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COPD and occupational lung disease

Section edited by Craig Hersh

This section concerns all aspects of COPD, occupational lung disease, and smoking-related disorders including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. While inhaled bronchodilators reduce symptoms and acute exacerbations of chronic obstructive pulmonary disease (COPD), their use is associated with increased cardiovascular events in some studies. This study i...

    Authors: Yen-Fu Chen, Yi-Ching Cheng, Chien-Hong Chou, Chung-Yu Chen and Chong-Jen Yu

    Citation: BMC Pulmonary Medicine 2019 19:233

    Content type: Research article

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  2. Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities. The main causes of COPD are Gene-env...

    Authors: Yadira Velasco-Torres, Victor Ruiz López, Oliver Pérez-Bautista, Ivette Buendía-Roldan, Alejandra Ramírez-Venegas, Julia Pérez-Ramos, Ramcés Falfán-Valencia, Carlos Ramos and Martha Montaño

    Citation: BMC Pulmonary Medicine 2019 19:227

    Content type: Research article

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  3. To explore patterns of brain structural alteration in chronic obstructive pulmonary disease (COPD) patients with different levels of lung function impairment and the associations of those patterns with cogniti...

    Authors: Minmin Yin, Haibao Wang, Xianwei Hu, Xiaoshu Li, Guanghe Fei and Yongqiang Yu

    Citation: BMC Pulmonary Medicine 2019 19:203

    Content type: Research article

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  4. There is evidence of an association between inflammatory bowel disease (IBD) and lung conditions such as chronic obstructive pulmonary disease (COPD). This systematic review and meta-analysis explored the risk...

    Authors: Gonzalo Labarca, Lauren Drake, Gloria Horta, Michael A. Jantz, Hiren J. Mehta, Sebastian Fernandez-Bussy, Erik Folch, Adnan Majid and Michael Picco

    Citation: BMC Pulmonary Medicine 2019 19:186

    Content type: Research article

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  5. Chronic obstructive pulmonary disease (COPD) is one of the major public health problems worldwide. Despite an increasing burden of COPD in the world, it is often a neglected disease in low income countries and...

    Authors: Gashaw Garedew Woldeamanuel, Alemu Basazin Mingude and Teshome Gensa Geta

    Citation: BMC Pulmonary Medicine 2019 19:181

    Content type: Research article

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  6. Chronic kidney disease (CKD) is a common comorbidity of chronic obstructive pulmonary disease (COPD). Although high hemoglobin (Hb) is detrimental to CKD patients, its relationship with poor outcomes in the CO...

    Authors: Libin Xu, Yuanhan Chen, Zhen Xie, Qiang He, Shixin Chen, Wenji Wang, Guohui Liu, Yuanjiang Liao, Chen Lu, Li Hao, Jin Sun, Wei Shi and Xinling Liang

    Citation: BMC Pulmonary Medicine 2019 19:174

    Content type: Research article

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  7. Chronic Obstructive Pulmonary Disease (COPD) encompasses various phenotypes that severely limit the applicability of precision respiratory medicine. The present investigation is aimed to assess the circadian r...

    Authors: Nicola Scichilone, Raffaele Antonelli Incalzi, Francesco Blasi, Pietro Schino, Giuseppina Cuttitta, Alessandro Zullo, Alessandra Ori and Giorgio Walter Canonica

    Citation: BMC Pulmonary Medicine 2019 19:171

    Content type: Research article

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    The Correction to this article has been published in BMC Pulmonary Medicine 2019 19:235

  8. Th17 cells are believed to be important proinflammatory cells in the pathogenesis of chronic obstructive pulmonary disease (COPD). Recent evidence demonstrates that Th17 cells display substantial developmental...

    Authors: Weihan Xu, Ruimin Li and Yongchang Sun

    Citation: BMC Pulmonary Medicine 2019 19:137

    Content type: Research article

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  9. In patients with chronic obstructive pulmonary disease, all efforts should be made to prevent exacerbations because each event modifies the trajectory of the disease. Treatment recommendations are mostly built...

