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COPD and occupational lung disease

This section concerns all aspects of COPD, occupational lung disease, and smoking-related disorders including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Diet can help preserve lung function in smokers, in addition to avoidance of smoking. The study aimed to evaluate associations between dietary patterns and lung function in smokers without respiratory disease.

    Authors: Mar Sorli-Aguilar, Francisco Martin-Lujan, Gemma Flores-Mateo, Victoria Arija-Val, Josep Basora-Gallisa and Rosa Sola-Alberich

    Citation: BMC Pulmonary Medicine 2016 16:162

    Content type: Research article

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  2. Carotid body O2-chemosensitivity determines the hypoxic ventilatory response (HVR) as part of crucial regulatory reflex within oxygen homeostasis. Nicotine has been suggested to attenuate HVR in neonates of smoki...

    Authors: Wulf Hildebrandt, Roland Sauer, Ulrich Koehler, Peter Bärtsch and Ralf Kinscherf

    Citation: BMC Pulmonary Medicine 2016 16:159

    Content type: Research article

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  3. The incidence and prevalence of chronic kidney disease (CKD) continue to rise worldwide. Increasing age, diabetes, hypertension, and cigarette smoking are well-recognized risk factors for CKD. Chronic obstruct...

    Authors: Swarna Gaddam, Sameer K. Gunukula, James W. Lohr and Pradeep Arora

    Citation: BMC Pulmonary Medicine 2016 16:158

    Content type: Research article

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  4. Although a number of studies have suggested that the use of Telemonitoring (TM) in patients with Chronic Obstructive Pulmonary Disease (COPD) can be useful and efficacious, its real utility in detecting Acute ...

    Authors: Andrea Vianello, Massimo Fusello, Lorenzo Gubian, Claudia Rinaldo, Claudio Dario, Alessandra Concas, Claudio Saccavini, Laura Battistella, Giulia Pellizzon, Giuseppe Zanardi and Silvia Mancin

    Citation: BMC Pulmonary Medicine 2016 16:157

    Content type: Research article

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  5. Reduced lung function in patients with chronic obstructive pulmonary disease (COPD) is likely due to both environmental and genetic factors. We report here a targeted high-throughput DNA sequencing approach to...

    Authors: Hans Matsson, Cilla Söderhäll, Elisabet Einarsdottir, Maxime Lamontagne, Sanna Gudmundsson, Helena Backman, Anne Lindberg, Eva Rönmark, Juha Kere, Don Sin, Dirkje S. Postma, Yohan Bossé, Bo Lundbäck and Joakim Klar

    Citation: BMC Pulmonary Medicine 2016 16:146

    Content type: Research article

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  6. Due to the heterogeneous and systemic nature of the chronic obstructive pulmonary disease (COPD), the new guidelines are oriented toward individualized attention. Multidimensional scales could facilitate its p...

    Authors: Maite Espantoso-Romero, Miguel Román Rodríguez, Ana Duarte-Pérez, Jaime Gonzálvez-Rey, Pedro A. Callejas-Cabanillas, Durdica Kasuba Lazic, Berta Anta-Agudo, Pere Torán Monserrat, Rosa Magallon-Botaya, Biljana Gerasimovska Kitanovska, Heidrun Lingner, Radost S. Assenova, Claudia Iftode, Francisco Gude-Sampedro and Ana Clavería

    Citation: BMC Pulmonary Medicine 2016 16:143

    Content type: Study protocol

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  7. Chronic obstructive pulmonary disease (COPD) patients often present considerable individual medical burden in their symptoms, limitations, and well-being that complicate medical treatment. To improve their ove...

    Authors: Bernardino Alcazar, Pilar de Lucas, Joan B. Soriano, Alonso Fernández-Nistal, Antonia Fuster, Jose Miguel Rodríguez González-Moro, Aurelio Arnedillo, Patricia García Sidro and María José Espinosa de los Monteros

    Citation: BMC Pulmonary Medicine 2016 16:140

    Content type: Research article

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  8. In many countries worldwide, the long-acting anticholinergic drug tiotropium is available as a dry powder formulation delivered by means of the HandiHaler® inhalation device and as an aqueous solution delivere...

