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  1. Resistance to gefitinib remains a major obstacle for the successful treatment of non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations. In this paper, we studied the precise...

    Authors: Daping Fan, Yue Yang and Wei Zhang
    Citation: BMC Pulmonary Medicine 2022 22:27
  2. Silicosis is a systemic disease characterized by persistent inflammation and incurable pulmonary fibrosis. Although great effort has been made to understand the pathogenesis of the disease, molecular mechanism...

    Authors: Cunxiang Bo, Juan Zhang, Linlin Sai, Zhongjun Du, Gongchang Yu, Chao Li, Ming Li, Cheng Peng, Qiang Jia and Hua Shao
    Citation: BMC Pulmonary Medicine 2022 22:13
  3. Incidental and screening-identified lung nodules are common, and a bronchoscopic evaluation is frequently nondiagnostic. The Percepta Genomic Sequencing Classifier (GSC) is a genomic classifier developed in cu...

    Authors: Sonali Sethi, Scott Oh, Alexander Chen, Christina Bellinger, Lori Lofaro, Marla Johnson, Jing Huang, Sangeeta Maruti Bhorade, William Bulman and Giulia C. Kennedy
    Citation: BMC Pulmonary Medicine 2022 22:26
  4. Various complications may arise from prolonged mechanical ventilation, but the risk of tracheal stenosis occurring late after translaryngeal intubation or tracheostomy is less common. This study aimed to deter...

    Authors: Alessandro Ghiani, Konstantinos Tsitouras, Joanna Paderewska, Dieter Munker, Swenja Walcher, Claus Neurohr and Nikolaus Kneidinger
    Citation: BMC Pulmonary Medicine 2022 22:24
  5. As one of the basic treatments performed in the intensive care unit, mechanical ventilation can cause ventilator-induced acute lung injury (VILI). The typical features of VILI are an uncontrolled inflammatory ...

    Authors: Leilei Zhou, Chunju Xue, Zongyu Chen, Wenqing Jiang, Shuang He and Xianming Zhang
    Citation: BMC Pulmonary Medicine 2022 22:9
  6. Mortality in severe COVID-19 pneumonia is associated with thrombo-inflammation. Corticosteroids are given to attenuate the inflammation, but they are associated with thrombosis. The aims of this study were to ...

    Authors: Ronaldo C. Go, Themba Nyirenda, Maryam Bojarian, Davood K. Hosseini, Mehek Rahim, Kevin Kim and Keith M. Rose
    Citation: BMC Pulmonary Medicine 2022 22:6
  7. The spirometer is an important element in lung function examinations, and its accuracy is directly related to the accuracy of the results of these examinations and to the diagnosis and treatment of diseases. O...

    Authors: Zhongping Wu, Ruibo Huang, Liping Zhong, Yi Gao and Jinping Zheng
    Citation: BMC Pulmonary Medicine 2022 22:23
  8. With the rapid advances of genetic and genomic technologies, the pathophysiological mechanisms of idiopathic pulmonary fibrosis (IPF) were gradually becoming clear, however, the prognosis of IPF was still poor...

    Authors: Yaowu He, Yu Shang, Yupeng Li, Menghan Wang, Dongping Yu, Yi Yang, Shangwei Ning and Hong Chen
    Citation: BMC Pulmonary Medicine 2022 22:15
  9. Chronic obstructive pulmonary disease (COPD) is a leading cause of global mortality. In high-income settings, the presence of cardiovascular disease among people with COPD increases mortality and complicates l...

    Authors: Rebecca F. Gilbert, Cody Cichowitz, Prossy Bibangambah, June-Ho Kim, Linda C. Hemphill, Isabelle T. Yang, Ruth N. Sentongo, Bernard Kakuhikire, David C. Christiani, Alexander C. Tsai, Samson Okello, Mark J. Siedner and Crystal M. North
    Citation: BMC Pulmonary Medicine 2022 22:12
  10. Accelerated nodulosis (ARN) is a rare variant of rheumatoid nodules (RNs) that is characterized by a rapid onset or the worsening of RNs. It generally develops at the fingers in patients with rheumatoid arthri...