    Authors: Laurie Pahus, Pierre-Régis Burgel, Nicolas Roche, Jean-Louis Paillasseur and Pascal Chanez

    Citation: BMC Pulmonary Medicine 2019 19:127

    Content type: Research article

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  10. Despite well-defined criteria for use of antibiotics in patients presenting with mild to moderate Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD), their overuse is widespread. We hypothesi...

    Authors: Mayanka Tickoo, Robin Ruthazer, Amit Bardia, Shira Doron, Gabriela M. Andujar-Vazquez, Bradley J. Gardiner, David R. Snydman and Sebastian G. Kurz

    Citation: BMC Pulmonary Medicine 2019 19:118

    Content type: Research article

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  11. This study assessed the effects of ursolic acid (UA) on airway-vessel remodeling and muscle atrophy in cigarette smoke (CS)-induced emphysema rats and investigated potential underlying mechanisms.

    Authors: Li Lin, Gang Hou, Dan Han, Yan Yin, Jian Kang and Qiuyue Wang

    Citation: BMC Pulmonary Medicine 2019 19:103

    Content type: Research article

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  12. Omega-3 fatty acids, including alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and derivatives, play a key role in the resolution of inflammation. Higher intake has been lin...

    Authors: Chantal M. Lemoine S, Emily P. Brigham, Han Woo, Corrine K. Hanson, Meredith C. McCormack, Abigail Koch, Nirupama Putcha and Nadia N. Hansel

    Citation: BMC Pulmonary Medicine 2019 19:97

    Content type: Research article

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  13. Breathlessness is the prominent symptom of chronic obstructive pulmonary disease (COPD). Despite optimal therapeutic management including pharmacological and non-pharmacological interventions, many COPD patien...

    Authors: H. Carette, M. Zysman, C. Morelot-Panzini, J. Perrin, E. Gomez, A. Guillaumot, P. R. Burgel, G. Deslee, P. Surpas, O. Le Rouzic, T. Perez, A. Chaouat, N. Roche and F. Chabot

    Citation: BMC Pulmonary Medicine 2019 19:95

    Content type: Research article

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  14. Few studies have examined the relationships between sputum inflammatory markers and subsequent annual decline in forced expiratory volume in 1 s (dFEV1). This study investigated whether indices of airway inflamma...

    Authors: Natalia Kononova, Liv Ingunn Bjoner Sikkeland, Faiza Mahmood, Maria Vistnes, Johny Kongerud, Gunnar Einvik and Vidar Søyseth

    Citation: BMC Pulmonary Medicine 2019 19:90

    Content type: Research article

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  15. Inhaled anticholinergics, recommended as first-line maintenance treatment for patients with moderate-to-severe chronic obstructive pulmonary disease (COPD), has been demonstrated to be associated with an incre...

    Authors: Wei Yuan, Shan Nie, Haoyan Wang, Qiufen Xu and Nan Jia

    Citation: BMC Pulmonary Medicine 2019 19:88

    Content type: Research article

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  16. Defective phagocytosis in alveolar macrophages is associated with chronic obstructive pulmonary disease (COPD). Transient receptor potential cation channel subfamily V member 2 (TRPV2), a type of nonselective ...

    Authors: Hiroaki Masubuchi, Manabu Ueno, Toshitaka Maeno, Koichi Yamaguchi, Kenichiro Hara, Hiroaki Sunaga, Hiroki Matsui, Masahiro Nagasawa, Itaru Kojima, Yuko Iwata, Shigeo Wakabayashi and Masahiko Kurabayashi

    Citation: BMC Pulmonary Medicine 2019 19:70

    Content type: Research article

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  17. Risk of exacerbations in chronic obstructive pulmonary disease (COPD) associated with biomass smoke has not been well addressed, although biomass smoke is similar in composition to tobacco smoke.

