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Infectious, Rare and Idiopathic Pulmonary Diseases

This section concerns all aspects of pulmonary infection, rare and idiopathic lung diseases including, but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has previously been demonstrated to play a pro-inflammatory role in allergic airways disease and COPD through the upregulation of the E3 ubiquit...

    Authors: Adam M. Collison, Junyao Li, Ana Pereira de Siqueira, Xuejiao Lv, Hamish D. Toop, Jonathan C. Morris, Malcolm R. Starkey, Philip M. Hansbro, Jie Zhang and Joerg Mattes

    Citation: BMC Pulmonary Medicine 2019 19:31

    Content type: Research article

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  2. Chronic cough is a difficult-to-treat comorbidity of idiopathic pulmonary fibrosis (IPF), and significantly impacts on the quality of life of patients with IPF. Transient receptor potential (TRP) channel prote...

    Authors: Yali Guo, Sun Ying, Xuehui Zhao, Jian Liu and Yuguang Wang

    Citation: BMC Pulmonary Medicine 2019 19:27

    Content type: Research article

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  3. Immunoglobulin G4-related disease (IgG4-RD) encompasses a group of immune-mediated disorders that are gaining increasing recognition. Pulmonary presentations are common, with four types of patterns been descri...

    Authors: Junping Fan, Ruie Feng, Xiaomeng Hou, Ji Li, Xuefeng Sun, Jinglan Wang, Juhong Shi, Mengzhao Wang and Yan Xu

    Citation: BMC Pulmonary Medicine 2019 19:26

    Content type: Case report

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  4. Any immunological mechanisms induced by influenza virus could cause severe secondary bacterial superinfection such as those by Streptococcus pyogenes [group A streptococcus (GAS)], Streptococcus pneumoniae or Sta...

    Authors: Nobuhiro Asai, Hiroyuki Suematsu, Daisuke Sakanashi, Hideo Kato, Mao Hagihara, Hiroki Watanabe, Arufumi Shiota, Yusuke Koizumi, Yuka Yamagishi and Hiroshige Mikamo

    Citation: BMC Pulmonary Medicine 2019 19:25

    Content type: Case report

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  5. Telehealth and telemonitoring is an emerging area of study in people with cystic fibrosis (CF), with the potential of increasing access to care, and minimising infection control risks to patients without compr...

    Authors: Ray Lei Lang, Christine Wilson, Kellie Stockton, Trevor Russell and Leanne Marie Johnston

    Citation: BMC Pulmonary Medicine 2019 19:21

    Content type: Study protocol

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  6. By comparing diagnoses made by pre-transplant surgical lung biopsy (SLB) and the final pathologic diagnosis of the explanted pathology (EP), we aimed to study the factors that could impact pathologic diagnoses...

    Authors: Tanmay S. Panchabhai, Andrea Valeria Arrossi, Kristin B. Highland, Debabrata Bandyopadhyay, Daniel A. Culver, Marie M. Budev and Carol F. Farver

    Citation: BMC Pulmonary Medicine 2019 19:20

    Content type: Research article

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  7. Standardization of trans-bronchial lung cryobiopsy in diffuse parenchymal lung diseases is imminent; however, the majority of published series on cryobiopsy include a limited number of patients and are charact...

    Authors: Claudia Ravaglia, Athol U. Wells, Sara Tomassetti, Carlo Gurioli, Christian Gurioli, Alessandra Dubini, Alberto Cavazza, Thomas V. Colby, Sara Piciucchi, Silvia Puglisi, Marcello Bosi and Venerino Poletti

    Citation: BMC Pulmonary Medicine 2019 19:16

    Content type: Research article

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  8. Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a severe condition with limited treatment strategies. Although respiratory infection is a major cause of AE-IPF, no reports have indicated pertus...

