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  1. This study investigated the efficacy and safety of a new asthma therapy combining fluticasone propionate and formoterol fumarate (fluticasone/formoterol; flutiform ®), administered twice daily (b.i.d.) via a sing...

    Authors: Robert A Nathan, Anthony D’Urzo, Viktor Blazhko and Kirsten Kaiser
    Citation: BMC Pulmonary Medicine 2012 12:67
  2. In well-child care it is difficult to determine whether preschool children with asthma symptoms actually have or will develop asthma at school age. The PIAMA (Prevention and Incidence of Asthma and Mite Allerg...

    Authors: Esther Hafkamp-de Groen, Hester F Lingsma, Daan Caudri, Alet Wijga, Vincent WV Jaddoe, Ewout W Steyerberg, Johan C de Jongste and Hein Raat
    Citation: BMC Pulmonary Medicine 2012 12:65
  3. Tobacco smoking remains the leading cause of preventable death in America, claiming 450,000 lives annually. Chronic Obstructive Pulmonary Disease, caused by smoking in the vast majority of cases, became the th...

    Authors: Stephen A Martin, Bartolome R Celli, Joseph R DiFranza, Stephen J Krinzman, Jennifer G Clarke, Herbert Beam, Sandra Howard, Melissa Foster and Robert J Goldberg
    Citation: BMC Pulmonary Medicine 2012 12:64
  4. The recommendations for the treatment of moderate persistent asthma in the Global Initiative for Asthma (GINA) guidelines for paediatric asthma are mainly based on scientific evidence extrapolated from studies...

    Authors: Lonneke B van der Mark, PH Edo Lyklema, Ronald B Geskus, Jacob Mohrs, Patrick JE Bindels, Wim MC van Aalderen and Gerben ter Riet
    Citation: BMC Pulmonary Medicine 2012 12:63
  5. Inhalation of helium-oxygen (He/O2) mixtures has been explored as a means to lower the work of breathing of patients with obstructive lung disease. Non-invasive ventilation (NIV) with positive pressure support is...

    Authors: Andrew R Martin, Ira M Katz, Katharina Jenöfi, Georges Caillibotte, Laurent Brochard and Joëlle Texereau
    Citation: BMC Pulmonary Medicine 2012 12:62
  6. Dyspnea is very frequent in obese subjects. However, its assessment is complex in clinical practice. The modified Medical Research Council scale (mMRC scale) is largely used in the assessment of dyspnea in chr...

    Authors: Claire Launois, Coralie Barbe, Eric Bertin, Julie Nardi, Jeanne-Marie Perotin, Sandra Dury, François Lebargy and Gaëtan Deslee
    Citation: BMC Pulmonary Medicine 2012 12:61
  7. Obstructive sleep apnea (OSA) is becoming increasingly prevalent in North America and has been described in association with specific chronic diseases, particularly cardiovascular diseases. In primary care, wh...

    Authors: Laurence Robichaud-Hallé, Michel Beaudry and Martin Fortin
    Citation: BMC Pulmonary Medicine 2012 12:60
  8. Mechanical ventilation (MV) is the primary form of support for acute respiratory distress syndrome (ARDS) patients. However, intra- and inter- patient-variability reduce the efficacy of general protocols. Mode...

    Authors: Yeong Shiong Chiew, J Geoffrey Chase, Bernard Lambermont, Nathalie Janssen, Christoph Schranz, Knut Moeller, Geoffrey M Shaw and Thomas Desaive
    Citation: BMC Pulmonary Medicine 2012 12:59
  9. Breathlessness is a common and distressing symptom affecting many patients with advanced disease both from malignant and non-malignant origin. A combination of pharmacological and non-pharmacological measures ...

    Authors: Claudia Bausewein, Caroline Jolley, Charles Reilly, Paula Lobo, Jane Kelly, Helene Bellas, Preety Madan, Caty Panell, Elmien Brink, Chiara De Biase, Wei Gao, Caroline Murphy, Paul McCrone, John Moxham and Irene J Higginson
    Citation: BMC Pulmonary Medicine 2012 12:58
  10. 18F-FDG PET/CT (PET) is useful in assessing inflammatory activity in sarcoidosis. However, no appropriate indications are available. The aim of this study was to develop a prediction rule that can be used to ide...

