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COPD and occupational lung disease

This section concerns all aspects of COPD, occupational lung disease, and smoking-related disorders including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Dysregulation of circRNAs has been reported to be functionally associated with chronic obstructive pulmonary disease (COPD). The present investigation elucidated the potential role of CircRNA0001859 in regulat...

    Authors: Shuifang Chen, Yinan Yao, Shan Lu, Junjun Chen, Guangdie Yang, Lingfang Tu and Lina Chen

    Citation: BMC Pulmonary Medicine 2020 20:311

    Content type: Research article

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  2. The increasing trend of Chronic Obstructive Pulmonary Disease (COPD) in becoming the third leading cause of deaths by 2020 is of great concern, globally as well as in India. Dysregulation of protease/anti-prot...

    Authors: Durga Mahor, Vandana Kumari, Kapil Vashisht, Ruma Galgalekar, Ravindra M. Samarth, Pradyumna K. Mishra, Nalok Banerjee, Rajnikant Dixit, Rohit Saluja, Sajal De and Kailash C. Pandey

    Citation: BMC Pulmonary Medicine 2020 20:302

    Content type: Research article

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  3. Chronic obstructive pulmonary disease (COPD) is an underdiagnosed condition sharing risk factors with lung cancer. Lung cancer screening may provide an opportunity to improve COPD diagnosis. Using Pan-Canadian...

    Authors: John R. Goffin, Gregory R. Pond, Serge Puksa, Alain Tremblay, Michael Johnston, Glen Goss, Garth Nicholas, Simon Martel, Rick Bhatia, Geoffrey Liu, Heidi Schmidt, Sukhinder Atkar-Khattra, Annette McWilliams, Ming-Sound Tsao, Martin C. Tammemagi and Stephen Lam

    Citation: BMC Pulmonary Medicine 2020 20:300

    Content type: Research article

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  4. Airway remodeling is a major pathological characteristic of chronic obstructive pulmonary disease (COPD), and has been shown to be associated with oxidative stress. Sestrin2 has recently drawn attention as an ...

    Authors: Da-Wei Zhang, Yuan-Yuan Wei, Shuang Ji and Guang-He Fei

    Citation: BMC Pulmonary Medicine 2020 20:297

    Content type: Research article

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  5. Chronic obstructive pulmonary disease (COPD) is a common respiratory condition characterised by dyspnoea during daily life. As the disease progresses, people with COPD can experience poor quality of life, redu...

    Authors: Sarah Hug, Vinicius Cavalheri, Daniel F. Gucciardi, Richard Norman and Kylie Hill

    Citation: BMC Pulmonary Medicine 2020 20:286

    Content type: Study protocol

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  6. We aimed to assess the association between inhaled corticosteroids (ICSs) and the risk of upper respiratory tract infection (URTI) in patients with chronic obstructive pulmonary disease (COPD).

    Authors: Hong Chen, Yulin Feng, Ke Wang, Jing Yang and Yuejun Du

    Citation: BMC Pulmonary Medicine 2020 20:282

    Content type: Research article

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  7. Exposure to toner, a substance used in photocopiers and printers, has been associated with siderosilicosis and other adverse effects. However, these findings are limited, and there is insufficient evidence on ...

    Authors: Niina Terunuma, Kazunori Ikegami, Hiroko Kitamura, Hajime Ando, Shizuka Kurosaki, Masashi Masuda, Takeshi Kochi, Nobuaki Yanagi, Yoshihisa Fujino, Akira Ogami and Toshiaki Higashi

    Citation: BMC Pulmonary Medicine 2020 20:280

    Content type: Research article

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  8. Chronic obstructive pulmonary disease (COPD) characterized by the airway and lung inflammation, is a leading cause of morbidity and mortality worldwide, especially among smokers over 40 years of age and indivi...

