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COPD and occupational lung disease

This section concerns all aspects of COPD, occupational lung disease, and smoking-related disorders including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Chronic obstructive pulmonary disease (COPD) has been classically divided into blue bloaters and pink puffers. The utility of these clinical subtypes is unclear. However, the broader distinction between airway...

    Authors: Craig P Hersh, Barry J Make, David A Lynch, R Graham Barr, Russell P Bowler, Peter MA Calverley, Peter J Castaldi, Michael H Cho, Harvey O Coxson, Dawn L DeMeo, Marilyn G Foreman, MeiLan K Han, Benjamin J Harshfield, John E Hokanson, Sharon Lutz, Joe W Ramsdell…

    Citation: BMC Pulmonary Medicine 2014 14:164

    Content type: Research article

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  2. The 2013 GOLD classification system for COPD distinguishes four stages: A (low symptoms, low exacerbation risk), B (high symptoms, low risk), C (low symptoms, high risk) and D (high symptoms, high risk). Asses...

    Authors: Lucas M A Goossens, Inge Leimer, Norbert Metzdorf, Karin Becker and Maureen P M H Rutten-van Mölken

    Citation: BMC Pulmonary Medicine 2014 14:163

    Content type: Research article

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  3. Indacaterol is a long-acting beta-2 agonist for once-daily treatment of COPD. We evaluated the effects of indacaterol 150 μg on lung hyperinflation compared with placebo and open-label tiotropium 18 μg. We mea...

    Authors: Henrik Watz, Felix Krippner, Anne Kirsten, Helgo Magnussen and Claus Vogelmeier

    Citation: BMC Pulmonary Medicine 2014 14:158

    Content type: Research article

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  4. Many people with clinically significant chronic obstructive pulmonary disease (COPD) remain undiagnosed worldwide. There are a number of small studies which have examined possible methods of case finding throu...

    Authors: Rachel E Jordan, Peymané Adab, Sue Jowett, Jen L Marsh, Richard D Riley, Alexandra Enocson, Martin R Miller, Brendan G Cooper, Alice M Turner, Jon G Ayres, Kar Keung Cheng, Kate Jolly, Robert A Stockley, Sheila Greenfield, Stanley Siebert, Amanda Daley…

    Citation: BMC Pulmonary Medicine 2014 14:157

    Content type: Study protocol

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  5. This retrospective cohort study aimed to determine if there are differences in cardiovascular co-morbidities, blood pressure (BP) and continuous positive airway pressure (CPAP) use between patients with positi...

    Authors: Yi-Chih Huang, Chun-Yao Lin, Chou-Chin Lan, Yao-Kuang Wu, Chor-Shen Lim, Chun-Yao Huang, Hsuan-Li Huang, Kuan-Hung Yeh, Yu-Chih Liu and Mei-Chen Yang

    Citation: BMC Pulmonary Medicine 2014 14:153

    Content type: Research article

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  6. Indoor particulate matter (PM) has been linked to respiratory symptoms in former smokers with COPD. While subjects with COPD and atopy have also been shown to have more frequent respiratory symptoms, whether t...

    Authors: Deepak A Kaji, Andrew J Belli, Meredith C McCormack, Elizabeth C Matsui, D’Ann L Williams, Laura Paulin, Nirupama Putcha, Roger D Peng, Gregory B Diette, Patrick N Breysse and Nadia N Hansel

    Citation: BMC Pulmonary Medicine 2014 14:147

    Content type: Research article

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  7. Strength training and neuromuscular electrical stimulation (NMES) are effective training modalities for improving muscle function, exercise performance and health status in individuals with COPD. The aim of th...

    Authors: Maurice JH Sillen, Frits ME Franssen, Anouk W Vaes, Jeannet ML Delbressine, Emiel FM Wouters and Martijn A Spruit

    Citation: BMC Pulmonary Medicine 2014 14:146

    Content type: Research article

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  8. Moderate-intensity exercise training improves skeletal muscle aerobic capacity and increased oxidative enzyme activity, as well as exercise tolerance in COPD patients.