    Authors: Akitake Suzuki, Shigeki Morita, Miho Ohshima, Nobuyoshi Minemura, Takeshi Suzuki, Masanobu Yoshida, Rikuo Machinami, Shuji Sakai and Chikao Torikata
    Citation: BMC Pulmonary Medicine 2022 22:10
  11. “Overlap syndrome” refers to obstructive sleep apnea (OSA) combined with chronic obstructive pulmonary disease (COPD), and has poorer outcomes than either condition alone. We aimed to evaluate the prevalence a...

    Authors: Pan Zhang, Bi Chen, Heqing Lou, Yanan Zhu, Peipei Chen, Zongmei Dong, Xuan Zhu, Ting Li and Peian Lou
    Citation: BMC Pulmonary Medicine 2022 22:16
  12. Pulmonary blastoma (PB) comprises a rare heterogeneous group of lung tumours typically containing immature epithelial and mesenchymal structures that imitate the embryonic lung tissue and extremely rarely occu...

    Authors: Michał P. Budzik, Grzegorz Panek, Małgorzata Bińkowska, Beata Osuch, Ewa Borkowska and Anna M. Badowska-Kozakiewicz
    Citation: BMC Pulmonary Medicine 2022 22:8
  13. Asthma exacerbation threatens patient's life. Several genetic studies have been conducted to determine the risk factors for asthma exacerbation, but this information is still lacking. We aimed to determine whe...

    Authors: Min-Hye Kim, Hun Soo Chang, Jong-Uk Lee, Ji-Su Shim, Jong-Sook Park, Young-Joo Cho and Choon-Sik Park
    Citation: BMC Pulmonary Medicine 2022 22:3
  14. Serum lactate dehydrogenase (LDH), carcinoembryonic antigen (CEA) and CYFRA21-1 are the commonly used biomarkers to identify patients with autoimmune pulmonary alveolar proteinosis (APAP). However, it is not c...

    Authors: Jiu-Wu Bai, Shui-Yi Gu, Xiao-Li Sun, Hai-Wen Lu, Shuo Liang and Jin-Fu Xu
    Citation: BMC Pulmonary Medicine 2022 22:2
  15. Quantitative evaluation of radiographic images has been developed and suggested for the diagnosis of coronavirus disease 2019 (COVID-19). However, there are limited opportunities to use these image-based diagn...

    Authors: Daisuke Yamada, Sachiko Ohde, Ryosuke Imai, Kengo Ikejima, Masaki Matsusako and Yasuyuki Kurihara
    Citation: BMC Pulmonary Medicine 2022 22:1
  16. Allergic bronchopulmonary aspergillosis (ABPA) is a bronchopulmonary disease caused by a complex hypersensitivity to Aspergillus and is usually associated with underlying respiratory diseases such as asthma or cy...

    Authors: N. Benkalfate, S. Dirou, P. Germaud, C. Defrance, A. Cavailles, T. Pigeanne, M. Robert, T. Madjer, F. Corne, L. Cellerin, C. Sagan and F. X. Blanc
    Citation: BMC Pulmonary Medicine 2021 21:425
  17. To evaluate cytokine profile, vitamin D status, symptom score and quality of life in patients with persistent allergic airway diseases sensitised to house dust mites (HDM) in comparison with healthy individuals.

    Authors: Laura Tamasauskiene and Brigita Sitkauskiene
    Citation: BMC Pulmonary Medicine 2021 21:424
  18. Endobronchial ultrasound (EBUS) elastography has been used in EBUS-guided transbronchial needle aspiration (EBUS-TBNA) to identify malignant lymph nodes based on tissue stiffness. Rapid onsite cytological eval...

    Authors: Jing Huang, Yuan Lu, Xihua Wang, Xiaoli Zhu, Ping Li, Jing Chen, Pingsheng Chen and Ming Ding
    Citation: BMC Pulmonary Medicine 2021 21:423
  19. Self-administration of helminths has gained attention among patients as a potential but unproven therapy for autoimmune disease. We present a case of rapidly progressive respiratory failure in a patient with s...

    Authors: Anahit A. Zeynalyan, Balaji Kolasani, Chetan Naik, Christopher J. G. Sigakis, Leann Silhan and Susan K. Mathai
    Citation: BMC Pulmonary Medicine 2021 21:422
  20. In recent years, immunotherapies and targeted therapies contribute to population-level improvement in NSCLC cancer-specific survival, however, the two novel therapeutic options have mainly benefit patients con...