    Authors: Ronald Dahl and Alan Kaplan

    Citation: BMC Pulmonary Medicine 2016 16:135

    Content type: Research article

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  9. Pulmonary rehabilitation (PR) is an effective intervention for the management of people with chronic obstructive pulmonary disease (COPD). However, available resources are often limited, and many patients bear...

    Authors: Paolo Zanaboni, Birthe Dinesen, Audhild Hjalmarsen, Hanne Hoaas, Anne E. Holland, Cristino Carneiro Oliveira and Richard Wootton

    Citation: BMC Pulmonary Medicine 2016 16:126

    Content type: Study protocol

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  10. Inability to maintain upper-airway patency during sleep is a cause of obstructive sleep apnea (OSA) and its sequelae. The associated syndrome (OSAS) is common in obese populations, currently, nocturnal polysom...

    Authors: Arikin Abdeyrim, Liang Tang, Arzugl Muhamat, Kelimu Abudeyrim, YongPing Zhang, NanFang Li, Yinchun Wang and Minghua Zhao

    Citation: BMC Pulmonary Medicine 2016 16:125

    Content type: Research article

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  11. Autonomic dysfunction in patients with chronic obstructive pulmonary disease (COPD) may increase the risks of arrhythmia and sudden death. We studied cardiac autonomic function in patients with acute exacerbat...

    Authors: Xingde Wang, Zhaohua Jiang, Bin Chen, Li Zhou, Zhibin Kong, Sheng Zuo, Hua Liu and Shaojun Yin

    Citation: BMC Pulmonary Medicine 2016 16:124

    Content type: Research article

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  12. COPD is a highly complex disease to manage as patients show great variation in symptoms and limitations in daily life. In the last decade self-management support of COPD has been introduced as an effective met...

    Authors: E. P. W. A. Talboom-Kamp, N. A. Verdijk, C. M. G. Blom, L. M. Harmans, I. J. S. H. Talboom, M. E. Numans and N. H. Chavannes

    Citation: BMC Pulmonary Medicine 2016 16:121

    Content type: Study protocol

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  13. Sleep disturbance is a common complaint in patients with chronic obstructive lung disease (COPD). However, the factors resulting in sleep disturbance remain unclear. This retrospective, observational, multicen...

    Authors: Chih-Hao Chang, Li-Pang Chuang, Shih-Wei Lin, Chung-Shu Lee, Ying-Huang Tsai, Yu-Feng Wei, Shih-Lung Cheng, Jeng-Yuan Hsu, Ping-Hung Kuo, Chong-Jen Yu and Ning-Hung Chen

    Citation: BMC Pulmonary Medicine 2016 16:118

    Content type: Research article

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  14. Promotion of a healthy lifestyle and non-pharmacological interventions in the treatment of chronic obstructive pulmonary disease (COPD) has received great attention in recent decades. The aim of this study was...

    Authors: Henrik Hansen, Nina Føns Johnsen and Stig Molsted

    Citation: BMC Pulmonary Medicine 2016 16:110

    Content type: Research article

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  15. Abediterol is a novel, once-daily long-acting β2-agonist in development for the treatment of chronic obstructive pulmonary disease (COPD) and asthma in combination with an anti-inflammatory agent. This Phase IIa,...

    Authors: Jutta Beier, Helena Pujol, Beatriz Seoane, Eulalia Jimenez, Carol Astbury, Eric Massana, Sandrine Ruiz and Gonzalo de Miquel

    Citation: BMC Pulmonary Medicine 2016 16:102

    Content type: Research article

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  16. Chronic Obstructive Pulmonary Disease (COPD) influences different aspects of patient’s health-related quality of life (HRQL). While disease-specific HRQL instruments focus on symptoms and functional impairment...

    Authors: Margarethe E. Wacker, Rudolf A. Jörres, Annika Karch, Sarah Wilke, Joachim Heinrich, Stefan Karrasch, Armin Koch, Holger Schulz, Henrik Watz, Reiner Leidl, Claus Vogelmeier and Rolf Holle

    Citation: BMC Pulmonary Medicine 2016 16:70

    Content type: Research article

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  17. Endotoxin from Gram-negative bacteria are found in different concentrations in dust and on the ground of laboratories dealing with small animals and animal houses.

