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COPD and occupational lung disease

This section concerns all aspects of COPD, occupational lung disease, and smoking-related disorders including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Chronic obstructive pulmonary disease (COPD) is an important cause of morbidity and mortality around the world. The aim of our study was to determine the association between specific comorbidities and COPD sev...

    Authors: Chantal Raherison, El-Hassane Ouaalaya, Alain Bernady, Julien Casteigt, Cecilia Nocent-Eijnani, Laurent Falque, Frédéric Le Guillou, Laurent Nguyen, Annaig Ozier and Mathieu Molimard

    Citation: BMC Pulmonary Medicine 2018 18:117

    Content type: Research article

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  2. Prognostic stratification of elderly patients with chronic obstructive pulmonary disease (COPD) is difficult due to the wide inter-individual variability in the course of the disease. No marker can exactly str...

    Authors: Domenico Acanfora, Pietro Scicchitano, Mauro Carone, Chiara Acanfora, Giuseppe Piscosquito, Roberto Maestri, Annapaola Zito, Ilaria Dentamaro, Marialaura Longobardi, Gerardo Casucci, Raffaele Antonelli-Incalzi and Marco Matteo Ciccone

    Citation: BMC Pulmonary Medicine 2018 18:116

    Content type: Research article

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  3. Pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) is suggested as the consequence of emphysematous destruction of vascular bed and hypoxia of pulmonary microenvironment, mechanisms un...

    Authors: Xiaotong Guo, Yuchun Fan, Jieda Cui, Binwei Hao, Li Zhu, Xiao Sun, Jinxi He, Jiali Yang, Jianda Dong, Yanyang Wang, Xiaoming Liu and Juan Chen

    Citation: BMC Pulmonary Medicine 2018 18:111

    Content type: Research article

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  4. The chronic and progressive nature of chronic obstructive pulmonary disease (COPD) requires self-administration of inhaled medication. Dry powder inhalers (DPIs) are increasingly being used for inhalation ther...

    Authors: Pablo Altman, Luis Wehbe, Juergen Dederichs, Tadhg Guerin, Brian Ament, Miguel Cardenas Moronta, Andrea Valeria Pino and Pankaj Goyal

    Citation: BMC Pulmonary Medicine 2018 18:100

    Content type: Research article

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  5. Occupational lung diseases, such as pneumoconiosis, are one of the health problems of dental workers that have been receiving increasing interest. Pulmonary amyloidosis is a heterogenous group of diseases, and...

    Authors: Taizou Hirano, Tadahisa Numakura, Hiroshi Moriyama, Ryoko Saito, Yutaka Shishikura, Jun Shiihara, Hisatoshi Sugiura and Masakazu Ichinose

    Citation: BMC Pulmonary Medicine 2018 18:77

    Content type: Case report

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  6. Pulmonary rehabilitation is an effective therapeutic intervention for people with chronic respiratory disease. However, fewer than 5% of eligible individuals receive pulmonary rehabilitation on an annual basis...

    Authors: Narelle S. Cox, Christine F. McDonald, Jennifer A. Alison, Ajay Mahal, Richard Wootton, Catherine J. Hill, Janet Bondarenko, Heather Macdonald, Paul O’Halloran, Paolo Zanaboni, Ken Clarke, Deidre Rennick, Kaye Borgelt, Angela T. Burge, Aroub Lahham, Bruna Wageck…

    Citation: BMC Pulmonary Medicine 2018 18:71

    Content type: Study protocol

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  7. Neutrophil-to-lymphocyte ratio (NLR) is a biomarker of inflammation in chronic obstructive pulmonary disease (COPD) patients. But, a meaningful threshold and the longitudinal changes are unknown. We aimed to i...

    Authors: Kaori Sakurai, Shotaro Chubachi, Hidehiro Irie, Akihiro Tsutsumi, Naofumi Kameyama, Takashi Kamatani, Hidefumi Koh, Takeshi Terashima, Hidetoshi Nakamura, Koichiro Asano and Tomoko Betsuyaku

    Citation: BMC Pulmonary Medicine 2018 18:65

    Content type: Research article

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  8. Recently awareness of the importance of Aspergillus colonization in the airway of patients with chronic obstructive pulmonary disease (COPD) was rising. The aim of this study was to investigate the clinical fe...