    Authors: Haifeng Zhou, Lei Zhang, Yang Li, Guorao Wu, He Zhu, Huilan Zhang, Jia-Kun Su, Lei Guo, Qing Zhou, Fei Xiong, Qilin Yu, Ping Yang, Shu Zhang, Jibao Cai and Cong-Yi Wang

    Citation: BMC Pulmonary Medicine 2020 20:276

    Content type: Research article

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  9. Disease progression in COPD patient is associated to lung function decline, leading to a higher risk of hypoxaemia and associated comorbidities, notably cardiovascular diseases (CVD). Adiponectin (Ad) is an ad...

    Authors: Mélany Pierard, Alexandra Tassin, Antoine Legrand and Alexandre Legrand

    Citation: BMC Pulmonary Medicine 2020 20:255

    Content type: Research article

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  10. The Spanish chronic obstructive pulmonary disease (COPD) guideline phenotypes patients according to the exacerbation frequency and COPD subtypes. In this study, we compared the patients’ health-related quality...

    Authors: Chee-Shee Chai, Sumastika Bt Mos, Diana-Leh-Ching Ng, Greta-Miranda-Kim-Choo Goh, Anselm-Ting Su, Muhammad Amin B. Ibrahim, Aisya Natasya Bt Musa, Seng-Beng Tan, Yong-Kek Pang and Chong-Kin Liam

    Citation: BMC Pulmonary Medicine 2020 20:254

    Content type: Research article

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  11. Comorbidities and adherence to inhaled therapy appears to have a major impact on treatment goals, health status and disease control in chronic obstructive pulmonary disease (COPD). Aim of the study was to asse...

    Authors: Despo Ierodiakonou, Dimitra Sifaki-Pistolla, Maria Kampouraki, Ioannis Poulorinakis, Polyvios Papadokostakis, Ioannis Gialamas, Polyxeni Athanasiou, Vasiliki Bempi, Irene Lampraki and Ioanna Tsiligianni

    Citation: BMC Pulmonary Medicine 2020 20:253

    Content type: Research article

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  12. This study aimed to evaluate whether the Homocysteine (Hcy) level was elevated in chronic obstructive pulmonary disease (COPD) patients and its correlation with the occurrence and acute progression of COPD.

    Authors: Bing Wei, Tian Tian, Yugeng Liu and Chunsheng Li

    Citation: BMC Pulmonary Medicine 2020 20:237

    Content type: Research article

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  13. Taking into consideration a recent surge of a lung injury condition associated with electronic cigarette use, we devised an in vitro model of sub-chronic exposure of human bronchial epithelial cells (HBECs) in...

    Authors: Baishakhi Ghosh, Hermes Reyes-Caballero, Sevcan Gül Akgün-Ölmez, Kristine Nishida, Lakshmana Chandrala, Lena Smirnova, Shyam Biswal and Venkataramana K. Sidhaye

    Citation: BMC Pulmonary Medicine 2020 20:216

    Content type: Research article

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  14. Blood eosinophil counts (BEC) were recently included in the 2019 Global Initiative for Obstructive Lung Disease (GOLD) guideline as an easily accessible theragnostic biomarker for Chronic Obstructive Pulmonary...

    Authors: Inès Van Rossem, Jan Vandevoorde, Shane Hanon, Sander Deridder and Eef Vanderhelst

    Citation: BMC Pulmonary Medicine 2020 20:200

    Content type: Research article

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  15. Chronic obstructive pulmonary disease (COPD) is a common lung disorder characterized by persistent and progressive airflow limitation as well as systemic changes. Metabolic changes in blood may help detect COP...

    Authors: Ivana Prokić, Lies Lahousse, Maaike de Vries, Jun Liu, Marita Kalaoja, Judith M. Vonk, Diana A. van der Plaat, Cleo C. van Diemen, Ashley van der Spek, Alexandra Zhernakova, Jingyuan Fu, Mohsen Ghanbari, Mika Ala-Korpela, Johannes Kettunen, Aki S. Havulinna, Markus Perola…

    Citation: BMC Pulmonary Medicine 2020 20:193

    Content type: Research article

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  16. In recent years, many studies have discovered that cystatin C (Cys C) may play an important role in respiratory diseases, especially in chronic obstructive pulmonary disease (COPD). However, the findings of th...

