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  1. Pulmonary involvement is a common feature of MPA. Although alveolar hemorrhage is the most common pulmonary manifestation of MPA, a few recent studies have described instances of MPA patients with pulmonary fi...

    Authors: Hui Huang, Yan xun Wang, Chun guo Jiang, Jia Liu, Ji Li, Kai Xu and Zuo jun Xu
    Citation: BMC Pulmonary Medicine 2014 14:8
  2. Mortality after pneumonia in immunocompromised patients is higher than for immunocompetent patients. The use of non-invasive mechanical ventilation for patients with severe pneumonia may provide beneficial out...

    Authors: Christopher S Johnson, Christopher R Frei, Mark L Metersky, Antonio R Anzueto and Eric M Mortensen
    Citation: BMC Pulmonary Medicine 2014 14:7
  3. Chronic obstructive pulmonary disease (COPD) has significant systemic effects that substantially impact quality of life and survival. The purpose of this study was to assess and compare peripheral muscle stren...

    Authors: Ebru Calik-Kutukcu, Sema Savci, Melda Saglam, Naciye Vardar-Yagli, Deniz Inal-Ince, Hulya Arikan, Zeynep Aribas, Ozge Ozer, Meral Bosnak-Guclu and Lutfi Coplu
    Citation: BMC Pulmonary Medicine 2014 14:6
  4. Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with no effective medical therapies. Recent research has focused on identifying the biological processes essential to the development and ...

    Authors: Sydney B Montesi, Susan K Mathai, Laura N Brenner, Irina A Gorshkova, Evgeny V Berdyshev, Andrew M Tager and Barry S Shea
    Citation: BMC Pulmonary Medicine 2014 14:5
  5. Two once-daily long-acting muscarinic antagonists (LAMAs) are currently available for the treatment of chronic obstructive pulmonary disease (COPD) – tiotropium and glycopyrronium. Previous studies have compar...

    Authors: Kenneth R Chapman, Kai-Michael Beeh, Jutta Beier, Eric D Bateman, Anthony D’Urzo, Robert Nutbrown, Michelle Henley, Hungta Chen, Tim Overend and Peter D’Andrea
    Citation: BMC Pulmonary Medicine 2014 14:4
  6. S-nitrosoglutathione (GSNO) serves as a reservoir for nitric oxide (NO) and thus is a key homeostatic regulator of airway smooth muscle tone and inflammation. Decreased levels of GSNO in the lungs of asthmatic...

    Authors: Joan P Blonder, Sarah C Mutka, Xicheng Sun, Jian Qiu, Lucia H Green, Navdeep K Mehra, Ramakrishna Boyanapalli, Michael Suniga, Kirsten Look, Chris Delany, Jane P Richards, Doug Looker, Charles Scoggin and Gary J Rosenthal
    Citation: BMC Pulmonary Medicine 2014 14:3
  7. Cardiovascular morbidity and mortality is high in patients with chronic obstructive pulmonary disease (COPD) and arterial stiffness is a potentially modifiable risk factor with added predictive value beyond th...

    Authors: Surya P Bhatt, Adam G Cole, James Michael Wells, Hrudaya Nath, Jubal R Watts, John R Cockcroft and Mark T Dransfield
    Citation: BMC Pulmonary Medicine 2014 14:1
  8. Chronic obstructive pulmonary disease (COPD) is hallmarked by inflammatory processes and a progressive decline of lung function. YKL-40 is a potential biomarker of inflammation and mortality in patients suffer...

    Authors: Dennis B Holmgaard, Lone H Mygind, Ingrid L Titlestad, Hanne Madsen, Svend Stenvang Pedersen, Julia S Johansen and Court Pedersen
    Citation: BMC Pulmonary Medicine 2013 13:77
  9. Cardiac surgery is frequently complicated by an acute vascular lung injury and this may be mediated, at least in part, by the (soluble) receptor for advanced glycation end products (sRAGE).

