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  1. The echinoderm microtubule-associated protein-like-4 anaplastic lymphoma kinase (EML4-ALK) fusion gene was identified in a subset of non-small cell lung cancer (NSCLC) patients. They responded positively to AL...

    Authors: Ying Li, Yongwen Li, Hongbing Zhang, Ruifeng Shi, Zihe Zhang, Hongyu Liu and Jun Chen
    Citation: BMC Pulmonary Medicine 2021 21:190
  2. Different from current cognition, our study demonstrated that adrenergic receptors agonist phenylephrine significantly relaxed isolated pulmonary artery but constricted pulmonary veins. Through comparing diffe...

    Authors: Li-mei Liao, Li Zhou, Chen-ran Wang, Jian-ying Hu, Yao-jun Lu and Shaoqiang Huang
    Citation: BMC Pulmonary Medicine 2021 21:189
  3. Idiopathic Pulmonary Fibrosis (IPF) is a degenerative interstitial lung disease with both a poor prognosis and quality of life once the diagnosis is made. In the last decade many features of the disease have b...

    Authors: Donato Lacedonia, Giulia Scioscia, Piera Soccio, Massimo Conese, Lucia Catucci, Grazia P. Palladino, Filomena Simone, Carla M. I. Quarato, Sante Di Gioia, Roberto Rana, Francesco Sollitto and Maria P. Foschino-Barbaro
    Citation: BMC Pulmonary Medicine 2021 21:188
  4. Previous studies suggest that transient receptor potential (TRP) channels and neurogenic inflammation may be involved in idiopathic pulmonary fibrosis (IPF)-related high cough sensitivity, although the details...

    Authors: Mengyue Guan, Sun Ying and Yuguang Wang
    Citation: BMC Pulmonary Medicine 2021 21:187
  5. Acute exacerbation (AE) of interstitial pneumonia (IP) is the most fatal complication after lung resection for lung cancer. To improve the prognosis of lung cancer with IP, the risk factors of AE of IP after l...

    Authors: Atsushi Kagimoto, Yasuhiro Tsutani, Kei Kushitani, Takahiro Kambara, Takahiro Mimae, Yoshihiro Miyata, Yukio Takeshima and Morihito Okada
    Citation: BMC Pulmonary Medicine 2021 21:186
  6. It is not well-known if diagnosing and treating sleep breathing disorders among individuals with idiopathic pulmonary fibrosis (IPF) improves health outcomes. We evaluated the association between receipt of la...

    Authors: Nicholas T. Vozoris, Andrew S. Wilton, Peter C. Austin, Tetyana Kendzerska, Clodagh M. Ryan and Andrea S. Gershon
    Citation: BMC Pulmonary Medicine 2021 21:185
  7. Current interstitial lung disease (ILD) diagnostic guidelines assess criteria across clinical, radiologic and pathologic domains. Significant interobserver variation in histopathologic evaluation has previousl...

    Authors: Robert Camp, Maxwell L. Smith, Brandon T. Larsen, Anja C. Roden, Carol Farver, Andre L. Moreira, Richard Attanoos, Raghavendra Pillappa, Irene Sansano, Alexandre Todorovic Fabro and Robert J. Homer
    Citation: BMC Pulmonary Medicine 2021 21:184
  8. Heterogeneity in acute respiratory distress syndrome (ARDS) has led to many statistically negative clinical trials. Etiology is considered an important source of pathogenesis heterogeneity in ARDS but previous...

    Authors: Sheng-Yuan Ruan, Chun-Ta Huang, Ying-Chun Chien, Chun-Kai Huang, Jung-Yien Chien, Lu-Cheng Kuo, Ping-Hung Kuo, Shih-Chi Ku and Huey-Dong Wu
    Citation: BMC Pulmonary Medicine 2021 21:183
  9. Pneumothorax is one complication of transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS-TBB). We sought to clarify the risk factors for pneumothorax after EBUS-GS-TBB u...

    Authors: Yusuke Gotoh, Teppei Yamaguchi, Hiroshi Yatsuya, Aki Ikeda, Takuya Okamura, Yosuke Sakakibara, Takuma Ina, Yuri Maeda, Mariko Hirochi, Hisashi Kako, Yasuhiro Goto, Sumito Isogai, Naoki Yamamoto, Masashi Kondo and Kazuyoshi Imaizumi
    Citation: BMC Pulmonary Medicine 2021 21:181
  10. Although depression is a common comorbidity of chronic obstructive pulmonary disease (COPD), the role of sex remains unexplored. We evaluated sex differences of risk factors of depressive symptoms in adults wi...

    Authors: Ji Soo Choi, Se Hyun Kwak, Nak-Hoon Son, Jae Won Oh, San Lee and Eun Hye Lee
    Citation: BMC Pulmonary Medicine 2021 21:180
  11. Worldwide, pneumonia is the third leading cause of death in under 5 years children. Ethiopia is ranked 4th out of 15 countries having the highest burdens of the death rate among under-five children due to pneu...

    Authors: Muluken Genetu Chanie, Mequannent Sharew Melaku, Melaku Yalew, Mastewal Arefaynie, Gedamnesh Bitew, Erkihun Tadesse Amsalu, Bereket Kefale, Amare Muche, Zinabu Fentaw, Reta Dewau, Bezawit Adane, Yitayish Damtie, Wolde Melese Ayele, Gojjam Eshetie Ewunetie and Metadel Adane
    Citation: BMC Pulmonary Medicine 2021 21:179
  12. The excess adiposity, even in the absence of diseases, is responsible for a decline in pulmonary function, which is considered a predictor of mortality and a risk factor for diseases in several epidemiological...

