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  1. The pathological appearance of idiopathic pleuroparenchymal fibroelastosis (IPPFE) with hematoxylin-eosin staining is similar to that of usual interstitial pneumonia (UIP) in patients with idiopathic pulmonary...

    Authors: Noriyuki Enomoto, Hideki Kusagaya, Yoshiyuki Oyama, Masato Kono, Yusuke Kaida, Shigeki Kuroishi, Dai Hashimoto, Tomoyuki Fujisawa, Koshi Yokomura, Naoki Inui, Yutaro Nakamura and Takafumi Suda
    Citation: BMC Pulmonary Medicine 2014 14:91
    Content type: Research article Published on:

  2. Remodelling in COPD has at least two dimensions: small airway wall thickening and destruction of alveolar walls. Recent studies indicate that there is some similarity between alveolar and small airway wall mat...

    Authors: Irene MJ Eurlings, Mieke A Dentener, Jack PM Cleutjens, Carine J Peutz, Gernot GU Rohde, Emiel FM Wouters and Niki L Reynaert
    Citation: BMC Pulmonary Medicine 2014 14:90
    Content type: Research article Published on:

  3. Huntington’s disease (HD) is a neurodegenerative disorder characterized by progressive motor, cognitive and psychiatric disturbances. Chest muscle rigidity, respiratory muscle weakness, difficulty in clearing ...

    Authors: Alvaro Reyes, Travis Cruickshank, Mel Ziman and Kazunori Nosaka
    Citation: BMC Pulmonary Medicine 2014 14:89
    Content type: Research article Published on:

  4. Chronic Obstructive Pulmonary Disease (COPD) is the most common severe chronic disease in primary care. It is typically diagnosed at a late stage, and it is also difficult to predict its trajectory and hence t...

    Authors: Jens Søndergaard and Anders Halling
    Citation: BMC Pulmonary Medicine 2014 14:88
    Content type: Study protocol Published on:

  5. Whole-lung lavage (WLL) is classically the first-line treatment for symptomatic pulmonary alveolar proteinosis (PAP). However, some patients require multiple WLLs because of refractory nature of their PAP. In ...

    Authors: Hong yan Yu, Xue feng Sun, Yan xun Wang, Zuo jun Xu and Hui Huang
    Citation: BMC Pulmonary Medicine 2014 14:87
    Content type: Case report Published on:

  6. Idiopathic interstitial pneumonias such as idiopathic pulmonary fibrosis or fibrotic nonspecific interstitial pneumonia are irreversible progressive pulmonary diseases that often have fatal outcomes. Although ...

    Authors: Koichiro Kamio, Arata Azuma, Ken Ohta, Yukihiko Sugiyama, Toshihiro Nukiwa, Shoji Kudoh and Tohru Mizushima
    Citation: BMC Pulmonary Medicine 2014 14:86
    Content type: Research article Published on:

  7. We have shown that chronic obstructive pulmonary disease (COPD) is associated with increased production of pro-inflammatory cytokines and the cytotoxic mediator, granzyme B by peripheral blood steroid resistan...

    Authors: Greg Hodge, Mark Holmes, Hubertus Jersmann, Paul N Reynolds and Sandra Hodge
    Citation: BMC Pulmonary Medicine 2014 14:85
    Content type: Research article Published on:

  8. The pathogenesis of obstructive sleep apnoea/hypopnoea syndrome (OSAHS), a highly prevalent disease, is not completely understood. The purpose of this study was to investigate the contributions of Th17 cells a...

    Authors: Lin Ying, Hequan Li, Zhijie Pan, Shanni Ma, Pei Zhang, Qing Wang, Guohua Lu and Jianying Zhou
    Citation: BMC Pulmonary Medicine 2014 14:84
    Content type: Research article Published on:

  9. The discovery of the fusion gene echinodermmicro tubule associated proteinlike 4-anaplastic lymphoma kinase, EML4-ALK, in patients with non-small-cell lung cancer has led to the remarkable development of anapl...

