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  1. RGM medium is an agar-based, selective culture medium designed for the isolation of nontuberculous mycobacteria (NTM) from the sputum of patients with cystic fibrosis (CF). We evaluated RGM medium for the dete...

    Authors: D. Stephenson, A. Perry, M. R. Appleby, D. Lee, J. Davison, A. Johnston, A. L. Jones, A. Nelson, S. J. Bourke, M. F. Thomas, A. De Soyza, J. L. Lordan, J. Lumb, A. E. Robb, J. R. Samuel, K. E. Walton…
    Citation: BMC Pulmonary Medicine 2019 19:19
    Content type: Research article Published on:

  2. The high cost and low availability of polysomnography (PSG) limits the timely diagnosis of OSA. Herein, we developed and validated a simple-to-use nomogram for predicting OSA.

    Authors: Huajun Xu, Xiaolong Zhao, Yue Shi, Xinyi Li, Yingjun Qian, Jianyin Zou, Hongliang Yi, Hengye Huang, Jian Guan and Shankai Yin
    Citation: BMC Pulmonary Medicine 2019 19:18
    Content type: Research article Published on:

  3. Extra-pulmonary tuberculosis (EPTB) is defined as any bacteriologically confirmed or clinically diagnosed case of TB involving organs other than the lungs. It is frequently a diagnostic and therapeutic challen...

    Authors: Teyim Pride Mbuh, Irene Ane-Anyangwe, Wandji Adeline, Benjamin D. Thumamo Pokam, Henry Dilonga Meriki and Wilfred Fon Mbacham
    Citation: BMC Pulmonary Medicine 2019 19:17
    Content type: Research article Published on:

  4. Standardization of trans-bronchial lung cryobiopsy in diffuse parenchymal lung diseases is imminent; however, the majority of published series on cryobiopsy include a limited number of patients and are charact...

    Authors: Claudia Ravaglia, Athol U. Wells, Sara Tomassetti, Carlo Gurioli, Christian Gurioli, Alessandra Dubini, Alberto Cavazza, Thomas V. Colby, Sara Piciucchi, Silvia Puglisi, Marcello Bosi and Venerino Poletti
    Citation: BMC Pulmonary Medicine 2019 19:16
    Content type: Research article Published on:

  5. Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a severe condition with limited treatment strategies. Although respiratory infection is a major cause of AE-IPF, no reports have indicated pertus...

    Authors: Kuniaki Hirai, Tetsuya Homma, Fumihiro Yamaguchi, Munehiro Yamaguchi, Shintaro Suzuki, Akihiko Tanaka, Tsukasa Ohnishi and Hironori Sagara
    Citation: BMC Pulmonary Medicine 2019 19:15
    Content type: Case report Published on:

  6. Endosonography with needle aspiration (EBUS/EUS-NA) is recommended as the first choice for mediastinal nodal assessment in non-small cell lung cancer (NSCLC). It is important to maintain adequate negative pred...

    Authors: Sukyeon Kim, Beomsu Shin, Hyun Lee, Jick Hwan Ha, Kyungjong Lee, Sang-Won Um, Hojoong Kim and Byeong-Ho Jeong
    Citation: BMC Pulmonary Medicine 2019 19:14
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Pulmonary Medicine 2019 19:69

  7. The Severe Respiratory Insufficiency (SRI) questionnaire is a specific measure of health-related quality of life (HRQoL) in patients treated with long-term mechanical ventilation (LTMV). The aim of the present...

    Authors: Heidi Markussen, Sverre Lehmann, Roy M. Nilsen and Gerd K. Natvig
    Citation: BMC Pulmonary Medicine 2019 19:13
    Content type: Research article Published on:

  8. Sporadic lymphangioleiomyomatosis (LAM) is a rare form of diffuse parenchymal lung disease. PD-1 blocking antibodies constitute an essential treatment option for advanced non-small-cell lung cancer (NSCLC). Th...

