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Respiratory critical care

Section edited by Raffaele Scala

This section concerns all aspects dealing with pulmonary critically ill patients: models of acute setting ; epidemiology, monitoring and treatment of acute respiratory failure; patho-physiology and clinical applications of invasive e non-invasive mechanical ventilation; weaning strategies; morbidity and mortality; ethical problems; imaging and interventional procedures; nurse and physiotherapist's issues.

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  1. Community-acquired pneumonia (CAP) requires urgent and specific antimicrobial therapy. However, the causal pathogen is typically unknown at the point when anti-infective therapeutics must be initiated. Physicia.....

    Authors: Claire Lhommet, Denis Garot, Leslie Grammatico-Guillon, Cassandra Jourdannaud, Pierre Asfar, Christophe Faisy, Grégoire Muller, Kimberly A. Barker, Emmanuelle Mercier, Sylvie Robert, Philippe Lanotte, Alain Goudeau, Helene Blasco and Antoine Guillon

    Citation: BMC Pulmonary Medicine 2020 20:62

    Content type: Research article

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  2. This study aimed to explore the feasibility of applying the respiratory “critical care-sub-critical care-rehabilitation integrated management model” in severe stroke-associated pneumonia and evaluate its effect.

    Authors: Xue-Lin Wang, Li-Jun Ma, Xin-Gang Hu, Kai Wang and Jian-Jian Cheng

    Citation: BMC Pulmonary Medicine 2020 20:61

    Content type: Research article

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  3. Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) is devastating with no established treatment. This phenomenon involves disordered coagulation and excessive inflammatory reactions. As recombinant...

    Authors: Hiroyuki Kamiya and Ogee Mer Panlaqui

    Citation: BMC Pulmonary Medicine 2020 20:57

    Content type: Research article

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  4. Because of its analgesic and light sedative properties, the highly selective alpha-2 adrenergic receptor agonist dexmedetomidine (DEX) has been suggested for the treatment of septic patients, but its effect on...

    Authors: Peifen Chen, Jihong Jiang, Yunhe Zhang, Guobao Li, Zhihui Qiu, Mitchell M. Levy and Baoji Hu

    Citation: BMC Pulmonary Medicine 2020 20:42

    Content type: Research article

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  5. Respiratory virome is an integral part of the human microbiome and its characterization may contribute to a better understanding of the changes that arise in the disease and, consequently, influence the approa...

    Authors: Raquel Nazareth, Maria-Jesus Chasqueira, Maria-Lúcia Rodrigues, Carolina Paulino, Catarina Conceição, Lia Lêdo, Úrsula Segura, Madalena Santos, António Messias, Pedro Póvoa and Paulo Paixão

    Citation: BMC Pulmonary Medicine 2020 20:39

    Content type: Research article

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  6. Prolonged and difficult weaning is associated with higher rates of complications and mortality. Therefore, it is important to identify the associated factors.

    Authors: Renyu Ding, Yulan Meng, Xingjuan Jia and Xiaochun Ma

    Citation: BMC Pulmonary Medicine 2020 20:37

    Content type: Case report

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  7. Hump-nosed viper bite, the commonest venomous snake bite in Sri Lanka, is associated with significant morbidity. Specific anti-venom is not available for hump-nosed viper envenomation which is usually managed ...

    Authors: Arthihai Srirangan, Jagath Pushpakumara and Kamani Wanigasuriya

    Citation: BMC Pulmonary Medicine 2020 20:35

    Content type: Case report

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  8. Obstructive sleep apnea syndrome (OSAS) is a common disorder that is accompanied by structural brain changes. This meta-analysis aimed to evaluate the effect of OSAS on the serum levels of astrocytic protein (...

    Authors: Farzad Rezaei, Hooshyar Abbasi, Masoud Sadeghi and Mohammad Moslem Imani

    Citation: BMC Pulmonary Medicine 2020 20:31

    Content type: Research article

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  9. Previous studies demonstrated an important role for connexin 43 (Cx43) in the regulation of apoptosis by influencing mitochondrial functions. This study aimed to investigate the relationship between Cx43 and l...

    Authors: Jia-wei Ma, Dan-dan Ji, Qian-qian Li, Ting Zhang and Liang Luo

    Citation: BMC Pulmonary Medicine 2020 20:19

    Content type: Research article

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  10. Adenosine deaminase (ADA) activity is typically elevated in patients with tuberculous pleural effusion (TPE), but low ADA has occasionally been reported in patients with TPE. The characteristics of these patie...