    Authors: Jaeyoung Cho, Chang-Hoon Lee, Seung-sik Hwang, Ki Uk Kim, Sang Haak Lee, Hye Yun Park, Seoung Ju Park, Kyung Hoon Min, Yeon-Mok Oh, Kwang Ha Yoo and Ki-Suck Jung

    Citation: BMC Pulmonary Medicine 2019 19:68

    Content type: Research article

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  18. Frailty is a state of increased vulnerability that has a significant risk of unfavorable outcomes such as increased dependency and/or death, but little is known about frailty in people with chronic obstructive...

    Authors: Despo Ierodiakonou, Maria Kampouraki, Ioannis Poulonirakis, Polyvios Papadokostakis, Eleftheria Lintovoi, Dimitris Karanassos, Kyriakos Maltezis, Maria Chorti, Evangelos Petrovitsos, Sofia Dimopoulou, Sam Hamind, Ioannis Gialamas, Polyxeni Athanasiou, Vasiliki Bempi, Irene Lambraki and Ioanna Tsiligianni

    Citation: BMC Pulmonary Medicine 2019 19:63

    Content type: Research article

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  19. Exercise training is an important component of pulmonary rehabilitation (PR) programmes in chronic obstructive pulmonary disease (COPD), but the great majority of COPD patients who would benefit from PR never ...

    Authors: Anja Frei, Thomas Radtke, Kaba Dalla Lana, Julia Braun, Ramona M. Müller and Milo A. Puhan

    Citation: BMC Pulmonary Medicine 2019 19:57

    Content type: Study protocol

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  20. Long-term oxygen therapy (LTOT) during 15 h/day or more prolongs survival in patients with chronic obstructive pulmonary disease (COPD) and severe hypoxemia. No randomized controlled trial has evaluated the ne...

    Authors: Josefin Sundh, Anna Bornefalk-Hermansson, Zainab Ahmadi, Anders Blomberg, Christer Janson, David C. Currow, Christine F. McDonald, Nikki McCaffrey and Magnus Ekström

    Citation: BMC Pulmonary Medicine 2019 19:50

    Content type: Study protocol

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  21. Aerosol delivery through a nasal high flow (NHF) system is attractive for clinicians as it allows for simultaneous administration of oxygen and inhalable drugs. However, delivering a fine particle fraction (FP...

    Authors: Martin Wallin, Patricia Tang, Rachel Yoon Kyung Chang, Mingshi Yang, Warren H. Finlay and Hak-Kim Chan

    Citation: BMC Pulmonary Medicine 2019 19:42

    Content type: Research article

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  22. CD147 is expressed in many tissues and is involved in many inflammatory diseases. Emerging evidence suggests that the overproduction of mucus is a malignant factor in chronic obstructive pulmonary disease (COP...

    Authors: Qiao Yu, Danhui Yang, Xi Chen and Qiong Chen

    Citation: BMC Pulmonary Medicine 2019 19:29

    Content type: Research article

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  23. Although the prevalence of pneumoconiosis has been decreasing due to improvements in working conditions and regular health examinations, occupational hygiene measures are still being established. Plasterers en...

    Authors: Fumio Kurosaki, Tamiko Takemura, Masashi Bando, Tomonori Kuroki, Toshio Numao, Hiroshi Moriyama and Koichi Hagiwara

    Citation: BMC Pulmonary Medicine 2019 19:6

    Content type: Case report

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  24. Evidence from several studies show poor guideline adherence to COPD treatment, but no such study has been undertaken in Norway. The objectives of this study, was to estimate and compare the guideline adherence...

