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Respiratory critical care

This section concerns all aspects dealing with pulmonary critically ill patients: models of acute setting; epidemiology, monitoring and treatment of acute respiratory failure; patho-physiology and clinical applications of invasive e non-invasive mechanical ventilation; weaning strategies; morbidity and mortality; ethical problems; imaging and interventional procedures; nurse and physiotherapist's issues.

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  1. Oxygen therapy is routinely administered to mechanically ventilated patients. However, there remains uncertainty about the optimal oxygen titration target in patients with the acute respiratory distress syndro...

    Authors: Andrew J. Boyle, David N. Holmes, Jonathan Hackett, Susanna Gilliland, Michael McCloskey, Cecilia M. O’Kane, Paul Young, Stefania Di Gangi and Daniel F. McAuley

    Citation: BMC Pulmonary Medicine 2021 21:285

    Content type: Research article

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  2. Treatment for interstitial lung disease (ILD) patients with acute respiratory failure (ARF) is challenging, and literature to guide such treatment is scarce. The reported in-hospital mortality rates of ILD pat...

    Authors: Johanna P. van Gemert, Inge A. H. van den Berk, Esther J. Nossent, Leo M. A. Heunks, Rene E. Jonkers, Alexander P. Vlaar and Peter I. Bonta

    Citation: BMC Pulmonary Medicine 2021 21:249

    Content type: Research article

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  3. Invasive and non-invasive mechanical ventilation (MV) have been combined as sequential MV in the treatment of respiratory failure. However, the effectiveness remains unclear. Here, we performed a randomized co...

    Authors: Nai-Min Kang, Nan Zhang, Bao-Jian Luo, En-Dong Wu, Jian-Quan Shi, Liang Li and Li Jiang

    Citation: BMC Pulmonary Medicine 2021 21:203

    Content type: Research article

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  4. Ventilator-associated pneumonia (VAP) is an important diagnosis in critical care. VAP research is complicated by the lack of agreed diagnostic criteria and reference standard test criteria. Our aim was to revi...

    Authors: Basem Al-Omari, Peter McMeekin, A. Joy Allen, Ahsan R. Akram, Sara Graziadio, Jana Suklan, William S. Jones, B. Clare Lendrem, Amanda Winter, Milo Cullinan, Joanne Gray, Kevin Dhaliwal, Timothy S. Walsh and Thomas H. Craven

    Citation: BMC Pulmonary Medicine 2021 21:196

    Content type: Research article

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  5. Acute respiratory distress syndrome (ARDS) often requires controlled ventilation, yielding high mechanical power and possibly further injury. Veno-venous extracorporeal membrane oxygenation (VV-ECMO) can be us...

    Authors: Malou Janssen, J. Han. J. Meeder, Leonard Seghers and Corstiaan A. den Uil

    Citation: BMC Pulmonary Medicine 2021 21:176

    Content type: Case report

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  6. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the development of life-threatening COVID-19 are believed to disproportionately affect certain at-risk populations. However, it is not...

    Authors: Hannah R. Mathew, May Y. Choi, Michael D. Parkins and Marvin J. Fritzler

    Citation: BMC Pulmonary Medicine 2021 21:173

    Content type: Research article

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  7. Suspicion and clinical criteria continue to serve as the foundation for ventilator-associated pneumonia (VAP) diagnosis, however the criteria used to diagnose VAP vary widely. Data from head-to-head comparison...

    Authors: Farshid Rahimibashar, Andrew C. Miller, Mojtaba H. Yaghoobi and Amir Vahedian-Azimi

    Citation: BMC Pulmonary Medicine 2021 21:161

    Content type: Research article

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  8. To investigate the indications for high-flow nasal cannula oxygen (HFNC) therapy in patients with hypoxemia during ventilator weaning and to explore the predictors of reintubation when treatment fails.

    Authors: Taotao Liu, Qinyu Zhao and Bin Du

    Citation: BMC Pulmonary Medicine 2021 21:160

    Content type: Research article

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    The Correction to this article has been published in BMC Pulmonary Medicine 2021 21:194

  9. Factors that may increase the risk for delirium and the firm knowledge around mechanism for delirium in noninvasive ventilation (NIV) patients is lacking. We investigated the incidence, characteristics, and ou...

