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Respiratory critical care

This section concerns all aspects dealing with pulmonary critically ill patients: models of acute setting; epidemiology, monitoring and treatment of acute respiratory failure; patho-physiology and clinical applications of invasive e non-invasive mechanical ventilation; weaning strategies; morbidity and mortality; ethical problems; imaging and interventional procedures; nurse and physiotherapist's issues.

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  1. Bronchoscopy is applied broadly in the diagnosis and treatment of pulmonary diseases. Over the past few decades, an increasing number of studies about bronchoscopy have been published. However, little is known...

    Authors: Boxue He, Pengfei Zhang, Qidong Cai, Shuai Shi, Hui Xie, Yuqian Zhang, Xiong Peng, Zhenyu Zhao, Wei Yin and Xiang Wang

    Citation: BMC Pulmonary Medicine 2020 20:229

    Content type: Research article

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  2. Each myositis-specific autoantibody (MSA) tends to have a distinct clinical presentation. Coexistence of MSAs do not commonly occur. If they do, it is unknown if there is an overlap of clinical features or pro...

    Authors: Zi Ying Li, Evanpaul Gill, Fan Mo and Candice Reyes

    Citation: BMC Pulmonary Medicine 2020 20:220

    Content type: Case report

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  3. Contradictory results regarding changes in serum club cell protein 16 (CC16) levels in patients with acute respiratory distress syndrome (ARDS) have been reported, challenging the value of CC16 as a diagnostic...

    Authors: Jinle Lin, Wuyuan Tao, Jian Wei, Jian Wu, Wenwu Zhang, Jianbing Ye, Xuan Fu, Shiyong Zeng, Qingli Dou, Lijun Wang and Fang Tian

    Citation: BMC Pulmonary Medicine 2020 20:212

    Content type: Research article

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  4. Acute respiratory distress syndrome (ARDS) in infants undergoing cardiac surgery is associated with significant mortality and prolonged ventilation; surfactant administration may be a useful therapy. The purpo...

    Authors: Rongyuan Zhang, Xu Wang, Shoujun Li and Jun Yan

    Citation: BMC Pulmonary Medicine 2020 20:210

    Content type: Research article

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  5. Plasma levels of cell-free DNA (cf-DNA) are known to be elevated in sepsis and high levels are associated with a poor prognosis. Mechanical ventilation affects systemic inflammation in which lung-protective venti...

    Authors: Axel Nyberg, Alexander Larsson, Juulia Jylhävä, Mikko Hurme, Jesper Sperber, Miklós Lipcsey and Markus Castegren

    Citation: BMC Pulmonary Medicine 2020 20:206

    Content type: Research article

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  6. Identification of pathologic features is helpful for the management of nonresolving acute respiratory distress syndrome (ARDS). Transbronchial lung cryobiopsy (TBLC) is a novel biopsy technique that may have c...

    Authors: Guowu Zhou, Yingying Feng, Shiyao Wang, Yi Zhang, Ye Tian, Xiaojing Wu, Ling Zhao, Dan Wang, Ying Li, Zheng Tian and Qingyuan Zhan

    Citation: BMC Pulmonary Medicine 2020 20:183

    Content type: Research article

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  7. This retrospective study aimed to investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and albumin for 30-day mortality in patients with postoperative acute pulmonary embolism (PAPE).

    Authors: Chuan Liu, Hui-lu Zhan, Zhang-Heng Huang, Chuan Hu, Yue-Xin Tong, Zhi-Yi Fan, Meng-Ying Zheng, Cheng-Liang Zhao and Gui-Yun Ma

    Citation: BMC Pulmonary Medicine 2020 20:180

    Content type: Research article

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  8. Forced expiratory volume in 1 second (FEV1) is the only parameter currently recognized as a surrogate endpoint in cystic fibrosis (CF) trials. However, FEV1 is relatively insensitive to changes in the small airwa...

    Authors: Sivagurunathan Sutharsan, Susanne Naehrig, Uwe Mellies, Christian Sieder and Jörg Ziegler

    Citation: BMC Pulmonary Medicine 2020 20:167

    Content type: Research article

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  9. The relationship between biomarkers and hospital-acquired pneumonia (HAP) is understudied, especially in severe cases admitted to the intensive care unit (ICU). Compared with community-acquired pneumonia (CAP)...

