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COPD and occupational lung disease

This section concerns all aspects of COPD, occupational lung disease, and smoking-related disorders including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Refractory dyspnea or breathlessness is a common symptom in patients with advanced chronic obstructive pulmonary disease (COPD), with a high negative impact on quality of life (QoL). Low dosed opioids have bee...

    Authors: Marlies van Dijk, Kris J. M. Mooren, Jan-Willem K. van den Berg, Wendy J. C. van Beurden-Moeskops, Roxane Heller-Baan, Sander M. de Hosson, Wai Yee Lam-Wong, Liesbeth Peters, Karin Pool and Huib A. M. Kerstjens

    Citation: BMC Pulmonary Medicine 2021 21:289

    Content type: Study protocol

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  2. Within the pathogenesis of the chronic obstructive pulmonary disease (COPD) there are interactions between different inflammatory mediators that are enhanced during an exacerbation. Arginase is present in bron...

    Authors: Marcel Jose Rodríguez-Guzmán, Germán Peces-Barba Romero, Sandra Pérez Rial, Cristina Serrano del Castillo, Miguel Ángel Palomero Rodríguez, Ignacio Mahillo-Fernandez and Felipe Villar-Álvarez

    Citation: BMC Pulmonary Medicine 2021 21:271

    Content type: Research article

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  3. Incorrect use of inhalers among asthma and COPD patients is very prevalent. Yet, no single intervention is considered standard of care. We aimed to conduct a COPD-specific investigation of active one-on-one co...

    Authors: Jin Sun Kim, Nader Hashweh, Hannah Li, Salik Choudhary, Sadashiv Santosh and Edward Charbek

    Citation: BMC Pulmonary Medicine 2021 21:266

    Content type: Research article

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  4. Adherence to chronic obstructive pulmonary disease (COPD) maintenance medication is important for managing symptoms and exacerbation risk, and is associated with reduced mortality, hospitalizations, and costs....

    Authors: David Slade, Riju Ray, Chad Moretz, Guillaume Germain, François Laliberté, Qin Shen, Mei Sheng Duh, Malena Mahendran and Beth Hahn

    Citation: BMC Pulmonary Medicine 2021 21:253

    Content type: Research article

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  5. Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) significantly increases the mortality of patients with COPD. Guidelines have recommended systemic glucocorticoid as a regular treatment. Rec...

    Authors: Qiu-Yu Li, Zhuo-Yu An, Zi-Han Pan and Rui-Ying Qi

    Citation: BMC Pulmonary Medicine 2021 21:250

    Content type: Study protocol

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  6. Secondary polycythemia is associated with cigarette smoking and chronic obstructive pulmonary disease (COPD). However, the prevalence of polycythemia in COPD and the contributing risk factors for polycythemia ...

    Authors: Jingzhou Zhang, Dawn L. DeMeo, Edwin K. Silverman, Barry J. Make, R. Chad Wade, J. Michael Wells, Michael H. Cho and Brian D. Hobbs

    Citation: BMC Pulmonary Medicine 2021 21:235

    Content type: Research article

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  7. Although depression is a common comorbidity of chronic obstructive pulmonary disease (COPD), the role of sex remains unexplored. We evaluated sex differences of risk factors of depressive symptoms in adults wi...

    Authors: Ji Soo Choi, Se Hyun Kwak, Nak-Hoon Son, Jae Won Oh, San Lee and Eun Hye Lee

    Citation: BMC Pulmonary Medicine 2021 21:180

    Content type: Research article

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  9. The effects of oral antihyperglycaemic drugs (OADs) for type 2 diabetes mellitus (T2DM) on the outcomes of co-existing chronic obstructive pulmonary disease (COPD) patients are not well studied. We examined th...

    Authors: Kuan-Yuan Chen, Sheng-Ming Wu, Chien-Hua Tseng, Kang-Yun Lee, Yu-Huei Lin, Hung-Yi Liu and Li-Nien Chien

    Citation: BMC Pulmonary Medicine 2021 21:141

    Content type: Research article

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  10. This study was performed to evaluate the anti-inflammatory effect of atorvastatin in patients with chronic bronchitis, exposed to sulfur mustard gas.