    Authors: Kuniaki Hirai, Tetsuya Homma, Fumihiro Yamaguchi, Munehiro Yamaguchi, Shintaro Suzuki, Akihiko Tanaka, Tsukasa Ohnishi and Hironori Sagara

    Citation: BMC Pulmonary Medicine 2019 19:15

    Content type: Case report

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  9. Relapse of cryptogenic organizing pneumonia (COP) may lead to poor long-term prognosis and necessitates multiple rounds of steroid treatment with potential adverse effects. The objective of this study is to id...

    Authors: Zenya Saito, Yugo Kaneko, Tsukasa Hasegawa, Masahiro Yoshida, Kyuto Odashima, Tsugumi Horikiri, Akira Kinoshita, Keisuke Saitoh and Kazuyoshi Kuwano

    Citation: BMC Pulmonary Medicine 2019 19:10

    Content type: Research article

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  10. A clinical heterogeneity was reported in patients with Cystic Fibrosis (CF) with the same CFTR genotype and between siblings with CF.

    Authors: Vito Terlizzi, Marco Lucarelli, Donatello Salvatore, Adriano Angioni, Arianna Bisogno, Cesare Braggion, Roberto Buzzetti, Vincenzo Carnovale, Rosaria Casciaro, Giuseppe Castaldo, Natalia Cirilli, Mirella Collura, Carla Colombo, Antonella Miriam Di Lullo, Ausilia Elce, Vincenzina Lucidi…

    Citation: BMC Pulmonary Medicine 2018 18:196

    Content type: Research article

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  11. The present study aimed to develop an automated computed tomography (CT) score based on the CT quantification of high-attenuating lung structures, in order to provide a quantitative assessment of lung structur...

    Authors: Trieu-Nghi Hoang-Thi, Marie-Pierre Revel, Pierre-Régis Burgel, Laurence Bassinet, Isabelle Honoré, Thong Hua-Huy, Charlotte Martin, Bernard Maitre and Guillaume Chassagnon

    Citation: BMC Pulmonary Medicine 2018 18:194

    Content type: Research article

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  12. Guidelines currently do not recommend the routine use of chest x-ray (CXR) in bronchiolitis. However, CXR is still performed in a high percentage of cases, mainly to diagnose or rule out pneumonia. The inappro...

    Authors: Carlotta Biagi, Luca Pierantoni, Michelangelo Baldazzi, Laura Greco, Ada Dormi, Arianna Dondi, Giacomo Faldella and Marcello Lanari

    Citation: BMC Pulmonary Medicine 2018 18:191

    Content type: Research article

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  13. Coexistence of aspergilloma and allergic bronchopulmonary aspergillosis (ABPA) has rarely been reported. Although the treatment for ABPA includes administration of corticosteroids and antifungal agents, little...

    Authors: Kohei Horiuchi, Takanori Asakura, Naoki Hasegawa and Fumitake Saito

    Citation: BMC Pulmonary Medicine 2018 18:185

    Content type: Case report

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  14. Granulomatosis with polyangiitis (GPA) is a systemic ANCA-associated vasculitis characterized by necrotizing granulomatous inflammation and a predilection for the upper and lower respiratory tract. Eosinophili...

    Authors: Michele V. Quan, Stephen K. Frankel, Mehrnaz Maleki-Fischbach and Laren D. Tan

    Citation: BMC Pulmonary Medicine 2018 18:181

    Content type: Case report

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  15. 2′-5′-Oligoadenylate synthetase 1 (OAS1) plays an important role in inflammatory immune reactions. OAS1 polymorphisms have been associated with increased susceptibility to various diseases. We investigated the as...

    Authors: Shouquan Wu, Yu Wang, Guo Chen, Miaomiao Zhang, Minggui Wang and Jian-Qing He

    Citation: BMC Pulmonary Medicine 2018 18:180

    Content type: Research article

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  16. Pirfenidone is an antifibrotic compound approved for the treatment of idiopathic pulmonary fibrosis (IPF). We present our real-world experience in terms of Pirfenidone’s effect on mortality and adverse events ...

