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Respiratory critical care

Section edited by Raffaele Scala

This section concerns all aspects dealing with pulmonary critically ill patients: models of acute setting ; epidemiology, monitoring and treatment of acute respiratory failure; patho-physiology and clinical applications of invasive e non-invasive mechanical ventilation; weaning strategies; morbidity and mortality; ethical problems; imaging and interventional procedures; nurse and physiotherapist's issues.

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  1. Content type: Research article

    Aerosol administration is increasingly being used as a therapeutic intervention for mechanically ventilated preterm infants. However, the effects of inhalation therapy on retinopathy of prematurity (ROP) have ...

    Authors: Mei-Chin Yang, Hsiu-Feng Hsiao, Hsiu-Li Tseng, Ya-Wen Chiu and Yi-Hao Weng

    Citation: BMC Pulmonary Medicine 2019 19:145

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  2. Content type: Research article

    Noninvasive ventilation (NIV) reduces the rate of endotracheal intubation (ETI) and overall mortality in severe acute exacerbation of COPD (AECOPD) with acute respiratory failure and is increasingly applied in...

    Authors: Alexandru T. Steriade, Shirin Johari, Nicoleta Sargarovschi, Daniela Necula, Cornelia E. Tudose, Diana Ionita, Miron A. Bogdan and Dragos Bumbacea

    Citation: BMC Pulmonary Medicine 2019 19:131

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  3. Content type: Research article

    In people with and without Cystic Fibrosis (CF), does side lying during nebulisation change: the proportion of the dose loaded in the nebuliser that is deposited in the lungs; the uniformity of deposition thro...

    Authors: Ruth L. Dentice, Mark R. Elkins, Jordan Verschuer, Stefan Eberl, Genevieve Dwyer and Peter T. P. Bye

    Citation: BMC Pulmonary Medicine 2019 19:128

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  4. Content type: Research article

    We aimed to evaluate whether serum activin-A levels are elevated and have any value in predicting severity and prognosis in acute respiratory distress syndrome (ARDS).

    Authors: Jee-min Kim, Jung-Kyu Lee, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han and Sang-Min Lee

    Citation: BMC Pulmonary Medicine 2019 19:115

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  5. Content type: Research article

    Evaluating severity of illness of patients with prolonged mechanical ventilation (PMV) is important to adopt the best appropriate care management for each individual. Yet, no severity-of-illness scoring system...

    Authors: Joao C. Winck, Hélène Gilet, Peter Kalin, Javier Murcia, Fabian Plano, Antoine Regnault, Michael Dreher, Michele Vitacca and Nicolino Ambrosino

    Citation: BMC Pulmonary Medicine 2019 19:109

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  6. Content type: Research article

    We previously demonstrated that the pleural levels of proteins (neutrophil gelatinase-associated lipocalin/NGAL, calprotectin, bactericidal permeability-increasing/BPI, azurocidin 1/AZU-1) were valuable marker...

    Authors: Kuo-An Wu, Chih-Ching Wu, Yu-Ching Liu, Pei-Chun Hsueh, Chia-Yin Chin, Chih-Liang Wang, Chi-Ming Chu, Li-Jane Shih and Chia-Yu Yang

    Citation: BMC Pulmonary Medicine 2019 19:108

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  7. Content type: Research article

    Sepsis biomarkers have limited specificity and sensitivity. Few studies have investigated microRNA (miRNA) biomarkers for sepsis secondary to pneumonia. This study aims to investigate the diagnostic and progno...

    Authors: Wenping Zhang, Jianchao Jia, Zi Liu, Dan Si, Lijun Ma and Guojun Zhang

    Citation: BMC Pulmonary Medicine 2019 19:93

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  8. Content type: Research article

    Pneumothorax (PTX) is one of the most common complications of transbronchial biopsy (TBB). Previous research suggests that upper pulmonary lobe TBB may be associated with increased risk of PTX development. The...