    Authors: Limin Chai, Wei Feng, Cui Zhai, Wenhua Shi, Jian Wang, Xin Yan, Qingting Wang, Qianqian Zhang and Manxiang Li

    Citation: BMC Pulmonary Medicine 2020 20:182

    Content type: Research article

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  17. The cluster randomized controlled trial on (cost-)effectiveness of integrated chronic obstructive pulmonary disease (COPD) management in primary care (RECODE) showed that integrated disease management (IDM) in...

    Authors: Eline Meijer, Annelies E. van Eeden, Annemarije L. Kruis, Melinde R. S. Boland, Willem J. J. Assendelft, Apostolos Tsiachristas, Maureen P. M. H. Rutten-van Mölken, Marise J. Kasteleyn and Niels H. Chavannes

    Citation: BMC Pulmonary Medicine 2020 20:176

    Content type: Research article

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  18. COPD is a well-known risk factor for lung cancer, independent of smoking behavior. By investigating the retrospective National Health Insurance Service-National Sample Cohort (NHIS-NSC) in Korea, this study at...

    Authors: Song Vogue Ahn, Eunyoung Lee, Bumhee Park, Jin Hee Jung, Ji Eun Park, Seung Soo Sheen, Kwang Joo Park, Sung Chul Hwang, Jae Bum Park, Hae-Sim Park and Joo Hun Park

    Citation: BMC Pulmonary Medicine 2020 20:170

    Content type: Research article

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  19. Several lung structural and functional abnormalities may occur associated with aging, including emphysema. In this study, we evaluated the frequency and risk factors associated with emphysema in respiratory as...

    Authors: Ivette Buendia-Roldan, Alexia Palma-Lopez, Danaireth Chan-Padilla, Iliana Herrera, Mariel Maldonado, Rosario Fernández, David Martínez-Briseño, Mayra Mejia and Moises Selman

    Citation: BMC Pulmonary Medicine 2020 20:164

    Content type: Research article

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  20. Self-Management Support (SMS), refers to the actions taken by individuals to recognise and manage their own health. It is increasingly recognised that individuals with chronic obstructive pulmonary disease (CO...

    Authors: Lindsay Welch, Rosanna Orlando, Sharon X. Lin, Ivaylo Vassilev and Anne Rogers

    Citation: BMC Pulmonary Medicine 2020 20:162

    Content type: Research article

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  21. Forced expiratory volume in one second (FEV1) characterizes the pathophysiology of COPD and different trajectories of FEV1 decline have been observed in patients with COPD (e.g. gradual or episodic). There is lim...

    Authors: Johanna I. Lutter, Rudolf A. Jörres, Kathrin Kahnert, Larissa Schwarzkopf, Michael Studnicka, Stefan Karrasch, Holger Schulz, Claus F. Vogelmeier and Rolf Holle

    Citation: BMC Pulmonary Medicine 2020 20:148

    Content type: Research article

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  22. The association between chronic obstructive pulmonary disease (COPD), lung function and risk of type 2 diabetes mellitus (T2DM) remains controversial. We performed a meta-analysis to clarify this issue.

    Authors: Yang Peng, Guo-Chao Zhong, Lingxiao Wang, Lijuan Guan, Ao Wang, Kai Hu and Jing Shen

    Citation: BMC Pulmonary Medicine 2020 20:137

    Content type: Research article

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  23. Revefenacin, a once-daily, long-acting muscarinic antagonist delivered via standard jet nebulizer, increased trough forced expiratory volume in 1 s (FEV1) in patients with moderate to very severe chronic obstruct...

