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COPD and occupational lung disease

Section edited by Craig Hersh

This section concerns all aspects of COPD, occupational lung disease, and smoking-related disorders including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

Page 1 of 5

  1. Content type: Research article

    Chronic obstructive pulmonary disease (COPD) is a major and increasing global health problem. Serotonin is a neurotransmitter that participates in several pulmonary functions and it has been involved in oxidat...

    Authors: Pietro Pirina, Elisabetta Zinellu, Panagiotis Paliogiannis, Alessandro G. Fois, Viviana Marras, Salvatore Sotgia, Ciriaco Carru and Angelo Zinellu

    Citation: BMC Pulmonary Medicine 2018 18:167

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  2. Content type: Research article

    COPD is a treatable disease with increasing prevalence worldwide. Treatment aims to stop disease progression, to improve quality of life, and to reduce exacerbations. We aimed to evaluate the association of th...

    Authors: Magdalena Humenberger, Andreas Horner, Anna Labek, Bernhard Kaiser, Rupert Frechinger, Constanze Brock, Petra Lichtenberger and Bernd Lamprecht

    Citation: BMC Pulmonary Medicine 2018 18:163

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  3. Content type: Research article

    In exacerbations of chronic obstructive pulmonary disease, administration of high concentrations of oxygen may cause hypercapnia and increase mortality compared with oxygen titrated, if required, to achieve an...

    Authors: George Bardsley, Janine Pilcher, Steven McKinstry, Philippa Shirtcliffe, James Berry, James Fingleton, Mark Weatherall and Richard Beasley

    Citation: BMC Pulmonary Medicine 2018 18:157

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  4. Content type: Research article

    Pulmonary rehabilitation (PR), delivered as a supervised multidisciplinary program including exercise training, is one of the cornerstones in the chronic obstructive pulmonary disease (COPD) management. We per...

    Authors: Camilla Koch Ryrsø, Nina Skavlan Godtfredsen, Linette Marie Kofod, Marie Lavesen, Line Mogensen, Randi Tobberup, Ingeborg Farver-Vestergaard, Henriette Edemann Callesen, Britta Tendal, Peter Lange and Ulrik Winning Iepsen

    Citation: BMC Pulmonary Medicine 2018 18:154

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  5. Content type: Research article

    Despite the known occupational hazards, it is not yet clear whether long-term career firefighting leads to a greater rate of decline in lung function than would normally be expected, and how this rate of chang...

    Authors: Flynn Slattery, Kylie Johnston, Catherine Paquet, Hunter Bennett and Alan Crockett

    Citation: BMC Pulmonary Medicine 2018 18:149

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  6. Content type: Research article

    Cigarette smoke (CS) exposure causes an abnormal inflammatory response, which can result in chronic obstructive pulmonary disease (COPD). Previous studies show that this disorder predominantly occurs in periph...

    Authors: Hario Baskoro, Tadashi Sato, Keiko Karasutani, Yohei Suzuki, Aki Mitsui, Naoko Arano, Fariz Nurwidya, Motoyasu Kato, Fumiyuki Takahashi, Yuzo Kodama, Kuniaki Seyama and Kazuhisa Takahashi

    Citation: BMC Pulmonary Medicine 2018 18:148

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  7. Content type: Research article

    Mobile health applications are increasingly used in patients with Chronic Obstructive Pulmonary Disease (COPD) to improve their self-management, nonetheless, without firm evidence of their efficacy. This meta-...

    Authors: Fen Yang, Yuncui Wang, Chongming Yang, Hui Hu and Zhenfang Xiong

    Citation: BMC Pulmonary Medicine 2018 18:147

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  8. Content type: Research article

    The fractal dimension characterizing the cumulative size distribution of low attenuation area (LAA) clusters, identified with a fixed threshold such as − 950 Hounsfield Units (HU), on computed tomography (CT) ...