    Authors: Vladimir Herout, Michaela Heroutova, Zdenek Merta, Ivan Cundrle Jr and Kristian Brat

    Citation: BMC Pulmonary Medicine 2019 19:56

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  9. Content type: Research article

    Studies investigating the role of hyperoxia in critically ill patients have reported conflicting results. We did this analysis to reveal the effect of hyperoxia in the patients admitted to the intensive care u...

    Authors: Yue-Nan Ni, Yan-Mei Wang, Bin-Miao Liang and Zong-An Liang

    Citation: BMC Pulmonary Medicine 2019 19:53

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  10. Content type: Research article

    During invasive ventilation, the upper airway is bypassed and no longer participates in humidification of inspired gases, which is essential to avoid harmful consequences such as endotracheal tube occlusion. I...

    Authors: Noémie Haziot, Mohamed Ibrahim, Kaixian Zhu, Charles-Philippe Thevenin, Sebastien Hardy and Jésus Gonzalez-Bermejo

    Citation: BMC Pulmonary Medicine 2019 19:43

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  11. Content type: Research article

    In the Berlin definition, acute respiratory distress syndrome (ARDS) is stratified into three stages according to oxygenation severity at the onset. The relevance between ARDS severity and prognosis varies amo...

    Authors: Tetsuro Kamo, Sadatomo Tasaka, Takeshi Suzuki, Takanori Asakura, Shoji Suzuki, Kazuma Yagi, Ho Namkoong, Makoto Ishii, Hiroshi Morisaki and Tomoko Betsuyaku

    Citation: BMC Pulmonary Medicine 2019 19:37

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  12. Content type: Research article

    Self-expandable metallic stents (SEMSs) have enabled a approving management of malignant airway stenosis. However, the long-term efficacy and safety of this treatment in patients with benign airway stricture a...

    Authors: Xiao-feng Xiong, Li Xu, Li-li Fan, De-yun Cheng and Bi-xia Zheng

    Citation: BMC Pulmonary Medicine 2019 19:33

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  13. Content type: Case report

    Double lumen intubation and one-lung ventilation should be applied without delay in cases of traumatic main bronchial rupture. In most cases, when the patients’ vital signs have been stabilized, the repair can...

    Authors: Feng Yun Wang, Bin Fang, Zhi Hui Yu, Jing Song Shao, Wei Biao Wen and Li Xin Zhou

    Citation: BMC Pulmonary Medicine 2019 19:30

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  14. Content type: Research article

    The high cost and low availability of polysomnography (PSG) limits the timely diagnosis of OSA. Herein, we developed and validated a simple-to-use nomogram for predicting OSA.

    Authors: Huajun Xu, Xiaolong Zhao, Yue Shi, Xinyi Li, Yingjun Qian, Jianyin Zou, Hongliang Yi, Hengye Huang, Jian Guan and Shankai Yin

    Citation: BMC Pulmonary Medicine 2019 19:18

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  15. Content type: Research article

    Surfactant is usually deficiency in adult acute respiratory distress syndrome(ARDS) patients and surfactant administration may be a useful therapy. The aim of this study was to perform a meta-analysis of the effe...

    Authors: Shan-Shan Meng, Wei Chang, Zhong-Hua Lu, Jian-Feng Xie, Hai-Bo Qiu, Yi Yang and Feng-Mei Guo

    Citation: BMC Pulmonary Medicine 2019 19:9

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  16. Content type: Research article

    The lung ultrasound score has been regarded as a decent semiquantitative score to measure the lung aeration loss. The score has been proven to be valuable in diagnosing and monitoring lung pathology, but no st...

    Authors: Wanhong Yin, Tongjuan Zou, Yao Qin, Jing Yang, Yi Li, Xueying Zeng and Yan Kang

    Citation: BMC Pulmonary Medicine 2019 19:1

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  17. Content type: Research article

    Home mechanical ventilation is an established treatment for chronic respiratory failure resulting in improved survival and quality of life. Technological advancement, evolving health care reimbursement systems...