    Authors: Rui Zhang, Linfu Bai, Xiaoli Han, Shicong Huang, Lintong Zhou and Jun Duan

    Citation: BMC Pulmonary Medicine 2021 21:157

    Content type: Research article

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  10. Extracorporeal life support treatments such as extracorporeal membrane oxygenation (ECMO) have been recommended for the treatment of severe acute respiratory distress syndrome (ARDS) patients with coronavirus ...

    Authors: Shiqian Huang, Shuai Zhao, Huilin Luo, Zhouyang Wu, Jing Wu, Haifa Xia and Xiangdong Chen

    Citation: BMC Pulmonary Medicine 2021 21:116

    Content type: Review

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  11. Coronavirus Disease 2019 (COVID-19) is a pandemic affecting all countries in the world. Italy has been particularly afflicted by the health emergency, and since the peak phase has passed, major concern regardi...

    Authors: Emilia D’Elia, Mauro Gori, Aurelia Grosu, Annamaria Iorio, Ferdinando Luca Lorini, Anna Falanga, Fabiano Di Marco and Michele Senni

    Citation: BMC Pulmonary Medicine 2021 21:102

    Content type: Case report

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  12. To investigate if acute pulmonary vasodilation by sildenafil improves right ventricular function in patients with acute intermediate-high risk pulmonary embolism (PE).

    Authors: Asger Andersen, Farhad Waziri, Jacob Gammelgaard Schultz, Sarah Holmboe, Søren Warberg Becker, Tage Jensen, Hanne Maare Søndergaard, Karen Kaae Dodt, Ole May, Ulrik Markus Mortensen, Won Yong Kim, Søren Mellemkjær and Jens Erik Nielsen-Kudsk

    Citation: BMC Pulmonary Medicine 2021 21:72

    Content type: Research article

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  13. Sickle-cell anaemia is a widespread genetic disease prevalent worldwide among African and African-American populations. The pathogenesis is most often revealed by pulmonary conditions, including acute thoracic...

    Authors: Marion Teulier, Alexandre Elabbadi, Grigorios Gerotziafas, François Lionnet, Guillaume Voiriot and Muriel Fartoukh

    Citation: BMC Pulmonary Medicine 2021 21:46

    Content type: Case report

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  14. Rapid and accurate identification of right ventricular (RV) dysfunction is essential for decreasing mortality associated with acute pulmonary embolism (PE), particularly for non-high-risk patients without hypo...

    Authors: Yizhuo Gao, Lianghong Chen and Dong Jia

    Citation: BMC Pulmonary Medicine 2021 21:42

    Content type: Research article

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  15. Lung ultrasound score is a potential method for determining pulmonary edema in acute respiratory distress syndrome (ARDS). Continuous renal replacement therapy (CRRT) has become the preferred modality to manag...

    Authors: Fei Wang, Chunxia Wang, Jingyi Shi, Yijun Shan, Huijie Miao, Ting Sun, Yiping Zhou and Yucai Zhang

    Citation: BMC Pulmonary Medicine 2021 21:40

    Content type: Research article

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  16. Clinical management of COVID-19 requires close monitoring of lung function. While computed tomography (CT) offers ideal way to identify the phenotypes, it cannot monitor the patient response to therapeutic int...

    Authors: Zhanqi Zhao, Jin-Shou Zhang, Ying-Tzu Chen, Hou-Tai Chang, Yeong-Long Hsu, Inéz Frerichs and Andy Adler

    Citation: BMC Pulmonary Medicine 2021 21:38

    Content type: Case report

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  17. COVID-19 is a systemic viral infection which mainly targets the human respiratory system with many secondary clinical manifestations especially affecting the hematopoietic system and haemostasis. Few studies h...

    Authors: Albert Yick Hou Lim, Jun Leng Goh, Mae Chui Wei Chua, Bee Hoon Heng, John Arputham Abisheganaden and Pradeep Paul George

    Citation: BMC Pulmonary Medicine 2021 21:37

    Content type: Research article

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  18. Intermittent Prone Positioning (IPP) for Acute Respiratory Distress Syndrome (ARDS) decreases mortality. We present a program for IPP using expedient materials for settings of significant limitations in both o...