    Authors: Amanda Souza Freitas, Christian Silva Simoneti, Erica Ferraz, Ericson Bagatin, Izaira Tincani Brandão, Celio Lopes Silva, Marcos Carvalho Borges and Elcio Oliveira Vianna

    Citation: BMC Pulmonary Medicine 2016 16:69

    Content type: Research article

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  19. Determining physicians’ awareness about alpha-1 antitrypsin (AAT) deficiency (AATD) may help to explain the discrepancy between the observed and expected number of patients diagnosed with this disease.

    Authors: Cristina Esquinas, Miriam Barrecheguren, Maria Sucena, Esther Rodriguez, Sandra Fernandez and Marc Miravitlles

    Citation: BMC Pulmonary Medicine 2016 16:64

    Content type: Research article

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  20. Objectives of this study were to evaluate the prevalence of thoracic pain in patients with chronic obstructive pulmonary disease (COPD) and its relationship with Forced Expiratory Volume in the first second (FEV1

    Authors: D. J. A. Janssen, E. F. M. Wouters, Y. Lozano Parra, K. Stakenborg and F. M. E. Franssen

    Citation: BMC Pulmonary Medicine 2016 16:47

    Content type: Research article

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  21. In chronic obstructive pulmonary disease, the prognosis for patients who have survived an episode of acute hypercapnic respiratory failure due to an exacerbation is poor. Despite being shown to improve surviva...

    Authors: Kasper Linde Ankjærgaard, Philip Tønnesen, Lars Christian Laursen, Ejvind Frausing Hansen, Helle Frost Andreassen and Jon Torgny Wilcke

    Citation: BMC Pulmonary Medicine 2016 16:32

    Content type: Study protocol

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  22. Cigarette smoking-induced oxidative stress is known to be a key mechanism in COPD pathogenesis. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a central transcription factor that regulates the antioxida...

    Authors: Kazuhiro Yamada, Kazuhisa Asai, Fumihiro Nagayasu, Kanako Sato, Naoki Ijiri, Naoko Yoshii, Yumiko Imahashi, Tetsuya Watanabe, Yoshihiro Tochino, Hiroshi Kanazawa and Kazuto Hirata

    Citation: BMC Pulmonary Medicine 2016 16:27

    Content type: Research article

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  23. Oxygen desaturation during exercise is common in people with chronic obstructive pulmonary disease (COPD). The aim of the study is to determine, in people with COPD who desaturate during exercise, whether supp...

    Authors: Jennifer A Alison, Zoe J McKeough, Sue C Jenkins, Anne E Holland, Kylie Hill, Norman R Morris, Regina WM Leung, Kathleen A Williamson, Lissa M Spencer, Catherine J Hill, Annemarie L Lee, Helen Seale, Nola Cecins and Christine F McDonald

    Citation: BMC Pulmonary Medicine 2016 16:25

    Content type: Study protocol

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  24. Conventional spirometric parameters have shown poor correlation with symptoms and health status of chronic obstructive pulmonary disease (COPD). While it is well-known that the pattern of the expiratory flow-v...

    Authors: Jungsil Lee, Choon-Taek Lee, Jae Ho Lee, Young-Jae Cho, Jong Sun Park, Yeon-Mok Oh, Sang-Do Lee and Ho Il Yoon

    Citation: BMC Pulmonary Medicine 2016 16:18

    Content type: Research article

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    The Erratum to this article has been published in BMC Pulmonary Medicine 2016 16:115

  25. Precision and accuracy assurance in cardiopulmonary exercise testing (CPET) facilitates multicenter clinical trials by maximizing statistical power and minimizing participant risk. Current guidelines recommend...

    Authors: Janos Porszasz, Susan Blonshine, Robert Cao, Heather A. Paden, Richard Casaburi and Harry B. Rossiter

    Citation: BMC Pulmonary Medicine 2016 16:13

    Content type: Research article

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  26. Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder partially resistant to glucocorticoids. A reduced histone deacetylase (HDAC) activity has been proposed to explain this resistance. Haemoph...