    Authors: Luca Valko, Szabolcs Baglyas, Janos Gal and Andras Lorx

    Citation: BMC Pulmonary Medicine 2018 18:190

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  18. Content type: Research article

    There is a lack of robust data about factors predicting continuation (or termination) of positive airway pressure therapy (PAP) for sleep apnea. This analysis of big data from a German homecare provider descri...

    Authors: Holger Woehrle, Michael Arzt, Andrea Graml, Ingo Fietze, Peter Young, Helmut Teschler and Joachim H. Ficker

    Citation: BMC Pulmonary Medicine 2018 18:186

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  19. Content type: Research article

    Diaphragmatic dysfunction remains the main cause of weaning difficulty or failure. Ultrasonographic measurement of diaphragmatic function can be used to predict the outcomes of weaning from mechanical ventilat...

    Authors: Pongdhep Theerawit, Dararat Eksombatchai, Yuda Sutherasan, Thitiporn Suwatanapongched, Charn Kiatboonsri and Sumalee Kiatboonsri

    Citation: BMC Pulmonary Medicine 2018 18:175

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  20. Content type: Research article

    Pneumonia and septic pneumonic shock are the most common indications for long-term mechanical ventilation and prolonged weaning, independent of any comorbidities. Multidrug resistant (MDR) bacteria are emergin...

    Authors: Johannes Bickenbach, Daniel Schöneis, Gernot Marx, Nikolaus Marx, Sebastian Lemmen and Michael Dreher

    Citation: BMC Pulmonary Medicine 2018 18:141

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  21. Content type: Research article

    Lung ultrasound and echocardiography are mainly applied in critical care and emergency medicine. However, the diagnostic value of cardiopulmonary ultrasound in elderly patients with acute respiratory distress ...

    Authors: Daozheng Huang, Huan Ma, Zhiyuan Xiao, Michael Blaivas, Ying Chen, Jianyi Wen, Weixin Guo, Jun Liang, Xiaolong Liao, Zhonghua Wang, Hanbiao Li, Jie Li, Yangong Chao, Xiao ting Wang, Yan Wu, Tiehe Qin…

    Citation: BMC Pulmonary Medicine 2018 18:136

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  22. Content type: Case report

    Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare cause of pulmonary hypertension that is associated with malignancies and is marked by the presence of non-occlusive tumor emboli and fibrocellular in...

    Authors: Dante A. Suffredini, Jung-Min Lee, Cody J. Peer, Drew Pratt, David E. Kleiner, Jason M. Elinoff and Michael A. Solomon

    Citation: BMC Pulmonary Medicine 2018 18:112

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  23. Content type: Review

    Interstitial lung diseases (ILDs) are a heterogeneous group of diseases characterized by widespread fibrotic and inflammatory abnormalities of the lung. Respiratory failure is a common complication in advanced...

    Authors: Paola Faverio, Federica De Giacomi, Luca Sardella, Giuseppe Fiorentino, Mauro Carone, Francesco Salerno, Jousel Ora, Paola Rogliani, Giulia Pellegrino, Giuseppe Francesco Sferrazza Papa, Francesco Bini, Bruno Dino Bodini, Grazia Messinesi, Alberto Pesci and Antonio Esquinas

    Citation: BMC Pulmonary Medicine 2018 18:70

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  24. Content type: Research article

    Pleural effusion (PE) drainage can relieve the symptoms of dyspnea; however, details of the resulting hemodynamic changes remain undefined.

    Authors: Zheng Wang, Qi-Zhe Cai, Cheng-Jun Ban, Duo Chen, Li-Li Xu, Xiao-Juan Wang, Zhen Wang, Yuan Yang, Xiu-Zhang Lv and Huan-Zhong Shi

    Citation: BMC Pulmonary Medicine 2018 18:62

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  25. Content type: Case report

    Clinically hypomyopathic dermatomyositis is a rare disease that is important to recognize, investigate and treat early as it is associated with poor prognosis. In a proportion of patients, myositis specific an...