    Authors: Nan Zheng, Dongmei Zhu and Yi Han

    Citation: BMC Pulmonary Medicine 2020 20:166

    Content type: Research article

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  10. The collected works of Hippocrates were searched for concepts on the diagnosis, prognosis, and treatment of acute and urgent respiratory diseases, with the objective to trace their origins in the Hippocratic Coll...

    Authors: Georgios Stefanakis, Vasileia Nyktari, Alexandra Papaioannou and Helen Askitopoulou

    Citation: BMC Pulmonary Medicine 2020 20:165

    Content type: Research article

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  11. Obstructive sleep apnoea (OSA) is related with adverse pregnancy outcomes, including preeclampsia. However, there are small studies about treatment of OSA with automatic continuous positive airway pressure (CP...

    Authors: Mi Sun Kim, Myoung Jin Moon, Yoon Hee Lee, Kyu Young Chae and Eun Hee Ahn

    Citation: BMC Pulmonary Medicine 2020 20:157

    Content type: Case report

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  12. Statin-associated necrotizing myopathy (SANM) is a rare autoimmune disorder caused by administration of statins. SANM is characterized by weakness due to necrosis and regeneration of myofibers. Here we report ...

    Authors: Yuriko Yamamura, Yoshinori Matsumoto, Koh Tadokoro, Yasuyuki Ohta, Kota Sato, Toru Yamashita, Masahiro Yamamura, Ken-Ei Sada, Koji Abe and Jun Wada

    Citation: BMC Pulmonary Medicine 2020 20:156

    Content type: Case report

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  13. Usual clinical practice for arterial blood gas analysis (BGA) in conscious patients involves a one-time arterial puncture to be performed after a resting period of 20–30 min. The aim of this study was to evalu...

    Authors: Akira Umeda, Masahiro Ishizaka, Masamichi Tasaki, Tateki Yamane, Taiji Watanabe, Yasushi Inoue, Taichi Mochizuki, Yasumasa Okada and Sarah Kesler

    Citation: BMC Pulmonary Medicine 2020 20:151

    Content type: Research article

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  14. Previous analyses of combined pulmonary fibrosis and emphysema (CPFE) cohorts have provided conflicting data on the survival of patients with CPFE. Therefore, the aim of this study was to investigate the clini...

    Authors: Yuichi Ikuyama, Atsuhito Ushiki, Makoto Kosaka, Jumpei Akahane, Yuichi Mukai, Taisuke Araki, Yoshiaki Kitaguchi, Kazunari Tateishi, Kazuhisa Urushihata, Masanori Yasuo, Hiroshi Yamamoto and Masayuki Hanaoka

    Citation: BMC Pulmonary Medicine 2020 20:144

    Content type: Research article

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  15. Patients with a primary spontaneous pneumothorax (PSP) who are treated with chest tube drainage are traditionally connected to an analogue chest drainage system, containing a water seal and using a visual meth...

    Authors: Dieuwertje Ruigrok, Peter W. A. Kunst, Marielle M. J. Blacha, Ben Tomlow, Jacobine W. Herbrink, Eva J. Japenga, Wim Boersma, Paul Bresser, Ivo van der Lee and Kris Mooren

    Citation: BMC Pulmonary Medicine 2020 20:136

    Content type: Research article

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  16. Extracorporeal membrane oxygenation (ECMO) has been increasingly used for severe neonatal respiratory failure refractory to conventional treatments. To systematically evaluate the complications and mortality o...

    Authors: Jing Xiong, Li Zhang and Lei Bao

    Citation: BMC Pulmonary Medicine 2020 20:124

    Content type: Research article

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  17. Mechanical ventilation (MV), compared to spontaneous breathing (SB), has been found to increase abdominal edema and inflammation in experimental sepsis. Our hypothesis was that in primary acute respiratory dis...

    Authors: Silvia Marchesi, Göran Hedenstierna, Aki Hata, Ricardo Feinstein, Anders Larsson, Anders Olof Larsson and Miklós Lipcsey

    Citation: BMC Pulmonary Medicine 2020 20:106

    Content type: Research article

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  18. The tracheobronchomalacia is a life-threatening complication of mucopolysaccharidosis (MPS) without known effective, optimal treatment. The severe expiratory collapse of the trachea and bronchi is one of cause...