    Authors: Xunliang Tong, Anqi Cheng, Hongtao Xu, Jin Jin, Yimeng Yang, Sainan Zhu and Yanming Li

    Citation: BMC Pulmonary Medicine 2018 18:55

    Content type: Research article

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  9. Interferon lambdas (IFNLs) have important anti-viral/bacterial and immunomodulatory functions in the respiratory tract. How do IFNLs impact COPD and its exacerbations?

    Authors: Adrian Egli, Jyotshna Mandal, Desiree M. Schumann, Michael Roth, Brad Thomas, D. Lorne Tyrrell, Francesco Blasi, Kostantinos Kostikas, Wim Boersma, Branislava Milenkovic, Alicia Lacoma, Katharina Rentsch, Gernot G. U. Rohde, Renaud Louis, Joachim G. Aerts, Tobias Welte…

    Citation: BMC Pulmonary Medicine 2018 18:51

    Content type: Research article

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  10. Club cell protein-16 (CC16) expression has been associated with smoking-related lung function decline. The study hypothesis was that CC16 expression in both serum and bronchial epithelium is associated with lu...

    Authors: David Chi-Leung Lam, Hoi-Hin Kwok, Wai-Cho Yu, Fanny Wai-San Ko, Cheuk-Yin Tam, Arthur Chun-Wing Lau, Daniel Yee-Tak Fong and Mary Sau-Man Ip

    Citation: BMC Pulmonary Medicine 2018 18:47

    Content type: Research article

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  11. An adequate threshold for the Clinical Chronic Obstructive Pulmonary Disease (COPD) Questionnaire (CCQ) defining more symptomatic COPD patients has not been determined. We aimed to determine the efficacy of th...

    Authors: Yong Suk Jo, Sangshin Park, Deog Kyeom Kim, Chul-Gyu Yoo and Chang-Hoon Lee

    Citation: BMC Pulmonary Medicine 2018 18:38

    Content type: Research article

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  12. In the Commonwealth of Independent States (CIS) countries the epidemiology of chronic obstructive pulmonary disease (COPD) is poorly characterized. The objective of this analysis is to present the prevalence, ...

    Authors: Damilya Nugmanova, Yuriy Feshchenko, Liudmyla Iashyna, Olga Gyrina, Kateryna Malynovska, Eljan Mammadbayov, Irada Akhundova, Nadezhda Nurkina, Luqman Tariq, Janina Makarova and Averyan Vasylyev

    Citation: BMC Pulmonary Medicine 2018 18:26

    Content type: Research article

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  13. Pneumoconiosis may play an important role in the development of chronic obstructive pulmonary disease (COPD), and the complication of COPD may impose a heavy burden of illness.

    Authors: Yating Peng, Xin Li, Shan Cai, Yan Chen, Weirong Dai, Wenfeng Liu, Zijing Zhou, Jiaxi Duan and Ping Chen

    Citation: BMC Pulmonary Medicine 2018 18:22

    Content type: Research article

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  14. Hospitalization for a severe exacerbation of COPD (eCOPD) is an important event in the natural history of COPD. Identifying factors related to mortality 1 year after hospitalization could help determine interv...

    Authors: Cristóbal Esteban, Ady Castro-Acosta, Carlos Jose Alvarez-Martínez, Alberto Capelastegui, José Luis López-Campos and Francisco Pozo-Rodriguez

    Citation: BMC Pulmonary Medicine 2018 18:18

    Content type: Research article

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  15. Nasal Highflow (NHF) delivers a humidified and heated airflow via nasal prongs. Current data provide evidence for efficacy of NHF in patients with hypoxemic respiratory failure. Preliminary data suggest that N...

    Authors: Jens Bräunlich, Friederike Mauersberger and Hubert Wirtz

    Citation: BMC Pulmonary Medicine 2018 18:14

    Content type: Research article

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  16. Chronic obstructive pulmonary disease is a global problem and available data from sub-Saharan Africa is very limited.

