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COPD and occupational lung disease

Section edited by Craig Hersh

This section concerns all aspects of COPD, occupational lung disease, and smoking-related disorders including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. In recent years, many studies have discovered that cystatin C (Cys C) may play an important role in respiratory diseases, especially in chronic obstructive pulmonary disease (COPD). However, the findings of th...

    Authors: Limin Chai, Wei Feng, Cui Zhai, Wenhua Shi, Jian Wang, Xin Yan, Qingting Wang, Qianqian Zhang and Manxiang Li

    Citation: BMC Pulmonary Medicine 2020 20:182

    Content type: Research article

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  2. The cluster randomized controlled trial on (cost-)effectiveness of integrated chronic obstructive pulmonary disease (COPD) management in primary care (RECODE) showed that integrated disease management (IDM) in...

    Authors: Eline Meijer, Annelies E. van Eeden, Annemarije L. Kruis, Melinde R. S. Boland, Willem J. J. Assendelft, Apostolos Tsiachristas, Maureen P. M. H. Rutten-van Mölken, Marise J. Kasteleyn and Niels H. Chavannes

    Citation: BMC Pulmonary Medicine 2020 20:176

    Content type: Research article

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  3. COPD is a well-known risk factor for lung cancer, independent of smoking behavior. By investigating the retrospective National Health Insurance Service-National Sample Cohort (NHIS-NSC) in Korea, this study at...

    Authors: Song Vogue Ahn, Eunyoung Lee, Bumhee Park, Jin Hee Jung, Ji Eun Park, Seung Soo Sheen, Kwang Joo Park, Sung Chul Hwang, Jae Bum Park, Hae-Sim Park and Joo Hun Park

    Citation: BMC Pulmonary Medicine 2020 20:170

    Content type: Research article

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  4. Several lung structural and functional abnormalities may occur associated with aging, including emphysema. In this study, we evaluated the frequency and risk factors associated with emphysema in respiratory as...

    Authors: Ivette Buendia-Roldan, Alexia Palma-Lopez, Danaireth Chan-Padilla, Iliana Herrera, Mariel Maldonado, Rosario Fernández, David Martínez-Briseño, Mayra Mejia and Moises Selman

    Citation: BMC Pulmonary Medicine 2020 20:164

    Content type: Research article

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  5. Self-Management Support (SMS), refers to the actions taken by individuals to recognise and manage their own health. It is increasingly recognised that individuals with chronic obstructive pulmonary disease (CO...

    Authors: Lindsay Welch, Rosanna Orlando, Sharon X. Lin, Ivaylo Vassilev and Anne Rogers

    Citation: BMC Pulmonary Medicine 2020 20:162

    Content type: Research article

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  6. Forced expiratory volume in one second (FEV1) characterizes the pathophysiology of COPD and different trajectories of FEV1 decline have been observed in patients with COPD (e.g. gradual or episodic). There is lim...

    Authors: Johanna I. Lutter, Rudolf A. Jörres, Kathrin Kahnert, Larissa Schwarzkopf, Michael Studnicka, Stefan Karrasch, Holger Schulz, Claus F. Vogelmeier and Rolf Holle

    Citation: BMC Pulmonary Medicine 2020 20:148

    Content type: Research article

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  7. The association between chronic obstructive pulmonary disease (COPD), lung function and risk of type 2 diabetes mellitus (T2DM) remains controversial. We performed a meta-analysis to clarify this issue.

    Authors: Yang Peng, Guo-Chao Zhong, Lingxiao Wang, Lijuan Guan, Ao Wang, Kai Hu and Jing Shen

    Citation: BMC Pulmonary Medicine 2020 20:137

    Content type: Research article

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  8. Revefenacin, a once-daily, long-acting muscarinic antagonist delivered via standard jet nebulizer, increased trough forced expiratory volume in 1 s (FEV1) in patients with moderate to very severe chronic obstruct...

    Authors: James F. Donohue, Edward Kerwin, Chris N. Barnes, Edmund J. Moran, Brett Haumann and Glenn D. Crater

    Citation: BMC Pulmonary Medicine 2020 20:134

    Content type: Research article

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  9. COPD exacerbations have negative impact on patients’ survival. Several risk factors for grave outcomes of such exacerbations have been descried. Muscle dysfunction and mass loss were shown to impact negatively...