    Authors: Chun-Hua Wang, Pai-Chien Chou, Wen-Ching Joa, Li-Fei Chen, Te-Fang Sheng, Shu-Chuan Ho, Horng-Chyuan Lin, Chien-Da Huang, Fu-Tsai Chung, Kian Fan Chung and Han-Pin Kuo

    Citation: BMC Pulmonary Medicine 2014 14:142

    Content type: Research article

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  9. Chronic thromboembolic pulmonary hypertension (CTEPH) is a long-term complication following an acute pulmonary embolism (PE). It is frequently diagnosed at advanced stages which is concerning as delayed treatm...

    Authors: Matthias Held, Alexander Hesse, Franziska Gött, Regina Holl, Gudrun Hübner, Philipp Kolb, Heinz Jakob Langen, Tobias Romen, Franziska Walter, Hans Joachim Schäfers, Heinrike Wilkens and Berthold Jany

    Citation: BMC Pulmonary Medicine 2014 14:141

    Content type: Research article

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  10. The 6-minute walk test (6MWT) is used to measure exercise capacity and assess prognosis in interstitial lung disease (ILD). Although the 6MWT is usually considered to be a test of submaximal exercise capacity ...

    Authors: Anne E Holland, Leona Dowman, Julio Fiore Jr, Danny Brazzale, Catherine J Hill and Christine F McDonald

    Citation: BMC Pulmonary Medicine 2014 14:136

    Content type: Research article

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  11. It is widely recognized that health-related quality of life (HRQL) is impaired in patients with Chronic Obstructive Pulmonary Disease (COPD), but there is a lack of research on longitudinal associations of COP...

    Authors: Margarethe E Wacker, Matthias Hunger, Stefan Karrasch, Joachim Heinrich, Annette Peters, Holger Schulz and Rolf Holle

    Citation: BMC Pulmonary Medicine 2014 14:134

    Content type: Research article

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  12. Inheritance of the F variant of alpha-1-antitrypsin is associated with normal circulating protein levels, but it is believed to be dysfunctional in its ability to inhibit neutrophil elastase and therefore has ...

    Authors: Nicola Jane Sinden, Firas Koura and Robert Andrew Stockley

    Citation: BMC Pulmonary Medicine 2014 14:132

    Content type: Research article

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  13. Long term oxygen therapy (LTOT) has a strong evidence base in COPD patients with respiratory failure, but prescribing practices are recognized to need reform to ensure appropriate use and minimize costs. In th...

    Authors: Alice M Turner, Sourav Sen, Cathryn Steeley, Yasmin Khan, Pamela Sweeney, Yvonne Richards and Rahul Mukherjee

    Citation: BMC Pulmonary Medicine 2014 14:127

    Content type: Research article

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  14. The effectiveness of clinic-based pulmonary rehabilitation in advanced COPD is well established, but few data exist for less severe patients treated in alternative settings. The purpose of this study was to in...

    Authors: Shefalee Amin, Marlon Abrazado, Molly Quinn, Thomas W Storer, Chi-Hong Tseng and Christopher B Cooper

    Citation: BMC Pulmonary Medicine 2014 14:125

    Content type: Research article

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  15. Bronchodilator medications are central to the symptomatic management of chronic obstructive pulmonary disease (COPD). Metered-dose inhalers (MDIs) are the most commonly used devices to deliver treatment to pat...

    Authors: Stephen Rennard, Charles Fogarty, Colin Reisner, Carlos Fernandez, Tracy Fischer, Michael Golden, Earl St Rose, Patrick Darken, Gregory Tardie and Chadwick Orevillo

    Citation: BMC Pulmonary Medicine 2014 14:118

    Content type: Research article

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  16. Obstructive sleep apnea (OSA) is associated with increased risk for cardiovascular morbidity and mortality. Epidemiological and animal models studies generate hypotheses for innovative strategies in OSA manage...