    Authors: Thomas Zoller, Elirehema H. Mfinanga, Tresphory B. Zumba, Peter J. Asilia, Edwin M. Mutabazi, David Wimmersberger, Florian Kurth, Francis Mhimbira, Frederick Haraka and Klaus Reither

    Citation: BMC Pulmonary Medicine 2018 18:11

    Content type: Research article

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  17. Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with variable clinical manifestations, structural changes, and treatment responses. In a cohort study, we performed a baseline cluster an...

    Authors: Suhyun Kim, Myoung-Nam Lim, Yoonki Hong, Seon-Sook Han, Seung-Joon Lee and Woo Jin Kim

    Citation: BMC Pulmonary Medicine 2017 17:209

    Content type: Research article

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  18. Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the most common reason for the hospitalization and death of pulmonary patients. The use of antibiotics as adjuvant therapy for AECOPD, ho...

    Authors: Hai-Lin Zhang, Min Tan, Ai-Min Qiu, Zhang Tao and Chang-Hui Wang

    Citation: BMC Pulmonary Medicine 2017 17:196

    Content type: Research article

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  19. Recent studies have shown that both adenosine monophosphate activated protein kinase (AMPK) and the mammalian target of rapamycin (mTOR) are energy sensors and are related to autophagy. Our recent reports have...

    Authors: Di Gui, Zhimin Cui, Lin Zhang, Chang Yu, Dan Yao, Min Xu, Mayun Chen, Peiliang Wu, Guoping Li, Liangxing Wang and Xiaoying Huang

    Citation: BMC Pulmonary Medicine 2017 17:191

    Content type: Research article

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  20. Systemic morphine has evidence to support its use for reducing breathlessness in patients with severe chronic obstructive pulmonary disease (COPD). The effectiveness of the nebulized route, however, has not ye...

    Authors: Piotr Janowiak, Małgorzata Krajnik, Zygmunt Podolec, Tomasz Bandurski, Iwona Damps-Konstańska, Piotr Sobański, David C. Currow and Ewa Jassem

    Citation: BMC Pulmonary Medicine 2017 17:186

    Content type: Research article

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  21. Multiple breath washout (MBW) became a valuable research tool assessing ventilation heterogeneity. However, routine clinical application still faces several challenges. Deriving MBW parameters from three techn...

    Authors: Frederik Trinkmann, Johannes Götzmann, Daniel Saur, Michele Schroeter, Katharina Roth, Ksenija Stach, Martin Borggrefe, Joachim Saur, Ibrahim Akin and Julia D. Michels

    Citation: BMC Pulmonary Medicine 2017 17:185

    Content type: Research article

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  22. Change in forced expiratory volume in one second (FEV1) is important for defining severity of chronic obstructive pulmonary disease (COPD). Serological neoepitope markers of collagen turnover may predict rate of ...

    Authors: Diana J. Leeming, Inger Byrjalsen, Jannie M. B. Sand, Asger R. Bihlet, Peter Lange, Ruth Thal-Singer, Bruce E. Miller, Morten A. Karsdal and Jørgen Vestbo

    Citation: BMC Pulmonary Medicine 2017 17:164

    Content type: Research article

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  23. Recently, it was shown that chronic tobacco smoking evokes specific cellular and molecular changes in white blood cells by an excess of G protein-coupled receptor 15 (GPR15)-expressing T cells as well as a hyp...

    Authors: Mario Bauer, Beate Fink, Hans-Jürgen Seyfarth, Hubert Wirtz and Armin Frille

    Citation: BMC Pulmonary Medicine 2017 17:159

    Content type: Research article

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  24. Combined effects of leaks, mechanical property of respiratory system and upper airway (UA) patency on patient-ventilator synchrony (PVA) and the level of clinically “tolerable” leaks are not well established i...

    Authors: Kaixian Zhu, Claudio Rabec, Jésus Gonzalez-Bermejo, Sébastien Hardy, Sami Aouf, Pierre Escourrou and Gabriel Roisman

    Citation: BMC Pulmonary Medicine 2017 17:145

    Content type: Research article

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  25. Asbestosis and silicosis are progressive pneumoconioses characterized by interstitial fibrosis following exposure to asbestos or silica dust. We evaluated the potential diagnostic biomarkers for these diseases.