    Authors: Johan Pluvy, Solenn Brosseau, Sandrine Stelianides, Claire Danel, Marina Nguenang, Antoine Khalil, Bruno Crestani, Gérard Zalcman and Valérie Gounant
    Citation: BMC Pulmonary Medicine 2019 19:12
    Content type: Case report Published on:

  9. Idiopathic pulmonary fibrosis (IPF) is a rare life-threating interstitial lung disease (ILD). This study characterizes demographics, health care utilization, and comorbidities among elderly IPF patients and es...

    Authors: Kathleen Mortimer, Nadine Hartmann, Christine Chan, Heather Norman, Laura Wallace and Cheryl Enger
    Citation: BMC Pulmonary Medicine 2019 19:11
    Content type: Research article Published on:

  10. Relapse of cryptogenic organizing pneumonia (COP) may lead to poor long-term prognosis and necessitates multiple rounds of steroid treatment with potential adverse effects. The objective of this study is to id...

    Authors: Zenya Saito, Yugo Kaneko, Tsukasa Hasegawa, Masahiro Yoshida, Kyuto Odashima, Tsugumi Horikiri, Akira Kinoshita, Keisuke Saitoh and Kazuyoshi Kuwano
    Citation: BMC Pulmonary Medicine 2019 19:10
    Content type: Research article Published on:

  11. Surfactant is usually deficiency in adult acute respiratory distress syndrome(ARDS) patients and surfactant administration may be a useful therapy. The aim of this study was to perform a meta-analysis of the effe...

    Authors: Shan-Shan Meng, Wei Chang, Zhong-Hua Lu, Jian-Feng Xie, Hai-Bo Qiu, Yi Yang and Feng-Mei Guo
    Citation: BMC Pulmonary Medicine 2019 19:9
    Content type: Research article Published on:

  12. Cystic lung lesions involving both lungs include a variety of diseases, such as pulmonary Langerhans cell histiocytosis, lymphangioleiomyomatosis and pulmonary metastasis. Primary pulmonary meningioma accompan...

    Authors: Xin Wang, Pengfei Li, Ping Zhou, Yiyun Fu, Yutian Lai and Guowei Che
    Citation: BMC Pulmonary Medicine 2019 19:8
    Content type: Case report Published on:

  13. Bronchiectasis is a major contributor to respiratory morbidity and health care utilization in children and youth. Current treatment guidelines for bronchiectasis recommend participation in regular physical act...

    Authors: Barbara Joschtel, Sjaan R. Gomersall, Sean Tweedy, Helen Petsky, Anne B. Chang and Stewart G. Trost
    Citation: BMC Pulmonary Medicine 2019 19:7
    Content type: Research article Published on:

  14. Although the prevalence of pneumoconiosis has been decreasing due to improvements in working conditions and regular health examinations, occupational hygiene measures are still being established. Plasterers en...

    Authors: Fumio Kurosaki, Tamiko Takemura, Masashi Bando, Tomonori Kuroki, Toshio Numao, Hiroshi Moriyama and Koichi Hagiwara
    Citation: BMC Pulmonary Medicine 2019 19:6
    Content type: Case report Published on:

  15. Inhibition of interleukin (IL)-13, a Type 2 inflammatory mediator in asthma, improves lung function and reduces exacerbations; however, more effective therapies are needed. A subset of asthma patients also exh...

    Authors: Tracy L. Staton, Kun Peng, Ryan Owen, David F. Choy, Christopher R. Cabanski, Alice Fong, Flavia Brunstein, Kathila R. Alatsis and Hubert Chen
    Citation: BMC Pulmonary Medicine 2019 19:5
    Content type: Research article Published on:

  16. Up to fifty percent of microbiologically cured tuberculosis (TB) patients may be left with permanent, moderate or severe pulmonary function impairment. Very few studies have systematically examined pulmonary o...

