehab Billatos, Fenghai Duan, Elizabeth Moses, Helga Marques, Irene Mahon, Lindsey Dymond, Charles Apgar, Denise Aberle, George Washko and Avrum Spira

Clinical significance of long non-coding RNA HOTTIP in early-stage non-small-cell lung cancer

HOTTIP, a long non-coding RNA located in the HOXA cluster, plays a role in the patterning of tissues with mesodermal components, including the lung. Overexpression of HOXA genes, including HOTTIP, has been associ...

Authors: Alfons Navarro, Jorge Moises, Sandra Santasusagna, Ramon M. Marrades, Nuria Viñolas, Joan J. Castellano, Jordi Canals, Carmen Muñoz, José Ramírez, Laureano Molins and Mariano Monzo

The impact of early diagnosis on the prognosis of extranodal NK/T-cell lymphoma with massive lung involvement: a case report

Pulmonary non-Hodgkin lymphoma (NHL) is rare. The most frequent subtype of pulmonary NHL is low-grade B-cell lymphoma, such as lymphoma of mucosa-associated lymphoma tissue. Extranodal natural killer cell/T-ce...

Authors: Tomohiro Yabushita, Satoshi Yoshioka, Takeru Furumiya, Momoko Nakamura, Daisuke Yamashita, Yukihiro Imai and Takayuki Ishikawa

Postpneumonectomy-like syndrome due to bronchial carcinoid: a unique case report

Postpneumonectomy-like syndrome is a rare condition resulting from unilateral lung disease with severe lung volume loss leading to excessive mediastinal shift and herniation of the healthy lung into the contra...

Authors: Athanasios K. Konstantinidis, Vlasios V. Vitsas, Konstantinos Tatsis, Thomas Vadivoulis, Apostolos Kittas, Christos Chronis, Vanesa Bellou, Ioannis N. Vamvakaris, Rodoula Tringidou and Grigoris K. Stratakos

Atypical bronchial carcinoid with postobstructive mycobacterial infection: case report and review of literature

Pulmonary carcinoids are included in the group of neuroendocrine tumors (NET) and derive from pulmonary neuroendocrine cells. The incidence of these tumors is increasing, but disease awareness remains low amon...

Authors: Abdulrahman Hakami, Evita Zwartkruis, Teodora Radonic and Johannes M. A. Daniels

Are there differences among operators in false-negative rates of endosonography with needle aspiration for mediastinal nodal staging of non-small cell lung cancer?

Endosonography with needle aspiration (EBUS/EUS-NA) is recommended as the first choice for mediastinal nodal assessment in non-small cell lung cancer (NSCLC). It is important to maintain adequate negative pred...

Authors: Sukyeon Kim, Beomsu Shin, Hyun Lee, Jick Hwan Ha, Kyungjong Lee, Sang-Won Um, Hojoong Kim and Byeong-Ho Jeong

Safe and effective use of nivolumab for treating lung adenocarcinoma associated with sporadic lymphangioleiomyomatosis: a rare case report

Sporadic lymphangioleiomyomatosis (LAM) is a rare form of diffuse parenchymal lung disease. PD-1 blocking antibodies constitute an essential treatment option for advanced non-small-cell lung cancer (NSCLC). Th...

Authors: Johan Pluvy, Solenn Brosseau, Sandrine Stelianides, Claire Danel, Marina Nguenang, Antoine Khalil, Bruno Crestani, Gérard Zalcman and Valérie Gounant

Intrapulmonary metastasis from primary pulmonary meningioma presenting as multiple cystic lesions: a case report

Cystic lung lesions involving both lungs include a variety of diseases, such as pulmonary Langerhans cell histiocytosis, lymphangioleiomyomatosis and pulmonary metastasis. Primary pulmonary meningioma accompan...

Authors: Xin Wang, Pengfei Li, Ping Zhou, Yiyun Fu, Yutian Lai and Guowei Che

Real-time molecular optical micro-imaging of EGFR mutations using a fluorescent erlotinib based tracer

EGFR mutations are routinely explored in lung adenocarcinoma by sequencing tumoral DNA. The aim of this study was to evaluate a fluorescent-labelled erlotinib based theranostic agent for the molecular imaging of ...

Authors: Maxime Patout, Florian Guisier, Xavier Brune, Pierre Bohn, Anthony Romieu, Nasrin Sarafan-Vasseur, Richard Sesboüé, Pierre-Yves Renard, Luc Thiberville and Mathieu Salaün

Pulmonary carcinosarcoma showing an obvious response to pazopanib: a case report

Pulmonary carcinosarcoma (PCS) is a rare primary lung malignancy and has a poor prognosis among lung tumor histological subtypes. However, an appropriate treatment strategy has not been developed for unresecta...