    Authors: James F. Donohue, Edward Kerwin, Chris N. Barnes, Edmund J. Moran, Brett Haumann and Glenn D. Crater

    Citation: BMC Pulmonary Medicine 2020 20:134

    Content type: Research article

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  24. COPD exacerbations have negative impact on patients’ survival. Several risk factors for grave outcomes of such exacerbations have been descried. Muscle dysfunction and mass loss were shown to impact negatively...

    Authors: N. Lasman, M. Shalom, N. Turpashvili, G. Goldhaber, Y. Lifshitz, E. Leibowitz, G. Berger, G. Saltzman-Shenhav, A. Brom, D. Cohen, C. Avaky and G. Segal

    Citation: BMC Pulmonary Medicine 2020 20:133

    Content type: Research article

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  25. Previous studies have established a higher prevalence of vitamin D deficiency in patients with COPD, but the relationship between vitamin D levels and COPD exacerbations remains controversial. In addition, the...

    Authors: Auyon J. Ghosh, Matthew Moll, Lystra P. Hayden, Jessica Bon, Elizabeth Regan and Craig P. Hersh

    Citation: BMC Pulmonary Medicine 2020 20:123

    Content type: Research article

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  26. Although many studies on people with Chronic Obstructive Pulmonary Disease (COPD) have examined the mutual impact of physical status and emotional experience, there is limited knowledge about the way COPD peop...

    Authors: Marta Pozzar, Eleonora Volpato, Chiara Valota, Francesco Pagnini and Paolo Innocente Banfi

    Citation: BMC Pulmonary Medicine 2020 20:120

    Content type: Research article

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  27. Batefenterol (BAT) is a bi-functional molecule with both muscarinic antagonist and β2-adrenoceptor agonist pharmacology. This Phase II, randomized, placebo-controlled, double-blind study evaluated the safety and ...

    Authors: Courtney Crim, Mark Gotfried, Selwyn Spangenthal, Michael Watkins, Amanda Emmett, Catriona Crawford, Charlotte Baidoo and Ramiro Castro-Santamaria

    Citation: BMC Pulmonary Medicine 2020 20:119

    Content type: Research article

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  28. Inhaled bronchodilators including long-acting beta-agonist (LABA) and long-acting muscarinic antagonist (LAMA) play a central role in the treatment of stable chronic obstructive pulmonary disease (COPD). Howev...

    Authors: Akira Koarai, Hisatoshi Sugiura, Mitsuhiro Yamada, Tomohiro Ichikawa, Naoya Fujino, Tomotaka Kawayama and Masakazu Ichinose

    Citation: BMC Pulmonary Medicine 2020 20:111

    Content type: Research article

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  29. To investigate whether, in patients hospitalized for COPD, the addition of social factors improves the predictive ability for the risk of overall 30-day readmissions, early readmissions (within 7 days after di...

    Authors: Tadahiro Goto, Kazuki Yoshida, Mohammad Kamal Faridi, Carlos A. Camargo Jr and Kohei Hasegawa

    Citation: BMC Pulmonary Medicine 2020 20:107

    Content type: Research article

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  30. Chronic obstructive pulmonary disease (COPD) patients with different phenotypes show different clinical characteristics. Therefore, we conducted a meta-analysis to explore the clinical characteristics between ...

    Authors: Jian-jun Wu, Hong-ri Xu, Ying-xue Zhang, Yi-xuan Li, Hui-yong Yu, Liang-duo Jiang, Cheng-xiang Wang and Mei Han

    Citation: BMC Pulmonary Medicine 2020 20:103

    Content type: Research article

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  31. Obstructive sleep apnea (OSA) is associated with pulmonary fibrosis and endothelial apoptosis in pulmonary tissues. Chronic intermittent hypoxia (IH) is considered to be the primary player in OSA, but the mech...