    Authors: Wojciech Gocyk, Janusz Warmus, Henryk Olechnowicz, Miroslaw Bik-Multanowski, Lukasz Pawlinski and Beata Kiec-Wilk

    Citation: BMC Pulmonary Medicine 2020 20:99

    Content type: Case report

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  19. Community-acquired pneumonia (CAP) requires urgent and specific antimicrobial therapy. However, the causal pathogen is typically unknown at the point when anti-infective therapeutics must be initiated. Physicia.....

    Authors: Claire Lhommet, Denis Garot, Leslie Grammatico-Guillon, Cassandra Jourdannaud, Pierre Asfar, Christophe Faisy, Grégoire Muller, Kimberly A. Barker, Emmanuelle Mercier, Sylvie Robert, Philippe Lanotte, Alain Goudeau, Helene Blasco and Antoine Guillon

    Citation: BMC Pulmonary Medicine 2020 20:62

    Content type: Research article

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  20. This study aimed to explore the feasibility of applying the respiratory “critical care-sub-critical care-rehabilitation integrated management model” in severe stroke-associated pneumonia and evaluate its effect.

    Authors: Xue-Lin Wang, Li-Jun Ma, Xin-Gang Hu, Kai Wang and Jian-Jian Cheng

    Citation: BMC Pulmonary Medicine 2020 20:61

    Content type: Research article

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  21. Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) is devastating with no established treatment. This phenomenon involves disordered coagulation and excessive inflammatory reactions. As recombinant...

    Authors: Hiroyuki Kamiya and Ogee Mer Panlaqui

    Citation: BMC Pulmonary Medicine 2020 20:57

    Content type: Research article

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  22. Because of its analgesic and light sedative properties, the highly selective alpha-2 adrenergic receptor agonist dexmedetomidine (DEX) has been suggested for the treatment of septic patients, but its effect on...

    Authors: Peifen Chen, Jihong Jiang, Yunhe Zhang, Guobao Li, Zhihui Qiu, Mitchell M. Levy and Baoji Hu

    Citation: BMC Pulmonary Medicine 2020 20:42

    Content type: Research article

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  23. Respiratory virome is an integral part of the human microbiome and its characterization may contribute to a better understanding of the changes that arise in the disease and, consequently, influence the approa...

    Authors: Raquel Nazareth, Maria-Jesus Chasqueira, Maria-Lúcia Rodrigues, Carolina Paulino, Catarina Conceição, Lia Lêdo, Úrsula Segura, Madalena Santos, António Messias, Pedro Póvoa and Paulo Paixão

    Citation: BMC Pulmonary Medicine 2020 20:39

    Content type: Research article

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  24. Prolonged and difficult weaning is associated with higher rates of complications and mortality. Therefore, it is important to identify the associated factors.

    Authors: Renyu Ding, Yulan Meng, Xingjuan Jia and Xiaochun Ma

    Citation: BMC Pulmonary Medicine 2020 20:37

    Content type: Case report

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  25. Hump-nosed viper bite, the commonest venomous snake bite in Sri Lanka, is associated with significant morbidity. Specific anti-venom is not available for hump-nosed viper envenomation which is usually managed ...

    Authors: Arthihai Srirangan, Jagath Pushpakumara and Kamani Wanigasuriya

    Citation: BMC Pulmonary Medicine 2020 20:35

    Content type: Case report

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  26. Obstructive sleep apnea syndrome (OSAS) is a common disorder that is accompanied by structural brain changes. This meta-analysis aimed to evaluate the effect of OSAS on the serum levels of astrocytic protein (...

    Authors: Farzad Rezaei, Hooshyar Abbasi, Masoud Sadeghi and Mohammad Moslem Imani

    Citation: BMC Pulmonary Medicine 2020 20:31

    Content type: Research article

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  27. Previous studies demonstrated an important role for connexin 43 (Cx43) in the regulation of apoptosis by influencing mitochondrial functions. This study aimed to investigate the relationship between Cx43 and l...

    Authors: Jia-wei Ma, Dan-dan Ji, Qian-qian Li, Ting Zhang and Liang Luo

    Citation: BMC Pulmonary Medicine 2020 20:19

    Content type: Research article

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  28. Adenosine deaminase (ADA) activity is typically elevated in patients with tuberculous pleural effusion (TPE), but low ADA has occasionally been reported in patients with TPE. The characteristics of these patie...