    Authors: Behrooz Momeni, Saeed Nazer, Seyed Masoom Masoompour, Bita Geramizadeh and Seyed Vahid Sajadi

    Citation: BMC Pulmonary Medicine 2021 21:112

    Content type: Research article

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  11. Alpha-1 antitrypsin deficiency (AATD) is a significantly under-diagnosed genetic condition caused by reduced levels and/or functionality of alpha-1 antitrypsin (AAT), predisposing individuals to lung, liver or...

    Authors: Igor Barjaktarevic and Marc Miravitlles

    Citation: BMC Pulmonary Medicine 2021 21:99

    Content type: Review

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  12. Blood eosinophil count may predict treatment response in patients with chronic obstructive pulmonary disease (COPD) during acute exacerbations (AE). However, the ability and thresholds of blood eosinophil coun...

    Authors: Hye Seon Kang, Sung Kyoung Kim, Yong Hyun Kim, Jin Woo Kim, Sang Haak Lee, Hyung Kyu Yoon and Chin Kook Rhee

    Citation: BMC Pulmonary Medicine 2021 21:74

    Content type: Research article

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  13. Cigarette smoke (CS) is a major risk factor for Chronic Obstructive Pulmonary Disease (COPD). Follistatin-like protein 1 (FSTL1), a critical factor during embryogenesis particularly in respiratory lung develop...

    Authors: Ying Liu, Jiawei Xu, Tian Liu, Jinxiang Wu, Jiping Zhao, Junfei Wang, Minfang Zou, Lili Cao, Xiaofei Liu, Yun Pan, Siyuan Huang and Liang Dong

    Citation: BMC Pulmonary Medicine 2021 21:45

    Content type: Research article

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  14. It is necessary to analyze the CT pulmonary vascular parameters and disease severity in chronic obstructive pulmonary disease (COPD) patients to provide evidence support for the management of COPD.

    Authors: Tao Yang, Chihua Chen and Zhongyuanlong Chen

    Citation: BMC Pulmonary Medicine 2021 21:34

    Content type: Research article

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  15. Bilirubin is a potent antioxidant and higher serum bilirubin levels have been associated with improved COPD outcomes. We performed a systematic review to evaluate the association between serum bilirubin levels...

    Authors: David M. MacDonald, Ken M. Kunisaki, Timothy J. Wilt and Arianne K. Baldomero

    Citation: BMC Pulmonary Medicine 2021 21:33

    Content type: Research article

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  16. Regular exercise is important in the management of COPD. Pulmonary rehabilitation (PR) facilitates a more physically active lifestyle through exercise participation, ideally without compromising non-exercise p...

    Authors: Sarah Ward, Mark Orme, Jakub Zatloukal and Sally Singh

    Citation: BMC Pulmonary Medicine 2021 21:30

    Content type: Research article

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  17. In chronic obstructive pulmonary disease (COPD) patients, combination treatment with long-acting muscarinic antagonist (LAMA) and long-acting β2 agonist (LABA) increases forced expiratory volume in one second ...

    Authors: Masato Muraki, Yuki Kunita, Ken Shirahase, Ryo Yamazaki, Soichiro Hanada, Hirochiyo Sawaguchi and Yuji Tohda

    Citation: BMC Pulmonary Medicine 2021 21:26

    Content type: Research article

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  18. The interaction between the pulmonary function and cardiovascular mechanics is a crucial issue, particularly when treating patients with chronic obstructive pulmonary disease (COPD). Synchrogram index is a new...

    Authors: Yu-Chen Huang, Ting-Yu Lin, Hau-Tieng Wu, Po-Jui Chang, Chun-Yu Lo, Tsai-Yu Wang, Chih-Hsi Scott Kuo, Shu-Min Lin, Fu-Tsai Chung, Horng-Chyuan Lin, Meng-Heng Hsieh and Yu-Lun Lo

    Citation: BMC Pulmonary Medicine 2021 21:22

    Content type: Research article

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  19. Chronic obstructive pulmonary disease (COPD) is a common lung disease during middle age which one of its complications is depression. Depression is considered one of the major causes of severe disability world...