    Authors: Jose M Marin, Jorge Artal, Teresa Martin, Santiago J Carrizo, Marta Andres, Inmaculada Martin-Burriel, Rosa Bolea, Arianne Sanz, Luis Varona, Javier Godino, Begoña Gallego, Jose A Garcia-Erce, Isabel Villar, Victoria Gil, Marta Forner, Jose P Cubero…

    Citation: BMC Pulmonary Medicine 2014 14:114

    Content type: Study protocol

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  17. Eosinophilic airway inflammation is observed in 10-30% of COPD subjects. Whether increased eosinophils or impairment in their clearance by macrophages is associated with the severity and frequency of exacerbat...

    Authors: Osama Eltboli, Mona Bafadhel, Fay Hollins, Adam Wright, Beverley Hargadon, Neeta Kulkarni and Christopher Brightling

    Citation: BMC Pulmonary Medicine 2014 14:112

    Content type: Research article

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  18. There is still limited information on systemic inflammation in alpha-1-antitrypsin-deficient (AATD) COPD patients and what effect alpha-1-antitrypsin augmentation therapy and/or exercise might have on circulat...

    Authors: I Mark Olfert, Moh H Malek, Tomas ML Eagan, Harrieth Wagner and Peter D Wagner

    Citation: BMC Pulmonary Medicine 2014 14:106

    Content type: Research article

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  19. Clinical evaluation to differentiate the characteristic features of pulmonary fibrosis and emphysema is often difficult in patients with combined pulmonary fibrosis and emphysema (CPFE), but diagnosis of pulmo...

    Authors: Minoru Inomata, Soichiro Ikushima, Nobuyasu Awano, Keisuke Kondoh, Kohta Satake, Masahiro Masuo, Yuji Kusunoki, Atsuko Moriya, Hiroyuki Kamiya, Tsunehiro Ando, Noriyo Yanagawa, Toshio Kumasaka, Takashi Ogura, Fumikazu Sakai, Arata Azuma, Akihiko Gemma…

    Citation: BMC Pulmonary Medicine 2014 14:104

    Content type: Research article

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  20. Patients with severe chronic obstructive pulmonary disease (COPD) are at increased risk of infection by P. aeruginosa. The specific role of bronchiectasis in both infection and chronic colonization by this microo...

    Authors: Miguel Gallego, Xavier Pomares, Mateu Espasa, Eva Castañer, Mar Solé, David Suárez, Eduard Monsó and Concepción Montón

    Citation: BMC Pulmonary Medicine 2014 14:103

    Content type: Research article

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  21. Co-morbidities are common in chronic obstructive pulmonary disease (COPD). We assessed the contribution of common co-morbidities on health related quality of life (HRQoL) among COPD patients.

    Authors: Jukka Koskela, Maritta Kilpeläinen, Henna Kupiainen, Witold Mazur, Harri Sintonen, Marike Boezen, Ari Lindqvist, Dirkje Postma and Tarja Laitinen

    Citation: BMC Pulmonary Medicine 2014 14:102

    Content type: Research article

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  22. COPD patients have decreased physical fitness, and have an increased risk of vascular disease. In the general population, fitness is positively associated with resting cerebral blood flow velocity, however, li...

    Authors: Sara E Hartmann, Richard Leigh and Marc J Poulin

    Citation: BMC Pulmonary Medicine 2014 14:99

    Content type: Research article

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  23. During most COPD exacerbations, patients continue to live in the community but there is little information on changes in activity during exacerbations due to the difficulties of obtaining recent, prospective b...

    Authors: Ayedh D Alahmari, Anant RC Patel, Beverly S Kowlessar, Alex J Mackay, Richa Singh, Jadwiga A Wedzicha and Gavin C Donaldson

    Citation: BMC Pulmonary Medicine 2014 14:98

    Content type: Research article

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  24. Exercise tolerance can be assessed by the cycle endurance test (CET) and six-minute walk test (6MWT) in patients with Chronic Obstructive Pulmonary Disease (COPD). We sought to investigate the characteristics ...