    Authors: Sae Byol Kim, Beomsu Shin, Ji-Ho Lee, Seok Jeong Lee, Myoung Kyu Lee, Won-Yeon Lee, Suk Joong Yong and Sang-Ha Kim

    Citation: BMC Pulmonary Medicine 2020 20:13

    Content type: Research article

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  29. Persistent hypercapnia after COPD exacerbation is associated with excess mortality and early rehospitalization. High Flow Nasal cannula (HFNC), may be theoretically an alternative to long-term noninvasive vent...

    Authors: Lara Pisani, Sara Betti, Carlotta Biglia, Luca Fasano, Vito Catalanotti, Irene Prediletto, Vittoria Comellini, Letizia Bacchi-Reggiani and Stefano Nava FERS

    Citation: BMC Pulmonary Medicine 2020 20:12

    Content type: Research article

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  30. Marfan Syndrome (MFS) is a heritable connective tissue disorder with a high degree of clinical variability including respiratory diseases; a rare case of MFS with massive intrathoracic bleeding has been report...

    Authors: Yuki Yabuuchi, Hitomi Goto, Mizu Nonaka, Hiroaki Tachi, Tatsuya Akiyama, Naoki Arai, Hiroaki Ishikawa, Kentaro Hyodo, Kenji Nemoto, Yukiko Miura, Isano Hase, Shingo Usui, Shuji Oh-ishi, Kenji Hayashihara, Takefumi Saito and Tatsuya Chonan

    Citation: BMC Pulmonary Medicine 2020 20:4

    Content type: Case report

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  31. Multiple studies have shown that diaphragmatic ultrasound can better predict the outcome of weaning in adults. However, there are few studies focusing on children, leading to a lack of sufficient clinical evid...

    Authors: Yang Xue, Zhen Zhang, Chu-Qiao Sheng, Yu-Mei Li and Fei-Yong Jia

    Citation: BMC Pulmonary Medicine 2019 19:270

    Content type: Research article

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  32. The initial management of pneumothorax remains controversial, and we speculated that this might be because there is no method available for evaluation of air leak during initial management. We have developed a...

    Authors: Hiroyuki Kaneda, Takahito Nakano and Tomohiro Murakawa

    Citation: BMC Pulmonary Medicine 2019 19:267

    Content type: Technical advance

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  33. The impact of anemia and red blood cell (RBC) transfusion on weaning from mechanical ventilation is not known. In theory, transfusions could facilitate liberation from the ventilator by improving oxygen transp...

    Authors: Alessandro Ghiani, Alexandros Sainis, Georgios Sainis and Claus Neurohr

    Citation: BMC Pulmonary Medicine 2019 19:250

    Content type: Research article

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  34. Rapid stratification and appropriate treatment on admission are critical to saving lives of patients with acute pulmonary embolism (PE). None of the clinical prediction tools perform well when applied to all p...

    Authors: Yan Wang, He Yang, Lisong Qiao, Zheng Tan, Jin Jin, Jingjing Yang, Li Zhang, Bao Min Fang and Xiaomao Xu

    Citation: BMC Pulmonary Medicine 2019 19:242

    Content type: Research article

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  35. There are limited data regarding the efficacy and safety of remifentanil sedation for diagnostic bronchoscopy. The aim of this study was to evaluate the clinical efficacy and safety of remifentanil by comparin...

    Authors: Hyun Lee, Yeong Hun Choe and Seungyong Park

    Citation: BMC Pulmonary Medicine 2019 19:240

    Content type: Research article

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  36. The use of extracorporeal membrane oxygenation (ECMO) in awake, spontaneously breathing and non-intubated patients (awake ECMO) may be a novel therapeutic strategy for severe acute respiratory distress syndrom...

    Authors: Jingen Xia, Sichao Gu, Min Li, Donglin Liu, Xu Huang, Li Yi, Lijuan Wu, Guohui Fan and Qingyuan Zhan

    Citation: BMC Pulmonary Medicine 2019 19:237

    Content type: Research article

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  37. To study the effects of different positive end expiratory pressure (PEEP) on blood pressure and heart function in elderly patients with hypertension.

    Authors: Lili Zhou, Guoen Cai, Zhihui Xu, Qinyong Weng, Qinyong Ye and Cunrong Chen

    Citation: BMC Pulmonary Medicine 2019 19:224

    Content type: Research article

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  38. Malignant central airway obstruction (CAO) occurs in approximately 20–30% of patients with lung cancer and is associated with debilitating symptoms and poor prognosis. Multimodality therapeutic bronchoscopy ca...