    Authors: Sae Byol Kim, Beomsu Shin, Ji-Ho Lee, Seok Jeong Lee, Myoung Kyu Lee, Won-Yeon Lee, Suk Joong Yong and Sang-Ha Kim

    Citation: BMC Pulmonary Medicine 2020 20:13

    Content type: Research article

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  11. Persistent hypercapnia after COPD exacerbation is associated with excess mortality and early rehospitalization. High Flow Nasal cannula (HFNC), may be theoretically an alternative to long-term noninvasive vent...

    Authors: Lara Pisani, Sara Betti, Carlotta Biglia, Luca Fasano, Vito Catalanotti, Irene Prediletto, Vittoria Comellini, Letizia Bacchi-Reggiani and Stefano Nava FERS

    Citation: BMC Pulmonary Medicine 2020 20:12

    Content type: Research article

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  12. Marfan Syndrome (MFS) is a heritable connective tissue disorder with a high degree of clinical variability including respiratory diseases; a rare case of MFS with massive intrathoracic bleeding has been report...

    Authors: Yuki Yabuuchi, Hitomi Goto, Mizu Nonaka, Hiroaki Tachi, Tatsuya Akiyama, Naoki Arai, Hiroaki Ishikawa, Kentaro Hyodo, Kenji Nemoto, Yukiko Miura, Isano Hase, Shingo Usui, Shuji Oh-ishi, Kenji Hayashihara, Takefumi Saito and Tatsuya Chonan

    Citation: BMC Pulmonary Medicine 2020 20:4

    Content type: Case report

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  13. Multiple studies have shown that diaphragmatic ultrasound can better predict the outcome of weaning in adults. However, there are few studies focusing on children, leading to a lack of sufficient clinical evid...

    Authors: Yang Xue, Zhen Zhang, Chu-Qiao Sheng, Yu-Mei Li and Fei-Yong Jia

    Citation: BMC Pulmonary Medicine 2019 19:270

    Content type: Research article

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  14. The initial management of pneumothorax remains controversial, and we speculated that this might be because there is no method available for evaluation of air leak during initial management. We have developed a...

    Authors: Hiroyuki Kaneda, Takahito Nakano and Tomohiro Murakawa

    Citation: BMC Pulmonary Medicine 2019 19:267

    Content type: Technical advance

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  15. The impact of anemia and red blood cell (RBC) transfusion on weaning from mechanical ventilation is not known. In theory, transfusions could facilitate liberation from the ventilator by improving oxygen transp...

    Authors: Alessandro Ghiani, Alexandros Sainis, Georgios Sainis and Claus Neurohr

    Citation: BMC Pulmonary Medicine 2019 19:250

    Content type: Research article

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  16. Rapid stratification and appropriate treatment on admission are critical to saving lives of patients with acute pulmonary embolism (PE). None of the clinical prediction tools perform well when applied to all p...

    Authors: Yan Wang, He Yang, Lisong Qiao, Zheng Tan, Jin Jin, Jingjing Yang, Li Zhang, Bao Min Fang and Xiaomao Xu

    Citation: BMC Pulmonary Medicine 2019 19:242

    Content type: Research article

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  17. There are limited data regarding the efficacy and safety of remifentanil sedation for diagnostic bronchoscopy. The aim of this study was to evaluate the clinical efficacy and safety of remifentanil by comparin...

    Authors: Hyun Lee, Yeong Hun Choe and Seungyong Park

    Citation: BMC Pulmonary Medicine 2019 19:240

    Content type: Research article

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  18. The use of extracorporeal membrane oxygenation (ECMO) in awake, spontaneously breathing and non-intubated patients (awake ECMO) may be a novel therapeutic strategy for severe acute respiratory distress syndrom...

    Authors: Jingen Xia, Sichao Gu, Min Li, Donglin Liu, Xu Huang, Li Yi, Lijuan Wu, Guohui Fan and Qingyuan Zhan

    Citation: BMC Pulmonary Medicine 2019 19:237

    Content type: Research article

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  19. To study the effects of different positive end expiratory pressure (PEEP) on blood pressure and heart function in elderly patients with hypertension.

    Authors: Lili Zhou, Guoen Cai, Zhihui Xu, Qinyong Weng, Qinyong Ye and Cunrong Chen

    Citation: BMC Pulmonary Medicine 2019 19:224

    Content type: Research article

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  20. Malignant central airway obstruction (CAO) occurs in approximately 20–30% of patients with lung cancer and is associated with debilitating symptoms and poor prognosis. Multimodality therapeutic bronchoscopy ca...