    Authors: Naoya Tanabe, Shigeo Muro, Susumu Sato, Tsuyoshi Oguma, Atsuyasu Sato and Toyohiro Hirai

    Citation: BMC Pulmonary Medicine 2018 18:144

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  9. Content type: Research article

    Pneumoconiosis patients receive community-based or home-based pulmonary rehabilitation (PR) for symptom management and enhancement of physical and mental well-being. This study aimed to review the clinical ben...

    Authors: Eric W. Tsang, Henry Kwok, Aidan K. Y. Chan, Kah Lin Choo, Kin Sang Chan, Kam Shing Lau and Chetwyn C. H. Chan

    Citation: BMC Pulmonary Medicine 2018 18:133

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  10. Content type: Research article

    Respiratory tract deposition of airborne particles is a key link to understand their health impact. Experimental data are limited for vulnerable groups such as individuals with respiratory diseases. The aim of...

    Authors: Jonas K F Jakobsson, H Laura Aaltonen, Hanna Nicklasson, Anders Gudmundsson, Jenny Rissler, Per Wollmer and Jakob Löndahl

    Citation: BMC Pulmonary Medicine 2018 18:129

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  11. Content type: Research article

    Chronic obstructive pulmonary disease (COPD) with carbon dioxide retention is associated with a worsening clinical condition and the beginning of pulmonary ventilation decompensation. This study aimed to ident...

    Authors: Xia Wei, Nan Yu, Qi Ding, Jingting Ren, Jiuyun Mi, Lu Bai, Jianying Li, Min Qi and Youmin Guo

    Citation: BMC Pulmonary Medicine 2018 18:124

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  12. Content type: Research article

    c-Kit + lung stem cells have been described in the human healthy lung. Their potential relation with smoking and/or chronic obstructive pulmonary disease (COPD) is unknown.

    Authors: Alejandra López-Giraldo, Tamara Cruz, Laureano Molins, Ángela Guirao, Adela Saco, Sandra Cuerpo, Josep Ramirez, Álvar Agustí and Rosa Faner

    Citation: BMC Pulmonary Medicine 2018 18:123

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  13. Content type: Research article

    Cardiovascular disease (CVD) is remarkably frequent in patients with chronic obstructive pulmonary disease (COPD). Albuminuria is a marker of vascular endothelial dysfunction and predictor of CVD events. Album...

    Authors: Festo K. Shayo and Janet Lutale

    Citation: BMC Pulmonary Medicine 2018 18:125

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  14. Content type: Research article

    Chronic obstructive pulmonary disease (COPD) is an important cause of morbidity and mortality around the world. The aim of our study was to determine the association between specific comorbidities and COPD sev...

    Authors: Chantal Raherison, El-Hassane Ouaalaya, Alain Bernady, Julien Casteigt, Cecilia Nocent-Eijnani, Laurent Falque, Frédéric Le Guillou, Laurent Nguyen, Annaig Ozier and Mathieu Molimard

    Citation: BMC Pulmonary Medicine 2018 18:117

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  15. Content type: Research article

    Prognostic stratification of elderly patients with chronic obstructive pulmonary disease (COPD) is difficult due to the wide inter-individual variability in the course of the disease. No marker can exactly str...

    Authors: Domenico Acanfora, Pietro Scicchitano, Mauro Carone, Chiara Acanfora, Giuseppe Piscosquito, Roberto Maestri, Annapaola Zito, Ilaria Dentamaro, Marialaura Longobardi, Gerardo Casucci, Raffaele Antonelli-Incalzi and Marco Matteo Ciccone

    Citation: BMC Pulmonary Medicine 2018 18:116

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  16. Content type: Research article

    Pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) is suggested as the consequence of emphysematous destruction of vascular bed and hypoxia of pulmonary microenvironment, mechanisms un...

    Authors: Xiaotong Guo, Yuchun Fan, Jieda Cui, Binwei Hao, Li Zhu, Xiao Sun, Jinxi He, Jiali Yang, Jianda Dong, Yanyang Wang, Xiaoming Liu and Juan Chen

    Citation: BMC Pulmonary Medicine 2018 18:111

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  17. Content type: Research article

    The chronic and progressive nature of chronic obstructive pulmonary disease (COPD) requires self-administration of inhaled medication. Dry powder inhalers (DPIs) are increasingly being used for inhalation ther...