    Authors: Changjiang Xue, Na Wu, Xue Li, Meihua Qiu, Xuqin Du and Qiao Ye

    Citation: BMC Pulmonary Medicine 2017 17:144

    Content type: Research article

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  26. Nasal high-flow oxygen therapy (HFOT) is a novel treatment option for patients suffering from acute or chronic respiratory failure. Aim of our study was to compare safety and efficacy of HFOT with those of con...

    Authors: Helene Vogelsinger, Michael Halank, Silke Braun, Heinrike Wilkens, Thomas Geiser, Sebastian Ott, Armin Stucki and Christian M. Kaehler

    Citation: BMC Pulmonary Medicine 2017 17:143

    Content type: Research article

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  27. Rehabilitation of patients with chronic obstructive pulmonary disease (COPD) is a key treatment in COPD. However, despite the existing evidence and a strong recommendation from lung associations worldwide, 50%...

    Authors: Henrik Hansen, Theresa Bieler, Nina Beyer, Nina Godtfredsen, Thomas Kallemose and Anne Frølich

    Citation: BMC Pulmonary Medicine 2017 17:140

    Content type: Study protocol

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  28. Although proxies of patients with chronic obstructive pulmonary disease (COPD) need health-related knowledge to support patients in managing their disease, their current level of knowledge remains unknown. We ...

    Authors: Nienke Nakken, Daisy J. A. Janssen, Esther H. A. van den Bogaart, Jean W. M. Muris, Jan H. Vercoulen, Frank L. Custers, Gerben P. Bootsma, Michiel H. M. Gronenschild, Emiel F. M. Wouters and Martijn A. Spruit

    Citation: BMC Pulmonary Medicine 2017 17:136

    Content type: Research article

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  29. Inhalation of particulate matter, as part of air pollution, is associated with increased morbidity and mortality. Nanoparticles (< 100 nm) are likely candidates for triggering inflammatory responses and activa...

    Authors: Marieke Berger, Johannes D. de Boer, René Lutter, Michiel Makkee, Peter J. Sterk, Elles M. Kemper and Jaring S. van der Zee

    Citation: BMC Pulmonary Medicine 2017 17:121

    Content type: Research article

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  31. Physical activity promotion in people with Chronic Obstructive Pulmonary Disease (COPD) is focus of research and public health. Patient-centred interventions like counselling are promising approaches to help p...

    Authors: Anne-Kathrin Rausch-Osthoff, Nicola Greco, Ariane Schwank, Swantje Beyer, David Gisi, Mandy Scheermesser, André Meichtry, Noriane Sievi, Thomas Hess and Markus Wirz

    Citation: BMC Pulmonary Medicine 2017 17:115

    Content type: Study protocol

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  32. The most commonly applied treatment for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is a 5-day course of high-dose systemic corticosteroids. However, this treatment has not been shown...

    Authors: Pradeesh Sivapalan, Mia Moberg, Josefin Eklöf, Julie Janner, Jørgen Vestbo, Rasmus Rude Laub, Andrea Browatzki, Karin Armbruster, Jon Torgny Wilcke, Niels Seersholm, Ulla Møller Weinreich, Ingrid Louise Titlestad, Helle Frost Andreassen, Charlotte Suppli Ulrik, Uffe Bødtger, Thyge Lynghøj Nielsen…

    Citation: BMC Pulmonary Medicine 2017 17:114

    Content type: Study protocol

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  33. Brain pathology is relatively unexplored in chronic obstructive pulmonary disease (COPD). This study is a comprehensive investigation of grey matter (GM) and white matter (WM) changes and how these relate to d...

    Authors: Catherine A. Spilling, Paul W. Jones, James W. Dodd and Thomas R. Barrick

    Citation: BMC Pulmonary Medicine 2017 17:92

    Content type: Research article

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  34. Chronic obstructive pulmonary disease (COPD) severely hinders quality of life for those affected and is costly to the health care system. Care gaps in areas such as pharmacotherapy, inhaler technique, and know...