    Authors: Coral X. Giovacchini, Edward R. Kessler, Christopher M. Merrick, Junheng Gao, Xiaofei Wang, Momen M. Wahidi, Scott L. Shofer, George Z. Cheng and Kamran Mahmood

    Citation: BMC Pulmonary Medicine 2019 19:219

    Content type: Research article

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  21. The expiratory time constant (RCEXP), which is defined as the product of airway resistance and lung compliance, enable us to assess the mechanical properties of the respiratory system in mechanically ventilated p...

    Authors: Takamitsu Ikeda, Yasuhiro Yamauchi, Kanji Uchida, Koji Oba, Takahide Nagase and Yoshitsugu Yamada

    Citation: BMC Pulmonary Medicine 2019 19:208

    Content type: Research article

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  22. Lung injury is common in post-cardiac arrest syndrome, and is associated with increased morbidity and mortality. The aim of this study was to evaluate the effect of mild hypothermia on lung injury after cardia...

    Authors: Chunshuang Wu, Jiefeng Xu, Xiaohong Jin, Qijiang Chen, Zilong Li and Mao Zhang

    Citation: BMC Pulmonary Medicine 2019 19:198

    Content type: Research article

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  23. Epidemiologic studies have shown inconsistent conclusions about the effect of ulinastain treatment for acute respiratory distress syndrome (ARDS). It is necessary to perform a meta-analysis of ulinastatin’s ra...

    Authors: Xiangyun Zhang, Zhaozhong Zhu, Weijie Jiao, Wei Liu, Fang Liu and Xi Zhu

    Citation: BMC Pulmonary Medicine 2019 19:196

    Content type: Research article

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  24. Idiopathic pulmonary arterial hypertension (IPAH) is a fatal illness. Despite many improvements in the treatment of these patients, there is no unique prognostic variable available to track these patients. The...

    Authors: Majid Malekmohammad, Gert Folkerts, Babak Sharif Kashani, Parisa Adimi Naghan, Zahra Habibi Dastenae, Batoul Khoundabi, Johan Garssen, Esmaeil Mortaz and Ian M. Adcock

    Citation: BMC Pulmonary Medicine 2019 19:188

    Content type: Research article

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    The Correction to this article has been published in BMC Pulmonary Medicine 2019 19:197

  25. To compare the microbiological culture within endotracheal aspirate specimens (ETAs) and endotracheal tube specimens (ETTs) in patients undergoing mechanical ventilation (MV) by statistical tools.

    Authors: Lijuan Shen, Fei Wang, Junfeng Shi, Weixin Xu, Tingting Jiang, Huifang Tang, Xiuwen Yu, Hao Yin, Shanyou Hu, Xiao Wu, Siu Kit Chan, Jie Sun and Qing Chang

    Citation: BMC Pulmonary Medicine 2019 19:162

    Content type: Research article

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  26. Diaphragmatic assessment by ultrasound (US) is a non-invasive and useful method in the clinical management of patients with Amyotrophic Lateral Sclerosis (ALS). The aim of our observational study was to evalua...

    Authors: Riccardo Fantini, Roberto Tonelli, Ivana Castaniere, Luca Tabbì, Maria Rosaria Pellegrino, Stefania Cerri, Francesco Livrieri, Francesco Giaroni, Marco Monelli, Valentina Ruggieri, Nicola Fini, Jessica Mandrioli, Enrico Clini and Alessandro Marchioni

    Citation: BMC Pulmonary Medicine 2019 19:160

    Content type: Research article

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  27. Aerosol administration is increasingly being used as a therapeutic intervention for mechanically ventilated preterm infants. However, the effects of inhalation therapy on retinopathy of prematurity (ROP) have ...

    Authors: Mei-Chin Yang, Hsiu-Feng Hsiao, Hsiu-Li Tseng, Ya-Wen Chiu and Yi-Hao Weng

    Citation: BMC Pulmonary Medicine 2019 19:145

    Content type: Research article

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  28. Noninvasive ventilation (NIV) reduces the rate of endotracheal intubation (ETI) and overall mortality in severe acute exacerbation of COPD (AECOPD) with acute respiratory failure and is increasingly applied in...

    Authors: Alexandru T. Steriade, Shirin Johari, Nicoleta Sargarovschi, Daniela Necula, Cornelia E. Tudose, Diana Ionita, Miron A. Bogdan and Dragos Bumbacea

    Citation: BMC Pulmonary Medicine 2019 19:131

    Content type: Research article

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  29. In people with and without Cystic Fibrosis (CF), does side lying during nebulisation change: the proportion of the dose loaded in the nebuliser that is deposited in the lungs; the uniformity of deposition thro...