    Authors: N. Lasman, M. Shalom, N. Turpashvili, G. Goldhaber, Y. Lifshitz, E. Leibowitz, G. Berger, G. Saltzman-Shenhav, A. Brom, D. Cohen, C. Avaky and G. Segal

    Citation: BMC Pulmonary Medicine 2020 20:133

    Content type: Research article

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  10. Previous studies have established a higher prevalence of vitamin D deficiency in patients with COPD, but the relationship between vitamin D levels and COPD exacerbations remains controversial. In addition, the...

    Authors: Auyon J. Ghosh, Matthew Moll, Lystra P. Hayden, Jessica Bon, Elizabeth Regan and Craig P. Hersh

    Citation: BMC Pulmonary Medicine 2020 20:123

    Content type: Research article

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  11. Although many studies on people with Chronic Obstructive Pulmonary Disease (COPD) have examined the mutual impact of physical status and emotional experience, there is limited knowledge about the way COPD peop...

    Authors: Marta Pozzar, Eleonora Volpato, Chiara Valota, Francesco Pagnini and Paolo Innocente Banfi

    Citation: BMC Pulmonary Medicine 2020 20:120

    Content type: Research article

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  12. Batefenterol (BAT) is a bi-functional molecule with both muscarinic antagonist and β2-adrenoceptor agonist pharmacology. This Phase II, randomized, placebo-controlled, double-blind study evaluated the safety and ...

    Authors: Courtney Crim, Mark Gotfried, Selwyn Spangenthal, Michael Watkins, Amanda Emmett, Catriona Crawford, Charlotte Baidoo and Ramiro Castro-Santamaria

    Citation: BMC Pulmonary Medicine 2020 20:119

    Content type: Research article

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  13. Inhaled bronchodilators including long-acting beta-agonist (LABA) and long-acting muscarinic antagonist (LAMA) play a central role in the treatment of stable chronic obstructive pulmonary disease (COPD). Howev...

    Authors: Akira Koarai, Hisatoshi Sugiura, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Tomotaka Kawayama and Masakazu Ichinose

    Citation: BMC Pulmonary Medicine 2020 20:111

    Content type: Research article

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  14. To investigate whether, in patients hospitalized for COPD, the addition of social factors improves the predictive ability for the risk of overall 30-day readmissions, early readmissions (within 7 days after di...

    Authors: Tadahiro Goto, Kazuki Yoshida, Mohammad Kamal Faridi, Carlos A. Camargo Jr and Kohei Hasegawa

    Citation: BMC Pulmonary Medicine 2020 20:107

    Content type: Research article

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  15. Chronic obstructive pulmonary disease (COPD) patients with different phenotypes show different clinical characteristics. Therefore, we conducted a meta-analysis to explore the clinical characteristics between ...

    Authors: Jian-jun Wu, Hong-ri Xu, Ying-xue Zhang, Yi-xuan Li, Hui-yong Yu, Liang-duo Jiang, Cheng-xiang Wang and Mei Han

    Citation: BMC Pulmonary Medicine 2020 20:103

    Content type: Research article

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  16. Obstructive sleep apnea (OSA) is associated with pulmonary fibrosis and endothelial apoptosis in pulmonary tissues. Chronic intermittent hypoxia (IH) is considered to be the primary player in OSA, but the mech...

    Authors: Zhihui Shi, Linhao Xu, Hui Xie, Ruoyun Ouyang, Ya Ke, Rui Zhou and Wing-Ho Yung

    Citation: BMC Pulmonary Medicine 2020 20:92

    Content type: Research article

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  17. Work-related respiratory disorders are major contributors to the global burden of respiratory diseases. Agricultural workers are exposed to a number of dusts, which may contribute to the development of respira...

    Authors: Gashaw Garedew Woldeamanuel, Alemu Basazin Mingude, Getachew Yideg Yitbarek and Mitku Mammo Taderegew

    Citation: BMC Pulmonary Medicine 2020 20:86

    Content type: Research article

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  18. Chronic obstructive pulmonary disease (COPD) skeletal muscle dysfunction is a prevalent malady that significantly affects patients’ prognosis and quality of life. Although the study of this disease has attract...

    Authors: Jianqing Su, Jian Li, Yufan Lu, Ning Li, Peijun Li, Zhengrong Wang, Weibing Wu and Xiaodan Liu

    Citation: BMC Pulmonary Medicine 2020 20:74

    Content type: Research article

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  19. The discriminatory ability of multi-attribute utility (MAU) measures compared to condition-specific measures (CSM) in assessing health-related quality of life (HRQoL) among patients with chronic obstructive pu...