    Authors: Andrea Rachow, Olena Ivanova, Robert Wallis, Salome Charalambous, Ilesh Jani, Nilesh Bhatt, Beate Kampmann, Jayne Sutherland, Nyanda E. Ntinginya, Denise Evans, Knut Lönnroth, Stefan Niemann, Ulrich E. Schaible, Christof Geldmacher, Ian Sanne, Michael Hoelscher…
    Citation: BMC Pulmonary Medicine 2019 19:4
    Content type: Study protocol Published on:

  17. EGFR mutations are routinely explored in lung adenocarcinoma by sequencing tumoral DNA. The aim of this study was to evaluate a fluorescent-labelled erlotinib based theranostic agent for the molecular imaging of ...

    Authors: Maxime Patout, Florian Guisier, Xavier Brune, Pierre Bohn, Anthony Romieu, Nasrin Sarafan-Vasseur, Richard Sesboüé, Pierre-Yves Renard, Luc Thiberville and Mathieu Salaün
    Citation: BMC Pulmonary Medicine 2019 19:3
    Content type: Research article Published on:

  18. Although dynamic lung volume is not considered a limiting factor of peak oxygen uptake (VO2peak) in healthy subjects, an association between forced expiratory lung volume in one second (FEV1) and VO2peak has been...

    Authors: Øystein Rasch-Halvorsen, Erlend Hassel, Arnulf Langhammer, Ben M. Brumpton and Sigurd Steinshamn
    Citation: BMC Pulmonary Medicine 2019 19:2
    Content type: Research article Published on:

  19. The lung ultrasound score has been regarded as a decent semiquantitative score to measure the lung aeration loss. The score has been proven to be valuable in diagnosing and monitoring lung pathology, but no st...

    Authors: Wanhong Yin, Tongjuan Zou, Yao Qin, Jing Yang, Yi Li, Xueying Zeng and Yan Kang
    Citation: BMC Pulmonary Medicine 2019 19:1
    Content type: Research article Published on:

  20. Impaired angiogenesis is assumed to be an important factor in the development of chronic thromboembolic pulmonary hypertension (CTEPH). However, the role of endothelial cells (ECs) in CTEPH remains unclear. Th...

    Authors: Akira Naito, Seiichiro Sakao, Irene M. Lang, Norbert F. Voelkel, Takayuki Jujo, Keiichi Ishida, Toshihiko Sugiura, Goro Matsumiya, Ichiro Yoshino, Nobuhiro Tanabe and Koichiro Tatsumi
    Citation: BMC Pulmonary Medicine 2018 18:197
    Content type: Research article Published on:

  21. A clinical heterogeneity was reported in patients with Cystic Fibrosis (CF) with the same CFTR genotype and between siblings with CF.

    Authors: Vito Terlizzi, Marco Lucarelli, Donatello Salvatore, Adriano Angioni, Arianna Bisogno, Cesare Braggion, Roberto Buzzetti, Vincenzo Carnovale, Rosaria Casciaro, Giuseppe Castaldo, Natalia Cirilli, Mirella Collura, Carla Colombo, Antonella Miriam Di Lullo, Ausilia Elce, Vincenzina Lucidi…
    Citation: BMC Pulmonary Medicine 2018 18:196
    Content type: Research article Published on:

  22. Evidence from several studies show poor guideline adherence to COPD treatment, but no such study has been undertaken in Norway. The objectives of this study, was to estimate and compare the guideline adherence...

    Authors: Bahareh Jouleh, Marta Erdal, Tomas Mikal Eagan, Per Bakke, Amund Gulsvik and Rune Nielsen
    Citation: BMC Pulmonary Medicine 2018 18:195
    Content type: Research article Published on:

  23. The present study aimed to develop an automated computed tomography (CT) score based on the CT quantification of high-attenuating lung structures, in order to provide a quantitative assessment of lung structur...