    Authors: Ruth L. Dentice, Mark R. Elkins, Jordan Verschuer, Stefan Eberl, Genevieve Dwyer and Peter T. P. Bye

    Citation: BMC Pulmonary Medicine 2019 19:128

    Content type: Research article

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  30. We aimed to evaluate whether serum activin-A levels are elevated and have any value in predicting severity and prognosis in acute respiratory distress syndrome (ARDS).

    Authors: Jee-min Kim, Jung-Kyu Lee, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han and Sang-Min Lee

    Citation: BMC Pulmonary Medicine 2019 19:115

    Content type: Research article

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  31. Evaluating severity of illness of patients with prolonged mechanical ventilation (PMV) is important to adopt the best appropriate care management for each individual. Yet, no severity-of-illness scoring system...

    Authors: Joao C. Winck, Hélène Gilet, Peter Kalin, Javier Murcia, Fabian Plano, Antoine Regnault, Michael Dreher, Michele Vitacca and Nicolino Ambrosino

    Citation: BMC Pulmonary Medicine 2019 19:109

    Content type: Research article

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  32. We previously demonstrated that the pleural levels of proteins (neutrophil gelatinase-associated lipocalin/NGAL, calprotectin, bactericidal permeability-increasing/BPI, azurocidin 1/AZU-1) were valuable marker...

    Authors: Kuo-An Wu, Chih-Ching Wu, Yu-Ching Liu, Pei-Chun Hsueh, Chia-Yin Chin, Chih-Liang Wang, Chi-Ming Chu, Li-Jane Shih and Chia-Yu Yang

    Citation: BMC Pulmonary Medicine 2019 19:108

    Content type: Research article

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  33. Sepsis biomarkers have limited specificity and sensitivity. Few studies have investigated microRNA (miRNA) biomarkers for sepsis secondary to pneumonia. This study aims to investigate the diagnostic and progno...

    Authors: Wenping Zhang, Jianchao Jia, Zi Liu, Dan Si, Lijun Ma and Guojun Zhang

    Citation: BMC Pulmonary Medicine 2019 19:93

    Content type: Research article

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  34. Pneumothorax (PTX) is one of the most common complications of transbronchial biopsy (TBB). Previous research suggests that upper pulmonary lobe TBB may be associated with increased risk of PTX development. The...

    Authors: Vladimir Herout, Michaela Heroutova, Zdenek Merta, Ivan Cundrle Jr and Kristian Brat

    Citation: BMC Pulmonary Medicine 2019 19:56

    Content type: Research article

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  35. Studies investigating the role of hyperoxia in critically ill patients have reported conflicting results. We did this analysis to reveal the effect of hyperoxia in the patients admitted to the intensive care u...

    Authors: Yue-Nan Ni, Yan-Mei Wang, Bin-Miao Liang and Zong-An Liang

    Citation: BMC Pulmonary Medicine 2019 19:53

    Content type: Research article

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  36. During invasive ventilation, the upper airway is bypassed and no longer participates in humidification of inspired gases, which is essential to avoid harmful consequences such as endotracheal tube occlusion. I...

    Authors: Noémie Haziot, Mohamed Ibrahim, Kaixian Zhu, Charles-Philippe Thevenin, Sebastien Hardy and Jésus Gonzalez-Bermejo

    Citation: BMC Pulmonary Medicine 2019 19:43

    Content type: Research article

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  37. In the Berlin definition, acute respiratory distress syndrome (ARDS) is stratified into three stages according to oxygenation severity at the onset. The relevance between ARDS severity and prognosis varies amo...

    Authors: Tetsuro Kamo, Sadatomo Tasaka, Takeshi Suzuki, Takanori Asakura, Shoji Suzuki, Kazuma Yagi, Ho Namkoong, Makoto Ishii, Hiroshi Morisaki and Tomoko Betsuyaku

    Citation: BMC Pulmonary Medicine 2019 19:37

    Content type: Research article

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  38. Self-expandable metallic stents (SEMSs) have enabled a approving management of malignant airway stenosis. However, the long-term efficacy and safety of this treatment in patients with benign airway stricture a...

    Authors: Xiao-feng Xiong, Li Xu, Li-li Fan, De-yun Cheng and Bi-xia Zheng

    Citation: BMC Pulmonary Medicine 2019 19:33

    Content type: Research article

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  39. Double lumen intubation and one-lung ventilation should be applied without delay in cases of traumatic main bronchial rupture. In most cases, when the patients’ vital signs have been stabilized, the repair can...