    Authors: Safi Alqatari, Peter Riddell, Sinead Harney, Michael Henry and Grainne Murphy

    Citation: BMC Pulmonary Medicine 2018 18:59

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  26. Content type: Research article

    To compare, in terms of patient-ventilator interaction and performance, a new nasal mask (Respireo, AirLiquide, FR) with the Endotracheal tube (ET) and a commonly used nasal mask (FPM, Fisher and Paykel, NZ) f...

    Authors: Giorgio Conti, Giorgia Spinazzola, Cesare Gregoretti, Giuliano Ferrone, Andrea Cortegiani, Olimpia Festa, Marco Piastra, Luca Tortorolo and Roberta Costa

    Citation: BMC Pulmonary Medicine 2018 18:57

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  27. Content type: Research article

    Bacterial respiratory infections (BRI) are major complications contributing to increased morbidity and mortality after lung transplantation (LT). This study analyzed epidemiology and outcome of 175 consecutive...

    Authors: Sebastien Tanaka, Claire Geneve, Gianpiero Tebano, Nathalie Grall, Pascal Piednoir, Régis Bronchard, Mathieu Godement, Enora Atchade, Pascal Augustin, Herve Mal, Yves Castier, Philippe Montravers and Mathieu Desmard

    Citation: BMC Pulmonary Medicine 2018 18:43

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  28. Content type: Research article

    In the 1980s, randomized-controlled trials showed that high-dose corticosteroid treatment did not improve the mortality of acute respiratory distress syndrome (ARDS). However, while the diagnostic criteria for...

    Authors: Takashi Kido, Keiji Muramatsu, Takeshi Asakawa, Hiroki Otsubo, Takaaki Ogoshi, Keishi Oda, Tatsuhiko Kubo, Yoshihisa Fujino, Shinya Matsuda, Toshihiko Mayumi, Hiroshi Mukae and Kazuhiro Yatera

    Citation: BMC Pulmonary Medicine 2018 18:28

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  29. Content type: Research article

    Pulmonary emphysema combined with systemic sclerosis (SSc)-associated interstitial lung disease (ILD) occurs more often in smokers but also in never-smokers. This study aimed to describe a new finding characte...

    Authors: Hideaki Yamakawa, Tamiko Takemura, Tae Iwasawa, Yumie Yamanaka, Satoshi Ikeda, Akimasa Sekine, Hideya Kitamura, Tomohisa Baba, Shinichiro Iso, Koji Okudela, Kazuyoshi Kuwano and Takashi Ogura

    Citation: BMC Pulmonary Medicine 2018 18:25

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  30. Content type: Research article

    Pneumococcal pneumonia causes high morbidity and mortality among adults. This study aimed to identify risk factors for bacteremic pneumococcal pneumonia, and to construct a prediction model for the development...

    Authors: Yasuyoshi Washio, Akihiro Ito, Shogo Kumagai, Tadashi Ishida and Akio Yamazaki

    Citation: BMC Pulmonary Medicine 2018 18:24

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  31. Content type: Research article

    Early onset of lung injury is considerable common after cardiac surgery and is associated with increasing in morbidity and mortality, but current clinical predictors for the occurrence of this complication alw...

    Authors: XiWang Liu, QiXing Chen, YuJia Luo, YaoQin Hu, DengMing Lai, XiaoLe Zhang, XiangHong Zhang, JianGen Yu, XiangMing Fang and Qiang Shu

    Citation: BMC Pulmonary Medicine 2017 17:218

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  32. Content type: Case report

    Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe hypersensitivity drug reaction involving the skin and multiple internal organ systems. The symptoms typically present with fever and sk...