    Authors: Pieter R Tuinman, Alexander D Cornet, Maria T Kuipers, Alexander P Vlaar, Marcus J Schultz, Albertus Beishuizen, AB Johan Groeneveld and Nicole P Juffermans
    Citation: BMC Pulmonary Medicine 2013 13:76
  10. So far, the accuracy of tidal volume (VT) and leak measures provided by the built-in software of commercial home ventilators has only been tested using bench linear models with fixed calibrated and continuous ...

    Authors: Ana Sogo, Jaume Montanyà, Eduard Monsó, Lluís Blanch, Xavier Pomares and Manel Lujàn
    Citation: BMC Pulmonary Medicine 2013 13:75
  11. Hemodynamic status and cardiac function are important factors for predicting pulmonary embolism (PE) prognosis. Although inflammation is considered a risk factor for deep vein thrombosis, the prognostic signif...

    Authors: Jun Yeon Jo, Mi Young Lee, Jin Wook Lee, Byung Hak Rho and Won-Il Choi
    Citation: BMC Pulmonary Medicine 2013 13:74
  12. There is limited information on the causes of death in asthma patients.

    Authors: Jose Gregorio Soto-Campos, Vicente Plaza, Joan B Soriano, Carlos Cabrera-López, Carlos Almonacid-Sánchez, Rosa Vazquez-Oliva, Jose Serrano, Aitor Ballaz-Quincoces, Alicia Padilla-Galo and Vanessa Santos
    Citation: BMC Pulmonary Medicine 2013 13:73
  13. Medications for respiratory disorders including asthma and chronic obstructive pulmonary disease (COPD) are typically delivered to the lung by means of a handheld inhaler. Patient preference for and ability to...

    Authors: Henrik Svedsater, Peter Dale, Karl Garrill, Richard Walker and Mark W Woepse
    Citation: BMC Pulmonary Medicine 2013 13:72
  14. Ventilatory impairment is known to occur in patients with heart failure (HF). Alveolar volume (VA) is measured by the dilution of an inert gas during a single breath-hold maneuver. Such measurement is sensitive t...

    Authors: Massimo Miniati, Simonetta Monti, Matteo Bottai, Ivana Pavlickova, Claudio Passino, Michele Emdin and Roberta Poletti
    Citation: BMC Pulmonary Medicine 2013 13:69
  15. Bronchodilators are a mainstay of treatment for patients with airflow obstruction. We hypothesized that patients with obesity and no objective documentation of airflow obstruction are inappropriately treated w...

    Authors: Spyridon Fortis, Joseph Kittah, Manuel De Aguirre, Maria Plataki, Armand Wolff, Yaw Amoateng-Adjepong and Constantine A Manthous
    Citation: BMC Pulmonary Medicine 2013 13:68
  16. Mechanical ventilation (MV) is an essential supportive therapy for acute lung injury (ALI); however it can also contribute to systemic inflammation. Since pulmonary surfactant has anti-inflammatory properties,...

    Authors: Valeria Puntorieri, Josh Qua Hiansen, Lynda A McCaig, Li-Juan Yao, Ruud AW Veldhuizen and James F Lewis
    Citation: BMC Pulmonary Medicine 2013 13:67
  17. The fraction of exhaled nitric oxide (FeNO) has been suggested as a non-invasive marker of eosinophilic inflammation in asthma, but lately rather as a biomarker of atopy than of asthma itself. Asthma after bro...

    Authors: Ingvild Bruun Mikalsen, Thomas Halvorsen and Knut Øymar
    Citation: BMC Pulmonary Medicine 2013 13:66
  18. The acute inhalation of endotoxin mimicks several aspects of the inflammation related to chronic obstructive pulmonary disease (COPD). The aim of the current study was to identify and to validate biomarkers of...

    Authors: Olivier Michel, Virginie Doyen, Baptiste Leroy, Benjamin Bopp, Duc Huy Phong Dinh, Francis Corazza and Ruddy Wattiez
    Citation: BMC Pulmonary Medicine 2013 13:65
  19. Due to the pleiotropic effects of nitric oxide (NO) within the lungs, it is likely that NO is a significant factor in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of this study was...