    Authors: Rémy LM Mostard, Sander MJ Van Kuijk, Johny A Verschakelen, Marinus JPG van Kroonenburgh, Patty J Nelemans, Petal AHM Wijnen and Marjolein Drent
    Citation: BMC Pulmonary Medicine 2012 12:57
  11. The association between endotoxin exposure and asthma is complex and has been associated with rural living. We examined the relationship between domestic endotoxin and asthma or wheeze among rural school-aged ...

    Authors: Joshua A Lawson, James A Dosman, Donna C Rennie, Jeremy R Beach, Stephen C Newman, Trever Crowe and Ambikaipakan Senthilselvan
    Citation: BMC Pulmonary Medicine 2012 12:56
  12. Napsin A, an aspartic protease, is mainly expressed in alveolar type-II cells and renal proximal tubules and is a putative immunohistochemical marker for pulmonary adenocarcinomas. This study sought to determi...

    Authors: Takuya Samukawa, Tsutomu Hamada, Hirofumi Uto, Masakazu Yanagi, Go Tsukuya, Tsuyoshi Nosaki, Masahiro Maeda, Takashi Hirano, Hirohito Tsubouchi and Hiromasa Inoue
    Citation: BMC Pulmonary Medicine 2012 12:55
  13. The 6-minute walk test evaluates the effect of pharmacologic intervention in adults with pulmonary arterial hypertension (PAH) but, for reasons of compliance or reliability, may not be appropriate for children...

    Authors: Joseph C Cappelleri, Lie-Ju Hwang, Jack Mardekian and Marko A Mychaskiw
    Citation: BMC Pulmonary Medicine 2012 12:54
  14. Patients with chronic obstructive pulmonary disease (COPD) often experience depression and anxiety, but little information is available regarding Chinese patients with these conditions. The present study asses...

    Authors: Peian Lou, Yanan Zhu, Peipei Chen, Pan Zhang, Jiaxi Yu, Ning Zhang, Na Chen, Lei Zhang, Hongmin Wu and Jing Zhao
    Citation: BMC Pulmonary Medicine 2012 12:53
  15. Regular review and support for asthma self-management is promoted in guidelines. A randomised controlled trial suggested that unscheduled health care usage was similar when patients were offered self managemen...

    Authors: Nicola J Roberts, Kathleen A Boyd, Andrew H Briggs, Ann L Caress and Martyn R Partridge
    Citation: BMC Pulmonary Medicine 2012 12:52
  16. Respiratory tract infections (RTIs) may be more severe in those with asthma or COPD and these patients are more frequently in need of health care. The aim of the study was to describe the frequency of RTI symp...

    Authors: Hasse Melbye, Lisa Joensen, Mette Bech Risør and Peder A Halvorsen
    Citation: BMC Pulmonary Medicine 2012 12:51
  17. The most common cystic fibrosis (CF) manifestation is the progressive chronic obstructive pulmonary disease caused by deficiency, dysfunction, or absence of the CFTR (Cystic Fibrosis Transmembrane Regulator) p...

    Authors: Fernando A L Marson, Carmen S Bertuzzo, Antônio F Ribeiro and José D Ribeiro
    Citation: BMC Pulmonary Medicine 2012 12:50
  18. Bronchodilator response in patients with asthma is evaluated based on post-bronchodilator increase in forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). However, the need for additiona...

    Authors: Karen S Azevedo, Ronir R Luiz, Patricia RM Rocco and Marcus B Conde
    Citation: BMC Pulmonary Medicine 2012 12:49
  19. Despite the benefits of beta-blockers in patients with established or sub-clinical coronary artery disease, their use in patients with chronic obstructive pulmonary disease (COPD) has been controversial. Curre...

