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COPD and occupational lung disease

This section concerns all aspects of COPD, occupational lung disease, and smoking-related disorders including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Claims data are potentially useful for identifying long-acting β-agonist (LABA) use by patients with asthma, a practice that is associated with increased mortality. We evaluated the accuracy of claims data for...

    Authors: David D Dore, Najat Ziyadeh, Bin Cai, C Robin Clifford, Heather Norman and John D Seeger

    Citation: BMC Pulmonary Medicine 2014 14:47

    Content type: Research article

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  2. The study evaluated the efficacy of beclomethasone dipropionate/formoterol fumarate (BDP/FF) extrafine combination versus fluticasone propionate/salmeterol (FP/S) combination in COPD patients.

    Authors: Dave Singh, Gabriele Nicolini, Eddi Bindi, Massimo Corradi, Daniele Guastalla, Jorg Kampschulte, Władysław Pierzchała, Abdullah Sayiner, Mária Szilasi, Claudio Terzano and Jørgen Vestbo

    Citation: BMC Pulmonary Medicine 2014 14:43

    Content type: Research article

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  4. Benefits of community-based whole-body vibration (WBV) as a mode of exercise training for people with chronic obstructive pulmonary disease (COPD) have not been investigated. The low skill demand of WBV may en...

    Authors: Trentham Furness, Corey Joseph, Geraldine Naughton, Liam Welsh and Christian Lorenzen

    Citation: BMC Pulmonary Medicine 2014 14:38

    Content type: Research article

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  5. Dynamic gas compression during forced expiration has an influence on conventional flow-volume spirometry results. The extent of gas compression in different pulmonary disorders remains obscure. Utilizing a flo...

    Authors: Päivi L Piirilä, Ulla Hodgson, Tomi Wuorimaa, Hans-Jürgen Smith and Anssi RA Sovijärvi

    Citation: BMC Pulmonary Medicine 2014 14:34

    Content type: Research article

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  6. Patients with acute respiratory distress syndrome (ARDS) risk lung collapse, severely altering the breath-to-breath respiratory mechanics. Model-based estimation of respiratory mechanics characterising patient...

    Authors: Erwin J van Drunen, Yeong Shiong Chiew, Christopher Pretty, Geoffrey M Shaw, Bernard Lambermont, Nathalie Janssen, J Geoffrey Chase and Thomas Desaive

    Citation: BMC Pulmonary Medicine 2014 14:33

    Content type: Technical advance

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  7. Cigarette smoke induces a pro-inflammatory response in airway epithelial cells but it is not clear which of the various chemicals contained within cigarette smoke (CS) should be regarded as predominantly respo...

    Authors: David M Comer, Joseph Stuart Elborn and Madeleine Ennis

    Citation: BMC Pulmonary Medicine 2014 14:32

    Content type: Research article

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  8. The aim of this study was to test whether repeatable biomarkers collected from serum, bronchoalveolar lavage (BAL) and sputum of healthy smokers and smokers with COPD would have a prognostic value with respect...

    Authors: Olaf Holz, Benjamin Waschki, Stefan Roepcke, Henrik Watz, Gereon Lauer, Cornelia Faulenbach and Jens M Hohlfeld

    Citation: BMC Pulmonary Medicine 2014 14:30

    Content type: Research article

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  9. Small airways are regarded as the elective anatomic site of obstruction in most chronic airway diseases. Expiratory computed tomography (CT) is increasingly used to assess obstruction at this level but there i...

    Authors: Sébastien Bommart, Grégory Marin, Arnaud Bourdin, Nicolas Molinari, François Klein, Maurice Hayot, Isabelle Vachier, Pascal Chanez, Jacques Mercier and Hélène Vernhet-Kovacsik

    Citation: BMC Pulmonary Medicine 2014 14:29

    Content type: Research article

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  10. We investigated patients with chronic obstructive pulmonary disease (COPD) to analyze patterns and identify determinants of healthcare use, according to the severity of airflow obstruction. We used retrospecti...