    Authors: Farzian Aminuddin, Tillie-Louise Hackett, Dorota Stefanowicz, Aabida Saferali, Peter D Paré, Amund Gulsvik, Per Bakke, Michael H Cho, Augusto Litonjua, David A Lomas, Wayne H Anderson, Terri H Beaty, Edwin K Silverman and Andrew J Sandford
    Citation: BMC Pulmonary Medicine 2013 13:64
  20. Airway epithelial cells provide a protective barrier against environmental particles including potential pathogens. Epithelial repair in response to tissue damage is abnormal in asthmatic airway epithelium in ...

    Authors: Aleksandra Szczepankiewicz, Peter M Lackie and John W Holloway
    Citation: BMC Pulmonary Medicine 2013 13:63
  21. Anxiety and depression are common co-morbidities in patients with chronic obstructive pulmonary disease (COPD). Serious implications can result from psychological difficulties in COPD including reduced surviva...

    Authors: Karen Heslop, Julia Newton, Christine Baker, Graham Burns, Debbie Carrick-Sen and Anthony De Soyza
    Citation: BMC Pulmonary Medicine 2013 13:62
  22. The relevance of Trichosporon species for cystic fibrosis (CF) patients has not yet been extensively investigated.

    Authors: Carolin Kröner, Matthias Kappler, Ann-Christin Grimmelt, Gudrun Laniado, Benjamin Würstl and Matthias Griese
    Citation: BMC Pulmonary Medicine 2013 13:61
  23. The aim of this case–control study was to analyse the clinical characteristics of children with recurrent community-acquired pneumonia (rCAP) affecting different lung areas (DLAs) and compare them with those o...

    Authors: Francesca Patria, Benedetta Longhi, Claudia Tagliabue, Rossana Tenconi, Patrizia Ballista, Giuseppe Ricciardi, Carlotta Galeone, Nicola Principi and Susanna Esposito
    Citation: BMC Pulmonary Medicine 2013 13:60
  24. It has been suggested that smoking asthmatics benefit less from corticosteroid treatment than never-smoking asthmatics. We investigated differences in blood and sputum inflammatory profiles between ex-, curren...

    Authors: Eef D Telenga, Huib A M Kerstjens, Nick H T ten Hacken, Dirkje S Postma and Maarten van den Berge
    Citation: BMC Pulmonary Medicine 2013 13:58
  25. Pulmonary rehabilitation is widely advocated for people with chronic obstructive pulmonary disease (COPD) to improve exercise capacity, symptoms and quality of life, however only a minority of individuals with...

    Authors: Anne E Holland, Ajay Mahal, Catherine J Hill, Annemarie L Lee, Angela T Burge, Rosemary Moore, Caroline Nicolson, Paul O’Halloran, Narelle S Cox, Aroub Lahham, Rebecca Ndongo, Emily Bell and Christine F McDonald
    Citation: BMC Pulmonary Medicine 2013 13:57
  26. Genetic variation within GSTM2-5 genes may interfere with detoxification of environmental compounds, thereby having a detrimental effect on lung function following exposures such as tobacco smoke. We aim to inves...

    Authors: Melannie Alexander, Wilfried Karmaus, John W Holloway, Hongmei Zhang, Graham Roberts, Ramesh J Kurukulaaratchy, Syed Hasan Arshad and Susan Ewart
    Citation: BMC Pulmonary Medicine 2013 13:56
  27. Hyponatremia based on syndrome of inappropriate antidiuretic hormone hypersecretion (SIADH) is observed in up to 15% of patients with small cell lung cancer (SCLC). The electrolyte imbalance is associated with...

    Authors: Claudia Petereit, Okan Zaba, Ishak Teber, Heike Lüders and Christian Grohé
    Citation: BMC Pulmonary Medicine 2013 13:55
  28. Although chronic obstructive pulmonary disease (COPD) is a major global health burden there is a lack of patient awareness of disease severity, particularly in relation to exacerbations.