    Authors: Fahimeh Dinparast, Akbar Sharifi, Sara Moradi, Maedeh Alipour and Beitullah Alipour

    Citation: BMC Pulmonary Medicine 2021 21:8

    Content type: Research article

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  20. For patients with acute exacerbation of COPD (AECOPD), type 2 diabetes mellitus (T2DM) as comorbidity have poor outcomes. However, data on the impact of previously diagnosed and new- diagnosed T2DM in such a p...

    Authors: Li Lin, Jianxin Shi, Jian Kang and Qiuyue Wang

    Citation: BMC Pulmonary Medicine 2021 21:7

    Content type: Research article

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  21. Exacerbations are critical events in chronic pulmonary obstructive disease (COPD). The frequency of COPD exacerbations is associated with the prognosis, including mortality, but no useful biomarker has been es...

    Authors: Hiroki Tashiro, Yuki Kurihara, Koichiro Takahashi, Hironori Sadamatsu, Tetsuro Haraguchi, Ryo Tajiri, Ayako Takamori, Shinya Kimura and Naoko Sueoka-Aragane

    Citation: BMC Pulmonary Medicine 2020 20:318

    Content type: Research article

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  22. Dysregulation of circRNAs has been reported to be functionally associated with chronic obstructive pulmonary disease (COPD). The present investigation elucidated the potential role of CircRNA0001859 in regulat...

    Authors: Shuifang Chen, Yinan Yao, Shan Lu, Junjun Chen, Guangdie Yang, Lingfang Tu and Lina Chen

    Citation: BMC Pulmonary Medicine 2020 20:311

    Content type: Research article

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  23. The increasing trend of Chronic Obstructive Pulmonary Disease (COPD) in becoming the third leading cause of deaths by 2020 is of great concern, globally as well as in India. Dysregulation of protease/anti-prot...

    Authors: Durga Mahor, Vandana Kumari, Kapil Vashisht, Ruma Galgalekar, Ravindra M. Samarth, Pradyumna K. Mishra, Nalok Banerjee, Rajnikant Dixit, Rohit Saluja, Sajal De and Kailash C. Pandey

    Citation: BMC Pulmonary Medicine 2020 20:302

    Content type: Research article

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  24. Chronic obstructive pulmonary disease (COPD) is an underdiagnosed condition sharing risk factors with lung cancer. Lung cancer screening may provide an opportunity to improve COPD diagnosis. Using Pan-Canadian...

    Authors: John R. Goffin, Gregory R. Pond, Serge Puksa, Alain Tremblay, Michael Johnston, Glen Goss, Garth Nicholas, Simon Martel, Rick Bhatia, Geoffrey Liu, Heidi Schmidt, Sukhinder Atkar-Khattra, Annette McWilliams, Ming-Sound Tsao, Martin C. Tammemagi and Stephen Lam

    Citation: BMC Pulmonary Medicine 2020 20:300

    Content type: Research article

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  25. Airway remodeling is a major pathological characteristic of chronic obstructive pulmonary disease (COPD), and has been shown to be associated with oxidative stress. Sestrin2 has recently drawn attention as an ...

    Authors: Da-Wei Zhang, Yuan-Yuan Wei, Shuang Ji and Guang-He Fei

    Citation: BMC Pulmonary Medicine 2020 20:297

    Content type: Research article

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  26. Chronic obstructive pulmonary disease (COPD) is a common respiratory condition characterised by dyspnoea during daily life. As the disease progresses, people with COPD can experience poor quality of life, redu...

    Authors: Sarah Hug, Vinicius Cavalheri, Daniel F. Gucciardi, Richard Norman and Kylie Hill

    Citation: BMC Pulmonary Medicine 2020 20:286

    Content type: Study protocol

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  27. We aimed to assess the association between inhaled corticosteroids (ICSs) and the risk of upper respiratory tract infection (URTI) in patients with chronic obstructive pulmonary disease (COPD).