    Authors: Kyungsoo Chung, Kyungjoo Kim, Jiye Jung, Kyungwon Oh, Yeonmok Oh, Sekyu Kim, Jinhee Kim and Youngsam Kim

    Citation: BMC Pulmonary Medicine 2014 14:27

    Content type: Research article

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  11. Little is known about iron deficiency (ID) and anemia in Chronic Obstructive Pulmonary Disease (COPD). The purposes of this study were: (i) To study the prevalence and treatment of anemia and ID in patients ho...

    Authors: Donald S Silverberg, Ram Mor, Melanie Tia Weu, Doron Schwartz, Idit F Schwartz and Gil Chernin

    Citation: BMC Pulmonary Medicine 2014 14:24

    Content type: Research article

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  12. Expiratory flow limitation (EFL) during tidal breathing is common in patients with severe COPD, and a major determinant of dynamic hyperinflation and exercise limitation. EFL can be measured by the forced osci...

    Authors: Masashi Mikamo, Toshihiro Shirai, Kazutaka Mori, Yuichiro Shishido, Takefumi Akita, Satoru Morita, Kazuhiro Asada, Masato Fujii and Takafumi Suda

    Citation: BMC Pulmonary Medicine 2014 14:23

    Content type: Research article

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  14. Amyotrophic lateral sclerosis (ALS) leads to chronic respiratory failure. Diaphragmatic dysfunction, a major driver of dyspnea and mortality, is associated with a shift of the burden of ventilation to extradia...

    Authors: Marjolaine Georges, Capucine Morélot-Panzini, Thomas Similowski and Jesus Gonzalez-Bermejo

    Citation: BMC Pulmonary Medicine 2014 14:17

    Content type: Research article

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  15. A higher slow vital capacity (VC) compared with forced vital capacity (FVC) indicates small airway collapse and air trapping. We hypothesized that a larger difference between VC and FVC (VC-FVC) would predict ...

    Authors: Wei Yuan, Xin He, Qiu-Fen Xu, Hao-Yan Wang and Richard Casaburi

    Citation: BMC Pulmonary Medicine 2014 14:16

    Content type: Research article

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  16. Appropriate sedation benefits patients by reducing the stress response, but it requires an appropriate method of assessment to adjust the dosage of sedatives. The aim of this study was to compare the differenc...

    Authors: Chien-Wei Hsu, Shu-Fen Sun, Kuo-An Chu, David Lin Lee and Kam-Fai Wong

    Citation: BMC Pulmonary Medicine 2014 14:15

    Content type: Research article

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  17. Recent studies suggest that coexistence of chronic obstructive pulmonary disease (COPD) might be independently related to a worse prognosis for lung cancer. However, because data on the substantial prevalence ...

    Authors: Naozumi Hashimoto, Asuka Matsuzaki, Yu Okada, Naoyuki Imai, Shingo Iwano, Kenji Wakai, Kazuyoshi Imaizumi, Kohei Yokoi and Yoshinori Hasegawa

    Citation: BMC Pulmonary Medicine 2014 14:14

    Content type: Research article

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  18. Low levels of physical activity are common in patients with chronic obstructive pulmonary disease (COPD), and a sedentary lifestyle is associated with poor outcomes including increased mortality, frequent hosp...

    Authors: Carlos H Martinez, Marilyn L Moy, Huong Q Nguyen, Miriam Cohen, Reema Kadri, Pia Roman, Robert G Holleman, Hyungjin Myra Kim, David E Goodrich, Nicholas D Giardino and Caroline R Richardson

    Citation: BMC Pulmonary Medicine 2014 14:12

    Content type: Study protocol

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  19. Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease mediated by an array of inflammatory cells and mediators, but above all, CD8+ T-lymphocytes, macrophages and neutrophils are impor...

    Authors: Neil C Barnes, Marina Saetta and Klaus F Rabe

    Citation: BMC Pulmonary Medicine 2014 14:9

    Content type: Study protocol

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  20. Chronic obstructive pulmonary disease (COPD) has significant systemic effects that substantially impact quality of life and survival. The purpose of this study was to assess and compare peripheral muscle stren...