    Authors: Trieu-Nghi Hoang-Thi, Marie-Pierre Revel, Pierre-Régis Burgel, Laurence Bassinet, Isabelle Honoré, Thong Hua-Huy, Charlotte Martin, Bernard Maitre and Guillaume Chassagnon
    Citation: BMC Pulmonary Medicine 2018 18:194
    Content type: Research article Published on:

  24. Pulmonary carcinosarcoma (PCS) is a rare primary lung malignancy and has a poor prognosis among lung tumor histological subtypes. However, an appropriate treatment strategy has not been developed for unresecta...

    Authors: Azusa Tanimoto, Shinji Takeuchi, Hiroshi Kotani, Kaname Yamashita, Tadaaki Yamada, Koushiro Ohtsubo, Hiromichi Ebi, Hiroko Ikeda and Seiji Yano
    Citation: BMC Pulmonary Medicine 2018 18:193
    Content type: Case report Published on:

  25. The optimal procedure for maximizing the diagnostic yield and minimizing the procedural complexity of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is controversial. We conducted...

    Authors: Xiaoxiao Lin, Min Ye, Yuping Li, Jing Ren, Qiyan Lou, Yangyang Li, Xiaohui Jin, Ko-Pen Wang and Chengshui Chen
    Citation: BMC Pulmonary Medicine 2018 18:192
    Content type: Research article Published on:

  26. Guidelines currently do not recommend the routine use of chest x-ray (CXR) in bronchiolitis. However, CXR is still performed in a high percentage of cases, mainly to diagnose or rule out pneumonia. The inappro...

    Authors: Carlotta Biagi, Luca Pierantoni, Michelangelo Baldazzi, Laura Greco, Ada Dormi, Arianna Dondi, Giacomo Faldella and Marcello Lanari
    Citation: BMC Pulmonary Medicine 2018 18:191
    Content type: Research article Published on:

  27. Home mechanical ventilation is an established treatment for chronic respiratory failure resulting in improved survival and quality of life. Technological advancement, evolving health care reimbursement systems...

    Authors: Luca Valko, Szabolcs Baglyas, Janos Gal and Andras Lorx
    Citation: BMC Pulmonary Medicine 2018 18:190
    Content type: Research article Published on:

  28. Hepatic ischemia-reperfusion injury (IRI) is a common pathological phenomenon, which causes hepatic injury as well as remote organ injuries such as the lung. Several mediators, such as oxidative stress, Ca2+ over...

    Authors: Yao Tong, Zhuang Yu, Renlingzi Zhang, Xibing Ding, Zhixia Chen and Quan Li
    Citation: BMC Pulmonary Medicine 2018 18:189
    Content type: Research article Published on:

  29. Hsp90-beta has been investigated to be correlated with the occurrence and development of tumor. The intention of this research was to test the level of Hsp90-beta in malignant pleural effusion (MPE) of patient...

    Authors: Rong Biaoxue, Li Min, Fu Tian, Gao Wenlong and Liu Hua
    Citation: BMC Pulmonary Medicine 2018 18:188
    Content type: Research article Published on:

  30. Lung hyperinflation contributes to dyspnea, morbidity and mortality in chronic obstructive pulmonary disease (COPD). The inspiratory-to-total lung capacity (IC/TLC) ratio is a measure of lung hyperinflation an...

    Authors: Linn T. Aalstad, Jon A. Hardie, Birgitte Espehaug, Einar Thorsen, Per S. Bakke, Tomas M. L. Eagan and Bente Frisk
    Citation: BMC Pulmonary Medicine 2018 18:187
    Content type: Research article Published on:

  31. There is a lack of robust data about factors predicting continuation (or termination) of positive airway pressure therapy (PAP) for sleep apnea. This analysis of big data from a German homecare provider descri...