    Authors: Vasileios Andrianopoulos, Scott S Wagers, Miriam TJ Groenen, Lowie E Vanfleteren, Frits ME Franssen, Frank WJM Smeenk, Ioannis Vogiatzis, Emiel F M Wouters and Martijn A Spruit

    Citation: BMC Pulmonary Medicine 2014 14:97

    Content type: Research article

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  25. Obese patients (OB) with COPD may better tolerate exercise as compared to normal weight (NW) COPD patients, even if the reason for this is not yet fully understood. We investigated the interactions between obe...

    Authors: Marina Aiello, Elisabetta Teopompi, Panagiota Tzani, Sara Ramponi, Maria Rosaria Gioia, Emilio Marangio and Alfredo Chetta

    Citation: BMC Pulmonary Medicine 2014 14:96

    Content type: Research article

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  26. Chronic systemic inflammatory syndrome has been implicated in the pathobiology of extrapulmonary manifestations of chronic obstructive pulmonary disease (COPD). We aimed to investigate which cell types within ...

    Authors: Carmen Calero, Elena Arellano, Jose Luis Lopez-Villalobos, Verónica Sánchez-López, Nicolás Moreno-Mata and José Luis López-Campos

    Citation: BMC Pulmonary Medicine 2014 14:95

    Content type: Research article

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  27. Occludin, a tight junction protein, plays an important role in maintaining the integrity of the lung epithelial barrier; however, its role in ventilation-induced lung injury has not been explored. Here, we mea...

    Authors: Mengjie Liu, Changping Gu and Yuelan Wang

    Citation: BMC Pulmonary Medicine 2014 14:94

    Content type: Research article

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  28. Ataxia telangiectasia (A-T) is a rare but devastating and progressive disorder characterized by cerebellar dysfunction, lymphoreticular malignancies and recurrent sinopulmonary infections. In A-T, disease of t...

    Authors: Olaf Eickmeier, Su Youn Kim, Eva Herrmann, Constanze Döring, Ruth Duecker, Sandra Voss, Sibylle Wehner, Christoph Hölscher, Julia Pietzner, Stefan Zielen and Ralf Schubert

    Citation: BMC Pulmonary Medicine 2014 14:93

    Content type: Research article

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  29. Risk factors of anxiety and depression symptoms in patients with chronic obstructive pulmonary disease (COPD) have been widely researched, but most of them cannot be addressed clinically. The aim of this study...

    Authors: Qiao Zhang, Jiangrong Liao, Xiuqing Liao, Xiuling Wu, Min Wan, Changzheng Wang and Qianli Ma

    Citation: BMC Pulmonary Medicine 2014 14:92

    Content type: Research article

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  30. Remodelling in COPD has at least two dimensions: small airway wall thickening and destruction of alveolar walls. Recent studies indicate that there is some similarity between alveolar and small airway wall mat...

    Authors: Irene MJ Eurlings, Mieke A Dentener, Jack PM Cleutjens, Carine J Peutz, Gernot GU Rohde, Emiel FM Wouters and Niki L Reynaert

    Citation: BMC Pulmonary Medicine 2014 14:90

    Content type: Research article

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  31. We have shown that chronic obstructive pulmonary disease (COPD) is associated with increased production of pro-inflammatory cytokines and the cytotoxic mediator, granzyme B by peripheral blood steroid resistan...

    Authors: Greg Hodge, Mark Holmes, Hubertus Jersmann, Paul N Reynolds and Sandra Hodge

    Citation: BMC Pulmonary Medicine 2014 14:85

    Content type: Research article

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  32. There is a need for agents that suppress inflammation and progression of chronic obstructive pulmonary disease. p38 mitogen-activated protein kinase (p38 MAPK) has been associated with this disorder, and sever...

    Authors: Satoshi Marumo, Yuma Hoshino, Hirofumi Kiyokawa, Naoya Tanabe, Atsuyasu Sato, Emiko Ogawa, Shigeo Muro, Toyohiro Hirai and Michiaki Mishima

    Citation: BMC Pulmonary Medicine 2014 14:79

    Content type: Research article

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  33. Obstructive sleep apnea (OSA) is a high prevalence sleep disorder characterized by upper airway obstruction during sleep, nocturnal intermittent hypoxemia, poor sleep quality, risk for cardiovascular and metab...