    Authors: Eunmi Bae, Sang-Eun Choi, Haeyoung Lee, Gyeongseon Shin and Daewon Kang

    Citation: BMC Pulmonary Medicine 2020 20:73

    Content type: Research article

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  20. Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is associated with infective triggers including bacterial or viral in many cases, and pneumonia is a major contributor to hospitalization f...

    Authors: Sunmin Park, Sang Jun Lee, Beomsu Shin, Seok Jeong Lee, Sang-Ha Kim, Woo Cheol Kwon, Jihye Kim and Myoung Kyu Lee

    Citation: BMC Pulmonary Medicine 2020 20:47

    Content type: Research article

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  21. Targeted lung denervation (TLD) is a bronchoscopically delivered ablation therapy that selectively interrupts pulmonary parasympathetic nerve signaling. The procedure has the potential to alter airway smooth m...

    Authors: Dirk-Jan Slebos, Bruno Degano, Arschang Valipour, Pallav L. Shah, Gaetan Deslée and Frank C. Sciurba

    Citation: BMC Pulmonary Medicine 2020 20:41

    Content type: Study protocol

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  22. Chronic hypersensitivity pneumonitis (cHP) is a disease caused by exposure to inhaled environmental antigens. Diagnosis of cHP is influenced by the awareness of the disease prevalence, which varies significant...

    Authors: Jessie P. Gu, Chen-Liang Tsai, Nicholas G. Wysham and Yuh-Chin T. Huang

    Citation: BMC Pulmonary Medicine 2020 20:32

    Content type: Research article

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  23. Both mitophagy, a selective mechanism for clearance of mitochondria, and mitochondrial biogenesis are key processes determining mitochondrial content and oxidative capacity of the musculature. Abnormalities in...

    Authors: Pieter A. Leermakers, Alexander H. V. Remels, Ramon C. J. Langen, Annemie M. W. J. Schols and Harry R. Gosker

    Citation: BMC Pulmonary Medicine 2020 20:20

    Content type: Research article

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  24. Dyspnea, fatigue, and decline in sleep quality are symptoms of chronic obstructive pulmonary disease (COPD). Pulmonary rehabilitation programs have been shown to ameliorate dyspnea and fatigue. However, only a...

    Authors: Leandro Nobeschi, Juliana Zangirolami-Raimundo, Priscila Kessar Cordoni, Selma Denis Squassoni, Elie Fiss, Andrés Ricardo Pérez-Riera, Luiz Carlos de Abreu and Rodrigo Daminello Raimundo

    Citation: BMC Pulmonary Medicine 2020 20:14

    Content type: Research article

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  25. Chronic obstructive pulmonary disease (COPD) is the fifth leading cause of death in China with a reported prevalence of 8.2% people aged ≥40 years. It is recommended that Chinese physicians follow Global Initi...

    Authors: Ting Yang, Baiqiang Cai, Bin Cao, Jian Kang, Fuqiang Wen, Wanzhen Yao, Jinping Zheng, Xia Ling, Hongyan Shang and Chen Wang

    Citation: BMC Pulmonary Medicine 2020 20:11

    Content type: Study protocol

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  26. Gastroesophageal reflux disease (GERD) was suggested to be associated with exacerbations of chronic obstructive pulmonary disease (COPD) in recent years. The aim of this study was to examine the association be...

    Authors: Chunrong Huang, Yahui Liu and Guochao Shi

    Citation: BMC Pulmonary Medicine 2020 20:2

    Content type: Research article

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  27. Peripheral muscle weakness can be caused by both peripheral muscle and neural alterations. Although peripheral alterations cannot totally explain peripheral muscle weakness in COPD, the existence of an activat...

    Authors: Francois Alexandre, Nelly Héraud, Emilie Tremey, Nicolas Oliver, Dominique Bourgouin and Alain Varray

    Citation: BMC Pulmonary Medicine 2020 20:1

    Content type: Research article

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  28. While inhaled bronchodilators reduce symptoms and acute exacerbations of chronic obstructive pulmonary disease (COPD), their use is associated with increased cardiovascular events in some studies. This study i...

    Authors: Yen-Fu Chen, Yi-Ching Cheng, Chien-Hong Chou, Chung-Yu Chen and Chong-Jen Yu

    Citation: BMC Pulmonary Medicine 2019 19:233

    Content type: Research article

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  29. Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities. The main causes of COPD are Gene-env...