    Authors: Liyuan Song, Xianhui Wang, Wang Cheng, Yi Wu, Min Liu, Ruizi Liu, Shenyi Zhang, Hong Xia, Hao Liu, Xuejiao Tai, Huzi Zhao, Xihua Li and Fuyun Ji
    Citation: BMC Pulmonary Medicine 2021 21:420
  21. Relapse after effective bronchial arterial embolization (BAE) for controlling hemoptysis is not uncommon. Studies reported diverse predictors of recurrence. However, a model to assess the probability of recurr...

    Authors: Hai-Tao Yan, Guang-Dong Lu, Xiang-Zhong Huang, Da-Zhong Zhang, Kun-Yuan Ge, Jin-Xing Zhang, Jin Liu, Sheng Liu, Hai-Bin Shi and Qing-Quan Zu
    Citation: BMC Pulmonary Medicine 2021 21:419
  22. Mechanisms of positive effects of pulmonary artery (PA) denervation (PADN) remain poorly understood. The study aimed to evaluate pulmonary hemodynamic changes after PADN and their association with the extent o...

    Authors: Natalia S. Goncharova, Heber Ivan Condori Leandro, Aleksandr D. Vakhrushev, Elena G. Koshevaya, Yury A. Skorik, Lubov B. Mitrofanova, Lada A. Murashova, Lev E. Korobchenko, Elizaveta M. Andreeva, Dmitry S. Lebedev, Olga M. Moiseeva and Evgeny N. Mikhaylov
    Citation: BMC Pulmonary Medicine 2021 21:418
  23. Benralizumab, a monoclonal antibody targeting the human interleukin-5 (IL-5) receptor (IL-5R), was used before marketing authorisation in Spain in a real world setting as part of an early-access programme (EAP...

    Authors: Eva Martínez-Moragón, Ismael García-Moguel, Javier Nuevo and Gustavo Resler
    Citation: BMC Pulmonary Medicine 2021 21:417
  24. Idiopathic pulmonary fibrosis (IPF) and chronic hypersensitivity pneumonitis share commonalities in pathogenesis shifting haemostasis balance towards the procoagulant and antifibrinolytic activity. Several stu...

    Authors: Małgorzata Sobiecka, Monika Szturmowicz, Katarzyna Lewandowska, Agata Kowalik, Ewa Łyżwa, Katarzyna Zimna, Inga Barańska, Lilia Jakubowska, Jan Kuś, Renata Langfort and Witold Tomkowski
    Citation: BMC Pulmonary Medicine 2021 21:416
  25. Asthma is the most commonly occurring respiratory illness during pregnancy. Associations with complications of pregnancy and adverse perinatal outcome have been established. However, little is known about qual...

    Authors: Nasrin Fazel, Michael Kundi, Erika Jensen-Jarolim, Isabella Maria Pali-Schöll, Asghar Kazemzadeh, Habibollah Esmaily, Mojtaba Fattahi Abdizadeh, Roya Akbarzadeh, Raheleh Ahmadi and Hossain Jabbari
    Citation: BMC Pulmonary Medicine 2021 21:415
  26. The use of galactomannan (GM) testing in plasma and bronchoalveolar lavage fluid (BALF) has improved the diagnosis of invasive pulmonary aspergillosis (IPA) in patients with chronic obstructive pulmonary disea...

    Authors: Qian He, Ming Zhang and Chunlai Feng
    Citation: BMC Pulmonary Medicine 2021 21:414
  27. Immunoglobulin G4-related lung disease (IgG4-RLD) is a rare entity. We retrospectively analyzed the clinical and histopathological characteristics of patients with pathologically confirmed IgG4-RLD to improve ...

    Authors: Jia Liu, Yuxiang Liu, Ximing Shen, Zhanghai He, Tingfeng Yu, Li Pang, Xiaoyan Jin and Lingyun Wang
    Citation: BMC Pulmonary Medicine 2021 21:413
  28. Research questions To compare the efficacy of nintedanib and pirfenidone in the treatment of progressive pulmonary fibrosis; and to compare the efficacy of anti-fibrotic therapy (grouping nintedanib and pirfenido...