    Authors: Mahyar Etminan, Siavash Jafari, Bruce Carleton and John Mark FitzGerald
    Citation: BMC Pulmonary Medicine 2012 12:48
  20. Granulomatosis with polyangitis (Wegener’s) is a vasculitic disease predominantly affecting the lungs, skin, kidneys, ears, nose and throat. Mycobacterium abscessus is an uncommon rapidly growing mycobacterium ca...

    Authors: Senyo K Tagboto and Ajay G Venkatesh
    Citation: BMC Pulmonary Medicine 2012 12:47
  21. The impact of HIV infection on the evolution of acute community-acquired pneumonia (CAP) is still controversial. The aim of this study was to investigate possible differences in the clinical presentation and i...

    Authors: Eric Walter Pefura Yone, Adamou Dodo Balkissou, André Pascal Kengne and Christopher Kuaban
    Citation: BMC Pulmonary Medicine 2012 12:46
  22. The design of new interventions to improve health care for patients with chronic obstructive pulmonary disease (COPD) requires knowledge about what patients with an acute exacerbation experience as important a...

    Authors: Ying Wang, Torbjørn Haugen, Sissel Steihaug and Anne Werner
    Citation: BMC Pulmonary Medicine 2012 12:45
  23. Neutrophils sequestered in lower respiratory tract secretions in the inflamed lung may undergo apoptosis and/or necrosis and release toxic cellular contents that can injure airways or parenchyma. This study ex...

    Authors: Francis H C Tsao, Zhuzai Xiang, Adnan Abbasi and Keith C Meyer
    Citation: BMC Pulmonary Medicine 2012 12:44
  24. Acute lung injury (ALI) is characterized by a pro-coagulant state. Heparin is an anticoagulant with anti-inflammatory properties. Unfractionated heparin has been found to be protective in experimental models o...

    Authors: Jorrit J Hofstra, Alexander P J Vlaar, David J Prins, Gavin Koh, Marcel Levi, Marcus J Schultz, Jan M Binnekade and Nicole P Juffermans
    Citation: BMC Pulmonary Medicine 2012 12:43
  25. Right-to-left shunt (RLS) may be the cause of marked hypoxemia, a respiratory insufficiency which is usually difficult to diagnose by respiratory physicians as it develops in the absence of an intrinsic lung d...

    Authors: Cristiano Carbonelli, Marialuisa Zedde, Alberto Cavazza, Nicola Facciolongo, Francesco Menzella, Lucia Spaggiari and Luigi Zucchi
    Citation: BMC Pulmonary Medicine 2012 12:42
  26. Cystic Fibrosis (CF) is a monogenic disease with complex expression because of the action of genetic and environmental factors. We investigated whether the ACE gene D/I polymorphism is associated with severity of...

    Authors: Fernando A L Marson, Carmen S Bertuzzo, Taís D R Hortencio, José D Ribeiro, Luciana C Bonadia and Antônio F Ribeiro
    Citation: BMC Pulmonary Medicine 2012 12:41
  27. Tuberculosis (TB) remains a public health issue worldwide. The lack of specific clinical symptoms to diagnose TB makes the correct decision to admit patients to respiratory isolation a difficult task for the c...

    Authors: Fabio S Aguiar, Luciana L Almeida, Antonio Ruffino-Netto, Afranio Lineu Kritski, Fernanda CQ Mello and Guilherme L Werneck
    Citation: BMC Pulmonary Medicine 2012 12:40
  28. In some situations, practice guidelines do not provide firm evidence-based guidance regarding COPD treatment choices, especially when large trials have failed to identify subgroups of particularly good or poor...

    Authors: Nicolas Roche, Christos Chouaid, Bertrand Delclaux, Yan Martinat, Jean-Michel Marcos, Hervé Pégliasco and Bruno Scherrer
    Citation: BMC Pulmonary Medicine 2012 12:39
  29. Titanium dioxide (TiO2) and carbon black (CB) nanoparticles (NPs) have biological effects that could aggravate pulmonary emphysema. The aim of this study was to evaluate whether pulmonary administration of TiO2 o...