    Authors: Zhihui Shi, Linhao Xu, Hui Xie, Ruoyun Ouyang, Ya Ke, Rui Zhou and Wing-Ho Yung

    Citation: BMC Pulmonary Medicine 2020 20:92

    Content type: Research article

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  32. Work-related respiratory disorders are major contributors to the global burden of respiratory diseases. Agricultural workers are exposed to a number of dusts, which may contribute to the development of respira...

    Authors: Gashaw Garedew Woldeamanuel, Alemu Basazin Mingude, Getachew Yideg Yitbarek and Mitku Mammo Taderegew

    Citation: BMC Pulmonary Medicine 2020 20:86

    Content type: Research article

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  33. Chronic obstructive pulmonary disease (COPD) skeletal muscle dysfunction is a prevalent malady that significantly affects patients’ prognosis and quality of life. Although the study of this disease has attract...

    Authors: Jianqing Su, Jian Li, Yufan Lu, Ning Li, Peijun Li, Zhengrong Wang, Weibing Wu and Xiaodan Liu

    Citation: BMC Pulmonary Medicine 2020 20:74

    Content type: Research article

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  34. The discriminatory ability of multi-attribute utility (MAU) measures compared to condition-specific measures (CSM) in assessing health-related quality of life (HRQoL) among patients with chronic obstructive pu...

    Authors: Eunmi Bae, Sang-Eun Choi, Haeyoung Lee, Gyeongseon Shin and Daewon Kang

    Citation: BMC Pulmonary Medicine 2020 20:73

    Content type: Research article

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  35. Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is associated with infective triggers including bacterial or viral in many cases, and pneumonia is a major contributor to hospitalization f...

    Authors: Sunmin Park, Sang Jun Lee, Beomsu Shin, Seok Jeong Lee, Sang-Ha Kim, Woo Cheol Kwon, Jihye Kim and Myoung Kyu Lee

    Citation: BMC Pulmonary Medicine 2020 20:47

    Content type: Research article

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  36. Targeted lung denervation (TLD) is a bronchoscopically delivered ablation therapy that selectively interrupts pulmonary parasympathetic nerve signaling. The procedure has the potential to alter airway smooth m...

    Authors: Dirk-Jan Slebos, Bruno Degano, Arschang Valipour, Pallav L. Shah, Gaetan Deslée and Frank C. Sciurba

    Citation: BMC Pulmonary Medicine 2020 20:41

    Content type: Study protocol

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  37. Chronic hypersensitivity pneumonitis (cHP) is a disease caused by exposure to inhaled environmental antigens. Diagnosis of cHP is influenced by the awareness of the disease prevalence, which varies significant...

    Authors: Jessie P. Gu, Chen-Liang Tsai, Nicholas G. Wysham and Yuh-Chin T. Huang

    Citation: BMC Pulmonary Medicine 2020 20:32

    Content type: Research article

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  38. Both mitophagy, a selective mechanism for clearance of mitochondria, and mitochondrial biogenesis are key processes determining mitochondrial content and oxidative capacity of the musculature. Abnormalities in...

    Authors: Pieter A. Leermakers, Alexander H. V. Remels, Ramon C. J. Langen, Annemie M. W. J. Schols and Harry R. Gosker

    Citation: BMC Pulmonary Medicine 2020 20:20

    Content type: Research article

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  39. Dyspnea, fatigue, and decline in sleep quality are symptoms of chronic obstructive pulmonary disease (COPD). Pulmonary rehabilitation programs have been shown to ameliorate dyspnea and fatigue. However, only a...

    Authors: Leandro Nobeschi, Juliana Zangirolami-Raimundo, Priscila Kessar Cordoni, Selma Denis Squassoni, Elie Fiss, Andrés Ricardo Pérez-Riera, Luiz Carlos de Abreu and Rodrigo Daminello Raimundo

    Citation: BMC Pulmonary Medicine 2020 20:14

    Content type: Research article

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  40. Chronic obstructive pulmonary disease (COPD) is the fifth leading cause of death in China with a reported prevalence of 8.2% people aged ≥40 years. It is recommended that Chinese physicians follow Global Initi...