    Authors: Ebru Calik-Kutukcu, Sema Savci, Melda Saglam, Naciye Vardar-Yagli, Deniz Inal-Ince, Hulya Arikan, Zeynep Aribas, Ozge Ozer, Meral Bosnak-Guclu and Lutfi Coplu

    Citation: BMC Pulmonary Medicine 2014 14:6

    Content type: Research article

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  21. Two once-daily long-acting muscarinic antagonists (LAMAs) are currently available for the treatment of chronic obstructive pulmonary disease (COPD) – tiotropium and glycopyrronium. Previous studies have compar...

    Authors: Kenneth R Chapman, Kai-Michael Beeh, Jutta Beier, Eric D Bateman, Anthony D’Urzo, Robert Nutbrown, Michelle Henley, Hungta Chen, Tim Overend and Peter D’Andrea

    Citation: BMC Pulmonary Medicine 2014 14:4

    Content type: Research article

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  23. Cardiovascular morbidity and mortality is high in patients with chronic obstructive pulmonary disease (COPD) and arterial stiffness is a potentially modifiable risk factor with added predictive value beyond th...

    Authors: Surya P Bhatt, Adam G Cole, James Michael Wells, Hrudaya Nath, Jubal R Watts, John R Cockcroft and Mark T Dransfield

    Citation: BMC Pulmonary Medicine 2014 14:1

    Content type: Research article

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  24. Chronic obstructive pulmonary disease (COPD) is hallmarked by inflammatory processes and a progressive decline of lung function. YKL-40 is a potential biomarker of inflammation and mortality in patients suffer...

    Authors: Dennis B Holmgaard, Lone H Mygind, Ingrid L Titlestad, Hanne Madsen, Svend Stenvang Pedersen, Julia S Johansen and Court Pedersen

    Citation: BMC Pulmonary Medicine 2013 13:77

    Content type: Research article

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  25. Cardiac surgery is frequently complicated by an acute vascular lung injury and this may be mediated, at least in part, by the (soluble) receptor for advanced glycation end products (sRAGE).

    Authors: Pieter R Tuinman, Alexander D Cornet, Maria T Kuipers, Alexander P Vlaar, Marcus J Schultz, Albertus Beishuizen, AB Johan Groeneveld and Nicole P Juffermans

    Citation: BMC Pulmonary Medicine 2013 13:76

    Content type: Research article

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  26. So far, the accuracy of tidal volume (VT) and leak measures provided by the built-in software of commercial home ventilators has only been tested using bench linear models with fixed calibrated and continuous ...

    Authors: Ana Sogo, Jaume Montanyà, Eduard Monsó, Lluís Blanch, Xavier Pomares and Manel Lujàn

    Citation: BMC Pulmonary Medicine 2013 13:75

    Content type: Research article

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  27. Medications for respiratory disorders including asthma and chronic obstructive pulmonary disease (COPD) are typically delivered to the lung by means of a handheld inhaler. Patient preference for and ability to...

    Authors: Henrik Svedsater, Peter Dale, Karl Garrill, Richard Walker and Mark W Woepse

    Citation: BMC Pulmonary Medicine 2013 13:72

    Content type: Research article

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  29. Ventilatory impairment is known to occur in patients with heart failure (HF). Alveolar volume (VA) is measured by the dilution of an inert gas during a single breath-hold maneuver. Such measurement is sensitive t...

    Authors: Massimo Miniati, Simonetta Monti, Matteo Bottai, Ivana Pavlickova, Claudio Passino, Michele Emdin and Roberta Poletti

    Citation: BMC Pulmonary Medicine 2013 13:69

    Content type: Research article

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  30. Mechanical ventilation (MV) is an essential supportive therapy for acute lung injury (ALI); however it can also contribute to systemic inflammation. Since pulmonary surfactant has anti-inflammatory properties,...

    Authors: Valeria Puntorieri, Josh Qua Hiansen, Lynda A McCaig, Li-Juan Yao, Ruud AW Veldhuizen and James F Lewis

    Citation: BMC Pulmonary Medicine 2013 13:67

    Content type: Research article

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  31. The acute inhalation of endotoxin mimicks several aspects of the inflammation related to chronic obstructive pulmonary disease (COPD). The aim of the current study was to identify and to validate biomarkers of...