    Authors: Agnès Roulet, Lucie Armand, Maylis Dagouassat, Françoise Rogerieux, Angélique Simon-Deckers, Esther Belade, Jeanne Tran Van Nhieu, Sophie Lanone, Jean-Claude Pairon, Ghislaine Lacroix and Jorge Boczkowski
    Citation: BMC Pulmonary Medicine 2012 12:38
  30. Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are often linked to respiratory infections. However, it is unknown if COPD patients who experience frequent exacerbations have impaired hum...

    Authors: Stephanie T Yerkovich, Belinda J Hales, Melanie L Carroll, Julie G Burel, Michelle A Towers, Daniel J Smith, Wayne R Thomas and John W Upham
    Citation: BMC Pulmonary Medicine 2012 12:37
  31. Several studies suggest an increase of oxidative stress and a reduction of endothelial function in obstructive sleep apnoea syndrome (OSAS). We assessed the association between OSAS, endothelial dysfunction an...

    Authors: Maria Del Ben, Mario Fabiani, Lorenzo Loffredo, Licia Polimeni, Roberto Carnevale, Francesco Baratta, Marco Brunori, Fabiana Albanese, Teresa Augelletti, Francesco Violi and Francesco Angelico
    Citation: BMC Pulmonary Medicine 2012 12:36
  32. Therapeutic reference pricing (TRP) based on the WHO daily defined dose (DDD) is a method frequently employed for the cost-containment of pharmaceuticals. Our objective was to compare average drug use in the r...

    Authors: Zoltan Kalo, Zsolt Abonyi-Toth, Zoltan Bartfai and Zoltan Voko
    Citation: BMC Pulmonary Medicine 2012 12:35
  33. Elastin is an essential component of selected connective tissues that provides a unique physiological elasticity. Elastin may be considered a signature protein of lungs where matrix metalloprotease (MMP) -9-an...

    Authors: Helene Skjøt-Arkil, Rikke E Clausen, Quoc Hai Trieu Nguyen, Yaguo Wang, Qinlong Zheng, Fernando J Martinez, Cory M Hogaboam, Meilan Han, Lloyd B Klickstein, Martin R Larsen, Arkadiusz Nawrocki, Diana J Leeming and Morten A Karsdal
    Citation: BMC Pulmonary Medicine 2012 12:34
  34. Diagnostic and treatment approaches for sarcoidosis have changed dramatically over the past decade. Yet, the most recent reports of trends in hospitalizations of sarcoidosis patients are over ten years old. Th...

    Authors: Alicia K Gerke, Ming Yang, Fan Tang, Joseph E Cavanaugh and Philip M Polgreen
    Citation: BMC Pulmonary Medicine 2012 12:19
  35. A high-sensitivity cardiac troponin T (hs-cTnT) concentration above the 99th percentile (i.e. 14 ng/L) is common during Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) and associated with inc...

    Authors: Arne Didrik Høiseth, Torbjørn Omland, Tor-Arne Hagve, Pål H Brekke and Vidar Søyseth
    Citation: BMC Pulmonary Medicine 2012 12:22
  36. Manual chest physiotherapy (MCP) techniques involving chest percussion, vibration, and shaking have long been used in the treatment of respiratory conditions. However, methodological limitations in existing re...

    Authors: Jane L Cross, Frances Elender, Gary Barton, Allan Clark, Lee Shepstone, Annie Blyth, Max O Bachmann and Ian Harvey
    Citation: BMC Pulmonary Medicine 2012 12:33
  37. This study examined associations of abdominal adiposity with lung function, asthma symptoms and current doctor-diagnosed asthma and mediation by insulin resistance (IR) and sleep disordered breathing (SDB).

    Authors: Matthew T Haren, Gary Misan, Tracey-Jayne Paterson, Richard E Ruffin, Janet F Grant, Jonathan D Buckley, Peter RC Howe, Jonathan Newbury, Anne W Taylor and Robyn A McDermott
    Citation: BMC Pulmonary Medicine 2012 12:31
  38. The evidence regarding the association between lung cancer and occupational exposure to cement is controversial. This study investigated causes of deaths from cancer of respiratory tract among cement workers.