    Authors: George A. Margaritopoulos, Athina Trachalaki, Athol U. Wells, Eirini Vasarmidi, Eleni Bibaki, George Papastratigakis, Stathis Detorakis, Nikos Tzanakis and Katerina M. Antoniou

    Citation: BMC Pulmonary Medicine 2018 18:177

    Content type: Research article

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  17. We aimed to determine the presepsin concentration in pleural fluid from patients with pleural effusions of different aetiologies and to compare its diagnostic value with that of pleural fluid C-reactive protei...

    Authors: Naoki Watanabe, Tomoya Ishii, Nobuyuki Kita, Nobuhiro Kanaji, Hiroyuki Nakamura, Nobuki Nanki, Yutaka Ueda, Yasunori Tojo, Norimitsu Kadowaki and Shuji Bandoh

    Citation: BMC Pulmonary Medicine 2018 18:176

    Content type: Research article

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  18. Idiopathic pulmonary fibrosis (IPF) is a chronic disease with a high symptom burden and poor survival that influences patients’ health-related quality of life (HRQOL). We aimed to evaluate IPF patients’ sympto...

    Authors: K. Rajala, J. T. Lehto, E. Sutinen, H. Kautiainen, M. Myllärniemi and T. Saarto

    Citation: BMC Pulmonary Medicine 2018 18:172

    Content type: Research article

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  19. Non-Tuberculous Mycobacterial–pulmonary disease (NTM-PD) is increasing in incidence and prevalence. Mycobacterium abscessus (M.abscessus) is a rapid growing multi-resistant NTM associated with severe NTM-PD requi...

    Authors: C. Addy, G. Doran, A. L. Jones, G. Wright, S. Caskey and D. G. Downey

    Citation: BMC Pulmonary Medicine 2018 18:170

    Content type: Case report

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  20. Until recently, lung transplantation was not considered in patients with human immunodeficiency virus (HIV). HIV seropositive patients with suppressed viral loads can now expect long-term survival with the adv...

    Authors: Shaun Ong, Robert D Levy, John Yee, Nilu Partovi, Andrew Churg, Philippe Roméo, Jean Chalaoui, Roland Nador, Alissa Wright, Hélène Manganas and Christopher J Ryerson

    Citation: BMC Pulmonary Medicine 2018 18:162

    Content type: Case report

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  21. Risk assessment of pulmonary arterial hypertension (PAH) contributes to its management. Unfortunately, the existing risk assessment approaches are defective for clinicians to practice in daily clinical setting...

    Authors: Wei Xiong, Yunfeng Zhao, Mei Xu, Bigyan Pudasaini, Xuejun Guo and Jinming Liu

    Citation: BMC Pulmonary Medicine 2018 18:161

    Content type: Research article

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  22. We explored the hypothesized importance of early knowledge of microbiological etiology in patients with pleural infection, including comorbidity and treatment factors in the outcome analyses.

    Authors: Christian Niels Meyer, Karin Armbruster, Michael Kemp, Trine Rolighed Thomsen and Ram Benny Dessau

    Citation: BMC Pulmonary Medicine 2018 18:160

    Content type: Research article

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  23. The sweat test (ST) is the gold standard for the diagnosis of cystic fibrosis (CF). However, little is known about sweat induction using different types of currents and waves. In this context, our objective wa...

    Authors: Carla Cristina Souza Gomez, Fernando Augusto Lima Marson, Maria Fátima Servidoni, Antônio Fernando Ribeiro, Maria Ângela Gonçalves Oliveira Ribeiro, Veruska Acioli Lopes Gama, Eduardo Tavares Costa, José Dirceu Ribeiro and Francisco Ubaldo Vieira Junior

    Citation: BMC Pulmonary Medicine 2018 18:153

    Content type: Research article

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  24. Nontuberculous mycobacterial (NTM) pulmonary disease has conventionally been classified on the basis of radiology into fibrocavitary and nodular-bronchiectatic disease. Whilst being of great clinical utility, ...