    Authors: Bahareh Jouleh, Marta Erdal, Tomas Mikal Eagan, Per Bakke, Amund Gulsvik and Rune Nielsen

    Citation: BMC Pulmonary Medicine 2018 18:195

    Content type: Research article

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  25. Lung hyperinflation contributes to dyspnea, morbidity and mortality in chronic obstructive pulmonary disease (COPD). The inspiratory-to-total lung capacity (IC/TLC) ratio is a measure of lung hyperinflation an...

    Authors: Linn T. Aalstad, Jon A. Hardie, Birgitte Espehaug, Einar Thorsen, Per S. Bakke, Tomas M. L. Eagan and Bente Frisk

    Citation: BMC Pulmonary Medicine 2018 18:187

    Content type: Research article

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  26. Disease control is an important objective of COPD management. The SINCON study evaluated the level of control in terms of respiratory symptoms and exacerbations in Spanish patients with COPD for ≥2 years.

    Authors: Adolfo Baloira, José Miguel Rodriguez Gonzalez-Moro, Estefanía Sanjuán, Juan Antonio Trigueros and Ricard Casamor

    Citation: BMC Pulmonary Medicine 2018 18:183

    Content type: Research article

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  27. Chronic obstructive pulmonary disease (COPD) is a major and increasing global health problem. Serotonin is a neurotransmitter that participates in several pulmonary functions and it has been involved in oxidat...

    Authors: Pietro Pirina, Elisabetta Zinellu, Panagiotis Paliogiannis, Alessandro G. Fois, Viviana Marras, Salvatore Sotgia, Ciriaco Carru and Angelo Zinellu

    Citation: BMC Pulmonary Medicine 2018 18:167

    Content type: Research article

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  28. COPD is a treatable disease with increasing prevalence worldwide. Treatment aims to stop disease progression, to improve quality of life, and to reduce exacerbations. We aimed to evaluate the association of th...

    Authors: Magdalena Humenberger, Andreas Horner, Anna Labek, Bernhard Kaiser, Rupert Frechinger, Constanze Brock, Petra Lichtenberger and Bernd Lamprecht

    Citation: BMC Pulmonary Medicine 2018 18:163

    Content type: Research article

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  29. In exacerbations of chronic obstructive pulmonary disease, administration of high concentrations of oxygen may cause hypercapnia and increase mortality compared with oxygen titrated, if required, to achieve an...

    Authors: George Bardsley, Janine Pilcher, Steven McKinstry, Philippa Shirtcliffe, James Berry, James Fingleton, Mark Weatherall and Richard Beasley

    Citation: BMC Pulmonary Medicine 2018 18:157

    Content type: Research article

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  30. Pulmonary rehabilitation (PR), delivered as a supervised multidisciplinary program including exercise training, is one of the cornerstones in the chronic obstructive pulmonary disease (COPD) management. We per...

    Authors: Camilla Koch Ryrsø, Nina Skavlan Godtfredsen, Linette Marie Kofod, Marie Lavesen, Line Mogensen, Randi Tobberup, Ingeborg Farver-Vestergaard, Henriette Edemann Callesen, Britta Tendal, Peter Lange and Ulrik Winning Iepsen

    Citation: BMC Pulmonary Medicine 2018 18:154

    Content type: Research article

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  31. Despite the known occupational hazards, it is not yet clear whether long-term career firefighting leads to a greater rate of decline in lung function than would normally be expected, and how this rate of chang...

    Authors: Flynn Slattery, Kylie Johnston, Catherine Paquet, Hunter Bennett and Alan Crockett

    Citation: BMC Pulmonary Medicine 2018 18:149

    Content type: Research article

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    The Correction to this article has been published in BMC Pulmonary Medicine 2019 19:86

  32. Cigarette smoke (CS) exposure causes an abnormal inflammatory response, which can result in chronic obstructive pulmonary disease (COPD). Previous studies show that this disorder predominantly occurs in periph...