    Authors: James Patrick Finnerty, Aravind Ponnuswamy, Prosjenjit Dutta, Ammar Abdelaziz and Hafiz Kamil
    Citation: BMC Pulmonary Medicine 2021 21:411
  29. Acute pulmonary embolism (PE) is a common cause for hospitalization associated with significant mortality and morbidity. Disorders of calcium metabolism are a frequently encountered medical problem. The effect...

    Authors: Mukunthan Murthi, Hafeez Shaka, Zain El-amir, Sujitha Velagapudi, Abdul Jamil, Farah Wani, Ramtej Atluri, Akshay Kumar and Asim Kichloo
    Citation: BMC Pulmonary Medicine 2021 21:410
  30. The nutritional status can potentially affect the efficacy of cancer therapy. The Geriatric Nutritional Risk Index (GNRI), a simple index for evaluating nutritional status calculated from body weight and serum...

    Authors: Masato Karayama, Yusuke Inoue, Hideki Yasui, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui and Takafumi Suda
    Citation: BMC Pulmonary Medicine 2021 21:409
  31. Hospital-acquired pneumonia (HAP) is the second most common nosocomial infection in intensive care units (ICUs). The present study aims to determine the prevalence of pathogenic bacteria, their biofilm formati...

    Authors: Farzad Mazloomirad, Sajad Hasanzadeh, Asghar Sharifi, Gordafarin Nikbakht, Narges Roustaei and Seyed Sajjad Khoramrooz
    Citation: BMC Pulmonary Medicine 2021 21:408
  32. Chronic thromboembolic pulmonary hypertension (CTEPH) is a type of pulmonary hypertension caused by persistent thromboembolism of the pulmonary arteries. In clinical practice, CTEPH patients often show obstruc...

    Authors: Asako Yanagisawa, Akira Naito, Takayuki Jujo-Sanada, Nobuhiro Tanabe, Keiichi Ishida, Goro Matsumiya, Rika Suda, Hajime Kasai, Ayumi Sekine, Toshihiko Sugiura, Ayako Shigeta, Seiichiro Sakao, Koichiro Tatsumi and Takuji Suzuki
    Citation: BMC Pulmonary Medicine 2021 21:407
  33. Diagnosis of pneumonia is critical in managing patients with febrile neutropenia (FN), however, chest X-ray (CXR) has limited performance in the detection of pneumonia. We aimed to evaluate the performance of ...

    Authors: Eui Jin Hwang, Jong Hyuk Lee, Jae Hyun Kim, Woo Hyeon Lim, Jin Mo Goo and Chang Min Park
    Citation: BMC Pulmonary Medicine 2021 21:406
  34. Patients with influenza pneumonia are at high risk of rapid progression to acute respiratory distress syndrome (ARDS). Mean platelet volume (MPV), which reflects platelet size, is considered to be a crucial in...

    Authors: Teeraphat Reangvilaikul, Piyaphat Udompongpaiboon and Veerapong Vattanavanit
    Citation: BMC Pulmonary Medicine 2021 21:405
  35. Idiopathic pulmonary fibrosis (IPF) is a devastating disease with a high clinical burden. The molecular signatures of IPF were analyzed to distinguish molecular subgroups and identify key driver genes and ther...

    Authors: Sung Kyoung Kim, Seung Min Jung, Kyung-Su Park and Ki-Jo Kim
    Citation: BMC Pulmonary Medicine 2021 21:404
  36. To meet the surging demands for intubation and invasive ventilation as more COVID-19 patients begin their recovery, clinicians are challenged to find an ultra-brief and minimally invasive screen for postextuba...

    Authors: Shu-Fen Siao, Wen-Hsuan Tseng, Tyng-Guey Wang, Yu-Chung Wei, Tzu-Yu Hsiao, Shih-Chi Ku and Cheryl Chia-Hui Chen
    Citation: BMC Pulmonary Medicine 2021 21:403
  37. Eosinophilic pleural effusion (EPE) is a distinct entity among pleural effusions, but its diagnostic and prognostic significance is still controversial. This study aimed to evaluate the incidence and aetiologi...