    Authors: Beatrice Huang, Rachel Willard-Grace, Denise De Vore, Jessica Wolf, Chris Chirinos, Stephanie Tsao, Danielle Hessler, George Su and David H. Thom

    Citation: BMC Pulmonary Medicine 2017 17:90

    Content type: Study protocol

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    The Correction to this article has been published in BMC Pulmonary Medicine 2019 19:96

  35. Influenza is a frequent cause of exacerbations of chronic obstructive pulmonary disease (COPD). Exacerbations are associated with worsening of the airflow obstruction, hospitalisation, reduced quality of life,...

    Authors: Rafik Bekkat-Berkani, Tom Wilkinson, Philippe Buchy, Gael Dos Santos, Dimitris Stefanidis, Jeanne-Marie Devaster and Nadia Meyer

    Citation: BMC Pulmonary Medicine 2017 17:79

    Content type: Research article

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  36. In patients with diffuse lung diseases, differentiating occupational lung diseases from other diseases is clinically important. However, the value of assessing asbestos and particles in bronchoalveolar lavage ...

    Authors: Takashi Kido, Yasuo Morimoto, Kazuhiro Yatera, Hiroshi Ishimoto, Takaaki Ogoshi, Keishi Oda, Kei Yamasaki, Toshinori Kawanami, Shohei Shimajiri and Hiroshi Mukae

    Citation: BMC Pulmonary Medicine 2017 17:71

    Content type: Research article

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  37. Asthma–COPD overlap syndrome (ACOS) prevalence varies depending on the studied population and definition criteria. The prevalence and clinical characteristics of ACOS in an at-risk COPD primary care population...

    Authors: Maria Montes de Oca, Maria Victorina Lopez Varela, Maria E. Laucho-Contreras, Alejandro Casas, Eduardo Schiavi and Juan Carlos Mora

    Citation: BMC Pulmonary Medicine 2017 17:69

    Content type: Research article

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  38. Infective exacerbations of COPD are common and are accompanied by neutrophilic bronchitis in sputum. Increased respiratory iron content has been associated with respiratory tract infection, though it is unclea...

    Authors: Sindu Mohan, Terence Ho, Melanie Kjarsgaard, Katherine Radford, A. S. M. Borhan, Lehana Thabane and Parameswaran Nair

    Citation: BMC Pulmonary Medicine 2017 17:60

    Content type: Research article

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  39. The characteristics and natural history of GOLD B COPD patients are not well described. The clinical characteristics and natural history of GOLD B patients over 1 year in a multicentre cohort of COPD patients ...

    Authors: Philip J. Lawrence, Umme Kolsum, Vandana Gupta, Gavin Donaldson, Richa Singh, Bethan Barker, Leena George, Adam Webb, Anthony J. Brookes, Christopher Brightling, Jadwiga Wedzicha and Dave Singh

    Citation: BMC Pulmonary Medicine 2017 17:42

    Content type: Research article

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  41. Main risk factor for the development of chronic obstructive pulmonary disease (COPD) is smoking, although only less than 1/3 of smokers develop clinically manifest COPD. COPD’s progressive nature with high dis...

    Authors: Žarko Vrbica, Marina Labor, Ivan Gudelj, Slavica Labor, Iva Jurić and Davor Plavec

    Citation: BMC Pulmonary Medicine 2017 17:36

    Content type: Study protocol

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  42. To investigate if age, gender and smoking are associated with airway wall thickness (AWT) measured by high resolution computed tomography (HRCT) and if higher AWT is associated with lower levels of pulmonary f...

    Authors: Eef D. Telenga, Matthijs Oudkerk, Peter M. A. van Ooijen, Rozemarijn Vliegenthart, Nick H. T. ten Hacken, Dirkje S. Postma and Maarten van den Berge

    Citation: BMC Pulmonary Medicine 2017 17:27

    Content type: Research article

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  43. The purpose of this study was to evaluate the correlation between immediate responsiveness with the short-acting β2-agonist salbutamol and effects of treatment with the ultra-long-acting β2-agonist indacaterol in...