    Authors: Borja G. Cosío, Andreas Jahn, Amanda Iglesias, Hanaa Shafiek, Xavier Busquets and Alvar Agustí

    Citation: BMC Pulmonary Medicine 2015 15:157

    Content type: Research article

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  27. Little is known about the relationship between hemoglobin concentrations, functional status and health related quality of life (HRQL) in chronic obstructive pulmonary disease (COPD). Our aim was to investigate...

    Authors: Marcello Ferrari, Lorenzo Manea, Kamel Anton, Paola Bruzzone, Mara Meneghello, Francesco Zamboni, Luigi Purgato, Lucia Cazzoletti, Pietro Ferrari and Renato Testi

    Citation: BMC Pulmonary Medicine 2015 15:58

    Content type: Research article

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  28. Dietary nitrate supplementation has been shown to decrease the oxygen cost of exercise and prolong exercise tolerance, as measured by sub-maximal exercise endurance distance and time at 85% V̇O2max, in both elite...

    Authors: Paul Leong, Jane E Basham, Theresa Yong, Adrian Chazan, Paul Finlay, Sara Barnes, Phillip G Bardin and Donald Campbell

    Citation: BMC Pulmonary Medicine 2015 15:52

    Content type: Research article

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  29. Neurohumoral activation is present in COPD and might provide a link between pulmonary and systemic effects, especially cardiovascular disease. Because long acting inhaled β-agonists reduce hyperinflation, they...

    Authors: Helge Haarmann, Cordula Mohrlang, Uta Tschiesner, David B Rubin, Thore Bornemann, Karin Rüter, Slavtcho Bonev, Tobias Raupach, Gerd Hasenfuß and Stefan Andreas

    Citation: BMC Pulmonary Medicine 2015 15:46

    Content type: Research article

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  30. We studied the value of routine biochemical variables albumin, C-reactive protein (CRP) and lactate dehydrogenase (LDH) to improve prediction and monitoring of acute respiratory distress syndrome (ARDS) severi...

    Authors: Sandra H Hoeboer, Heleen M Oudemans-van Straaten and AB Johan Groeneveld

    Citation: BMC Pulmonary Medicine 2015 15:22

    Content type: Research article

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  31. Secretory leukocyte protease inhibitor (SLPI) is a protein with anti-protease and antimicrobial properties that is constitutively secreted from the airway epithelium. The importance of maintaining a balance be...

    Authors: Lisa I Påhlman, Annika Jögi, Magnus Gram, Michiko Mori and Arne Egesten

    Citation: BMC Pulmonary Medicine 2015 15:19

    Content type: Research article

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  32. The prevalence of diagnosed chronic obstructive pulmonary disease (COPD) in the UK is 1.8%, although it is estimated that this represents less than half of the total disease in the population as much remains u...

    Authors: Manbinder S Sidhu, Amanda Daley, Rachel Jordan, Peter A Coventry, Carl Heneghan, Sue Jowett, Sally Singh, Jennifer Marsh, Peymane Adab, Jinu Varghese, David Nunan, Amy Blakemore, Jenny Stevens, Lee Dowson, David Fitzmaurice and Kate Jolly

    Citation: BMC Pulmonary Medicine 2015 15:16

    Content type: Study protocol

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  33. Patients with precapillary pulmonary hypertension (PH) have been reported to suffer from poor sleep quality, however, if this is related to physical exercise performance has not yet been thoroughly investigated.

    Authors: Henning Tiede, Janet Rorzyczka, Rio Dumitrascu, Michael Belly, Frank Reichenberger, Hossein Ardeschir Ghofrani, Werner Seeger, Jörg Heitmann and Richard Schulz

    Citation: BMC Pulmonary Medicine 2015 15:11

    Content type: Research article

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  34. Antibiotic-resistant strains of pathogenic bacteria are increasingly prevalent in hospitals and the community. Acute exacerbations of COPD (AE-COPD) often result in administration of antibiotics although more ...