    Authors: Alfredo J. Astua, Eli K. Michaels and Andrew J. Michaels

    Citation: BMC Pulmonary Medicine 2021 21:25

    Content type: Technical advance

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  19. The aim of the present study was to evaluate the therapeutic effect of high-flow nasal cannula (HFNC) oxygen therapy on patients with aspiration pneumonia accompanied by respiratory failure in the post-stroke ...

    Authors: Dong Xing, Yu-Hong Chen, Lan -Tao Wang, Bin Yu, Zhi -Bin Ran and Li Chen

    Citation: BMC Pulmonary Medicine 2021 21:17

    Content type: Research article

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  20. Pulmonary infiltrates of variable etiology are one of the main reasons for hypoxemic respiratory failure leading to invasive mechanical ventilation. If pulmonary infiltrates remain unexplained or progress desp...

    Authors: Alessandro Ghiani and Claus Neurohr

    Citation: BMC Pulmonary Medicine 2021 21:15

    Content type: Research article

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  21. Endoscopic removal is the most common method for removal of tracheal stents. Few studies have reported the technique of fluoroscopy-guided stent removal for tracheal fistula and tracheal stenosis. We aimed to ...

    Authors: Yonghua Bi, Jindong Li, Liangliang Bai, Xinwei Han and Jianzhuang Ren

    Citation: BMC Pulmonary Medicine 2021 21:14

    Content type: Research article

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  22. There is only limited clinical data on the benefit of intense immunosuppression in patients with severe interstitial pneumonia associated with autoimmune features or new-onset connective tissue disease.

    Authors: Philipp Eller, Holger Flick, Gernot Schilcher, Florentine Moazedi-Fürst, Kathrin Eller, Emina Talakic, Josef Hermann, Yannick Allanore and Horst Olschewski

    Citation: BMC Pulmonary Medicine 2021 21:13

    Content type: Case report

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  23. It had been shown that High-flow nasal cannula (HFNC) is an effective initial support strategy for patients with acute respiratory failure. However, the efficacy of HFNC for patients with COVID-19 has not been...

    Authors: Ming Hu, Qiang Zhou, Ruiqiang Zheng, Xuyan Li, Jianmin Ling, Yumei Chen, Jing Jia and Cuihong Xie

    Citation: BMC Pulmonary Medicine 2020 20:324

    Content type: Research article

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  24. Primary cardiac neoplasms are extremely rare, with an autopsy incidence of 0.0001–0.003%. Primary cardiac sarcoma is usually derived from the right atrium and it manifests as chest pain, arrhythmia, hemoptysis...

    Authors: Masaoki Saito, Takeshi Saraya, Miku Oda, Toshinori Minamishima, Ken Kongoji, Aya Isomura, Masachika Fujiwara, Kyoko Soejima and Haruyuki Ishii

    Citation: BMC Pulmonary Medicine 2020 20:321

    Content type: Case report

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  25. Oxidative stress plays an important role in acute lung injury, which is associated with the development and progression of acute respiratory failure. Here, we investigated whether the degree of oxidative stres...

    Authors: Ryo Nagasawa, Yu Hara, Kota Murohashi, Ayako Aoki, Nobuaki Kobayashi, Shigeto Takagi, Satoru Hashimoto, Akihiko Kawana and Takeshi Kaneko

    Citation: BMC Pulmonary Medicine 2020 20:310

    Content type: Research article

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  26. Community-acquired bacterial pneumonia (CABP) can lead to sepsis and is associated with high mortality rates in patients presenting with shock and/or respiratory failure and who require mechanical ventilation ...

    Authors: Pierre-François Laterre, Miguel Sánchez-García, Tom van der Poll, Olga de la Rosa, Kathy-Ann Cadogan, Eleuterio Lombardo and Bruno François

    Citation: BMC Pulmonary Medicine 2020 20:309

    Content type: Study protocol

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  27. Coronavirus disease 2019 (COVID-19) has reach pandemic proportions globally. For patients with symptoms of fever and cough accompanied by rapid lung damage progression, COVID-19 needs to be distinguished from ...