Authors: Azusa Tanimoto, Shinji Takeuchi, Hiroshi Kotani, Kaname Yamashita, Tadaaki Yamada, Koushiro Ohtsubo, Hiromichi Ebi, Hiroko Ikeda and Seiji Yano

Randomized controlled trial to evaluate the utility of suction and inner-stylet of EBUS-TBNA for mediastinal and hilar lymphadenopathy

The optimal procedure for maximizing the diagnostic yield and minimizing the procedural complexity of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is controversial. We conducted...

Authors: Xiaoxiao Lin, Min Ye, Yuping Li, Jing Ren, Qiyan Lou, Yangyang Li, Xiaohui Jin, Ko-Pen Wang and Chengshui Chen

Elevated Hsp90-beta contributes to differential diagnosis of pleural effusion caused by lung cancer and correlates with malignant biological behavior of lung cancer

Hsp90-beta has been investigated to be correlated with the occurrence and development of tumor. The intention of this research was to test the level of Hsp90-beta in malignant pleural effusion (MPE) of patient...

Authors: Rong Biaoxue, Li Min, Fu Tian, Gao Wenlong and Liu Hua

Erlotinib versus gefitinib for brain metastases in Asian patients with exon 19 EGFR-mutant lung adenocarcinoma: a retrospective, multicenter study

The purpose of this study was to compare clinical outcomes of Erlotinib versus Gefitinib in the treatment of Asian patients with exon 19 EGFR-mutant lung adenocarcinoma and newly diagnosed brain metastases.

Authors: Ye Jiang, Jing Zhang, Juanjuan Huang, Bo Xu, Ning Li, Lei Cao and Mingdong Zhao

Paraneoplastic syndrome as the presentation of limited stage small cell carcinoma

Small cell lung carcinoma (SCLC) is one of the deadliest forms of lung cancer due to its poor prognosis upon diagnosis, rapid doubling time, and affinity for metastasis. As 60–70% of patients with SCLC have di...

Authors: Kia Nikoomanesh, Julian Choi and Sarkis Arabian

Solid part size is an important predictor of nodal metastasis in lung cancer with a subsolid tumor

Candidates for preoperative or intraoperative nodal assessment among patients with non-small cell lung cancer (NSCLC) manifesting as a subsolid tumor are not established. The present study was conducted to dem...

Authors: Jun Yeun Cho, Cho Sun Leem, Youlim Kim, Eun Sun Kim, Sang Hoon Lee, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Jae Ho Lee, Choon-Taek Lee and Ho Il Yoon

Clinical updates of approaches for biopsy of pulmonary lesions based on systematic review

Convenient approaches for accurate biopsy are extremely important to the diagnosis of lung cancer. We aimed to systematically review the clinical updates and development trends of approaches for biopsy, i.e., ...

Authors: Chuan-Jiang Deng, Fu-Qiang Dai, Kai Qian, Qun-You Tan, Ru-Wen Wang, Bo Deng and Jing-Hai Zhou

Radial probe endobronchial ultrasound using a guide sheath for peripheral lung lesions in beginners

The diagnostic yields and safety profiles of transbronchial lung biopsy have not been evaluated in inexperienced physicians using the combined modality of radial probe endobronchial ultrasound and a guide shea...

Authors: Jung Seop Eom, Jeong Ha Mok, Insu Kim, Min Ki Lee, Geewon Lee, Hyemi Park, Ji Won Lee, Yeon Joo Jeong, Won-Young Kim, Eun Jung Jo, Mi Hyun Kim, Kwangha Lee, Ki Uk Kim and Hye-Kyung Park

Incidence and prevalence of neuroendocrine tumors of the lung: analysis of a US commercial insurance claims database

As reported in Surveillance, Epidemiology, and End Results (SEER) data, US incidence and prevalence of neuroendocrine tumors (NET) has increased over recent years. The study objective was to update incidence a...

Authors: Michael S. Broder, Beilei Cai, Eunice Chang and Maureen P. Neary

Survival after repeated surgery for lung cancer with idiopathic pulmonary fibrosis: a retrospective study

Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of developing lung cancer, but few studies have investigated the long-term outcomes of repeated surgery in such patients. The purpose of this ...

Authors: Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Hiroyuki Ishikawa, Takehiro Watanabe and Masanori Tsuchida

EGFR mutation status in Tunisian non-small-cell lung cancer patients evaluated by mutation-specific immunohistochemistry

Screening mutations in epidermal growth factor receptor (EGFR) to analyze non-small-cell lung cancer (NSCLC) profile is the criterion to choose the best therapeutic strategy.

Authors: Zohra Mraihi, Jihen Ben Amar, Hend Bouacha, Soumaya Rammeh and Lamia Hila