    Authors: Gernot G U Rohde, Armin Koch and Tobias Welte

    Citation: BMC Pulmonary Medicine 2015 15:5

    Content type: Study protocol

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  35. Under-diagnosis of COPD is an important unmet medical need. We investigated the characteristics and prognosis of hospitalised patients with undiagnosed COPD.

    Authors: Eva Balcells, Elena Gimeno-Santos, Jordi de Batlle, Maria Antonia Ramon, Esther Rodríguez, Marta Benet, Eva Farrero, Antoni Ferrer, Stefano Guerra, Jaume Ferrer, Jaume Sauleda, Joan A Barberà, Àlvar Agustí, Robert Rodriguez-Roisin, Joaquim Gea, Josep M Antó…

    Citation: BMC Pulmonary Medicine 2015 15:4

    Content type: Research article

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  36. A variety of large randomized controlled trials (RCT’s) evaluating pharmacotherapy in chronic obstructive pulmonary disease (COPD) patients does exist. One of the drugs that has been tested is the new long-act...

    Authors: Peter Kardos, Claus Vogelmeier, Roland Buhl, Carl-Peter Criée and Heinrich Worth

    Citation: BMC Pulmonary Medicine 2015 15:2

    Content type: Study protocol

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  37. This study evaluated the effects of aclidinium bromide, a long-acting muscarinic antagonist indicated for maintenance treatment of chronic obstructive pulmonary disease (COPD), on exercise endurance, dyspnea, ...

    Authors: Kai M Beeh, Henrik Watz, Luis Puente-Maestu, Luis de Teresa, Diana Jarreta, Cynthia Caracta, Esther Garcia Gil and Helgo Magnussen

    Citation: BMC Pulmonary Medicine 2014 14:209

    Content type: Research article

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  38. Tracheostomy is one of the most common surgical procedures performed in critical care patient management; more specifically, ventilation through tracheal cannula allows removal of the endotracheal tube (ETT). ...

    Authors: Pierachille Santus, Andrea Gramegna, Dejan Radovanovic, Rita Raccanelli, Vincenzo Valenti, Dimitri Rabbiosi, Michele Vitacca and Stefano Nava

    Citation: BMC Pulmonary Medicine 2014 14:201

    Content type: Research article

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  39. To evaluate noninvasive ventilation (NIV) in diffuse interstitial lung diseases (DILD) patients with acute respiratory failure (ARF) according to baseline radiological patterns and the etiology of ARF.

    Authors: Stefano Aliberti, Grazia Messinesi, Silvia Gamberini, Sveva Maggiolini, Dina Visca, Vanni Galavotti, Fabio Giuliani, Roberto Cosentini, Anna Maria Brambilla, Francesco Blasi, Raffaele Scala, Mauro Carone, Francesca Luisi, Sergio Harari, Antonio Voza, Antonio Esquinas…

    Citation: BMC Pulmonary Medicine 2014 14:194

    Content type: Research article

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  40. The COPD Assessment Test (CAT™) is a new questionnaire that has been developed recently for measuring the COPD patient’s health status. It is known to have a good correlation with disease specific health statu...

    Authors: Chaicharn Pothirat, Sumalee Kiatboonsri and Charoen Chuchottaworn

    Citation: BMC Pulmonary Medicine 2014 14:193

    Content type: Research article

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  41. An innovative approach to lung volume reduction (LVR) for emphysema is introduced in the design of the Sequential Segmental Treatment of Emphysema with Upper Lobe Predominance (STEP-UP) trial where vapour abla...

    Authors: Arschang Valipour, Felix JF Herth, Ralf Eberhardt, Pallav L Shah, Avina Gupta, Robert Barry, Erik Henne, Sourish Bandyopadhyay and Greg Snell

    Citation: BMC Pulmonary Medicine 2014 14:190

    Content type: Study protocol

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  42. Increased small airway resistance and decreased lung elasticity contribute to the airflow limitation in chronic obstructive pulmonary disease (COPD). The lesion that corresponds to loss of lung elasticity is e...

