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Infectious, Rare and Idiopathic Pulmonary Diseases

This section concerns all aspects of pulmonary infection, rare and idiopathic lung diseases including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Patients with COPD are at risk of non-tuberculous mycobacterial infection (NTM). This study examined the histology of lung tissue from COPD patients following lung volume reduction with particular focus on evi...

    Authors: Anjali Char, Nick S Hopkinson, David M Hansell, Andrew G Nicholson, Emily C Shaw, Samuel J Clark, Philip Sedgwick, Robert Wilson, Simon Jordan and Michael R Loebinger

    Citation: BMC Pulmonary Medicine 2014 14:124

    Content type: Research article

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  2. The role of mixed pneumonia (virus + bacteria) in community-acquired pneumonia (CAP) has been described in recent years. However, it is not known whether the systemic inflammatory profile is different compared...

    Authors: Salvador Bello, Elisa Mincholé, Sergio Fandos, Ana B Lasierra, María A Ruiz, Ana L Simon, Carolina Panadero, Carlos Lapresta, Rosario Menendez and Antoni Torres

    Citation: BMC Pulmonary Medicine 2014 14:123

    Content type: Research article

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  3. Idiopathic pulmonary fibrosis (IPF) is a progressive parenchymal lung disease of unknown aetiology and poor prognosis, characterized by altered tissue repair and fibrosis. The extracellular matrix (ECM) is a c...

    Authors: Susanna Estany, Vanesa Vicens-Zygmunt, Roger Llatjós, Ana Montes, Rosa Penín, Ignacio Escobar, Antoni Xaubet, Salud Santos, Frederic Manresa, Jordi Dorca and Maria Molina-Molina

    Citation: BMC Pulmonary Medicine 2014 14:120

    Content type: Research article

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  4. We aimed to determine adherence to inhaled antibiotics, other respiratory medicines and airway clearance and to determine the association between adherence to these treatments and health outcomes (pulmonary ex...

    Authors: Amanda R McCullough, Michael M Tunney, Alexandra L Quittner, J Stuart Elborn, Judy M Bradley and Carmel M Hughes

    Citation: BMC Pulmonary Medicine 2014 14:107

    Content type: Research article

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  5. Community acquired pneumonia (CAP) is a major cause of morbidity, hospitalization, and mortality worldwide. Management of CAP for many patients requires rapid initiation of empirical antibiotic treatment, base...

    Authors: Ilija Kuzman, Alexandr Bezlepko, Irena Kondova Topuzovska, László Rókusz, Liudmyla Iudina, Hans-Peter Marschall and Thomas Petri

    Citation: BMC Pulmonary Medicine 2014 14:105

    Content type: Research article

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  6. The aim was to measure flagellin concentrations in the expectorations of CF patients and to examine whether there are correlations with the level of respiratory insufficiency and inflammation.

    Authors: Viviane Balloy, Guiti Thévenot, Thierry Bienvenu, Philippe Morand, Harriet Corvol, Annick Clement, Reuben Ramphal, Dominique Hubert and Michel Chignard

    Citation: BMC Pulmonary Medicine 2014 14:100

    Content type: Research article

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  7. The pathological appearance of idiopathic pleuroparenchymal fibroelastosis (IPPFE) with hematoxylin-eosin staining is similar to that of usual interstitial pneumonia (UIP) in patients with idiopathic pulmonary...

    Authors: Noriyuki Enomoto, Hideki Kusagaya, Yoshiyuki Oyama, Masato Kono, Yusuke Kaida, Shigeki Kuroishi, Dai Hashimoto, Tomoyuki Fujisawa, Koshi Yokomura, Naoki Inui, Yutaro Nakamura and Takafumi Suda

    Citation: BMC Pulmonary Medicine 2014 14:91

    Content type: Research article

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  8. Whole-lung lavage (WLL) is classically the first-line treatment for symptomatic pulmonary alveolar proteinosis (PAP). However, some patients require multiple WLLs because of refractory nature of their PAP. In ...

    Authors: Hong yan Yu, Xue feng Sun, Yan xun Wang, Zuo jun Xu and Hui Huang

    Citation: BMC Pulmonary Medicine 2014 14:87

    Content type: Case report

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  9. Idiopathic interstitial pneumonias such as idiopathic pulmonary fibrosis or fibrotic nonspecific interstitial pneumonia are irreversible progressive pulmonary diseases that often have fatal outcomes. Although ...

    Authors: Koichiro Kamio, Arata Azuma, Ken Ohta, Yukihiko Sugiyama, Toshihiro Nukiwa, Shoji Kudoh and Tohru Mizushima

    Citation: BMC Pulmonary Medicine 2014 14:86

    Content type: Research article

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  10. In cystic fibrosis (CF) patients, the upper airways display the same ion channel defect as evident in the lungs, resulting in chronic inflammation and infection. Recognition of the sinonasal area as a site of ...