    Authors: Coral X. Giovacchini, Edward R. Kessler, Christopher M. Merrick, Junheng Gao, Xiaofei Wang, Momen M. Wahidi, Scott L. Shofer, George Z. Cheng and Kamran Mahmood

    Citation: BMC Pulmonary Medicine 2019 19:219

    Content type: Research article

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  39. The expiratory time constant (RCEXP), which is defined as the product of airway resistance and lung compliance, enable us to assess the mechanical properties of the respiratory system in mechanically ventilated p...

    Authors: Takamitsu Ikeda, Yasuhiro Yamauchi, Kanji Uchida, Koji Oba, Takahide Nagase and Yoshitsugu Yamada

    Citation: BMC Pulmonary Medicine 2019 19:208

    Content type: Research article

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  40. Lung injury is common in post-cardiac arrest syndrome, and is associated with increased morbidity and mortality. The aim of this study was to evaluate the effect of mild hypothermia on lung injury after cardia...

    Authors: Chunshuang Wu, Jiefeng Xu, Xiaohong Jin, Qijiang Chen, Zilong Li and Mao Zhang

    Citation: BMC Pulmonary Medicine 2019 19:198

    Content type: Research article

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  41. Epidemiologic studies have shown inconsistent conclusions about the effect of ulinastain treatment for acute respiratory distress syndrome (ARDS). It is necessary to perform a meta-analysis of ulinastatin’s ra...

    Authors: Xiangyun Zhang, Zhaozhong Zhu, Weijie Jiao, Wei Liu, Fang Liu and Xi Zhu

    Citation: BMC Pulmonary Medicine 2019 19:196

    Content type: Research article

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  42. Idiopathic pulmonary arterial hypertension (IPAH) is a fatal illness. Despite many improvements in the treatment of these patients, there is no unique prognostic variable available to track these patients. The...

    Authors: Majid Malekmohammad, Gert Folkerts, Babak Sharif Kashani, Parisa Adimi Naghan, Zahra Habibi Dastenae, Batoul Khoundabi, Johan Garssen, Esmaeil Mortaz and Ian M. Adcock

    Citation: BMC Pulmonary Medicine 2019 19:188

    Content type: Research article

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    The Correction to this article has been published in BMC Pulmonary Medicine 2019 19:197

  43. To compare the microbiological culture within endotracheal aspirate specimens (ETAs) and endotracheal tube specimens (ETTs) in patients undergoing mechanical ventilation (MV) by statistical tools.

    Authors: Lijuan Shen, Fei Wang, Junfeng Shi, Weixin Xu, Tingting Jiang, Huifang Tang, Xiuwen Yu, Hao Yin, Shanyou Hu, Xiao Wu, Siu Kit Chan, Jie Sun and Qing Chang

    Citation: BMC Pulmonary Medicine 2019 19:162

    Content type: Research article

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  44. Diaphragmatic assessment by ultrasound (US) is a non-invasive and useful method in the clinical management of patients with Amyotrophic Lateral Sclerosis (ALS). The aim of our observational study was to evalua...

    Authors: Riccardo Fantini, Roberto Tonelli, Ivana Castaniere, Luca Tabbì, Maria Rosaria Pellegrino, Stefania Cerri, Francesco Livrieri, Francesco Giaroni, Marco Monelli, Valentina Ruggieri, Nicola Fini, Jessica Mandrioli, Enrico Clini and Alessandro Marchioni

    Citation: BMC Pulmonary Medicine 2019 19:160

    Content type: Research article

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  45. Aerosol administration is increasingly being used as a therapeutic intervention for mechanically ventilated preterm infants. However, the effects of inhalation therapy on retinopathy of prematurity (ROP) have ...

    Authors: Mei-Chin Yang, Hsiu-Feng Hsiao, Hsiu-Li Tseng, Ya-Wen Chiu and Yi-Hao Weng

    Citation: BMC Pulmonary Medicine 2019 19:145

    Content type: Research article

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  46. Noninvasive ventilation (NIV) reduces the rate of endotracheal intubation (ETI) and overall mortality in severe acute exacerbation of COPD (AECOPD) with acute respiratory failure and is increasingly applied in...

    Authors: Alexandru T. Steriade, Shirin Johari, Nicoleta Sargarovschi, Daniela Necula, Cornelia E. Tudose, Diana Ionita, Miron A. Bogdan and Dragos Bumbacea

    Citation: BMC Pulmonary Medicine 2019 19:131

    Content type: Research article

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