    Authors: Anna Lo Bue, Adriana Salvaggio, Serena Iacono Isidoro, Salvatore Romano, Oreste Marrone and Giuseppe Insalaco

    Citation: BMC Pulmonary Medicine 2014 14:78

    Content type: Research article

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  34. A recent method determines regional gas flow of the lung by electrical impedance tomography (EIT). The aim of this study is to show the applicability of this method in a porcine model of mechanical ventilation...

    Authors: Marc Bodenstein, Stefan Boehme, Stephan Bierschock, Andreas Vogt, Matthias David and Klaus Markstaller

    Citation: BMC Pulmonary Medicine 2014 14:73

    Content type: Research article

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  36. Physical exercise training aims at reducing disease-specific impairments and improving quality of life in patients with chronic obstructive pulmonary disease (COPD). COPD exacerbations in particular negatively...

    Authors: Emmylou Beekman, Ilse Mesters, Erik JM Hendriks, Jean WM Muris, Geertjan Wesseling, Silvia MAA Evers, Guus M Asijee, Annemieke Fastenau, Hannah N Hoffenkamp, Rik Gosselink, Onno CP van Schayck and Rob A de Bie

    Citation: BMC Pulmonary Medicine 2014 14:71

    Content type: Study protocol

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  37. Therapeutic adherence of patients with chronic obstructive pulmonary disease (COPD) is poor. This study evaluated the effectiveness of a multifactorial intervention on improving the therapeutic adherence in ch...

    Authors: José Leiva-Fernández, Francisca Leiva-Fernández, Antonio García-Ruiz, Daniel Prados-Torres and Pilar Barnestein-Fonseca

    Citation: BMC Pulmonary Medicine 2014 14:70

    Content type: Research article

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  38. Exercise capacity is impaired in pulmonary arterial hypertension (PAH). We hypothesized that cardiovascular reserve abnormalities would be associated with impaired hemodynamic response to pharmacological stres...

    Authors: Enric Domingo, Juan C Grignola, Rio Aguilar, Christian Arredondo, Nadia Bouteldja, Manuel López Messeguer and Antonio Roman

    Citation: BMC Pulmonary Medicine 2014 14:69

    Content type: Research article

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  39. The receptor for advanced glycation end-products (RAGE) is highly expressed in the lung, where it is believed to have a homeostatic role. Reduced plasma levels of soluble RAGE (sRAGE) have been reported in pat...

    Authors: Hiroshi Iwamoto, Jing Gao, Ville Pulkkinen, Tuula Toljamo, Pentti Nieminen and Witold Mazur

    Citation: BMC Pulmonary Medicine 2014 14:68

    Content type: Research article

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  40. Technology offers opportunities to improve healthcare, but little is known about Internet use by COPD patients. We tested two hypotheses: Internet access is associated with socio-demographic disparities and fr...

    Authors: Carlos H Martinez, Beth L St Jean, Craig A Plauschinat, Barbara Rogers, Julen Beresford, Fernando J Martinez, Caroline R Richardson and MeiLan K Han

    Citation: BMC Pulmonary Medicine 2014 14:66

    Content type: Research article

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  41. Breathing and swallowing are physiologically linked to ensure effortless gas exchange during oronasal breathing and to prevent aspiration during swallowing. Studies have indicated consistent aspiration in chro...

    Authors: Rosane de Deus Chaves, Fernanda Chiarion Sassi, Laura Davison Mangilli, Shri Krishna Jayanthi, Alberto Cukier, Bruno Zilberstein and Claudia Regina Furquim de Andrade

    Citation: BMC Pulmonary Medicine 2014 14:62

    Content type: Research article

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  42. Patients with stable COPD show improvements in exercise capacity and muscular function after the application of whole body vibration. We aimed to evaluate whether this modality added to conventional physiother...