    Authors: Hong Chen, Yulin Feng, Ke Wang, Jing Yang and Yuejun Du

    Citation: BMC Pulmonary Medicine 2020 20:282

    Content type: Research article

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  28. Exposure to toner, a substance used in photocopiers and printers, has been associated with siderosilicosis and other adverse effects. However, these findings are limited, and there is insufficient evidence on ...

    Authors: Niina Terunuma, Kazunori Ikegami, Hiroko Kitamura, Hajime Ando, Shizuka Kurosaki, Masashi Masuda, Takeshi Kochi, Nobuaki Yanagi, Yoshihisa Fujino, Akira Ogami and Toshiaki Higashi

    Citation: BMC Pulmonary Medicine 2020 20:280

    Content type: Research article

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  29. Chronic obstructive pulmonary disease (COPD) characterized by the airway and lung inflammation, is a leading cause of morbidity and mortality worldwide, especially among smokers over 40 years of age and indivi...

    Authors: Haifeng Zhou, Lei Zhang, Yang Li, Guorao Wu, He Zhu, Huilan Zhang, Jia-Kun Su, Lei Guo, Qing Zhou, Fei Xiong, Qilin Yu, Ping Yang, Shu Zhang, Jibao Cai and Cong-Yi Wang

    Citation: BMC Pulmonary Medicine 2020 20:276

    Content type: Research article

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  30. Disease progression in COPD patient is associated to lung function decline, leading to a higher risk of hypoxaemia and associated comorbidities, notably cardiovascular diseases (CVD). Adiponectin (Ad) is an ad...

    Authors: Mélany Pierard, Alexandra Tassin, Antoine Legrand and Alexandre Legrand

    Citation: BMC Pulmonary Medicine 2020 20:255

    Content type: Research article

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  31. The Spanish chronic obstructive pulmonary disease (COPD) guideline phenotypes patients according to the exacerbation frequency and COPD subtypes. In this study, we compared the patients’ health-related quality...

    Authors: Chee-Shee Chai, Sumastika Bt Mos, Diana-Leh-Ching Ng, Greta-Miranda-Kim-Choo Goh, Anselm-Ting Su, Muhammad Amin B. Ibrahim, Aisya Natasya Bt Musa, Seng-Beng Tan, Yong-Kek Pang and Chong-Kin Liam

    Citation: BMC Pulmonary Medicine 2020 20:254

    Content type: Research article

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  32. Comorbidities and adherence to inhaled therapy appears to have a major impact on treatment goals, health status and disease control in chronic obstructive pulmonary disease (COPD). Aim of the study was to asse...

    Authors: Despo Ierodiakonou, Dimitra Sifaki-Pistolla, Maria Kampouraki, Ioannis Poulorinakis, Polyvios Papadokostakis, Ioannis Gialamas, Polyxeni Athanasiou, Vasiliki Bempi, Irene Lampraki and Ioanna Tsiligianni

    Citation: BMC Pulmonary Medicine 2020 20:253

    Content type: Research article

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  33. This study aimed to evaluate whether the Homocysteine (Hcy) level was elevated in chronic obstructive pulmonary disease (COPD) patients and its correlation with the occurrence and acute progression of COPD.

    Authors: Bing Wei, Tian Tian, Yugeng Liu and Chunsheng Li

    Citation: BMC Pulmonary Medicine 2020 20:237

    Content type: Research article

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  34. Taking into consideration a recent surge of a lung injury condition associated with electronic cigarette use, we devised an in vitro model of sub-chronic exposure of human bronchial epithelial cells (HBECs) in...