    Authors: Pablo Altman, Luis Wehbe, Juergen Dederichs, Tadhg Guerin, Brian Ament, Miguel Cardenas Moronta, Andrea Valeria Pino and Pankaj Goyal

    Citation: BMC Pulmonary Medicine 2018 18:100

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  18. Content type: Case report

    Occupational lung diseases, such as pneumoconiosis, are one of the health problems of dental workers that have been receiving increasing interest. Pulmonary amyloidosis is a heterogenous group of diseases, and...

    Authors: Taizou Hirano, Tadahisa Numakura, Hiroshi Moriyama, Ryoko Saito, Yutaka Shishikura, Jun Shiihara, Hisatoshi Sugiura and Masakazu Ichinose

    Citation: BMC Pulmonary Medicine 2018 18:77

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  19. Content type: Study protocol

    Pulmonary rehabilitation is an effective therapeutic intervention for people with chronic respiratory disease. However, fewer than 5% of eligible individuals receive pulmonary rehabilitation on an annual basis...

    Authors: Narelle S. Cox, Christine F. McDonald, Jennifer A. Alison, Ajay Mahal, Richard Wootton, Catherine J. Hill, Janet Bondarenko, Heather Macdonald, Paul O’Halloran, Paolo Zanaboni, Ken Clarke, Deidre Rennick, Kaye Borgelt, Angela T. Burge, Aroub Lahham, Bruna Wageck…

    Citation: BMC Pulmonary Medicine 2018 18:71

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  20. Content type: Research article

    Neutrophil-to-lymphocyte ratio (NLR) is a biomarker of inflammation in chronic obstructive pulmonary disease (COPD) patients. But, a meaningful threshold and the longitudinal changes are unknown. We aimed to i...

    Authors: Kaori Sakurai, Shotaro Chubachi, Hidehiro Irie, Akihiro Tsutsumi, Naofumi Kameyama, Takashi Kamatani, Hidefumi Koh, Takeshi Terashima, Hidetoshi Nakamura, Koichiro Asano and Tomoko Betsuyaku

    Citation: BMC Pulmonary Medicine 2018 18:65

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  21. Content type: Research article

    Recently awareness of the importance of Aspergillus colonization in the airway of patients with chronic obstructive pulmonary disease (COPD) was rising. The aim of this study was to investigate the clinical fe...

    Authors: Xunliang Tong, Anqi Cheng, Hongtao Xu, Jin Jin, Yimeng Yang, Sainan Zhu and Yanming Li

    Citation: BMC Pulmonary Medicine 2018 18:55

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  22. Content type: Research article

    Interferon lambdas (IFNLs) have important anti-viral/bacterial and immunomodulatory functions in the respiratory tract. How do IFNLs impact COPD and its exacerbations?

    Authors: Adrian Egli, Jyotshna Mandal, Desiree M. Schumann, Michael Roth, Brad Thomas, D. Lorne Tyrrell, Francesco Blasi, Kostantinos Kostikas, Wim Boersma, Branislava Milenkovic, Alicia Lacoma, Katharina Rentsch, Gernot G. U. Rohde, Renaud Louis, Joachim G. Aerts, Tobias Welte…

    Citation: BMC Pulmonary Medicine 2018 18:51

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  23. Content type: Research article

    Club cell protein-16 (CC16) expression has been associated with smoking-related lung function decline. The study hypothesis was that CC16 expression in both serum and bronchial epithelium is associated with lu...

    Authors: David Chi-Leung Lam, Hoi-Hin Kwok, Wai-Cho Yu, Fanny Wai-San Ko, Cheuk-Yin Tam, Arthur Chun-Wing Lau, Daniel Yee-Tak Fong and Mary Sau-Man Ip

    Citation: BMC Pulmonary Medicine 2018 18:47

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  24. Content type: Research article

    An adequate threshold for the Clinical Chronic Obstructive Pulmonary Disease (COPD) Questionnaire (CCQ) defining more symptomatic COPD patients has not been determined. We aimed to determine the efficacy of th...