    Authors: Julia Hentschel, Manuela Jäger, Natalie Beiersdorf, Nele Fischer, Franziska Doht, Ruth K Michl, Thomas Lehmann, Udo R Markert, Klas Böer, Peter M Keller, Mathias W Pletz and Jochen G Mainz

    Citation: BMC Pulmonary Medicine 2014 14:82

    Content type: Research article

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  11. Research that explores stigma in Cystic Fibrosis (CF) is limited. Productive cough, repeated lung infections, and periods of serious illness requiring hospitalizations are among common symptoms of CF. These sy...

    Authors: Smita Pakhale, Michael Armstrong, Crystal Holly, Rojiemiahd Edjoc, Ena Gaudet, Shawn Aaron, Giorgio Tasca, William Cameron and Louise Balfour

    Citation: BMC Pulmonary Medicine 2014 14:76

    Content type: Research article

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    The Correction to this article has been published in BMC Pulmonary Medicine 2020 20:145

  12. Adult patients with cystic fibrosis (CF) frequently have reduced exercise tolerance, which is multifactorial but mainly due to bronchial obstruction. The aim of this retrospective analysis was to determine the...

    Authors: Jean Pastré, Anne Prévotat, Catherine Tardif, Carole Langlois, Alain Duhamel and Benoit Wallaert

    Citation: BMC Pulmonary Medicine 2014 14:74

    Content type: Research article

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  13. Acute interstitial pneumonia is a rare interstitial lung disease that rapidly progresses to respiratory failure or death. Several studies showed that myofibroblast plays an important role in the evolution of d...

    Authors: Hongbo Li, Jinjin Zhang, Xiaodong Song, Tao Wang, Zhi Li, Dong Hao, Xiaozhi Wang, Qingyin Zheng, Cuiping Mao, Pan Xu and Changjun Lv

    Citation: BMC Pulmonary Medicine 2014 14:67

    Content type: Case report

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  14. Early diagnosis and treatment of nontuberculous mycobacterial lung diseases (NTM-LD) and pulmonary tuberculosis (PTB) are important clinical issues. The present study aimed to compare and identify the chest CT...

    Authors: Mei-Kang Yuan, Cheng-Yu Chang, Ping-Huang Tsai, Yuan-Ming Lee, Jen-Wu Huang and Shih-Chieh Chang

    Citation: BMC Pulmonary Medicine 2014 14:65

    Content type: Research article

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  15. Pulmonary fibrosis is an untreatable, fatal disease characterized by excess deposition of extracellular matrix and inflammation. Although the etiology of pulmonary fibrosis is unknown, recent studies have impl...

    Authors: Hongyun Zhao, Yee Chan-Li, Samuel L Collins, Yuan Zhang, Robert W Hallowell, Wayne Mitzner and Maureen R Horton

    Citation: BMC Pulmonary Medicine 2014 14:64

    Content type: Research article

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  16. The accuracy of currently available same-day diagnostic tools (smear microscopy and conventional nucleic acid amplification tests) for pleural tuberculosis (TB) is sub-optimal. Newer technologies may offer imp...

    Authors: Richard Meldau, Jonny Peter, Grant Theron, Greg Calligaro, Brian Allwood, Greg Symons, Hoosain Khalfey, Gina Ntombenhle, Ureshnie Govender, Anke Binder, Richard van Zyl-Smit and Keertan Dheda

    Citation: BMC Pulmonary Medicine 2014 14:58

    Content type: Research article

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  17. Heat shock protein (HSP) 47, a collagen-specific molecular chaperone, is involved in the processing and/or secretion of procollagen. We hypothesized that HSP47 could be a useful marker for fibrotic lung diseas...

    Authors: Tomoyuki Kakugawa, Shin-ichi Yokota, Yuji Ishimatsu, Tomayoshi Hayashi, Shota Nakashima, Shintaro Hara, Noriho Sakamoto, Hiroshi Kubota, Mariko Mine, Yasuhiro Matsuoka, Hiroshi Mukae, Kazuhiro Nagata and Shigeru Kohno

    Citation: BMC Pulmonary Medicine 2014 14:48

    Content type: Research article

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  18. This report describe for the first time a clinical case with a CFTR allelic variant 186-8T/C (c.54-8 T/C) in intron 1 of CFTR and underline the importance of applying a combination of genetic and functional te...

    Authors: Sara Caldrer, Genny Verzè, Jan Johansson, Claudio Sorio, Chiara Angiari, Mario Buffelli, Baroukh Maurice Assael and Paola Melotti

    Citation: BMC Pulmonary Medicine 2014 14:44

    Content type: Case report

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  19. Secondary pulmonary alveolar proteinosis (sPAP) is a very rare lung disorder comprising approximately 10% of cases of acquired PAP. Hematological disorders are the most common underlying conditions of sPAP, of...

    Authors: Haruyuki Ishii, John F Seymour, Ryushi Tazawa, Yoshikazu Inoue, Naoyuki Uchida, Aya Nishida, Yoshihito Kogure, Takeshi Saraya, Keisuke Tomii, Toshinori Takada, Yuko Itoh, Masayuki Hojo, Toshio Ichiwata, Hajime Goto and Koh Nakata

    Citation: BMC Pulmonary Medicine 2014 14:37

    Content type: Research article

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  20. Management of community-acquired pneumonia (CAP) places a considerable burden on hospital resources. REACH was a retrospective, observational study (NCT01293435) involving adults ≥18 years old hospitalized wit...