    Authors: Olivier Michel, Virginie Doyen, Baptiste Leroy, Benjamin Bopp, Duc Huy Phong Dinh, Francis Corazza and Ruddy Wattiez

    Citation: BMC Pulmonary Medicine 2013 13:65

    Content type: Research article

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  32. Due to the pleiotropic effects of nitric oxide (NO) within the lungs, it is likely that NO is a significant factor in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of this study was...

    Authors: Farzian Aminuddin, Tillie-Louise Hackett, Dorota Stefanowicz, Aabida Saferali, Peter D Paré, Amund Gulsvik, Per Bakke, Michael H Cho, Augusto Litonjua, David A Lomas, Wayne H Anderson, Terri H Beaty, Edwin K Silverman and Andrew J Sandford

    Citation: BMC Pulmonary Medicine 2013 13:64

    Content type: Research article

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  33. Anxiety and depression are common co-morbidities in patients with chronic obstructive pulmonary disease (COPD). Serious implications can result from psychological difficulties in COPD including reduced surviva...

    Authors: Karen Heslop, Julia Newton, Christine Baker, Graham Burns, Debbie Carrick-Sen and Anthony De Soyza

    Citation: BMC Pulmonary Medicine 2013 13:62

    Content type: Study protocol

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  34. Pulmonary rehabilitation is widely advocated for people with chronic obstructive pulmonary disease (COPD) to improve exercise capacity, symptoms and quality of life, however only a minority of individuals with...

    Authors: Anne E Holland, Ajay Mahal, Catherine J Hill, Annemarie L Lee, Angela T Burge, Rosemary Moore, Caroline Nicolson, Paul O’Halloran, Narelle S Cox, Aroub Lahham, Rebecca Ndongo, Emily Bell and Christine F McDonald

    Citation: BMC Pulmonary Medicine 2013 13:57

    Content type: Study protocol

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  35. Although chronic obstructive pulmonary disease (COPD) is a major global health burden there is a lack of patient awareness of disease severity, particularly in relation to exacerbations.

    Authors: Neil Barnes, Peter MA Calverley, Alan Kaplan and Klaus F Rabe

    Citation: BMC Pulmonary Medicine 2013 13:54

    Content type: Research article

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  36. Gastroesophageal reflux disease (GERD) is one of the most common causes of chronic cough and a potential risk factor for exacerbation of chronic obstructive pulmonary disease (COPD). The aim of this study was ...

    Authors: Jinhee Kim, Jin Hwa Lee, Yuri Kim, Kyungjoo Kim, Yeon-Mok Oh, Kwang Ha Yoo, Chin Kook Rhee, Hyoung Kyu Yoon, Young Sam Kim, Yong Bum Park, Sei Won Lee and Sang Do Lee

    Citation: BMC Pulmonary Medicine 2013 13:51

    Content type: Research article

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  37. Standardised evidenced-based materials and mechanisms to facilitate the delivery of the education component of pulmonary rehabilitation are not widely available. The aims of this study were: 1) to adapt the se...

    Authors: Denise Cosgrove, Joseph MacMahon, Jean Bourbeau, Judy M Bradley and Brenda O’Neill

    Citation: BMC Pulmonary Medicine 2013 13:50

    Content type: Research article

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  38. Chronic lung diseases are marked by progressive inflammation, tissue damage and remodelling. Bone marrow-derived progenitor cells may contribute to these processes. The objectives of this study were to (1) to ...

    Authors: Sarah E Gilpin, Kalvin Lung, Geoffrey T de Couto, Marcelo Cypel, Masaaki Sato, Lianne G Singer, Shaf Keshavjee and Thomas K Waddell

    Citation: BMC Pulmonary Medicine 2013 13:48

    Content type: Research article

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  39. Heparin-binding protein is released by neutrophils during inflammation and disrupts the integrity of the alveolar and capillary endothelial barrier implicated in the development of acute lung injury and system...