    Authors: Minfang Li, Yunxiang Zeng, Yaqing Li, Dan Jia, Sheng Chen and Jinlin Wang
    Citation: BMC Pulmonary Medicine 2021 21:402
  38. Association between sleep nocturnal breathing disorders and acute aortic syndrome (AAS) has been described but mid-term data are scarce.

    Authors: Pascal Delsart, Jerome Soquet, Adeline Pierache, Maxime Dedeken, Stephanie Fry, Anne Mallart, François Pontana, Richard Azzaoui, Francis Juthier, Jonathan Sobocinski and Claire Mounier-Vehier
    Citation: BMC Pulmonary Medicine 2021 21:401
  39. Lung adenocarcinoma (LUAD) is the leading cause of cancer deaths worldwide due to the lack of early diagnostic markers and specific drugs. Previous studies have shown the association of LUAD growth with aberra...

    Authors: Gongjun Wang, Weiwei Qi, Liwei Shen, Shasha Wang, Ruoxi Xiao, Wenqian Li, Yuqi Zhang, Xiaoqian Bian, Libin Sun and Wensheng Qiu
    Citation: BMC Pulmonary Medicine 2021 21:400
  40. Drug-resistant tuberculosis (DR-TB), obesity, and malnutrition are growing public health problems in the world. However, little has discussed the impact of different BMI status on the emergence of TB drug resi...

    Authors: Wan-mei Song, Jing Guo, Ting-ting Xu, Shi-jin Li, Jin-yue Liu, Ning-ning Tao, Yao Liu, Qian-yun Zhang, Si-qi Liu, Qi-qi An, Yi-fan Li, Chun-bao Yu, Ji-hua Dong and Huai-chen Li
    Citation: BMC Pulmonary Medicine 2021 21:399
  41. Recent asthma guidelines, such as the Global Initiative for Asthma (GINA), recommend in adult patients as-needed inhaled corticosteroids (ICS)-formoterol as an alternative to maintenance ICS in mild to moderat...

    Authors: Jefferson Antonio Buendía and Diana Guerrero Patiño
    Citation: BMC Pulmonary Medicine 2021 21:397
  42. Idiopathic pulmonary fibrosis (IPF) is characterized by a poor prognosis, with a progressive decline in lung function and considerable variability in the disease’s natural history. Besides lung transplantatio...

    Authors: Gian Marco Manzetti, Karishma Hosein, Matthew J. Cecchini, Keith Kwan, Mohamed Abdelrazek, Maurizio Zompatori, Paola Rogliani and Marco Mura
    Citation: BMC Pulmonary Medicine 2021 21:396
  43. Sarcoidosis is granulomatous disease of unknown origin affecting organ function and quality of life. The King’s Sarcoidosis Questionnaire (KSQ) serves as a tool to assess quality of life in sarcoidosis patient...

    Authors: Björn Christian Frye, Laura Potasso, Erik Farin-Glattacker, Surrinder Birring, Joachim Müller-Quernheim and Jonas Christian Schupp
    Citation: BMC Pulmonary Medicine 2021 21:395
  44. Home mechanical ventilation (HMV) is a viable and effective strategy for patients with chronic respiratory failure (CRF). The Chilean Ministry of Health started a program for adults in 2008.

    Authors: César Maquilón, Mónica Antolini, Nicolás Valdés, Marianela Andrade, Krishnna Canales, Claudio Rabec, Cristian Olave, Miguel Aguayo, Patricia Rivas, Carmen Andrade, Ángela Venegas, Sandra Zapata, María Elena Torres, Osvaldo Cabrera and Jorge Villalobos
    Citation: BMC Pulmonary Medicine 2021 21:394
  45. Some studies previously demonstrated that interleukin-17 (IL-17) involves in pulmonary diseases progression. Nevertheless, the role of IL-17 in community-acquired pneumonia (CAP) remains unknown. This study ai...

    Authors: Chun-Mei Feng, Xin-Ming Wang, Meng-Die Li, Zheng Xu, Dong-Xu Hua, Jia-Yi Cheng, Ling Zheng, Hui Zhao and Lin Fu
    Citation: BMC Pulmonary Medicine 2021 21:393

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