    Authors: Qiushi Wang, Yong He, Xin Yang, Yubo Wang and Hualiang Xiao
    Citation: BMC Pulmonary Medicine 2014 14:83
    Content type: Case report Published on:

  10. In cystic fibrosis (CF) patients, the upper airways display the same ion channel defect as evident in the lungs, resulting in chronic inflammation and infection. Recognition of the sinonasal area as a site of ...

    Authors: Julia Hentschel, Manuela Jäger, Natalie Beiersdorf, Nele Fischer, Franziska Doht, Ruth K Michl, Thomas Lehmann, Udo R Markert, Klas Böer, Peter M Keller, Mathias W Pletz and Jochen G Mainz
    Citation: BMC Pulmonary Medicine 2014 14:82
    Content type: Research article Published on:

  11. Chronic eosinophilic pneumonia (CEP) is characterized by chronic eosinophilic infiltration of the lung. It is dramatically responsive to corticosteroid treatment, but symptoms and radiopacities recur frequentl...

    Authors: Ji Young Park, Taehoon Lee, Hongyeul Lee, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Jae Ho Lee and Choon-Taek Lee
    Citation: BMC Pulmonary Medicine 2014 14:81
    Content type: Research article Published on:

  12. Bronchial asthma influences some chronic diseases such as coronary heart disease, diabetes mellitus, and hypertension, but the impact of asthma on vital diseases such as chronic kidney disease is not yet verif...

    Authors: Hui-Ling Huang, Shinn-Ying Ho, Chien-Hsun Li, Fang-Ying Chu, Li-Ping Ciou, Hua-Chin Lee, Wen-Liang Chen and Nian-Sheng Tzeng
    Citation: BMC Pulmonary Medicine 2014 14:80
    Content type: Research article Published on:

  13. There is a need for agents that suppress inflammation and progression of chronic obstructive pulmonary disease. p38 mitogen-activated protein kinase (p38 MAPK) has been associated with this disorder, and sever...

    Authors: Satoshi Marumo, Yuma Hoshino, Hirofumi Kiyokawa, Naoya Tanabe, Atsuyasu Sato, Emiko Ogawa, Shigeo Muro, Toyohiro Hirai and Michiaki Mishima
    Citation: BMC Pulmonary Medicine 2014 14:79
    Content type: Research article Published on:

  14. Obstructive sleep apnea (OSA) is a high prevalence sleep disorder characterized by upper airway obstruction during sleep, nocturnal intermittent hypoxemia, poor sleep quality, risk for cardiovascular and metab...

    Authors: Anna Lo Bue, Adriana Salvaggio, Serena Iacono Isidoro, Salvatore Romano, Oreste Marrone and Giuseppe Insalaco
    Citation: BMC Pulmonary Medicine 2014 14:78
    Content type: Research article Published on:

  15. A gene-based estimate of lung cancer risk in smokers has been shown to act as a smoking cessation motivator in hospital recruited subjects. The objective of this trial is to determine if this motivator is as e...

    Authors: John AA Nichols, Paul Grob, Simon de Lusignan, Wendy Kite and Peter Williams
    Citation: BMC Pulmonary Medicine 2014 14:77
    Content type: Study protocol Published on:

  16. Research that explores stigma in Cystic Fibrosis (CF) is limited. Productive cough, repeated lung infections, and periods of serious illness requiring hospitalizations are among common symptoms of CF. These sy...

    Authors: Smita Pakhale, Michael Armstrong, Crystal Holly, Rojiemiahd Edjoc, Ena Gaudet, Shawn Aaron, Giorgio Tasca, William Cameron and Louise Balfour
    Citation: BMC Pulmonary Medicine 2014 14:76
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Pulmonary Medicine 2020 20:145

  17. Several lung diseases are increasingly recognized as comorbidities with HIV; however, few data exist related to the spectrum of respiratory symptoms, diagnostic testing, and diagnoses in the current HIV era. T...