    Authors: Holger Woehrle, Michael Arzt, Andrea Graml, Ingo Fietze, Peter Young, Helmut Teschler and Joachim H. Ficker
    Citation: BMC Pulmonary Medicine 2018 18:186
    Content type: Research article Published on:

  32. Coexistence of aspergilloma and allergic bronchopulmonary aspergillosis (ABPA) has rarely been reported. Although the treatment for ABPA includes administration of corticosteroids and antifungal agents, little...

    Authors: Kohei Horiuchi, Takanori Asakura, Naoki Hasegawa and Fumitake Saito
    Citation: BMC Pulmonary Medicine 2018 18:185
    Content type: Case report Published on:

  33. This study was conducted in order to determine the prevalence of asthma and associated risk factors in the adult population of Karachi, Pakistan.

    Authors: Shama Razzaq, Asaad Ahmed Nafees, Unaib Rabbani, Muhammad Irfan, Shahla Naeem, Muhammad Arslan Khan, Zafar Fatmi and Peter Burney
    Citation: BMC Pulmonary Medicine 2018 18:184
    Content type: Research article Published on:

  34. Disease control is an important objective of COPD management. The SINCON study evaluated the level of control in terms of respiratory symptoms and exacerbations in Spanish patients with COPD for ≥2 years.

    Authors: Adolfo Baloira, José Miguel Rodriguez Gonzalez-Moro, Estefanía Sanjuán, Juan Antonio Trigueros and Ricard Casamor
    Citation: BMC Pulmonary Medicine 2018 18:183
    Content type: Research article Published on:

  36. Granulomatosis with polyangiitis (GPA) is a systemic ANCA-associated vasculitis characterized by necrotizing granulomatous inflammation and a predilection for the upper and lower respiratory tract. Eosinophili...

    Authors: Michele V. Quan, Stephen K. Frankel, Mehrnaz Maleki-Fischbach and Laren D. Tan
    Citation: BMC Pulmonary Medicine 2018 18:181
    Content type: Case report Published on:

  37. 2′-5′-Oligoadenylate synthetase 1 (OAS1) plays an important role in inflammatory immune reactions. OAS1 polymorphisms have been associated with increased susceptibility to various diseases. We investigated the as...

    Authors: Shouquan Wu, Yu Wang, Guo Chen, Miaomiao Zhang, Minggui Wang and Jian-Qing He
    Citation: BMC Pulmonary Medicine 2018 18:180
    Content type: Research article Published on:

  39. The breakdown of alveolar barrier dysfunction contributes to Lipopolysaccharide stimulated pulmonary edema and acute lung injury. Actin cytoskeleton has been implicated to be critical in regulation of epitheli...

    Authors: Weiju Wang, Jie Weng, Lei Yu, Qiaobing Huang, Yong Jiang and Xiaohua Guo
    Citation: BMC Pulmonary Medicine 2018 18:178
    Content type: Research article Published on:

  40. Pirfenidone is an antifibrotic compound approved for the treatment of idiopathic pulmonary fibrosis (IPF). We present our real-world experience in terms of Pirfenidone’s effect on mortality and adverse events ...

    Authors: George A. Margaritopoulos, Athina Trachalaki, Athol U. Wells, Eirini Vasarmidi, Eleni Bibaki, George Papastratigakis, Stathis Detorakis, Nikos Tzanakis and Katerina M. Antoniou
    Citation: BMC Pulmonary Medicine 2018 18:177
    Content type: Research article Published on:

  41. We aimed to determine the presepsin concentration in pleural fluid from patients with pleural effusions of different aetiologies and to compare its diagnostic value with that of pleural fluid C-reactive protei...

    Authors: Naoki Watanabe, Tomoya Ishii, Nobuyuki Kita, Nobuhiro Kanaji, Hiroyuki Nakamura, Nobuki Nanki, Yutaka Ueda, Yasunori Tojo, Norimitsu Kadowaki and Shuji Bandoh
    Citation: BMC Pulmonary Medicine 2018 18:176
    Content type: Research article Published on:

  42. Diaphragmatic dysfunction remains the main cause of weaning difficulty or failure. Ultrasonographic measurement of diaphragmatic function can be used to predict the outcomes of weaning from mechanical ventilat...