    Authors: Yadira Velasco-Torres, Victor Ruiz-López, Oliver Pérez-Bautista, Ivette Buendía-Roldan, Alejandra Ramírez-Venegas, Julia Pérez-Ramos, Ramcés Falfán-Valencia, Carlos Ramos and Martha Montaño

    Citation: BMC Pulmonary Medicine 2019 19:227

    Content type: Research article

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  30. To explore patterns of brain structural alteration in chronic obstructive pulmonary disease (COPD) patients with different levels of lung function impairment and the associations of those patterns with cogniti...

    Authors: Minmin Yin, Haibao Wang, Xianwei Hu, Xiaoshu Li, Guanghe Fei and Yongqiang Yu

    Citation: BMC Pulmonary Medicine 2019 19:203

    Content type: Research article

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  31. There is evidence of an association between inflammatory bowel disease (IBD) and lung conditions such as chronic obstructive pulmonary disease (COPD). This systematic review and meta-analysis explored the risk...

    Authors: Gonzalo Labarca, Lauren Drake, Gloria Horta, Michael A. Jantz, Hiren J. Mehta, Sebastian Fernandez-Bussy, Erik Folch, Adnan Majid and Michael Picco

    Citation: BMC Pulmonary Medicine 2019 19:186

    Content type: Research article

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  32. Chronic obstructive pulmonary disease (COPD) is one of the major public health problems worldwide. Despite an increasing burden of COPD in the world, it is often a neglected disease in low income countries and...

    Authors: Gashaw Garedew Woldeamanuel, Alemu Basazin Mingude and Teshome Gensa Geta

    Citation: BMC Pulmonary Medicine 2019 19:181

    Content type: Research article

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  33. Chronic kidney disease (CKD) is a common comorbidity of chronic obstructive pulmonary disease (COPD). Although high hemoglobin (Hb) is detrimental to CKD patients, its relationship with poor outcomes in the CO...

    Authors: Libin Xu, Yuanhan Chen, Zhen Xie, Qiang He, Shixin Chen, Wenji Wang, Guohui Liu, Yuanjiang Liao, Chen Lu, Li Hao, Jin Sun, Wei Shi and Xinling Liang

    Citation: BMC Pulmonary Medicine 2019 19:174

    Content type: Research article

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  34. Chronic Obstructive Pulmonary Disease (COPD) encompasses various phenotypes that severely limit the applicability of precision respiratory medicine. The present investigation is aimed to assess the circadian r...

    Authors: Nicola Scichilone, Raffaele Antonelli Incalzi, Francesco Blasi, Pietro Schino, Giuseppina Cuttitta, Alessandro Zullo, Alessandra Ori and Giorgio Walter Canonica

    Citation: BMC Pulmonary Medicine 2019 19:171

    Content type: Research article

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    The Correction to this article has been published in BMC Pulmonary Medicine 2019 19:235

  35. Th17 cells are believed to be important proinflammatory cells in the pathogenesis of chronic obstructive pulmonary disease (COPD). Recent evidence demonstrates that Th17 cells display substantial developmental...

    Authors: Weihan Xu, Ruimin Li and Yongchang Sun

    Citation: BMC Pulmonary Medicine 2019 19:137

    Content type: Research article

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  36. In patients with chronic obstructive pulmonary disease, all efforts should be made to prevent exacerbations because each event modifies the trajectory of the disease. Treatment recommendations are mostly built...

    Authors: Laurie Pahus, Pierre-Régis Burgel, Nicolas Roche, Jean-Louis Paillasseur and Pascal Chanez

    Citation: BMC Pulmonary Medicine 2019 19:127

    Content type: Research article

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  37. Despite well-defined criteria for use of antibiotics in patients presenting with mild to moderate Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD), their overuse is widespread. We hypothesi...

    Authors: Mayanka Tickoo, Robin Ruthazer, Amit Bardia, Shira Doron, Gabriela M. Andujar-Vazquez, Bradley J. Gardiner, David R. Snydman and Sebastian G. Kurz

    Citation: BMC Pulmonary Medicine 2019 19:118

    Content type: Research article

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  38. This study assessed the effects of ursolic acid (UA) on airway-vessel remodeling and muscle atrophy in cigarette smoke (CS)-induced emphysema rats and investigated potential underlying mechanisms.

    Authors: Li Lin, Gang Hou, Dan Han, Yan Yin, Jian Kang and Qiuyue Wang

    Citation: BMC Pulmonary Medicine 2019 19:103

    Content type: Research article

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  39. Omega-3 fatty acids, including alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and derivatives, play a key role in the resolution of inflammation. Higher intake has been lin...