    Authors: Matthew R Gingo, Goundappa K Balasubramani, Thomas B Rice, Lawrence Kingsley, Eric C Kleerup, Roger Detels, Eric C Seaberg, Ruth M Greenblatt, Susan Holman, Laurence Huang, Sarah H Sutton, Marnie Bertolet and Alison Morris
    Citation: BMC Pulmonary Medicine 2014 14:75
    Content type: Research article Published on:

  18. Adult patients with cystic fibrosis (CF) frequently have reduced exercise tolerance, which is multifactorial but mainly due to bronchial obstruction. The aim of this retrospective analysis was to determine the...

    Authors: Jean Pastré, Anne Prévotat, Catherine Tardif, Carole Langlois, Alain Duhamel and Benoit Wallaert
    Citation: BMC Pulmonary Medicine 2014 14:74
    Content type: Research article Published on:

  19. A recent method determines regional gas flow of the lung by electrical impedance tomography (EIT). The aim of this study is to show the applicability of this method in a porcine model of mechanical ventilation...

    Authors: Marc Bodenstein, Stefan Boehme, Stephan Bierschock, Andreas Vogt, Matthias David and Klaus Markstaller
    Citation: BMC Pulmonary Medicine 2014 14:73
    Content type: Research article Published on:

  21. Physical exercise training aims at reducing disease-specific impairments and improving quality of life in patients with chronic obstructive pulmonary disease (COPD). COPD exacerbations in particular negatively...

    Authors: Emmylou Beekman, Ilse Mesters, Erik JM Hendriks, Jean WM Muris, Geertjan Wesseling, Silvia MAA Evers, Guus M Asijee, Annemieke Fastenau, Hannah N Hoffenkamp, Rik Gosselink, Onno CP van Schayck and Rob A de Bie
    Citation: BMC Pulmonary Medicine 2014 14:71
    Content type: Study protocol Published on:

  22. Therapeutic adherence of patients with chronic obstructive pulmonary disease (COPD) is poor. This study evaluated the effectiveness of a multifactorial intervention on improving the therapeutic adherence in ch...

    Authors: José Leiva-Fernández, Francisca Leiva-Fernández, Antonio García-Ruiz, Daniel Prados-Torres and Pilar Barnestein-Fonseca
    Citation: BMC Pulmonary Medicine 2014 14:70
    Content type: Research article Published on:

  23. Exercise capacity is impaired in pulmonary arterial hypertension (PAH). We hypothesized that cardiovascular reserve abnormalities would be associated with impaired hemodynamic response to pharmacological stres...

    Authors: Enric Domingo, Juan C Grignola, Rio Aguilar, Christian Arredondo, Nadia Bouteldja, Manuel López Messeguer and Antonio Roman
    Citation: BMC Pulmonary Medicine 2014 14:69
    Content type: Research article Published on:

  24. The receptor for advanced glycation end-products (RAGE) is highly expressed in the lung, where it is believed to have a homeostatic role. Reduced plasma levels of soluble RAGE (sRAGE) have been reported in pat...

    Authors: Hiroshi Iwamoto, Jing Gao, Ville Pulkkinen, Tuula Toljamo, Pentti Nieminen and Witold Mazur
    Citation: BMC Pulmonary Medicine 2014 14:68
    Content type: Research article Published on:

  25. Acute interstitial pneumonia is a rare interstitial lung disease that rapidly progresses to respiratory failure or death. Several studies showed that myofibroblast plays an important role in the evolution of d...

    Authors: Hongbo Li, Jinjin Zhang, Xiaodong Song, Tao Wang, Zhi Li, Dong Hao, Xiaozhi Wang, Qingyin Zheng, Cuiping Mao, Pan Xu and Changjun Lv
    Citation: BMC Pulmonary Medicine 2014 14:67
    Content type: Case report Published on:

  26. Technology offers opportunities to improve healthcare, but little is known about Internet use by COPD patients. We tested two hypotheses: Internet access is associated with socio-demographic disparities and fr...