    Authors: Pierre-Régis Burgel, Vincent Le Gros, Laurent Decuypère, Isabelle Bourdeix, Thierry Perez and Gaëtan Deslée

    Citation: BMC Pulmonary Medicine 2017 17:25

    Content type: Research article

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  44. Chronic obstructive pulmonary disease (COPD) has been associated with periodontal disease (PD), and periodontal treatment (PT) has been connected to reduction of lung disease exacerbations. Bronchiectasis has ...

    Authors: Sergio Romero Santos, Erika Horácio Pinto, Priscila Larcher Longo, Simone Dal Corso, Fernanda Cordoba Lanza, Rafael Stelmach, Samia Zahi Rached, Adriana Lino-dos-Santos-Franco, Marcia Pinto Alves Mayer, Sandra Kalil Bussadori, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari and Anna Carolina Ratto Tempestini Horliana

    Citation: BMC Pulmonary Medicine 2017 17:23

    Content type: Study protocol

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    The Erratum to this article has been published in BMC Pulmonary Medicine 2017 17:51

  45. Patients with chronic obstructive pulmonary disease (COPD) have increased cardiovascular risk. Natriuretic peptides (NP) in other populations are useful in identifying cardiovascular disease, stratifying risk,...

    Authors: Nathaniel M. Hawkins, Amit Khosla, Sean A. Virani, John J. V. McMurray and J Mark FitzGerald

    Citation: BMC Pulmonary Medicine 2017 17:11

    Content type: Research article

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  46. Long-term oxygen therapy (LTOT) is the only component of the management of chronic obstructive pulmonary disease (COPD) that improves survival in patients with severe daytime hypoxemia. LTOT is usually provide...

    Authors: Yves Lacasse, Sarah Bernard, Frédéric Sériès, Van Hung Nguyen, Jean Bourbeau, Shawn Aaron and François Maltais

    Citation: BMC Pulmonary Medicine 2017 17:8

    Content type: Study protocol

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  47. Chronic obstructive pulmonary disease (COPD) is an important differential diagnosis in heart failure (HF). However, routine use of spirometry in outpatient HF clinics is not implemented. The aim of the present...

    Authors: Morten Dalsgaard, Louis Lind Plesner, Morten Schou, Erik Kjøller, Jørgen Vestbo and Kasper Iversen

    Citation: BMC Pulmonary Medicine 2017 17:6

    Content type: Research article

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  48. Physical and psychological symptoms are the hallmark of patients’ subjective perception of their illness. The purpose of this analysis was to determine if patients with COPD have distinctive symptom profiles a...

    Authors: Huong Q. Nguyen, Jerald R. Herting, Kenneth C. Pike, Sina A. Gharib, Gustavo Matute-Bello, Soo Borson, Ruth Kohen, Sandra G. Adams and Vincent S. Fan

    Citation: BMC Pulmonary Medicine 2016 16:173

    Content type: Research article

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  49. Hypoxemia is a major complication of COPD and is a strong predictor of mortality. We previously identified independent risk factors for the presence of resting hypoxemia in the COPDGene cohort. However, little...

    Authors: J. Michael Wells, Raul San Jose Estepar, Merry-Lynn N. McDonald, Surya P. Bhatt, Alejandro A. Diaz, William C. Bailey, Francine L. Jacobson, Mark T. Dransfield, George R. Washko, Barry J. Make, Richard Casaburi, Edwin J. R. van Beek, Eric A. Hoffman, Frank C. Sciurba, James D. Crapo, Edwin K. Silverman…

    Citation: BMC Pulmonary Medicine 2016 16:169

    Content type: Research article

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  50. Cardiovascular disease (CVD) is a common comorbidity in chronic obstructive pulmonary disease (COPD). Cardiac troponin (cTn) elevation, indicating myocardial injury, is frequent during acute COPD exacerbations...

    Authors: Anke Neukamm, Gunnar Einvik, Arne Didrik Høiseth, Vidar Søyseth, Nils Henrik Holmedahl, Natalia Kononova and Torbjørn Omland

    Citation: BMC Pulmonary Medicine 2016 16:164

    Content type: Research article

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