    Authors: Steven A. Cowman, Joseph Jacob, Sayed Obaidee, R. Andres Floto, Robert Wilson, Charles S. Haworth and Michael R. Loebinger

    Citation: BMC Pulmonary Medicine 2018 18:145

    Content type: Research article

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  25. Pulmonary nocardiosis frequently develops as an opportunistic infection in cell-mediated immunosuppressive patients, and sometimes requires differentiation from pulmonary malignancy. Ectopic adrenocorticotropi...

    Authors: Keigo Kobayashi, Takanori Asakura, Makoto Ishii, Soichiro Ueda, Hidehiro Irie, Hiroyuki Ozawa, Kohei Saitoh, Isao Kurihara, Hiroshi Itoh and Tomoko Betsuyaku

    Citation: BMC Pulmonary Medicine 2018 18:142

    Content type: Case report

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  26. Approximately a quarter of patients with advanced sarcoidosis develop pulmonary hypertension (PH), which affects their prognosis. We report unusual case of confirmed chronic thromboembolic pulmonary hypertensi...

    Authors: Andrzej Labyk, Dominik Wretowski, Sabina Zybińska-Oksiutowicz, Aleksandra Furdyna, Katarzyna Ciesielska, Dorota Piotrowska-Kownacka, Olga Dzikowska –Diduch, Barbara Lichodziejewska, Andrzej Biederman, Piotr Pruszczyk and Marek Roik

    Citation: BMC Pulmonary Medicine 2018 18:139

    Content type: Case report

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  27. Yellow nail syndrome (YNS) is a rare disease characterized by the triad of thickened, slow-growing yellow nails, lymphedema, and chronic respiratory manifestations. The cause of YNS is not known; however, it i...

    Authors: Sachi Matsubayashi, Manabu Suzuki, Tomoyuki Suzuki, Ayako Shiozawa, Konomi Kobayashi, Satoru Ishii, Motoyasu Iikura, Shinyu Izumi, Koichiro Kudo and Haruhito Sugiyama

    Citation: BMC Pulmonary Medicine 2018 18:138

    Content type: Research article

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  28. Pulmonary Mycobacterium avium complex (pMAC) disease is a chronic, slowly progressive disease. The aim of the present study was to determine the association of six-minute walk test (6MWT) parameters with pulmonar...

    Authors: Kazuma Yagi, Takanori Asakura, Ho Namkoong, Shoji Suzuki, Takahiro Asami, Satoshi Okamori, Tatsuya Kusumoto, Yohei Funatsu, Hirofumi Kamata, Tomoyasu Nishimura, Makoto Ishii, Tomoko Betsuyaku and Naoki Hasegawa

    Citation: BMC Pulmonary Medicine 2018 18:114

    Content type: Research article

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  29. Vitamin D is involved in the host immune response toward Mycobacterium tuberculosis. However, the efficacy of vitamin D supplementation on sputum conversion, clinical response to treatment, adverse events, and mo...

    Authors: Hong-xia Wu, Xiao-feng Xiong, Min Zhu, Jia Wei, Kai-quan Zhuo and De-yun Cheng

    Citation: BMC Pulmonary Medicine 2018 18:108

    Content type: Research article

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  30. Pulmonary arterial hypertension is a rare, progressive disease with poor prognosis. However, there is limited information available on the characteristics of PAH patients outside of North America and Europe. T...

    Authors: Ana Beatriz Valverde, Juliana M. Soares, Karynna P. Viana, Bruna Gomes, Claudia Soares and Rogerio Souza

    Citation: BMC Pulmonary Medicine 2018 18:106

    Content type: Research article

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  31. Cystic fibrosis (CF) is associated with bacterial pulmonary infections and neutrophil-dominated inflammation in the airways. The aim of this study was to evaluate the neutrophil-derived protein Heparin-binding...