    Authors: Ting Yang, Baiqiang Cai, Bin Cao, Jian Kang, Fuqiang Wen, Wanzhen Yao, Jinping Zheng, Xia Ling, Hongyan Shang and Chen Wang

    Citation: BMC Pulmonary Medicine 2020 20:11

    Content type: Study protocol

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  41. Gastroesophageal reflux disease (GERD) was suggested to be associated with exacerbations of chronic obstructive pulmonary disease (COPD) in recent years. The aim of this study was to examine the association be...

    Authors: Chunrong Huang, Yahui Liu and Guochao Shi

    Citation: BMC Pulmonary Medicine 2020 20:2

    Content type: Research article

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  42. Peripheral muscle weakness can be caused by both peripheral muscle and neural alterations. Although peripheral alterations cannot totally explain peripheral muscle weakness in COPD, the existence of an activat...

    Authors: Francois Alexandre, Nelly Héraud, Emilie Tremey, Nicolas Oliver, Dominique Bourgouin and Alain Varray

    Citation: BMC Pulmonary Medicine 2020 20:1

    Content type: Research article

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  43. While inhaled bronchodilators reduce symptoms and acute exacerbations of chronic obstructive pulmonary disease (COPD), their use is associated with increased cardiovascular events in some studies. This study i...

    Authors: Yen-Fu Chen, Yi-Ching Cheng, Chien-Hong Chou, Chung-Yu Chen and Chong-Jen Yu

    Citation: BMC Pulmonary Medicine 2019 19:233

    Content type: Research article

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  44. Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities. The main causes of COPD are Gene-env...

    Authors: Yadira Velasco-Torres, Victor Ruiz-López, Oliver Pérez-Bautista, Ivette Buendía-Roldan, Alejandra Ramírez-Venegas, Julia Pérez-Ramos, Ramcés Falfán-Valencia, Carlos Ramos and Martha Montaño

    Citation: BMC Pulmonary Medicine 2019 19:227

    Content type: Research article

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  45. To explore patterns of brain structural alteration in chronic obstructive pulmonary disease (COPD) patients with different levels of lung function impairment and the associations of those patterns with cogniti...

    Authors: Minmin Yin, Haibao Wang, Xianwei Hu, Xiaoshu Li, Guanghe Fei and Yongqiang Yu

    Citation: BMC Pulmonary Medicine 2019 19:203

    Content type: Research article

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  46. There is evidence of an association between inflammatory bowel disease (IBD) and lung conditions such as chronic obstructive pulmonary disease (COPD). This systematic review and meta-analysis explored the risk...

    Authors: Gonzalo Labarca, Lauren Drake, Gloria Horta, Michael A. Jantz, Hiren J. Mehta, Sebastian Fernandez-Bussy, Erik Folch, Adnan Majid and Michael Picco

    Citation: BMC Pulmonary Medicine 2019 19:186

    Content type: Research article

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  47. Chronic obstructive pulmonary disease (COPD) is one of the major public health problems worldwide. Despite an increasing burden of COPD in the world, it is often a neglected disease in low income countries and...

    Authors: Gashaw Garedew Woldeamanuel, Alemu Basazin Mingude and Teshome Gensa Geta

    Citation: BMC Pulmonary Medicine 2019 19:181

    Content type: Research article

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  48. Chronic kidney disease (CKD) is a common comorbidity of chronic obstructive pulmonary disease (COPD). Although high hemoglobin (Hb) is detrimental to CKD patients, its relationship with poor outcomes in the CO...

    Authors: Libin Xu, Yuanhan Chen, Zhen Xie, Qiang He, Shixin Chen, Wenji Wang, Guohui Liu, Yuanjiang Liao, Chen Lu, Li Hao, Jin Sun, Wei Shi and Xinling Liang

    Citation: BMC Pulmonary Medicine 2019 19:174

    Content type: Research article

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