    Authors: Helmut Ostermann, Javier Garau, Jesús Medina, Esther Pascual, Kyle McBride and Francesco Blasi

    Citation: BMC Pulmonary Medicine 2014 14:36

    Content type: Research article

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  21. Cystic fibrosis (CF) lung disease begins in early life and is progressive with the major risk factor being an exaggerated inflammatory response. Currently, assessment of neutrophilic inflammation in early cyst...

    Authors: Emmanuelle Fantino, Catherine L Gangell, Dominik Hartl and Peter D Sly

    Citation: BMC Pulmonary Medicine 2014 14:28

    Content type: Research article

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  22. Health-related and disease-specific quality of life (HRQoL) has been increasingly valued as relevant clinical parameter in cystic fibrosis (CF) clinical care and clinical trials. HRQoL measures should assess –...

    Authors: Helge Hebestreit, Kerstin Schmid, Stephanie Kieser, Sibylle Junge, Manfred Ballmann, Kristina Roth, Alexandra Hebestreit, Thomas Schenk, Christian Schindler, Hans-Georg Posselt and Susi Kriemler

    Citation: BMC Pulmonary Medicine 2014 14:26

    Content type: Research article

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  23. Many patients with pneumonia and lower respiratory tract infection that could be treated as outpatients according to their clinical severity score, are in fact admitted to hospital. We investigated whether, wi...

    Authors: Andrea M Collins, Odiri J Eneje, Carole A Hancock, Daniel G Wootton and Stephen B Gordon

    Citation: BMC Pulmonary Medicine 2014 14:25

    Content type: Research article

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  24. Gastro esophageal reflux (GER) is common in cystic fibrosis (CF) and may contribute to lung disease. Approximately 50% of patients with cystic fibrosis are being treated with proton pump inhibitors (PPIs).

    Authors: Emily DiMango, Patricia Walker, Claire Keating, Maria Berdella, Newell Robinson, Elinor Langfelder-Schwind, Diane Levy and Xinhua Liu

    Citation: BMC Pulmonary Medicine 2014 14:21

    Content type: Research article

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  25. Alterations in surfactant phospholipid compositions are a recognized feature of many acute and chronic lung diseases. Investigation of underlying mechanisms requires assessment of surfactant phospholipid molec...

    Authors: Ahilanandan Dushianthan, Victoria Goss, Rebecca Cusack, Michael PW Grocott and Anthony D Postle

    Citation: BMC Pulmonary Medicine 2014 14:10

    Content type: Research article

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  26. Pulmonary involvement is a common feature of MPA. Although alveolar hemorrhage is the most common pulmonary manifestation of MPA, a few recent studies have described instances of MPA patients with pulmonary fi...

    Authors: Hui Huang, Yan xun Wang, Chun guo Jiang, Jia Liu, Ji Li, Kai Xu and Zuo jun Xu

    Citation: BMC Pulmonary Medicine 2014 14:8

    Content type: Research article

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  27. Mortality after pneumonia in immunocompromised patients is higher than for immunocompetent patients. The use of non-invasive mechanical ventilation for patients with severe pneumonia may provide beneficial out...

    Authors: Christopher S Johnson, Christopher R Frei, Mark L Metersky, Antonio R Anzueto and Eric M Mortensen

    Citation: BMC Pulmonary Medicine 2014 14:7

    Content type: Research article

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  28. Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with no effective medical therapies. Recent research has focused on identifying the biological processes essential to the development and ...

    Authors: Sydney B Montesi, Susan K Mathai, Laura N Brenner, Irina A Gorshkova, Evgeny V Berdyshev, Andrew M Tager and Barry S Shea

    Citation: BMC Pulmonary Medicine 2014 14:5

    Content type: Research article

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  29. The relevance of Trichosporon species for cystic fibrosis (CF) patients has not yet been extensively investigated.

    Authors: Carolin Kröner, Matthias Kappler, Ann-Christin Grimmelt, Gudrun Laniado, Benjamin Würstl and Matthias Griese

    Citation: BMC Pulmonary Medicine 2013 13:61

    Content type: Research article

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  30. The aim of this case–control study was to analyse the clinical characteristics of children with recurrent community-acquired pneumonia (rCAP) affecting different lung areas (DLAs) and compare them with those o...

    Authors: Francesca Patria, Benedetta Longhi, Claudia Tagliabue, Rossana Tenconi, Patrizia Ballista, Giuseppe Ricciardi, Carlotta Galeone, Nicola Principi and Susanna Esposito

    Citation: BMC Pulmonary Medicine 2013 13:60

    Content type: Research article

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  31. Exhaled breath volatile organic compound (VOC) analysis for airway disease monitoring is promising. However, contrary to nitric oxide the method for exhaled breath collection has not yet been standardized and ...

    Authors: Andras Bikov, Koralia Paschalaki, Ron Logan-Sinclair, Ildiko Horváth, Sergei A Kharitonov, Peter J Barnes, Omar S Usmani and Paolo Paredi

    Citation: BMC Pulmonary Medicine 2013 13:43

    Content type: Research article

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