    Authors: Gisela Hovold, Victoria Palmcrantz, Fredrik Kahn, Arne Egesten and Lisa I. Påhlman

    Citation: BMC Pulmonary Medicine 2018 18:104

    Content type: Research article

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  32. “Velcro-type” crackles on chest auscultation are considered a typical acoustic finding of Fibrotic Interstitial Lung Disease (FILD), however whether they may have a role in the early detection of these disorde...

    Authors: Giacomo Sgalla, Simon L. F. Walsh, Nicola Sverzellati, Sophie Fletcher, Stefania Cerri, Borislav Dimitrov, Dragana Nikolic, Anna Barney, Fabrizio Pancaldi, Luca Larcher, Fabrizio Luppi, Mark G. Jones, Donna Davies and Luca Richeldi

    Citation: BMC Pulmonary Medicine 2018 18:103

    Content type: Research article

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  33. Regular airway clearance by chest physiotherapy and/or exercise is critical to lung health in cystic fibrosis (CF). Combination of cycling exercise and chest physiotherapy using the Flutter® device on sputum p...

    Authors: Thomas Radtke, Lukas Böni, Peter Bohnacker, Marion Maggi-Beba, Peter Fischer, Susi Kriemler, Christian Benden and Holger Dressel

    Citation: BMC Pulmonary Medicine 2018 18:99

    Content type: Research article

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  34. Understanding the risk factors that are associated with the development of interstitial lung disease might have an important role in understanding the pathogenetic mechanism of interstitial lung disease as wel...

    Authors: Won-Il Choi, Sonila Dauti, Hyun Jung Kim, Sun Hyo Park, Jae Seok Park and Choong Won Lee

    Citation: BMC Pulmonary Medicine 2018 18:96

    Content type: Research article

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  35. Active pulmonary tuberculosis (TB) is associated with intra-hospital spread of the disease. Expeditious diagnosis and isolation are critical for infection control. However, factors that lead to delayed isolati...

    Authors: Sho Nishiguchi, Shusaku Tomiyama, Izumi Kitagawa and Yasuharu Tokuda

    Citation: BMC Pulmonary Medicine 2018 18:94

    Content type: Research article

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  36. Plague is a life-threatening disease caused by the bacterium, Yersinia pestis. Madagascar is the leading country for human plague cases worldwide. Human plague is a serious disease, particularly in its septicaemi...

    Authors: Voahangy Andrianaivoarimanana, Eric Bertherat, Rojo Rajaonarison, Tiana Rakotondramaro, Christophe Rogier and Minoarisoa Rajerison

    Citation: BMC Pulmonary Medicine 2018 18:92

    Content type: Case report

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  37. lipopolysaccharide-binding protein (LBP) has been to be a surrogate marker of inflammation in OSA. This study aimed to test the hypothesis that the concentration of LBP is elevated in adult patients with obstr...

    Authors: Yinfeng Kong, Zhijun Li, Tingyu Tang, Haiyan Wu, Juan Liu, Liang Gu, Tian Zhao and Qingdong Huang

    Citation: BMC Pulmonary Medicine 2018 18:90

    Content type: Research article

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  38. Mortality prediction of pneumonia by severity scores in patients with multiple underlying health conditions has not fully been investigated. This prospective cohort study is to identify mortality-associated un...

    Authors: Sugihiro Hamaguchi, Motoi Suzuki, Kota Sasaki, Masahiko Abe, Takao Wakabayashi, Eiichiro Sando, Makito Yaegashi, Shimpei Morimoto, Norichika Asoh, Naohisa Hamashige, Masahiro Aoshima, Koya Ariyoshi and Konosuke Morimoto

    Citation: BMC Pulmonary Medicine 2018 18:88

    Content type: Research article

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  39. Data on the lung microbiome in HIV-infected children is limited. The current study sought to determine the lung microbiome in HIV-associated bronchiectasis and to assess its association with pulmonary exacerba...