    Authors: Mengke Cao, Shuangshuang Zhang, Dejie Chu, Ming Xiao, Xiaohong Liu, Lingling Yu, Jing Li, Yi Huang and Fang Fang

    Citation: BMC Pulmonary Medicine 2020 20:304

    Content type: Case report

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  28. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly reached pandemic proportions. Given that the main target of SARS-CoV-2 are lungs leading to severe pneumonia with hyperactivation of the inf...

    Authors: Laura Pandolfi, Tommaso Fossali, Vanessa Frangipane, Sara Bozzini, Monica Morosini, Maura D’Amato, Sara Lettieri, Mario Urtis, Alessandro Di Toro, Laura Saracino, Elena Percivalle, Stefano Tomaselli, Lorenzo Cavagna, Emanuela Cova, Francesco Mojoli, Paola Bergomi…

    Citation: BMC Pulmonary Medicine 2020 20:301

    Content type: Research article

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  29. Pneumothorax as a consequence of pulmonary barotrauma during explosive decompression military crew training in a hypobaric chamber is an extremely rare and sparsely diagnosed complication. Extensive bilateral ...

    Authors: Jakub Tlapák, Boris Oniščenko, Petr Došel, Pavel Požár, Petr Chmátal and Michal Hájek

    Citation: BMC Pulmonary Medicine 2020 20:291

    Content type: Case report

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  30. The clinical correlates, prognosis and determinants of acute kidney injury (AKI) in patients with coronavirus disease 2019 (Covid-19) remain largely unclear.

    Authors: Ling Sang, Sibei Chen, Xia Zheng, Weijie Guan, Zhihui Zhang, Wenhua Liang, Ming Zhong, Li Jiang, Chun Pan, Wei Zhang, Jiaan Xia, Nanshan Chen, Wenjuan Wu, Hongkai Wu, Yonghao Xu, Xuesong Liu…

    Citation: BMC Pulmonary Medicine 2020 20:290

    Content type: Research article

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  31. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has spread to almost 100 countries, infected over 31 M patients and resulted in 961 K deaths worldwi...

    Authors: Esmaeil Mortaz, Majid Malkmohammad, Hamidreza Jamaati, Parisa Adimi Naghan, Seyed MohamadReza Hashemian, Payam Tabarsi, Maohammad Varahram, Hamidreza Zaheri, Efsun Gonca Uğur Chousein, Gert Folkerts and Ian M. Adcock

    Citation: BMC Pulmonary Medicine 2020 20:269

    Content type: Research article

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    The Correction to this article has been published in BMC Pulmonary Medicine 2020 20:294

  32. Bronchoscopy is applied broadly in the diagnosis and treatment of pulmonary diseases. Over the past few decades, an increasing number of studies about bronchoscopy have been published. However, little is known...

    Authors: Boxue He, Pengfei Zhang, Qidong Cai, Shuai Shi, Hui Xie, Yuqian Zhang, Xiong Peng, Zhenyu Zhao, Wei Yin and Xiang Wang

    Citation: BMC Pulmonary Medicine 2020 20:229

    Content type: Research article

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  33. Each myositis-specific autoantibody (MSA) tends to have a distinct clinical presentation. Coexistence of MSAs do not commonly occur. If they do, it is unknown if there is an overlap of clinical features or pro...

    Authors: Zi Ying Li, Evanpaul Gill, Fan Mo and Candice Reyes

    Citation: BMC Pulmonary Medicine 2020 20:220

    Content type: Case report

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  34. Contradictory results regarding changes in serum club cell protein 16 (CC16) levels in patients with acute respiratory distress syndrome (ARDS) have been reported, challenging the value of CC16 as a diagnostic...

    Authors: Jinle Lin, Wuyuan Tao, Jian Wei, Jian Wu, Wenwu Zhang, Jianbing Ye, Xuan Fu, Shiyong Zeng, Qingli Dou, Lijun Wang and Fang Tian

    Citation: BMC Pulmonary Medicine 2020 20:212

    Content type: Research article

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    The Publisher Correction to this article has been published in BMC Pulmonary Medicine 2021 21:54

  35. Acute respiratory distress syndrome (ARDS) in infants undergoing cardiac surgery is associated with significant mortality and prolonged ventilation; surfactant administration may be a useful therapy. The purpo...