    Authors: Daniel F McAuley, Cecilia M O’Kane, Thelma R Craig, Murali Shyamsundar, Heiko Herwald and Karim Dib

    Citation: BMC Pulmonary Medicine 2013 13:47

    Content type: Research article

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  40. The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) and the Medical Outcomes Study Short Form 36 (SF-36) are widely used to assess patient-reported outcome in individuals with pulmonary hypertension ...

    Authors: James Twiss, Stephen McKenna, Louise Ganderton, Sue Jenkins, Mitra Ben-L’amri, Kevin Gain, Robin Fowler and Eli Gabbay

    Citation: BMC Pulmonary Medicine 2013 13:45

    Content type: Research article

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  41. Serum levels of N–terminal proB–type natriuretic peptide (NT–proBNP) are elevated in patients acute respiratory distress syndrome (ARDS). Recent studies showed a lower incidence of acute cor pulmonale in ARDS ...

    Authors: Rogier M Determann, Annick ANM Royakkers, Jacqueline Schaefers, Anita M de Boer, Jan M Binnekade, Jan P van Straalen and Marcus J Schultz

    Citation: BMC Pulmonary Medicine 2013 13:42

    Content type: Research article

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  42. Chronic Obstructive Pulmonary Disease (COPD) is a disease state characterized by airflow limitation that is not fully reversible and usually progressive. Current guidelines, among which the Dutch, have so far ...

    Authors: Janwillem Kocks, Corina de Jong, Marjolein Y Berger, Huib AM Kerstjens and Thys van der Molen

    Citation: BMC Pulmonary Medicine 2013 13:41

    Content type: Study protocol

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  43. The aim of this substudy of the ghrelin treatment, multicenter, randomized, double-blind, placebo-controlled trial was to investigate the effects of ghrelin administration on exercise capacity and the underlyi...

    Authors: Keisuke Miki, Ryoji Maekura, Noritoshi Nagaya, Seigo Kitada, Mari Miki, Kenji Yoshimura, Yoshitaka Tateishi, Masaharu Motone, Toru Hiraga, Masahide Mori and Kenji Kangawa

    Citation: BMC Pulmonary Medicine 2013 13:37

    Content type: Research article

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  44. The GOLD 2011 document proposed a new classification system for COPD combining symptom assessment by COPD assessment test (CAT) or modified Medical Research Council (mMRC) dyspnea scores, and exacerbation risk...

    Authors: Sunmin Kim, Jisun Oh, Yu-Il Kim, Hee-Jung Ban, Yong-Soo Kwon, In-Jae Oh, Kyu-Sik Kim, Young-Chul Kim and Sung-Chul Lim

    Citation: BMC Pulmonary Medicine 2013 13:35

    Content type: Research article

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  45. Indacaterol is a novel, once-daily (od), inhaled, long-acting ß2-agonist bronchodilator for maintenance treatment of airflow limitation in patients with COPD. The aim of this study was to evaluate the efficacy of...

    Authors: Jiangna Han, Lu Dai and Nanshan Zhong

    Citation: BMC Pulmonary Medicine 2013 13:26

    Content type: Research article

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  46. Inhalation of endotoxin (LPS) induces a predominantly neutrophilic airway inflammation and has been used as model to test the anti-inflammatory activity of novel drugs. In the past, a dose exceeding 15–50 μg w...

    Authors: Ole Janssen, Frank Schaumann, Olaf Holz, Bianca Lavae-Mokhtari, Lutz Welker, Carla Winkler, Heike Biller, Norbert Krug and Jens M Hohlfeld

    Citation: BMC Pulmonary Medicine 2013 13:19

    Content type: Research article

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  47. Favorable effects of formal pulmonary rehabilitation in selected moderate to severe COPD patients are well established. Few data are available on the effects and costs of integrated disease management (IDM) pr...

    Authors: Annemarije L Kruis, Melinde RS Boland, Catharina H Schoonvelde, Willem JJ Assendelft, Maureen PMH Rutten-van Mölken, Jacobijn Gussekloo, Apostolos Tsiachristas and Niels H Chavannes

    Citation: BMC Pulmonary Medicine 2013 13:17

    Content type: Study protocol

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