    Authors: Refiloe Masekela, Solize Vosloo, Stephanus N. Venter, Wilhelm Z. de Beer and Robin J. Green

    Citation: BMC Pulmonary Medicine 2018 18:87

    Content type: Research article

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  40. In people with cystic fibrosis infection with NonTuberculous Mycobacteria is of increasing prevalence. Mycobacterium abscessus complex is of particular concern and has been associated with adverse clinical outcom...

    Authors: Adrien Tissot, Matthew F. Thomas, Paul A. Corris and Malcolm Brodlie

    Citation: BMC Pulmonary Medicine 2018 18:86

    Content type: Research article

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  41. Non-tuberculous mycobacteria (NTM) infection is an increasing problem worldwide. The epidemiology of NTM in most Asian countries is unknown. This study investigated the epidemiology, and clinical profile of in...

    Authors: Albert Y. H. Lim, Sanjay H. Chotirmall, Eric T. K. Fok, Akash Verma, Partha P. De, Soon Keng Goh, Ser Hon Puah, Daryl E. L. Goh and John A. Abisheganaden

    Citation: BMC Pulmonary Medicine 2018 18:85

    Content type: Research article

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  42. Bronchiectasis is a chronic respiratory condition. Persistent bacterial colonisation in the stable state with increased and sometimes altered bacterial burden during exacerbations are accepted as key features ...

    Authors: Alicia B. Mitchell, Bassel Mourad, Lachlan Buddle, Matthew J. Peters, Brian G. G. Oliver and Lucy C. Morgan

    Citation: BMC Pulmonary Medicine 2018 18:84

    Content type: Research article

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  43. Bronchiectasis is a disease associated with chronic progressive and irreversible dilatation of the bronchi and is characterised by chronic infection and associated inflammation. The prevalence of bronchiectasi...

    Authors: Ravishankar Chandrasekaran, Micheál Mac Aogáin, James D. Chalmers, Stuart J. Elborn and Sanjay H. Chotirmall

    Citation: BMC Pulmonary Medicine 2018 18:83

    Content type: Review

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  44. Lung transplantation is a well-established treatment for end-stage non-cystic fibrosis bronchiectasis (BR), though information regarding outcomes of transplantation remains limited. Our results of lung transpl...

    Authors: Jodie Birch, Syba S. Sunny, Katy L. M. Hester, Gareth Parry, F. Kate Gould, John H. Dark, Stephen C. Clark, Gerard Meachery, James Lordan, Andrew J. Fisher, Paul A. Corris and Anthony De Soyza

    Citation: BMC Pulmonary Medicine 2018 18:82

    Content type: Research article

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  45. Bronchiectasis is a heterogeneous disease which affects quality of life. Measuring symptoms and quality of life has proved challenging and research is limited by extrapolation of questionnaires and treatments ...

    Authors: Emily K. Dudgeon, Megan Crichton and James D. Chalmers

    Citation: BMC Pulmonary Medicine 2018 18:81

    Content type: Research article

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  46. Bronchiectasis is an incurable lung disease characterised by irreversible airway dilatation. It causes symptoms including chronic productive cough, dyspnoea, and recurrent respiratory infections often requirin...

    Authors: Katy L. M. Hester, Julia Newton, Tim Rapley and Anthony De Soyza

    Citation: BMC Pulmonary Medicine 2018 18:80

    Content type: Review

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  47. Bronchiectasis is a common feature of severe inherited and acquired pulmonary disease conditions. Among inherited diseases, cystic fibrosis (CF) is the major disorder associated with bronchiectasis, while acqu...

    Authors: Jürgen Schäfer, Matthias Griese, Ravishankar Chandrasekaran, Sanjay H. Chotirmall and Dominik Hartl

    Citation: BMC Pulmonary Medicine 2018 18:79

    Content type: Review

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  48. Bronchiectasis has an increasing profile within respiratory medicine. This chronic and irreversible airways disease is common but suffers from a lack of evidenced based therapy for patients and, a lack of unde...

    Authors: Sanjay H. Chotirmall and James D. Chalmers

    Citation: BMC Pulmonary Medicine 2018 18:76

    Content type: Editorial

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