    Authors: Hario Baskoro, Tadashi Sato, Keiko Karasutani, Yohei Suzuki, Aki Mitsui, Naoko Arano, Fariz Nurwidya, Motoyasu Kato, Fumiyuki Takahashi, Yuzo Kodama, Kuniaki Seyama and Kazuhisa Takahashi

    Citation: BMC Pulmonary Medicine 2018 18:148

    Content type: Research article

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  33. Mobile health applications are increasingly used in patients with Chronic Obstructive Pulmonary Disease (COPD) to improve their self-management, nonetheless, without firm evidence of their efficacy. This meta-...

    Authors: Fen Yang, Yuncui Wang, Chongming Yang, Hui Hu and Zhenfang Xiong

    Citation: BMC Pulmonary Medicine 2018 18:147

    Content type: Research article

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  34. The fractal dimension characterizing the cumulative size distribution of low attenuation area (LAA) clusters, identified with a fixed threshold such as − 950 Hounsfield Units (HU), on computed tomography (CT) ...

    Authors: Naoya Tanabe, Shigeo Muro, Susumu Sato, Tsuyoshi Oguma, Atsuyasu Sato and Toyohiro Hirai

    Citation: BMC Pulmonary Medicine 2018 18:144

    Content type: Research article

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  35. Pneumoconiosis patients receive community-based or home-based pulmonary rehabilitation (PR) for symptom management and enhancement of physical and mental well-being. This study aimed to review the clinical ben...

    Authors: Eric W. Tsang, Henry Kwok, Aidan K. Y. Chan, Kah Lin Choo, Kin Sang Chan, Kam Shing Lau and Chetwyn C. H. Chan

    Citation: BMC Pulmonary Medicine 2018 18:133

    Content type: Research article

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  36. Respiratory tract deposition of airborne particles is a key link to understand their health impact. Experimental data are limited for vulnerable groups such as individuals with respiratory diseases. The aim of...

    Authors: Jonas K F Jakobsson, H Laura Aaltonen, Hanna Nicklasson, Anders Gudmundsson, Jenny Rissler, Per Wollmer and Jakob Löndahl

    Citation: BMC Pulmonary Medicine 2018 18:129

    Content type: Research article

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  37. Cardiovascular disease (CVD) is remarkably frequent in patients with chronic obstructive pulmonary disease (COPD). Albuminuria is a marker of vascular endothelial dysfunction and predictor of CVD events. Album...

    Authors: Festo K. Shayo and Janet Lutale

    Citation: BMC Pulmonary Medicine 2018 18:125

    Content type: Research article

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  38. Chronic obstructive pulmonary disease (COPD) with carbon dioxide retention is associated with a worsening clinical condition and the beginning of pulmonary ventilation decompensation. This study aimed to ident...

    Authors: Xia Wei, Nan Yu, Qi Ding, Jingting Ren, Jiuyun Mi, Lu Bai, Jianying Li, Min Qi and Youmin Guo

    Citation: BMC Pulmonary Medicine 2018 18:124

    Content type: Research article

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  39. c-Kit + lung stem cells have been described in the human healthy lung. Their potential relation with smoking and/or chronic obstructive pulmonary disease (COPD) is unknown.

    Authors: Alejandra López-Giraldo, Tamara Cruz, Laureano Molins, Ángela Guirao, Adela Saco, Sandra Cuerpo, Josep Ramirez, Álvar Agustí and Rosa Faner

    Citation: BMC Pulmonary Medicine 2018 18:123

    Content type: Research article

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  40. Chronic obstructive pulmonary disease (COPD) is an important cause of morbidity and mortality around the world. The aim of our study was to determine the association between specific comorbidities and COPD sev...

    Authors: Chantal Raherison, El-Hassane Ouaalaya, Alain Bernady, Julien Casteigt, Cecilia Nocent-Eijnani, Laurent Falque, Frédéric Le Guillou, Laurent Nguyen, Annaig Ozier and Mathieu Molimard

    Citation: BMC Pulmonary Medicine 2018 18:117

    Content type: Research article

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  41. Prognostic stratification of elderly patients with chronic obstructive pulmonary disease (COPD) is difficult due to the wide inter-individual variability in the course of the disease. No marker can exactly str...