    Authors: Carlos H Martinez, Beth L St Jean, Craig A Plauschinat, Barbara Rogers, Julen Beresford, Fernando J Martinez, Caroline R Richardson and MeiLan K Han
    Citation: BMC Pulmonary Medicine 2014 14:66
    Content type: Research article Published on:

  27. Early diagnosis and treatment of nontuberculous mycobacterial lung diseases (NTM-LD) and pulmonary tuberculosis (PTB) are important clinical issues. The present study aimed to compare and identify the chest CT...

    Authors: Mei-Kang Yuan, Cheng-Yu Chang, Ping-Huang Tsai, Yuan-Ming Lee, Jen-Wu Huang and Shih-Chieh Chang
    Citation: BMC Pulmonary Medicine 2014 14:65
    Content type: Research article Published on:

  28. Pulmonary fibrosis is an untreatable, fatal disease characterized by excess deposition of extracellular matrix and inflammation. Although the etiology of pulmonary fibrosis is unknown, recent studies have impl...

    Authors: Hongyun Zhao, Yee Chan-Li, Samuel L Collins, Yuan Zhang, Robert W Hallowell, Wayne Mitzner and Maureen R Horton
    Citation: BMC Pulmonary Medicine 2014 14:64
    Content type: Research article Published on:

  29. Selection bias is a systematic error in epidemiologic studies that may seriously distort true measures of associations between exposure and disease. Observational studies are highly susceptible to selection bi...

    Authors: Ane Johannessen, Giuseppe Verlato, Bryndis Benediktsdottir, Bertil Forsberg, Karl Franklin, Thorarinn Gislason, Mathias Holm, Christer Janson, Rain Jögi, Eva Lindberg, Ferenc Macsali, Ernst Omenaas, Francisco Gomez Real, Eirunn Waatevik Saure, Vivi Schlünssen, Torben Sigsgaard…
    Citation: BMC Pulmonary Medicine 2014 14:63
    Content type: Research article Published on:

  30. Breathing and swallowing are physiologically linked to ensure effortless gas exchange during oronasal breathing and to prevent aspiration during swallowing. Studies have indicated consistent aspiration in chro...

    Authors: Rosane de Deus Chaves, Fernanda Chiarion Sassi, Laura Davison Mangilli, Shri Krishna Jayanthi, Alberto Cukier, Bruno Zilberstein and Claudia Regina Furquim de Andrade
    Citation: BMC Pulmonary Medicine 2014 14:62
    Content type: Research article Published on:

  31. Many studies have investigated whether pleural cholesterol levels can aid in diagnosis of pleural exudates, and the results have varied considerably. To gain a more reliable answer to this question, we meta-an...

    Authors: Yongchun Shen, Hong Zhu, Chun Wan, Lei Chen, Tao Wang, Ting Yang and Fuqiang Wen
    Citation: BMC Pulmonary Medicine 2014 14:61
    Content type: Research article Published on:

  32. Patients with stable COPD show improvements in exercise capacity and muscular function after the application of whole body vibration. We aimed to evaluate whether this modality added to conventional physiother...

    Authors: Timm Greulich, Christoph Nell, Janine Koepke, Juliane Fechtel, Maja Franke, Bernd Schmeck, Daniel Haid, Sandra Apelt, Silke Filipovic, Klaus Kenn, Sabina Janciauskiene, Claus Vogelmeier and Andreas Rembert Koczulla
    Citation: BMC Pulmonary Medicine 2014 14:60
    Content type: Research article Published on:

  33. The lungs of very preterm human babies display deficits in alveolarization and vascularization as a result of the clinical use of high oxygen treatment (leading to hyperoxia) required to decrease the risk of m...