    Authors: Olivia Wilcox, Mohamed Hassanein, John Armstrong and Nader Kassis

    Citation: BMC Pulmonary Medicine 2017 17:217

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  33. Content type: Research article

    Pneumonia poses a significant burden to the U.S. health-care system. However, there are few data focusing on severe pneumonia, particularly cases of pneumonia associated with specialized care in intensive care...

    Authors: Aaron D. Storms, Jufu Chen, Lisa A. Jackson, James D. Nordin, Allison L. Naleway, Jason M. Glanz, Steven J. Jacobsen, Eric S. Weintraub, Nicola P. Klein, Paul M. Gargiullo and Alicia M. Fry

    Citation: BMC Pulmonary Medicine 2017 17:208

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  34. Content type: Research article

    Uncertainly prevails with regard to the use of inhalation or instillation steroids to prevent bronchopulmonary dysplasia in preterm infants. The meta-analysis with sequential analysis was designed to evaluate ...

    Authors: Zhi-Qun Zhang, Ying Zhong, Xian-Mei Huang and Li-Zhong Du

    Citation: BMC Pulmonary Medicine 2017 17:207

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  35. Content type: Research article

    Acute respiratory distress syndrome (ARDS) is potentially underrecognized by clinicians. Early recognition and subsequent optimal treatment of patients with ARDS may be facilitated by usage of biomarkers. Surf...

    Authors: Jinkyeong Park, Maria Pabon, Augustine M. K. Choi, Ilias I. Siempos, Laura E. Fredenburgh, Rebecca M. Baron, Kyeongman Jeon, Chi Ryang Chung, Jeong Hoon Yang, Chi-Min Park and Gee Young Suh

    Citation: BMC Pulmonary Medicine 2017 17:204

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  36. Content type: Research article

    Acute respiratory failure (ARF) is a common and life-threatening medical emergency in patients admitted to the hospital. Currently, there is a lack of large-scale evidence on the use of high-flow nasal cannula...

    Authors: Youfeng Zhu, Haiyan Yin, Rui Zhang and Jianrui Wei

    Citation: BMC Pulmonary Medicine 2017 17:201

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  37. Content type: Research article

    Bronchopulmonary dysplasia (BPD) is a neonatal chronic lung disease characterized by impaired pulmonary alveolar development in preterm infants. Until now, little is known about the molecular and cellular basi...

    Authors: Cheng Cai, Jiajun Qiu, Gang Qiu, Yihuan Chen, Zhijun Song, Juan Li and Xiaohui Gong

    Citation: BMC Pulmonary Medicine 2017 17:199

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  38. Content type: Research article

    Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a valuable life support in acute respiratory distress syndrome (ARDS) in adult patients. However, the success of VV-ECMO is known to be influenced by...

    Authors: Meng-Yu Wu, Yu-Sheng Chang, Chung-Chi Huang, Tzu-I Wu and Pyng-Jing Lin

    Citation: BMC Pulmonary Medicine 2017 17:181

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  39. Content type: Research article

    Ultrasound is a convenient tool to evaluate cardiac and diaphragm function. The ratio (E/Ea) of mitral Doppler inflow velocity to annular tissue Doppler wave velocity by transthoracic echocardiography (TTE) an...

    Authors: Ling Luo, Yidan Li, Xiukai Chen, Bing Sun, Wenxiong Li, Wei Gu, Shuo Wang, Song Zhao, Yanwei Lv, Mulei Chen, Jingen Xia, Feng Sui, Xue Mei, Huanzhong Shi and Zhaohui Tong

    Citation: BMC Pulmonary Medicine 2017 17:161

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  40. Content type: Research article

    The effects of high flow nasal cannula (HFNC) on adult patients after extubation remain controversial. We aimed to further determine the effectiveness of HFNC in comparison to noninvasive positive pressure ven...