    Authors: Yong Suk Jo, Sangshin Park, Deog Kyeom Kim, Chul-Gyu Yoo and Chang-Hoon Lee

    Citation: BMC Pulmonary Medicine 2018 18:38

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  25. Content type: Research article

    In the Commonwealth of Independent States (CIS) countries the epidemiology of chronic obstructive pulmonary disease (COPD) is poorly characterized. The objective of this analysis is to present the prevalence, ...

    Authors: Damilya Nugmanova, Yuriy Feshchenko, Liudmyla Iashyna, Olga Gyrina, Kateryna Malynovska, Eljan Mammadbayov, Irada Akhundova, Nadezhda Nurkina, Luqman Tariq, Janina Makarova and Averyan Vasylyev

    Citation: BMC Pulmonary Medicine 2018 18:26

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  26. Content type: Research article

    Pneumoconiosis may play an important role in the development of chronic obstructive pulmonary disease (COPD), and the complication of COPD may impose a heavy burden of illness.

    Authors: Yating Peng, Xin Li, Shan Cai, Yan Chen, Weirong Dai, Wenfeng Liu, Zijing Zhou, Jiaxi Duan and Ping Chen

    Citation: BMC Pulmonary Medicine 2018 18:22

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  27. Content type: Research article

    Hospitalization for a severe exacerbation of COPD (eCOPD) is an important event in the natural history of COPD. Identifying factors related to mortality 1 year after hospitalization could help determine interv...

    Authors: Cristóbal Esteban, Ady Castro-Acosta, Carlos Jose Alvarez-Martínez, Alberto Capelastegui, José Luis López-Campos and Francisco Pozo-Rodriguez

    Citation: BMC Pulmonary Medicine 2018 18:18

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  28. Content type: Research article

    Nasal Highflow (NHF) delivers a humidified and heated airflow via nasal prongs. Current data provide evidence for efficacy of NHF in patients with hypoxemic respiratory failure. Preliminary data suggest that N...

    Authors: Jens Bräunlich, Friederike Mauersberger and Hubert Wirtz

    Citation: BMC Pulmonary Medicine 2018 18:14

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  29. Content type: Research article

    Chronic obstructive pulmonary disease is a global problem and available data from sub-Saharan Africa is very limited.

    Authors: Thomas Zoller, Elirehema H. Mfinanga, Tresphory B. Zumba, Peter J. Asilia, Edwin M. Mutabazi, David Wimmersberger, Florian Kurth, Francis Mhimbira, Frederick Haraka and Klaus Reither

    Citation: BMC Pulmonary Medicine 2018 18:11

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  30. Content type: Research article

    Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with variable clinical manifestations, structural changes, and treatment responses. In a cohort study, we performed a baseline cluster an...

    Authors: Suhyun Kim, Myoung-Nam Lim, Yoonki Hong, Seon-Sook Han, Seung-Joon Lee and Woo Jin Kim

    Citation: BMC Pulmonary Medicine 2017 17:209

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  31. Content type: Research article

    Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the most common reason for the hospitalization and death of pulmonary patients. The use of antibiotics as adjuvant therapy for AECOPD, ho...

    Authors: Hai-Lin Zhang, Min Tan, Ai-Min Qiu, Zhang Tao and Chang-Hui Wang

    Citation: BMC Pulmonary Medicine 2017 17:196

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  32. Content type: Research article

    Recent studies have shown that both adenosine monophosphate activated protein kinase (AMPK) and the mammalian target of rapamycin (mTOR) are energy sensors and are related to autophagy. Our recent reports have...

    Authors: Di Gui, Zhimin Cui, Lin Zhang, Chang Yu, Dan Yao, Min Xu, Mayun Chen, Peiliang Wu, Guoping Li, Liangxing Wang and Xiaoying Huang

    Citation: BMC Pulmonary Medicine 2017 17:191

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  33. Content type: Research article

    Multiple breath washout (MBW) became a valuable research tool assessing ventilation heterogeneity. However, routine clinical application still faces several challenges. Deriving MBW parameters from three techn...