    Authors: Feng Yun Wang, Bin Fang, Zhi Hui Yu, Jing Song Shao, Wei Biao Wen and Li Xin Zhou

    Citation: BMC Pulmonary Medicine 2019 19:30

    Content type: Case report

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  40. The high cost and low availability of polysomnography (PSG) limits the timely diagnosis of OSA. Herein, we developed and validated a simple-to-use nomogram for predicting OSA.

    Authors: Huajun Xu, Xiaolong Zhao, Yue Shi, Xinyi Li, Yingjun Qian, Jianyin Zou, Hongliang Yi, Hengye Huang, Jian Guan and Shankai Yin

    Citation: BMC Pulmonary Medicine 2019 19:18

    Content type: Research article

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  41. Surfactant is usually deficiency in adult acute respiratory distress syndrome(ARDS) patients and surfactant administration may be a useful therapy. The aim of this study was to perform a meta-analysis of the effe...

    Authors: Shan-Shan Meng, Wei Chang, Zhong-Hua Lu, Jian-Feng Xie, Hai-Bo Qiu, Yi Yang and Feng-Mei Guo

    Citation: BMC Pulmonary Medicine 2019 19:9

    Content type: Research article

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  42. The lung ultrasound score has been regarded as a decent semiquantitative score to measure the lung aeration loss. The score has been proven to be valuable in diagnosing and monitoring lung pathology, but no st...

    Authors: Wanhong Yin, Tongjuan Zou, Yao Qin, Jing Yang, Yi Li, Xueying Zeng and Yan Kang

    Citation: BMC Pulmonary Medicine 2019 19:1

    Content type: Research article

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  43. Home mechanical ventilation is an established treatment for chronic respiratory failure resulting in improved survival and quality of life. Technological advancement, evolving health care reimbursement systems...

    Authors: Luca Valko, Szabolcs Baglyas, Janos Gal and Andras Lorx

    Citation: BMC Pulmonary Medicine 2018 18:190

    Content type: Research article

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  44. There is a lack of robust data about factors predicting continuation (or termination) of positive airway pressure therapy (PAP) for sleep apnea. This analysis of big data from a German homecare provider descri...

    Authors: Holger Woehrle, Michael Arzt, Andrea Graml, Ingo Fietze, Peter Young, Helmut Teschler and Joachim H. Ficker

    Citation: BMC Pulmonary Medicine 2018 18:186

    Content type: Research article

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  45. Diaphragmatic dysfunction remains the main cause of weaning difficulty or failure. Ultrasonographic measurement of diaphragmatic function can be used to predict the outcomes of weaning from mechanical ventilat...

    Authors: Pongdhep Theerawit, Dararat Eksombatchai, Yuda Sutherasan, Thitiporn Suwatanapongched, Charn Kiatboonsri and Sumalee Kiatboonsri

    Citation: BMC Pulmonary Medicine 2018 18:175

    Content type: Research article

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  46. Pneumonia and septic pneumonic shock are the most common indications for long-term mechanical ventilation and prolonged weaning, independent of any comorbidities. Multidrug resistant (MDR) bacteria are emergin...

    Authors: Johannes Bickenbach, Daniel Schöneis, Gernot Marx, Nikolaus Marx, Sebastian Lemmen and Michael Dreher

    Citation: BMC Pulmonary Medicine 2018 18:141

    Content type: Research article

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  47. Lung ultrasound and echocardiography are mainly applied in critical care and emergency medicine. However, the diagnostic value of cardiopulmonary ultrasound in elderly patients with acute respiratory distress ...

    Authors: Daozheng Huang, Huan Ma, Zhiyuan Xiao, Michael Blaivas, Ying Chen, Jianyi Wen, Weixin Guo, Jun Liang, Xiaolong Liao, Zhonghua Wang, Hanbiao Li, Jie Li, Yangong Chao, Xiao ting Wang, Yan Wu, Tiehe Qin…

    Citation: BMC Pulmonary Medicine 2018 18:136

    Content type: Research article

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  48. Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare cause of pulmonary hypertension that is associated with malignancies and is marked by the presence of non-occlusive tumor emboli and fibrocellular in...

    Authors: Dante A. Suffredini, Jung-Min Lee, Cody J. Peer, Drew Pratt, David E. Kleiner, Jason M. Elinoff and Michael A. Solomon

    Citation: BMC Pulmonary Medicine 2018 18:112

    Content type: Case report

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