    Authors: Pongdhep Theerawit, Dararat Eksombatchai, Yuda Sutherasan, Thitiporn Suwatanapongched, Charn Kiatboonsri and Sumalee Kiatboonsri
    Citation: BMC Pulmonary Medicine 2018 18:175
    Content type: Research article Published on:

  43. The acute respiratory distress syndrome (ARDS) is a serious disease in critically ill patients that is characterized by pulmonary dysfunctions, hypoxemia and significant mortality. Patients with immunodeficien...

    Authors: Eva Verjans, Stephanie Kanzler, Kim Ohl, Annette D. Rieg, Nadine Ruske, Angela Schippers, Norbert Wagner, Klaus Tenbrock, Stefan Uhlig and Christian Martin
    Citation: BMC Pulmonary Medicine 2018 18:174
    Content type: Research article Published on:

  44. Untreated Obstructive Sleep Apnea Hypnopnea Syndrome (OSAHS) is a known factor contributing to resistant hypertension (HT). Continuous Positive Airways Pressure (CPAP) is effective to decrease blood pressure (...

    Authors: Florent Seguro, Vincent Bard, Kamila Sedkaoui, Maya Riche, Alain Didier and Béatrice Bouhanick
    Citation: BMC Pulmonary Medicine 2018 18:173
    Content type: Research article Published on:

  45. Idiopathic pulmonary fibrosis (IPF) is a chronic disease with a high symptom burden and poor survival that influences patients’ health-related quality of life (HRQOL). We aimed to evaluate IPF patients’ sympto...

    Authors: K. Rajala, J. T. Lehto, E. Sutinen, H. Kautiainen, M. Myllärniemi and T. Saarto
    Citation: BMC Pulmonary Medicine 2018 18:172
    Content type: Research article Published on:

  46. The purpose of this study was to compare clinical outcomes of Erlotinib versus Gefitinib in the treatment of Asian patients with exon 19 EGFR-mutant lung adenocarcinoma and newly diagnosed brain metastases.

    Authors: Ye Jiang, Jing Zhang, Juanjuan Huang, Bo Xu, Ning Li, Lei Cao and Mingdong Zhao
    Citation: BMC Pulmonary Medicine 2018 18:171
    Content type: Research article Published on:

  47. Non-Tuberculous Mycobacterial–pulmonary disease (NTM-PD) is increasing in incidence and prevalence. Mycobacterium abscessus (M.abscessus) is a rapid growing multi-resistant NTM associated with severe NTM-PD requi...

    Authors: C. Addy, G. Doran, A. L. Jones, G. Wright, S. Caskey and D. G. Downey
    Citation: BMC Pulmonary Medicine 2018 18:170
    Content type: Case report Published on:

  49. Pulmonary nontuberculous mycobacteria (NTM) disease is of increasing public health concern in China. Information is limited regarding risk factors associated with this disease in China. The objective of this s...

    Authors: Yaoju Tan, Biyi Su, Wei Shu, Xingshan Cai, Shaojia Kuang, Haobin Kuang, Jianxiong Liu and Yu Pang
    Citation: BMC Pulmonary Medicine 2018 18:168
    Content type: Research article Published on:

  50. Chronic obstructive pulmonary disease (COPD) is a major and increasing global health problem. Serotonin is a neurotransmitter that participates in several pulmonary functions and it has been involved in oxidat...

    Authors: Pietro Pirina, Elisabetta Zinellu, Panagiotis Paliogiannis, Alessandro G. Fois, Viviana Marras, Salvatore Sotgia, Ciriaco Carru and Angelo Zinellu
    Citation: BMC Pulmonary Medicine 2018 18:167
    Content type: Research article Published on:
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BMC Pulmonary Medicine

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