    Authors: Chantal M. Lemoine S, Emily P. Brigham, Han Woo, Corrine K. Hanson, Meredith C. McCormack, Abigail Koch, Nirupama Putcha and Nadia N. Hansel

    Citation: BMC Pulmonary Medicine 2019 19:97

    Content type: Research article

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  40. Breathlessness is the prominent symptom of chronic obstructive pulmonary disease (COPD). Despite optimal therapeutic management including pharmacological and non-pharmacological interventions, many COPD patien...

    Authors: H. Carette, M. Zysman, C. Morelot-Panzini, J. Perrin, E. Gomez, A. Guillaumot, P. R. Burgel, G. Deslee, P. Surpas, O. Le Rouzic, T. Perez, A. Chaouat, N. Roche and F. Chabot

    Citation: BMC Pulmonary Medicine 2019 19:95

    Content type: Research article

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  41. Few studies have examined the relationships between sputum inflammatory markers and subsequent annual decline in forced expiratory volume in 1 s (dFEV1). This study investigated whether indices of airway inflamma...

    Authors: Natalia Kononova, Liv Ingunn Bjoner Sikkeland, Faiza Mahmood, Maria Vistnes, Johny Kongerud, Gunnar Einvik and Vidar Søyseth

    Citation: BMC Pulmonary Medicine 2019 19:90

    Content type: Research article

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  42. Inhaled anticholinergics, recommended as first-line maintenance treatment for patients with moderate-to-severe chronic obstructive pulmonary disease (COPD), has been demonstrated to be associated with an incre...

    Authors: Wei Yuan, Shan Nie, Haoyan Wang, Qiufen Xu and Nan Jia

    Citation: BMC Pulmonary Medicine 2019 19:88

    Content type: Research article

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  43. Defective phagocytosis in alveolar macrophages is associated with chronic obstructive pulmonary disease (COPD). Transient receptor potential cation channel subfamily V member 2 (TRPV2), a type of nonselective ...

    Authors: Hiroaki Masubuchi, Manabu Ueno, Toshitaka Maeno, Koichi Yamaguchi, Kenichiro Hara, Hiroaki Sunaga, Hiroki Matsui, Masahiro Nagasawa, Itaru Kojima, Yuko Iwata, Shigeo Wakabayashi and Masahiko Kurabayashi

    Citation: BMC Pulmonary Medicine 2019 19:70

    Content type: Research article

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  44. Risk of exacerbations in chronic obstructive pulmonary disease (COPD) associated with biomass smoke has not been well addressed, although biomass smoke is similar in composition to tobacco smoke.

    Authors: Jaeyoung Cho, Chang-Hoon Lee, Seung-sik Hwang, Ki Uk Kim, Sang Haak Lee, Hye Yun Park, Seoung Ju Park, Kyung Hoon Min, Yeon-Mok Oh, Kwang Ha Yoo and Ki-Suck Jung

    Citation: BMC Pulmonary Medicine 2019 19:68

    Content type: Research article

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  45. Frailty is a state of increased vulnerability that has a significant risk of unfavorable outcomes such as increased dependency and/or death, but little is known about frailty in people with chronic obstructive...

    Authors: Despo Ierodiakonou, Maria Kampouraki, Ioannis Poulonirakis, Polyvios Papadokostakis, Eleftheria Lintovoi, Dimitris Karanassos, Kyriakos Maltezis, Maria Chorti, Evangelos Petrovitsos, Sofia Dimopoulou, Sam Hamind, Ioannis Gialamas, Polyxeni Athanasiou, Vasiliki Bempi, Irene Lambraki and Ioanna Tsiligianni

    Citation: BMC Pulmonary Medicine 2019 19:63

    Content type: Research article

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  46. Exercise training is an important component of pulmonary rehabilitation (PR) programmes in chronic obstructive pulmonary disease (COPD), but the great majority of COPD patients who would benefit from PR never ...

    Authors: Anja Frei, Thomas Radtke, Kaba Dalla Lana, Julia Braun, Ramona M. Müller and Milo A. Puhan

    Citation: BMC Pulmonary Medicine 2019 19:57

    Content type: Study protocol

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  47. Long-term oxygen therapy (LTOT) during 15 h/day or more prolongs survival in patients with chronic obstructive pulmonary disease (COPD) and severe hypoxemia. No randomized controlled trial has evaluated the ne...

    Authors: Josefin Sundh, Anna Bornefalk-Hermansson, Zainab Ahmadi, Anders Blomberg, Christer Janson, David C. Currow, Christine F. McDonald, Nikki McCaffrey and Magnus Ekström

    Citation: BMC Pulmonary Medicine 2019 19:50

    Content type: Study protocol

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