    Authors: Neil Barnes, Peter MA Calverley, Alan Kaplan and Klaus F Rabe
    Citation: BMC Pulmonary Medicine 2013 13:54
  29. Recent studies suggest that the incidence of idiopathic pulmonary fibrosis (IPF) is rising. Accurate epidemiological data on IPF, however, are sparse and the results of previous studies are contradictory. This...

    Authors: Jaana Kaunisto, Eija-Riitta Salomaa, Ulla Hodgson, Riitta Kaarteenaho and Marjukka Myllärniemi
    Citation: BMC Pulmonary Medicine 2013 13:53
  30. The importance of the lung parenchyma in the pathophysiology of asthma has previously been demonstrated. Considering that nitric oxide synthases (NOS) and arginases compete for the same substrate, it is worthw...

    Authors: Luciana RCRB Aristoteles, Renato F Righetti, Nathalia Montouro Pinheiro, Rosana B Franco, Claudia M Starling, Julie CP da Silva, Patrícia Angeli Pigati, Luciana C Caperuto, Carla M Prado, Marisa Dolhnikoff, Milton A Martins, Edna A Leick and Iolanda FLC Tibério
    Citation: BMC Pulmonary Medicine 2013 13:52
  31. Gastroesophageal reflux disease (GERD) is one of the most common causes of chronic cough and a potential risk factor for exacerbation of chronic obstructive pulmonary disease (COPD). The aim of this study was ...

    Authors: Jinhee Kim, Jin Hwa Lee, Yuri Kim, Kyungjoo Kim, Yeon-Mok Oh, Kwang Ha Yoo, Chin Kook Rhee, Hyoung Kyu Yoon, Young Sam Kim, Yong Bum Park, Sei Won Lee and Sang Do Lee
    Citation: BMC Pulmonary Medicine 2013 13:51
  32. Standardised evidenced-based materials and mechanisms to facilitate the delivery of the education component of pulmonary rehabilitation are not widely available. The aims of this study were: 1) to adapt the se...

    Authors: Denise Cosgrove, Joseph MacMahon, Jean Bourbeau, Judy M Bradley and Brenda O’Neill
    Citation: BMC Pulmonary Medicine 2013 13:50
  33. The six-minute walk test (6MWT) is a simple, low tech, safe and well established, self-paced assessment tool to quantify functional exercise capacity in adults. The definition of normal 6MWT in children is esp...

    Authors: Silvia Ulrich, Florian F Hildenbrand, Ursula Treder, Manuel Fischler, Stephan Keusch, Rudolf Speich and Margrit Fasnacht
    Citation: BMC Pulmonary Medicine 2013 13:49
  34. Chronic lung diseases are marked by progressive inflammation, tissue damage and remodelling. Bone marrow-derived progenitor cells may contribute to these processes. The objectives of this study were to (1) to ...

    Authors: Sarah E Gilpin, Kalvin Lung, Geoffrey T de Couto, Marcelo Cypel, Masaaki Sato, Lianne G Singer, Shaf Keshavjee and Thomas K Waddell
    Citation: BMC Pulmonary Medicine 2013 13:48
  35. Heparin-binding protein is released by neutrophils during inflammation and disrupts the integrity of the alveolar and capillary endothelial barrier implicated in the development of acute lung injury and system...

    Authors: Daniel F McAuley, Cecilia M O’Kane, Thelma R Craig, Murali Shyamsundar, Heiko Herwald and Karim Dib
    Citation: BMC Pulmonary Medicine 2013 13:47
  36. It remains unclear to what extent asthma in adults is linked to allergic rhinitis (AR), gastroesophageal reflux disease (GERD), and acetylsalicylic acid exacerbated respiratory disease (AERD), and how these co...

    Authors: Henriette Steppuhn, Ute Langen, Christa Scheidt-Nave and Thomas Keil
    Citation: BMC Pulmonary Medicine 2013 13:46
  37. The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) and the Medical Outcomes Study Short Form 36 (SF-36) are widely used to assess patient-reported outcome in individuals with pulmonary hypertension ...