    Authors: George Rachiotis, Spyros Drivas, Konstantinos Kostikas, Vasilios Makropoulos and Christos Hadjichristodoulou
    Citation: BMC Pulmonary Medicine 2012 12:30
  39. The objective of this study was to evaluate the comparative efficacy of indacaterol 75 μg once daily (OD), tiotropium 18 μg OD, salmeterol 50 μg twice daily (BID), formoterol 12 μg BID, and placebo for the tre...

    Authors: Shannon Cope, Jie Zhang, James Williams and Jeroen P Jansen
    Citation: BMC Pulmonary Medicine 2012 12:29
  40. Exacerbations, a leading cause of hospitalization in patients with chronic obstructive pulmonary disease (COPD), affect the quality of life and prognosis. Treatment recommendations as provided in the evidence-...

    Authors: Andrea Ban, Aniza Ismail, Roslan Harun, Azahirafairud Abdul Rahman, Saperi Sulung and Aljunid Syed Mohamed
    Citation: BMC Pulmonary Medicine 2012 12:27
  41. Treatment of chronic diseases such as chronic obstructive pulmonary disease (COPD) is complicated by the presence of comorbidities. The objective of this analysis was to estimate the prevalence of comorbidity ...

    Authors: Kerry Schnell, Carlos O Weiss, Todd Lee, Jerry A Krishnan, Bruce Leff, Jennifer L Wolff and Cynthia Boyd
    Citation: BMC Pulmonary Medicine 2012 12:26
  42. Pulmonary hypertension (PH) is a complication of chronic obstructive pulmonary disease (COPD). This study examined genetic variations in mediators of vascular remodelling and their association with PH in patie...

    Authors: Janet G Shaw, Annette G Dent, Linda H Passmore, Darryl J Burstow, Rayleen V Bowman, Paul V Zimmerman, Kwun M Fong and Ian A Yang
    Citation: BMC Pulmonary Medicine 2012 12:25
  43. Pirfenidone is a novel anti-fibrotic and anti-inflammatory agent that inhibits the progression of fibrosis in animal models and in patients with idiopathic pulmonary fibrosis (IPF). We previously showed that p...

    Authors: Keiko Hisatomi, Hiroshi Mukae, Noriho Sakamoto, Yuji Ishimatsu, Tomoyuki Kakugawa, Shintaro Hara, Hanako Fujita, Seiko Nakamichi, Hisashi Oku, Yoshishige Urata, Hiroshi Kubota, Kazuhiro Nagata and Shigeru Kohno
    Citation: BMC Pulmonary Medicine 2012 12:24
  44. Increased ventilatory response has been shown to have a high prognostic value in patients with chronic heart failure. Our aim was therefore to determine the ventilatory efficiency in pulmonary arterial hyperte...

    Authors: Martin Schwaiblmair, Christian Faul, Wolfgang von Scheidt and Thomas M Berghaus
    Citation: BMC Pulmonary Medicine 2012 12:23
  45. Length of hospital stay (LOS) in patients with community-acquired pneumonia (CAP) is variable and directly related to medical costs. Accurate estimation of LOS on admission and during follow-up may result in e...

    Authors: Isabelle Suter-Widmer, Mirjam Christ-Crain, Werner Zimmerli, Werner Albrich, Beat Mueller and Philipp Schuetz
    Citation: BMC Pulmonary Medicine 2012 12:21
  46. Health status provides valuable information, complementary to spirometry and improvement of health status has become an important treatment goal in COPD management. We compared the usefulness and validity of t...

    Authors: Ioanna G Tsiligianni, Thys van der Molen, Despoina Moraitaki, Ilaine Lopez, Janwillem WH Kocks, Konstantinos Karagiannis, Nikolaos Siafakas and Nikolaos Tzanakis
    Citation: BMC Pulmonary Medicine 2012 12:20
  47. Quantification of lung tissue via analysis of computed tomography (CT) scans is increasingly common for monitoring disease progression and for planning of therapeutic interventions. The current study evaluates...

    Authors: Erik Henne, Joseph C Anderson, Norma Lowe and Steven Kesten
    Citation: BMC Pulmonary Medicine 2012 12:18

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