    Authors: Frederik Trinkmann, Johannes Götzmann, Daniel Saur, Michele Schroeter, Katharina Roth, Ksenija Stach, Martin Borggrefe, Joachim Saur, Ibrahim Akin and Julia D. Michels

    Citation: BMC Pulmonary Medicine 2017 17:185

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  34. Content type: Research article

    Systemic morphine has evidence to support its use for reducing breathlessness in patients with severe chronic obstructive pulmonary disease (COPD). The effectiveness of the nebulized route, however, has not ye...

    Authors: Piotr Janowiak, Małgorzata Krajnik, Zygmunt Podolec, Tomasz Bandurski, Iwona Damps-Konstańska, Piotr Sobański, David C. Currow and Ewa Jassem

    Citation: BMC Pulmonary Medicine 2017 17:186

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  35. Content type: Research article

    Change in forced expiratory volume in one second (FEV1) is important for defining severity of chronic obstructive pulmonary disease (COPD). Serological neoepitope markers of collagen turnover may predict rate of ...

    Authors: Diana J. Leeming, Inger Byrjalsen, Jannie M. B. Sand, Asger R. Bihlet, Peter Lange, Ruth Thal-Singer, Bruce E. Miller, Morten A. Karsdal and Jørgen Vestbo

    Citation: BMC Pulmonary Medicine 2017 17:164

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  36. Content type: Research article

    Recently, it was shown that chronic tobacco smoking evokes specific cellular and molecular changes in white blood cells by an excess of G protein-coupled receptor 15 (GPR15)-expressing T cells as well as a hyp...

    Authors: Mario Bauer, Beate Fink, Hans-Jürgen Seyfarth, Hubert Wirtz and Armin Frille

    Citation: BMC Pulmonary Medicine 2017 17:159

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  37. Content type: Research article

    Combined effects of leaks, mechanical property of respiratory system and upper airway (UA) patency on patient-ventilator synchrony (PVA) and the level of clinically “tolerable” leaks are not well established i...

    Authors: Kaixian Zhu, Claudio Rabec, Jésus Gonzalez-Bermejo, Sébastien Hardy, Sami Aouf, Pierre Escourrou and Gabriel Roisman

    Citation: BMC Pulmonary Medicine 2017 17:145

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  38. Content type: Research article

    Nasal high-flow oxygen therapy (HFOT) is a novel treatment option for patients suffering from acute or chronic respiratory failure. Aim of our study was to compare safety and efficacy of HFOT with those of con...

    Authors: Helene Vogelsinger, Michael Halank, Silke Braun, Heinrike Wilkens, Thomas Geiser, Sebastian Ott, Armin Stucki and Christian M. Kaehler

    Citation: BMC Pulmonary Medicine 2017 17:143

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  39. Content type: Research article

    Asbestosis and silicosis are progressive pneumoconioses characterized by interstitial fibrosis following exposure to asbestos or silica dust. We evaluated the potential diagnostic biomarkers for these diseases.

    Authors: Changjiang Xue, Na Wu, Xue Li, Meihua Qiu, Xuqin Du and Qiao Ye

    Citation: BMC Pulmonary Medicine 2017 17:144

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  40. Content type: Study protocol

    Rehabilitation of patients with chronic obstructive pulmonary disease (COPD) is a key treatment in COPD. However, despite the existing evidence and a strong recommendation from lung associations worldwide, 50%...

    Authors: Henrik Hansen, Theresa Bieler, Nina Beyer, Nina Godtfredsen, Thomas Kallemose and Anne Frølich

    Citation: BMC Pulmonary Medicine 2017 17:140

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  41. Content type: Research article

    Although proxies of patients with chronic obstructive pulmonary disease (COPD) need health-related knowledge to support patients in managing their disease, their current level of knowledge remains unknown. We ...