    Authors: Sergey Stepaniants, I-Ming Wang, Yves Boie, James Mortimer, Brian Kennedy, Mark Elliott, Shizu Hayashi, Honglin Luo, Jerry Wong, Leanna Loy, Silvija Coulter, Christopher J Roberts, James C Hogg, Don D Sin, Gary O’Neill, Michael Crackower…

    Citation: BMC Pulmonary Medicine 2014 14:187

    Content type: Research article

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  43. Depression is a common comorbidity among patients with Chronic Obstructive Pulmonary Disease (COPD) and has a significant impact on the course of the disease. The aim of this study is to determine association ...

    Authors: José Laerte R Silva Júnior, Marcus Barreto Conde, Krislainy de Sousa Corrêa, Christina da Silva, Leonardo da Silva Prestes and Marcelo Fouad Rabahi

    Citation: BMC Pulmonary Medicine 2014 14:186

    Content type: Research article

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  44. This paper reviews evidence and quality of Systematic Reviews (SRs) on the effects of breathing control exercises (BCEs) and respiratory muscle training (RMT) on breathlessness/dyspnea and other symptoms, and ...

    Authors: Christine Råheim Borge, Kåre Birger Hagen, Anne Marit Mengshoel, Ernst Omenaas, Torbjørn Moum and Astrid Klopstad Wahl

    Citation: BMC Pulmonary Medicine 2014 14:184

    Content type: Research article

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  45. Authors: Victoria M Lord, Victoria J Hume, Julia L Kelly, Phoene Cave, Judith Silver, Maya Waldman, Chris White, Cayley Smith, Rebecca Tanner, Melissa Sanchez, William D-C Man, Michael I Polkey and Nicholas S Hopkinson

    Citation: BMC Pulmonary Medicine 2014 14:181

    Content type: Erratum

    Published on:

    The original article was published in BMC Pulmonary Medicine 2012 12:69

  46. The study aimed to determine the short and long-term effects of exercise training on exercise capacity and health-related quality of life (HRQoL) compared to usual care in people with dust-related pleural and ...

    Authors: Marita T Dale, Zoe J McKeough, Phillip A Munoz, Peter Corte, Peter T P Bye and Jennifer A Alison

    Citation: BMC Pulmonary Medicine 2014 14:180

    Content type: Research article

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  47. The Global Initiative defines COPD for chronic obstructive lung disease as an entirely preventable and treatable disease characterized by sputum production, bacterial colonisation, neutrophilic bronchial airwa...

    Authors: Dachang Wu, Chenxia Hou, Yanxia Li, Zinan Zhao, Jianjun Liu, Xin Lu, Xueqi Shang and Yi Xin

    Citation: BMC Pulmonary Medicine 2014 14:179

    Content type: Research article

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  48. Aclidinium/formoterol is a twice-daily (BID) fixed-dose combination (FDC) in development for chronic obstructive pulmonary disease (COPD). The efficacy and safety of aclidinium/formoterol versus monotherapy an...

    Authors: Dave Singh, Paul W Jones, Eric D Bateman, Stephanie Korn, Cristina Serra, Eduard Molins, Cynthia Caracta, Esther Garcia Gil and Anne Leselbaum

    Citation: BMC Pulmonary Medicine 2014 14:178

    Content type: Research article

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  49. Genetic factors play a role in the development and severity of chronic obstructive pulmonary disease (COPD). The pathogenesis of COPD is a multifactorial process including an inflammatory cell profile. Recent ...

    Authors: Xinyan Wang, Wan Li, Kun Huang, Xiaowen Kang, Zhaoguo Li, Chengcheng Yang, Xiaomei Wu and Lina Chen

    Citation: BMC Pulmonary Medicine 2014 14:173

    Content type: Research article

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  50. The 6-Minute Walk Test (6MWT) is representative of daily-life activities and reflects the functional capacity of patients. The change of oxygen uptake (VO2) in the initial phase of low-intensity exercise (VO2 kin...

    Authors: Lukas Kern, Sophie Condrau, Florent Baty, Jan Wiegand, Arno JR van Gestel, Andrea Azzola, Michael Tamm and Martin Brutsche

    Citation: BMC Pulmonary Medicine 2014 14:167

    Content type: Research article

    Published on:

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