    Authors: Domenico Acanfora, Pietro Scicchitano, Mauro Carone, Chiara Acanfora, Giuseppe Piscosquito, Roberto Maestri, Annapaola Zito, Ilaria Dentamaro, Marialaura Longobardi, Gerardo Casucci, Raffaele Antonelli-Incalzi and Marco Matteo Ciccone

    Citation: BMC Pulmonary Medicine 2018 18:116

    Content type: Research article

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  42. Pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) is suggested as the consequence of emphysematous destruction of vascular bed and hypoxia of pulmonary microenvironment, mechanisms un...

    Authors: Xiaotong Guo, Yuchun Fan, Jieda Cui, Binwei Hao, Li Zhu, Xiao Sun, Jinxi He, Jiali Yang, Jianda Dong, Yanyang Wang, Xiaoming Liu and Juan Chen

    Citation: BMC Pulmonary Medicine 2018 18:111

    Content type: Research article

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  43. The chronic and progressive nature of chronic obstructive pulmonary disease (COPD) requires self-administration of inhaled medication. Dry powder inhalers (DPIs) are increasingly being used for inhalation ther...

    Authors: Pablo Altman, Luis Wehbe, Juergen Dederichs, Tadhg Guerin, Brian Ament, Miguel Cardenas Moronta, Andrea Valeria Pino and Pankaj Goyal

    Citation: BMC Pulmonary Medicine 2018 18:100

    Content type: Research article

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  44. Occupational lung diseases, such as pneumoconiosis, are one of the health problems of dental workers that have been receiving increasing interest. Pulmonary amyloidosis is a heterogenous group of diseases, and...

    Authors: Taizou Hirano, Tadahisa Numakura, Hiroshi Moriyama, Ryoko Saito, Yutaka Shishikura, Jun Shiihara, Hisatoshi Sugiura and Masakazu Ichinose

    Citation: BMC Pulmonary Medicine 2018 18:77

    Content type: Case report

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  45. Pulmonary rehabilitation is an effective therapeutic intervention for people with chronic respiratory disease. However, fewer than 5% of eligible individuals receive pulmonary rehabilitation on an annual basis...

    Authors: Narelle S. Cox, Christine F. McDonald, Jennifer A. Alison, Ajay Mahal, Richard Wootton, Catherine J. Hill, Janet Bondarenko, Heather Macdonald, Paul O’Halloran, Paolo Zanaboni, Ken Clarke, Deidre Rennick, Kaye Borgelt, Angela T. Burge, Aroub Lahham, Bruna Wageck…

    Citation: BMC Pulmonary Medicine 2018 18:71

    Content type: Study protocol

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  46. Neutrophil-to-lymphocyte ratio (NLR) is a biomarker of inflammation in chronic obstructive pulmonary disease (COPD) patients. But, a meaningful threshold and the longitudinal changes are unknown. We aimed to i...

    Authors: Kaori Sakurai, Shotaro Chubachi, Hidehiro Irie, Akihiro Tsutsumi, Naofumi Kameyama, Takashi Kamatani, Hidefumi Koh, Takeshi Terashima, Hidetoshi Nakamura, Koichiro Asano and Tomoko Betsuyaku

    Citation: BMC Pulmonary Medicine 2018 18:65

    Content type: Research article

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  47. Recently awareness of the importance of Aspergillus colonization in the airway of patients with chronic obstructive pulmonary disease (COPD) was rising. The aim of this study was to investigate the clinical fe...

    Authors: Xunliang Tong, Anqi Cheng, Hongtao Xu, Jin Jin, Yimeng Yang, Sainan Zhu and Yanming Li

    Citation: BMC Pulmonary Medicine 2018 18:55

    Content type: Research article

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