    Authors: Nienke Nakken, Daisy J. A. Janssen, Esther H. A. van den Bogaart, Jean W. M. Muris, Jan H. Vercoulen, Frank L. Custers, Gerben P. Bootsma, Michiel H. M. Gronenschild, Emiel F. M. Wouters and Martijn A. Spruit

    Citation: BMC Pulmonary Medicine 2017 17:136

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  42. Content type: Research article

    Inhalation of particulate matter, as part of air pollution, is associated with increased morbidity and mortality. Nanoparticles (< 100 nm) are likely candidates for triggering inflammatory responses and activa...

    Authors: Marieke Berger, Johannes D. de Boer, René Lutter, Michiel Makkee, Peter J. Sterk, Elles M. Kemper and Jaring S. van der Zee

    Citation: BMC Pulmonary Medicine 2017 17:121

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  43. Content type: Study protocol

    Physical activity promotion in people with Chronic Obstructive Pulmonary Disease (COPD) is focus of research and public health. Patient-centred interventions like counselling are promising approaches to help p...

    Authors: Anne-Kathrin Rausch-Osthoff, Nicola Greco, Ariane Schwank, Swantje Beyer, David Gisi, Mandy Scheermesser, André Meichtry, Noriane Sievi, Thomas Hess and Markus Wirz

    Citation: BMC Pulmonary Medicine 2017 17:115

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  44. Content type: Study protocol

    The most commonly applied treatment for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is a 5-day course of high-dose systemic corticosteroids. However, this treatment has not been shown...

    Authors: Pradeesh Sivapalan, Mia Moberg, Josefin Eklöf, Julie Janner, Jørgen Vestbo, Rasmus Rude Laub, Andrea Browatzki, Karin Armbruster, Jon Torgny Wilcke, Niels Seersholm, Ulla Møller Weinreich, Ingrid Louise Titlestad, Helle Frost Andreassen, Charlotte Suppli Ulrik, Uffe Bødtger, Thyge Lynghøj Nielsen…

    Citation: BMC Pulmonary Medicine 2017 17:114

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  45. Content type: Research article

    Brain pathology is relatively unexplored in chronic obstructive pulmonary disease (COPD). This study is a comprehensive investigation of grey matter (GM) and white matter (WM) changes and how these relate to d...

    Authors: Catherine A. Spilling, Paul W. Jones, James W. Dodd and Thomas R. Barrick

    Citation: BMC Pulmonary Medicine 2017 17:92

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  46. Content type: Study protocol

    Chronic obstructive pulmonary disease (COPD) severely hinders quality of life for those affected and is costly to the health care system. Care gaps in areas such as pharmacotherapy, inhaler technique, and know...

    Authors: Beatrice Huang, Rachel Willard-Grace, Denise De Vore, Jessica Wolf, Chris Chirinos, Stephanie Tsao, Danielle Hessler, George Su and David H. Thom

    Citation: BMC Pulmonary Medicine 2017 17:90

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  47. Content type: Research article

    Influenza is a frequent cause of exacerbations of chronic obstructive pulmonary disease (COPD). Exacerbations are associated with worsening of the airflow obstruction, hospitalisation, reduced quality of life,...

    Authors: Rafik Bekkat-Berkani, Tom Wilkinson, Philippe Buchy, Gael Dos Santos, Dimitris Stefanidis, Jeanne-Marie Devaster and Nadia Meyer

    Citation: BMC Pulmonary Medicine 2017 17:79

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  48. Content type: Research article

    In patients with diffuse lung diseases, differentiating occupational lung diseases from other diseases is clinically important. However, the value of assessing asbestos and particles in bronchoalveolar lavage ...

    Authors: Takashi Kido, Yasuo Morimoto, Kazuhiro Yatera, Hiroshi Ishimoto, Takaaki Ogoshi, Keishi Oda, Kei Yamasaki, Toshinori Kawanami, Shohei Shimajiri and Hiroshi Mukae

    Citation: BMC Pulmonary Medicine 2017 17:71

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