    Authors: Rongyuan Zhang, Xu Wang, Shoujun Li and Jun Yan

    Citation: BMC Pulmonary Medicine 2020 20:210

    Content type: Research article

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  36. Plasma levels of cell-free DNA (cf-DNA) are known to be elevated in sepsis and high levels are associated with a poor prognosis. Mechanical ventilation affects systemic inflammation in which lung-protective venti...

    Authors: Axel Nyberg, Alexander Larsson, Juulia Jylhävä, Mikko Hurme, Jesper Sperber, Miklós Lipcsey and Markus Castegren

    Citation: BMC Pulmonary Medicine 2020 20:206

    Content type: Research article

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  37. Identification of pathologic features is helpful for the management of nonresolving acute respiratory distress syndrome (ARDS). Transbronchial lung cryobiopsy (TBLC) is a novel biopsy technique that may have c...

    Authors: Guowu Zhou, Yingying Feng, Shiyao Wang, Yi Zhang, Ye Tian, Xiaojing Wu, Ling Zhao, Dan Wang, Ying Li, Zheng Tian and Qingyuan Zhan

    Citation: BMC Pulmonary Medicine 2020 20:183

    Content type: Research article

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  38. This retrospective study aimed to investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and albumin for 30-day mortality in patients with postoperative acute pulmonary embolism (PAPE).

    Authors: Chuan Liu, Hui-lu Zhan, Zhang-Heng Huang, Chuan Hu, Yue-Xin Tong, Zhi-Yi Fan, Meng-Ying Zheng, Cheng-Liang Zhao and Gui-Yun Ma

    Citation: BMC Pulmonary Medicine 2020 20:180

    Content type: Research article

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  39. Forced expiratory volume in 1 second (FEV1) is the only parameter currently recognized as a surrogate endpoint in cystic fibrosis (CF) trials. However, FEV1 is relatively insensitive to changes in the small airwa...

    Authors: Sivagurunathan Sutharsan, Susanne Naehrig, Uwe Mellies, Christian Sieder and Jörg Ziegler

    Citation: BMC Pulmonary Medicine 2020 20:167

    Content type: Research article

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  40. The relationship between biomarkers and hospital-acquired pneumonia (HAP) is understudied, especially in severe cases admitted to the intensive care unit (ICU). Compared with community-acquired pneumonia (CAP)...

    Authors: Nan Zheng, Dongmei Zhu and Yi Han

    Citation: BMC Pulmonary Medicine 2020 20:166

    Content type: Research article

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  41. The collected works of Hippocrates were searched for concepts on the diagnosis, prognosis, and treatment of acute and urgent respiratory diseases, with the objective to trace their origins in the Hippocratic Coll...

    Authors: Georgios Stefanakis, Vasileia Nyktari, Alexandra Papaioannou and Helen Askitopoulou

    Citation: BMC Pulmonary Medicine 2020 20:165

    Content type: Research article

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  42. Obstructive sleep apnoea (OSA) is related with adverse pregnancy outcomes, including preeclampsia. However, there are small studies about treatment of OSA with automatic continuous positive airway pressure (CP...

    Authors: Mi Sun Kim, Myoung Jin Moon, Yoon Hee Lee, Kyu Young Chae and Eun Hee Ahn

    Citation: BMC Pulmonary Medicine 2020 20:157

    Content type: Case report

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  43. Statin-associated necrotizing myopathy (SANM) is a rare autoimmune disorder caused by administration of statins. SANM is characterized by weakness due to necrosis and regeneration of myofibers. Here we report ...

    Authors: Yuriko Yamamura, Yoshinori Matsumoto, Koh Tadokoro, Yasuyuki Ohta, Kota Sato, Toru Yamashita, Masahiro Yamamura, Ken-Ei Sada, Koji Abe and Jun Wada

    Citation: BMC Pulmonary Medicine 2020 20:156

    Content type: Case report

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  44. Usual clinical practice for arterial blood gas analysis (BGA) in conscious patients involves a one-time arterial puncture to be performed after a resting period of 20–30 min. The aim of this study was to evalu...

    Authors: Akira Umeda, Masahiro Ishizaka, Masamichi Tasaki, Tateki Yamane, Taiji Watanabe, Yasushi Inoue, Taichi Mochizuki, Yasumasa Okada and Sarah Kesler

    Citation: BMC Pulmonary Medicine 2020 20:151

    Content type: Research article

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