    Authors: James Twiss, Stephen McKenna, Louise Ganderton, Sue Jenkins, Mitra Ben-L’amri, Kevin Gain, Robin Fowler and Eli Gabbay
    Citation: BMC Pulmonary Medicine 2013 13:45
  38. Tumors with a massive inflammatory infiltration are described in several organs. There is agreement about considering the inflammatory infiltration as the host’s immune response to neoplastic cells; such neopl...

    Authors: Alessandro Del Gobbo, Stefano Fiori, Gabriella Gaudioso, Mario Nosotti, Guido Coggi, Silvano Bosari and Stefano Ferrero
    Citation: BMC Pulmonary Medicine 2013 13:44
  39. Exhaled breath volatile organic compound (VOC) analysis for airway disease monitoring is promising. However, contrary to nitric oxide the method for exhaled breath collection has not yet been standardized and ...

    Authors: Andras Bikov, Koralia Paschalaki, Ron Logan-Sinclair, Ildiko Horváth, Sergei A Kharitonov, Peter J Barnes, Omar S Usmani and Paolo Paredi
    Citation: BMC Pulmonary Medicine 2013 13:43
  40. Serum levels of N–terminal proB–type natriuretic peptide (NT–proBNP) are elevated in patients acute respiratory distress syndrome (ARDS). Recent studies showed a lower incidence of acute cor pulmonale in ARDS ...

    Authors: Rogier M Determann, Annick ANM Royakkers, Jacqueline Schaefers, Anita M de Boer, Jan M Binnekade, Jan P van Straalen and Marcus J Schultz
    Citation: BMC Pulmonary Medicine 2013 13:42
  41. Chronic Obstructive Pulmonary Disease (COPD) is a disease state characterized by airflow limitation that is not fully reversible and usually progressive. Current guidelines, among which the Dutch, have so far ...

    Authors: Janwillem Kocks, Corina de Jong, Marjolein Y Berger, Huib AM Kerstjens and Thys van der Molen
    Citation: BMC Pulmonary Medicine 2013 13:41
  42. There is insufficient evidence of the cost-effectiveness of Chronic Obstructive Pulmonary Disease (COPD) Disease Management (COPD-DM) programs. The aim of this review is to evaluate the economic impact of COPD...

    Authors: Melinde RS Boland, Apostolos Tsiachristas, Annemarije L Kruis, Niels H Chavannes and Maureen PMH Rutten-van Mölken
    Citation: BMC Pulmonary Medicine 2013 13:40
  43. A clear relationship between asthma and obesity has been reported, but the mechanisms remain unclear. The aim of this study was to evaluate the influence of obesity on eosinophil activity (chemotaxis and adhes...

    Authors: Milena Baptistella Grotta, Dalize M Squebola-Cola, Adyleia ADC Toro, Maria Angela GO Ribeiro, Silvia B Mazon, Jose D Ribeiro and Edson Antunes
    Citation: BMC Pulmonary Medicine 2013 13:39
  44. The majority of the global population cannot afford existing asthma pharmacotherapy. Physical training as an airway anti-inflammatory therapy for asthma could potentially be a non-invasive, easily available, a...

    Authors: Smita Pakhale, Vanessa Luks, Andrew Burkett and Lucy Turner
    Citation: BMC Pulmonary Medicine 2013 13:38
  45. The aim of this substudy of the ghrelin treatment, multicenter, randomized, double-blind, placebo-controlled trial was to investigate the effects of ghrelin administration on exercise capacity and the underlyi...

    Authors: Keisuke Miki, Ryoji Maekura, Noritoshi Nagaya, Seigo Kitada, Mari Miki, Kenji Yoshimura, Yoshitaka Tateishi, Masaharu Motone, Toru Hiraga, Masahide Mori and Kenji Kangawa
    Citation: BMC Pulmonary Medicine 2013 13:37
  46. The imbalance between proteases and antiproteases has been proposed to participate to the pathogenesis of chronic obstructive pulmonary disease (COPD) and emphysema. Gene level variation in different metallopr...

    Authors: Mari K Kukkonen, Emmi Tiili, Tapio Vehmas, Panu Oksa, Päivi Piirilä and Ari Hirvonen
    Citation: BMC Pulmonary Medicine 2013 13:36

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