    Authors: Yue-Nan Ni, Jian Luo, He Yu, Dan Liu, Bin-Miao Liang, Rong Yao and Zong-An Liang

    Citation: BMC Pulmonary Medicine 2017 17:142

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  41. Content type: Research article

    Neurally Adjusted Ventilatory Assist (NAVA) is a proportional ventilatory mode that uses the electrical activity of the diaphragm (EAdi) to offer ventilatory assistance in proportion to patient effort. NAVA ha...

    Authors: Juliana C. Ferreira, Fabia Diniz-Silva, Henrique T. Moriya, Adriano M. Alencar, Marcelo B. P. Amato and Carlos R. R. Carvalho

    Citation: BMC Pulmonary Medicine 2017 17:139

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  42. Content type: Research article

    Analysis of respiratory mechanics during mechanical ventilation (MV) is able to estimate resistive, elastic and inertial components of the working pressure of the respiratory system. Our aim was to discriminat...

    Authors: Pablo Cruces, Sebastián González-Dambrauskas, Julio Quilodrán, Jorge Valenzuela, Javier Martínez, Natalia Rivero, Pablo Arias and Franco Díaz

    Citation: BMC Pulmonary Medicine 2017 17:129

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  43. Content type: Study protocol

    Acute respiratory failure (ARF) is still one of the most severe complications in immunocompromised patients. Our previous systematic review showed noninvasive mechanical ventilation (NIV) reduced mortality, le...

    Authors: Tao Wang, Gang Liu, Kun He, Xin Lu, Xianquan Liang, Meng Wang, Rong Zhu, Zongru Li, Feng Chen, Jun Ke, Qingming Lin, Chuanyun Qian, Bo Li, Jie Wei, Jingjun Lv, Li Li…

    Citation: BMC Pulmonary Medicine 2017 17:127

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  44. Content type: Research article

    Sedation and/or analgesia can relieve the patient-ventilator asynchrony. However, whether sedation and/or analgesia can benefit the clinical outcome of the patients with interface intolerance is still unclear.

    Authors: Yue-Nan Ni, Ting Wang, He Yu, Bin-Miao Liang and Zong-An Liang

    Citation: BMC Pulmonary Medicine 2017 17:125

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  45. Content type: Research article

    Expired gas (exhalome) analysis of ventilated critical ill patients can be used for drug monitoring and biomarker diagnostics. However, it remains unclear to what extent volatile organic compounds are present ...

    Authors: Tobias Hüppe, Dominik Lorenz, Mario Wachowiak, Felix Maurer, Andreas Meiser, Heinrich Groesdonk, Tobias Fink, Daniel I. Sessler and Sascha Kreuer

    Citation: BMC Pulmonary Medicine 2017 17:116

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  46. Content type: Research article

    Positive-pressure mechanical ventilation is essential in assisting patients with respiratory failure in the intensive care unit and facilitating oxygenation in the operating room. However, it was also recogniz...

    Authors: Nan-Chun Wu, Fan-Ting Liao, Hao-min Cheng, Shih-Hsien Sung, Yu-Chun Yang and Jiun-Jr Wang

    Citation: BMC Pulmonary Medicine 2017 17:105

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  47. Content type: Case report

    To describe the experience of combination therapy with extracorporeal membrane oxygenation(ECMO), high-frequency oscillatory ventilation(HFOV) and prone positioning in treating severe respiratory failure cause...

    Authors: Hangyong He, Hao Wang, Xuyan Li, Xiao Tang, Rui Wang, Bing Sun and Zhaohui Tong

    Citation: BMC Pulmonary Medicine 2017 17:103

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  48. Content type: Case report

    In patients with post-extubation respiratory distress, delayed reintubation may worsen clinical outcomes. Objective measures of extubation failure at the bedside are lacking, therefore clinical parameters are ...

    Authors: Fabia Diniz-Silva, Anna Miethke-Morais, Adriano M. Alencar, Henrique T. Moriya, Pedro Caruso, Eduardo L. V. Costa and Juliana C. Ferreira

    Citation: BMC Pulmonary Medicine 2017 17:91

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