    Authors: Baishakhi Ghosh, Hermes Reyes-Caballero, Sevcan Gül Akgün-Ölmez, Kristine Nishida, Lakshmana Chandrala, Lena Smirnova, Shyam Biswal and Venkataramana K. Sidhaye

    Citation: BMC Pulmonary Medicine 2020 20:216

    Content type: Research article

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  35. Blood eosinophil counts (BEC) were recently included in the 2019 Global Initiative for Obstructive Lung Disease (GOLD) guideline as an easily accessible theragnostic biomarker for Chronic Obstructive Pulmonary...

    Authors: Inès Van Rossem, Jan Vandevoorde, Shane Hanon, Sander Deridder and Eef Vanderhelst

    Citation: BMC Pulmonary Medicine 2020 20:200

    Content type: Research article

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  36. Chronic obstructive pulmonary disease (COPD) is a common lung disorder characterized by persistent and progressive airflow limitation as well as systemic changes. Metabolic changes in blood may help detect COP...

    Authors: Ivana Prokić, Lies Lahousse, Maaike de Vries, Jun Liu, Marita Kalaoja, Judith M. Vonk, Diana A. van der Plaat, Cleo C. van Diemen, Ashley van der Spek, Alexandra Zhernakova, Jingyuan Fu, Mohsen Ghanbari, Mika Ala-Korpela, Johannes Kettunen, Aki S. Havulinna, Markus Perola…

    Citation: BMC Pulmonary Medicine 2020 20:193

    Content type: Research article

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  37. In recent years, many studies have discovered that cystatin C (Cys C) may play an important role in respiratory diseases, especially in chronic obstructive pulmonary disease (COPD). However, the findings of th...

    Authors: Limin Chai, Wei Feng, Cui Zhai, Wenhua Shi, Jian Wang, Xin Yan, Qingting Wang, Qianqian Zhang and Manxiang Li

    Citation: BMC Pulmonary Medicine 2020 20:182

    Content type: Research article

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  38. The cluster randomized controlled trial on (cost-)effectiveness of integrated chronic obstructive pulmonary disease (COPD) management in primary care (RECODE) showed that integrated disease management (IDM) in...

    Authors: Eline Meijer, Annelies E. van Eeden, Annemarije L. Kruis, Melinde R. S. Boland, Willem J. J. Assendelft, Apostolos Tsiachristas, Maureen P. M. H. Rutten-van Mölken, Marise J. Kasteleyn and Niels H. Chavannes

    Citation: BMC Pulmonary Medicine 2020 20:176

    Content type: Research article

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  39. COPD is a well-known risk factor for lung cancer, independent of smoking behavior. By investigating the retrospective National Health Insurance Service-National Sample Cohort (NHIS-NSC) in Korea, this study at...

    Authors: Song Vogue Ahn, Eunyoung Lee, Bumhee Park, Jin Hee Jung, Ji Eun Park, Seung Soo Sheen, Kwang Joo Park, Sung Chul Hwang, Jae Bum Park, Hae-Sim Park and Joo Hun Park

    Citation: BMC Pulmonary Medicine 2020 20:170

    Content type: Research article

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  40. Several lung structural and functional abnormalities may occur associated with aging, including emphysema. In this study, we evaluated the frequency and risk factors associated with emphysema in respiratory as...

    Authors: Ivette Buendia-Roldan, Alexia Palma-Lopez, Danaireth Chan-Padilla, Iliana Herrera, Mariel Maldonado, Rosario Fernández, David Martínez-Briseño, Mayra Mejia and Moises Selman

    Citation: BMC Pulmonary Medicine 2020 20:164

    Content type: Research article

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  41. Self-Management Support (SMS), refers to the actions taken by individuals to recognise and manage their own health. It is increasingly recognised that individuals with chronic obstructive pulmonary disease (CO...

    Authors: Lindsay Welch, Rosanna Orlando, Sharon X. Lin, Ivaylo Vassilev and Anne Rogers

    Citation: BMC Pulmonary Medicine 2020 20:162

    Content type: Research article

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  42. Forced expiratory volume in one second (FEV1) characterizes the pathophysiology of COPD and different trajectories of FEV1 decline have been observed in patients with COPD (e.g. gradual or episodic). There is lim...