    Authors: Alexandra B Firsova, Timothy J Cole and Richard Mollard
    Citation: BMC Pulmonary Medicine 2014 14:59
    Content type: Research article Published on:

  34. The accuracy of currently available same-day diagnostic tools (smear microscopy and conventional nucleic acid amplification tests) for pleural tuberculosis (TB) is sub-optimal. Newer technologies may offer imp...

    Authors: Richard Meldau, Jonny Peter, Grant Theron, Greg Calligaro, Brian Allwood, Greg Symons, Hoosain Khalfey, Gina Ntombenhle, Ureshnie Govender, Anke Binder, Richard van Zyl-Smit and Keertan Dheda
    Citation: BMC Pulmonary Medicine 2014 14:58
    Content type: Research article Published on:

  35. Dyspnea may be a presenting symptom in progressive systemic sclerosis (SSc). Respiratory drive (mouth occlusion pressure, MOP, at rest and during CO2 rebreathing, 7% CO2, 93% O2) is a major determinant of dyspnea...

    Authors: Maarten K Ninaber, Willem BGJ Hamersma, Annemie JM Schuerwegh and Jan Stolk
    Citation: BMC Pulmonary Medicine 2014 14:57
    Content type: Research article Published on:

  36. In Europe, administration of an inhaled corticosteroid (ICS) combined with a long-acting β2 agonist is approved in chronic obstructive pulmonary disease (COPD) patients with a pre-bronchodilator FEV1 < 60% predic...

    Authors: Nicolas Roche, Céline Pribil, Eric Van Ganse, Philippe Serrier, Bruno Housset, Déborah Poirier, Nathalie Texier, Stéphane Schück and Isabelle Boucot
    Citation: BMC Pulmonary Medicine 2014 14:56
    Content type: Research article Published on:

  37. Altered cardiac repolarization and increased dispersion of repolarization have been identified as risk factors for sudden cardiac death (SCD). The prevalence of and the mechanisms contributing to altered cardi...

    Authors: Noriane A Sievi, Christian F Clarenbach, Giovanni Camen, Valentina A Rossi, Arnoldus JR van Gestel and Malcolm Kohler
    Citation: BMC Pulmonary Medicine 2014 14:55
    Content type: Research article Published on:

  38. Proactive palliative care is not yet common practice for patients with COPD. Important barriers are the identification of patients with a poor prognosis and the organization of proactive palliative care dedica...

    Authors: Ria G Duenk, Yvonne Heijdra, Stans C Verhagen, Richard PNR Dekhuijzen, Kris CP Vissers and Yvonne Engels
    Citation: BMC Pulmonary Medicine 2014 14:54
    Content type: Study protocol Published on:

  39. Epithelial-mesenchymal transition (EMT) has been proposed as a mechanism in the progression of airway diseases and cancer. Here, we explored the role of acetylcholine (ACh) and the pathway involved in the proc...

    Authors: Kai Yang, Yun Song, Ya-Bing Tang, Zu-Peng Xu, Wei Zhou, Li-Na Hou, Liang Zhu, Zhi-Hua Yu, Hong-Zhuan Chen and Yong-Yao Cui
    Citation: BMC Pulmonary Medicine 2014 14:53
    Content type: Research article Published on:

  40. AZD9164 has demonstrated potential as an inhaled, long-acting, muscarinic antagonist (LAMA) bronchodilator. However, in patients with COPD, but not in healthy subjects, a transient initial drop in FEV1 was observ...

    Authors: Carin Jorup, Thomas Bengtsson, Kerstin Strandgården and Ulf Sjöbring
    Citation: BMC Pulmonary Medicine 2014 14:52
    Content type: Research article Published on:

  41. Estimates of asthma incidence and its possible determinants in adolescent populations have rarely been obtained using prospective designs. We sought to identify socio-demographic and other patterns in the inci...

    Authors: Joshua A Lawson, Ian Janssen, Mark W Bruner, Alomgir Hossain and William Pickett
    Citation: BMC Pulmonary Medicine 2014 14:51
    Content type: Research article Published on:

  42. Sarcoidosis patients have accumulations of activated CD4+ T cells in affected organs, such as the lungs. T cell receptor (TCR) Vβ-chain usage has been incompletely characterized in these patients.