    Authors: Timm Greulich, Christoph Nell, Janine Koepke, Juliane Fechtel, Maja Franke, Bernd Schmeck, Daniel Haid, Sandra Apelt, Silke Filipovic, Klaus Kenn, Sabina Janciauskiene, Claus Vogelmeier and Andreas Rembert Koczulla

    Citation: BMC Pulmonary Medicine 2014 14:60

    Content type: Research article

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  43. The lungs of very preterm human babies display deficits in alveolarization and vascularization as a result of the clinical use of high oxygen treatment (leading to hyperoxia) required to decrease the risk of m...

    Authors: Alexandra B Firsova, Timothy J Cole and Richard Mollard

    Citation: BMC Pulmonary Medicine 2014 14:59

    Content type: Research article

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  44. Dyspnea may be a presenting symptom in progressive systemic sclerosis (SSc). Respiratory drive (mouth occlusion pressure, MOP, at rest and during CO2 rebreathing, 7% CO2, 93% O2) is a major determinant of dyspnea...

    Authors: Maarten K Ninaber, Willem BGJ Hamersma, Annemie JM Schuerwegh and Jan Stolk

    Citation: BMC Pulmonary Medicine 2014 14:57

    Content type: Research article

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  45. In Europe, administration of an inhaled corticosteroid (ICS) combined with a long-acting β2 agonist is approved in chronic obstructive pulmonary disease (COPD) patients with a pre-bronchodilator FEV1 < 60% predic...

    Authors: Nicolas Roche, Céline Pribil, Eric Van Ganse, Philippe Serrier, Bruno Housset, Déborah Poirier, Nathalie Texier, Stéphane Schück and Isabelle Boucot

    Citation: BMC Pulmonary Medicine 2014 14:56

    Content type: Research article

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  46. Altered cardiac repolarization and increased dispersion of repolarization have been identified as risk factors for sudden cardiac death (SCD). The prevalence of and the mechanisms contributing to altered cardi...

    Authors: Noriane A Sievi, Christian F Clarenbach, Giovanni Camen, Valentina A Rossi, Arnoldus JR van Gestel and Malcolm Kohler

    Citation: BMC Pulmonary Medicine 2014 14:55

    Content type: Research article

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  47. Proactive palliative care is not yet common practice for patients with COPD. Important barriers are the identification of patients with a poor prognosis and the organization of proactive palliative care dedica...

    Authors: Ria G Duenk, Yvonne Heijdra, Stans C Verhagen, Richard PNR Dekhuijzen, Kris CP Vissers and Yvonne Engels

    Citation: BMC Pulmonary Medicine 2014 14:54

    Content type: Study protocol

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  48. Epithelial-mesenchymal transition (EMT) has been proposed as a mechanism in the progression of airway diseases and cancer. Here, we explored the role of acetylcholine (ACh) and the pathway involved in the proc...

    Authors: Kai Yang, Yun Song, Ya-Bing Tang, Zu-Peng Xu, Wei Zhou, Li-Na Hou, Liang Zhu, Zhi-Hua Yu, Hong-Zhuan Chen and Yong-Yao Cui

    Citation: BMC Pulmonary Medicine 2014 14:53

    Content type: Research article

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  49. AZD9164 has demonstrated potential as an inhaled, long-acting, muscarinic antagonist (LAMA) bronchodilator. However, in patients with COPD, but not in healthy subjects, a transient initial drop in FEV1 was observ...

    Authors: Carin Jorup, Thomas Bengtsson, Kerstin Strandgården and Ulf Sjöbring

    Citation: BMC Pulmonary Medicine 2014 14:52

    Content type: Research article

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  50. Sarcoidosis patients have accumulations of activated CD4+ T cells in affected organs, such as the lungs. T cell receptor (TCR) Vβ-chain usage has been incompletely characterized in these patients.

    Authors: Kerstin M Ahlgren, Tina Ruckdeschel, Anders Eklund, Jan Wahlström and Johan Grunewald

    Citation: BMC Pulmonary Medicine 2014 14:50

    Content type: Research article

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