    Authors: Johanna I. Lutter, Rudolf A. Jörres, Kathrin Kahnert, Larissa Schwarzkopf, Michael Studnicka, Stefan Karrasch, Holger Schulz, Claus F. Vogelmeier and Rolf Holle

    Citation: BMC Pulmonary Medicine 2020 20:148

    Content type: Research article

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  43. The association between chronic obstructive pulmonary disease (COPD), lung function and risk of type 2 diabetes mellitus (T2DM) remains controversial. We performed a meta-analysis to clarify this issue.

    Authors: Yang Peng, Guo-Chao Zhong, Lingxiao Wang, Lijuan Guan, Ao Wang, Kai Hu and Jing Shen

    Citation: BMC Pulmonary Medicine 2020 20:137

    Content type: Research article

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  44. Revefenacin, a once-daily, long-acting muscarinic antagonist delivered via standard jet nebulizer, increased trough forced expiratory volume in 1 s (FEV1) in patients with moderate to very severe chronic obstruct...

    Authors: James F. Donohue, Edward Kerwin, Chris N. Barnes, Edmund J. Moran, Brett Haumann and Glenn D. Crater

    Citation: BMC Pulmonary Medicine 2020 20:134

    Content type: Research article

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  45. COPD exacerbations have negative impact on patients’ survival. Several risk factors for grave outcomes of such exacerbations have been descried. Muscle dysfunction and mass loss were shown to impact negatively...

    Authors: N. Lasman, M. Shalom, N. Turpashvili, G. Goldhaber, Y. Lifshitz, E. Leibowitz, G. Berger, G. Saltzman-Shenhav, A. Brom, D. Cohen, C. Avaky and G. Segal

    Citation: BMC Pulmonary Medicine 2020 20:133

    Content type: Research article

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  46. Previous studies have established a higher prevalence of vitamin D deficiency in patients with COPD, but the relationship between vitamin D levels and COPD exacerbations remains controversial. In addition, the...

    Authors: Auyon J. Ghosh, Matthew Moll, Lystra P. Hayden, Jessica Bon, Elizabeth Regan and Craig P. Hersh

    Citation: BMC Pulmonary Medicine 2020 20:123

    Content type: Research article

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  47. Although many studies on people with Chronic Obstructive Pulmonary Disease (COPD) have examined the mutual impact of physical status and emotional experience, there is limited knowledge about the way COPD peop...

    Authors: Marta Pozzar, Eleonora Volpato, Chiara Valota, Francesco Pagnini and Paolo Innocente Banfi

    Citation: BMC Pulmonary Medicine 2020 20:120

    Content type: Research article

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  48. Batefenterol (BAT) is a bi-functional molecule with both muscarinic antagonist and β2-adrenoceptor agonist pharmacology. This Phase II, randomized, placebo-controlled, double-blind study evaluated the safety and ...

    Authors: Courtney Crim, Mark Gotfried, Selwyn Spangenthal, Michael Watkins, Amanda Emmett, Catriona Crawford, Charlotte Baidoo and Ramiro Castro-Santamaria

    Citation: BMC Pulmonary Medicine 2020 20:119

    Content type: Research article

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  49. Inhaled bronchodilators including long-acting beta-agonist (LABA) and long-acting muscarinic antagonist (LAMA) play a central role in the treatment of stable chronic obstructive pulmonary disease (COPD). Howev...

    Authors: Akira Koarai, Hisatoshi Sugiura, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Tomotaka Kawayama and Masakazu Ichinose

    Citation: BMC Pulmonary Medicine 2020 20:111

    Content type: Research article

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  50. To investigate whether, in patients hospitalized for COPD, the addition of social factors improves the predictive ability for the risk of overall 30-day readmissions, early readmissions (within 7 days after di...

    Authors: Tadahiro Goto, Kazuki Yoshida, Mohammad Kamal Faridi, Carlos A. Camargo Jr and Kohei Hasegawa

    Citation: BMC Pulmonary Medicine 2020 20:107

    Content type: Research article

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