    Authors: Kerstin M Ahlgren, Tina Ruckdeschel, Anders Eklund, Jan Wahlström and Johan Grunewald
    Citation: BMC Pulmonary Medicine 2014 14:50
    Content type: Research article Published on:

  43. The diagnosis of chronic obstructive pulmonary disease (COPD) is based on airflow obstruction. In epidemiological studies, spirometric data have often been lacking and researchers have had to rely almost solel...

    Authors: Nicola Murgia, Jonas Brisman, Annika Claesson, Giacomo Muzi, Anna-Carin Olin and Kjell Torén
    Citation: BMC Pulmonary Medicine 2014 14:49
    Content type: Research article Published on:

  44. Heat shock protein (HSP) 47, a collagen-specific molecular chaperone, is involved in the processing and/or secretion of procollagen. We hypothesized that HSP47 could be a useful marker for fibrotic lung diseas...

    Authors: Tomoyuki Kakugawa, Shin-ichi Yokota, Yuji Ishimatsu, Tomayoshi Hayashi, Shota Nakashima, Shintaro Hara, Noriho Sakamoto, Hiroshi Kubota, Mariko Mine, Yasuhiro Matsuoka, Hiroshi Mukae, Kazuhiro Nagata and Shigeru Kohno
    Citation: BMC Pulmonary Medicine 2014 14:48
    Content type: Research article Published on:

  45. Claims data are potentially useful for identifying long-acting β-agonist (LABA) use by patients with asthma, a practice that is associated with increased mortality. We evaluated the accuracy of claims data for...

    Authors: David D Dore, Najat Ziyadeh, Bin Cai, C Robin Clifford, Heather Norman and John D Seeger
    Citation: BMC Pulmonary Medicine 2014 14:47
    Content type: Research article Published on:

  46. While reviews have been published on asthma management in pregnant women, none has examined the effectiveness of non-pharmacological healthcare interventions for optimizing asthma management in pregnant women....

    Authors: Elida Zairina, Kay Stewart, Michael J Abramson and Johnson George
    Citation: BMC Pulmonary Medicine 2014 14:46
    Content type: Research article Published on:

  47. Pulmonary arterial hypertension (PAH) is a severe and progressive disease characterized by increased pulmonary vascular resistance, ultimately leading to right heart failure and death. Epidemiological data fro...

    Authors: Pavel Jansa, Jiri Jarkovsky, Hikmet Al-Hiti, Jana Popelova, David Ambroz, Tomas Zatocil, Regina Votavova, Pavel Polacek, Jana Maresova, Michael Aschermann, Petr Brabec, Ladislav Dusek and Ales Linhart
    Citation: BMC Pulmonary Medicine 2014 14:45
    Content type: Research article Published on:

  48. This report describe for the first time a clinical case with a CFTR allelic variant 186-8T/C (c.54-8 T/C) in intron 1 of CFTR and underline the importance of applying a combination of genetic and functional te...

    Authors: Sara Caldrer, Genny Verzè, Jan Johansson, Claudio Sorio, Chiara Angiari, Mario Buffelli, Baroukh Maurice Assael and Paola Melotti
    Citation: BMC Pulmonary Medicine 2014 14:44
    Content type: Case report Published on:

  49. The study evaluated the efficacy of beclomethasone dipropionate/formoterol fumarate (BDP/FF) extrafine combination versus fluticasone propionate/salmeterol (FP/S) combination in COPD patients.

    Authors: Dave Singh, Gabriele Nicolini, Eddi Bindi, Massimo Corradi, Daniele Guastalla, Jorg Kampschulte, Władysław Pierzchała, Abdullah Sayiner, Mária Szilasi, Claudio Terzano and Jørgen Vestbo
    Citation: BMC Pulmonary Medicine 2014 14:43
    Content type: Research article Published on:
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