    Authors: Caren Ishikawa, Marco Antonio Barbieri, Heloisa Bettiol, Gabriel Bazo, Alexandre A. Ferraro and Elcio Oliveira Vianna
    Citation: BMC Pulmonary Medicine 2021 21:178
  13. Tuberculous pleural effusion (TPE) patients usually have elevated D-dimer levels. The diagnostic performance of D-dimer in predicting pulmonary embolism (PE) in the TPE population is unclear. This study aimed ...

    Authors: Xiaoming Li, Yajing Qin, Wenjing Ye, Xi Chen, Dezhi Sun, Xuejun Guo and Wen Gu
    Citation: BMC Pulmonary Medicine 2021 21:177
  14. Acute respiratory distress syndrome (ARDS) often requires controlled ventilation, yielding high mechanical power and possibly further injury. Veno-venous extracorporeal membrane oxygenation (VV-ECMO) can be us...

    Authors: Malou Janssen, J. Han. J. Meeder, Leonard Seghers and Corstiaan A. den Uil
    Citation: BMC Pulmonary Medicine 2021 21:176
  15. Chronic obstructive pulmonary disease (COPD) is an important risk factor for postoperative complications and mortality. To determine the effects of perioperative combination therapy, using a long-acting muscar...

    Authors: Yoko Azuma, Atsushi Sano, Takashi Sakai, Satoshi Koezuka, Hajime Otsuka, Naobumi Tochigi, Kazutoshi Isobe, Susumu Sakamoto, Yujiro Takai and Akira Iyoda
    Citation: BMC Pulmonary Medicine 2021 21:174
  16. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the development of life-threatening COVID-19 are believed to disproportionately affect certain at-risk populations. However, it is not...

    Authors: Hannah R. Mathew, May Y. Choi, Michael D. Parkins and Marvin J. Fritzler
    Citation: BMC Pulmonary Medicine 2021 21:173
  17. The purpose of this study was to compare the efficacy of osimertinib (OSI) versus afatinib (AFA) in patients with T790M-positive, non-small-cell lung cancer (NSCLC) and multiple central nervous system (CNS) me...

    Authors: Yang Yang, Qilong Liu, Lei Cao, Wei Sun, Xiaowei Gu, Bin Liu, Na Xiao, Fei Teng, Xiaoli Li, Meiji Chen, Weiguang Yu, Huanyi Lin and Guixing Xu
    Citation: BMC Pulmonary Medicine 2021 21:172
  18. Life-threatening hemoptysis presents an immediate diagnostic and therapeutic challenge, especially during the perinatal period.

    Authors: Yujun Li, Yuyao Wang, Zhike Liang, Chuzhi Pan, Xiaomei Huang, Zexun Mo, Guodong Chen, Dongliang Zhu, Ziwen Zhao and Shuquan Wei
    Citation: BMC Pulmonary Medicine 2021 21:171
  19. Despite the severe symptoms experienced by dying COPD patients, specialized palliative care (SPC) services focus mainly on cancer patients. We aimed to study the access to SPC that COPD and lung cancer (LC) pa...

    Authors: Peter Strang, Per Fürst, Christel Hedman, Jenny Bergqvist, Helena Adlitzer and Torbjörn Schultz
    Citation: BMC Pulmonary Medicine 2021 21:170
  20. Oroscomucoid 3 (ORMDL3) has been linked to susceptibility of childhood asthma and respiratory viral infection. Polyinosinic-polycytidylic acid (poly I:C) is a synthetic analog of viral double-stranded RNA, a t...

    Authors: Gemma Laura, Yi Liu, Kieran Fernandes, Saffron A. G. Willis-Owen, Kazuhiro Ito, William O. Cookson, Miriam F. Moffatt and Youming Zhang
    Citation: BMC Pulmonary Medicine 2021 21:167
  21. Lung adenocarcinoma (LUAD) is known to be one of the leading causes of cancer-related deaths globally. In recent decades, long non-coding RNAs (lncRNAs) have been indicated to exert pivotal regulating function...

    Authors: Honggang Kang, Dan Ma, Jing Zhang, Jun Zhao and Mengxiang Yang
    Citation: BMC Pulmonary Medicine 2021 21:166
  22. Nintedanib is effective for treating idiopathic pulmonary fibrosis (IPF), but some patients may exhibit a suboptimal response and develop on-treatment acute exacerbation (AE-IPF), hepatic injury, or mortality....

    Authors: Tang-Hsiu Huang, Chin-Wei Kuo, Chian-Wei Chen, Yau-Lin Tseng, Chao-Liang Wu and Sheng-Hsiang Lin
    Citation: BMC Pulmonary Medicine 2021 21:165

    The Correction to this article has been published in BMC Pulmonary Medicine 2021 21:193

  23. In this retrospective observational study, we analyzed all patients with pulmonary arterial hypertension undergoing LenusPro® pump implantation between November 2013 and October 2019 at our center. Periprocedu...

    Authors: Jan C. Kamp, Jan Fuge, Jan F. Karsten, Stefan Rümke, Marius M. Hoeper, Da-Hee Park, Christian Kühn and Karen M. Olsson
    Citation: BMC Pulmonary Medicine 2021 21:164
  24. ID1 is associated with resistance to the first generation of EGFR tyrosine kinase inhibitors (EGFR-TKIs) in non-small cell lung cancer (NSCLC). However, the effect of ID1 expression on osimertinib resistance i...

    Authors: Kejun Liu, Xianwen Chen, Ligang Wu, Shiyuan Chen, Nianxin Fang, Limin Cai and Jun Jia
    Citation: BMC Pulmonary Medicine 2021 21:163
  25. No national research has yet explored the prevalence of asthma among adults in Lebanon. This study aims to evaluate the prevalence of physician-diagnosed asthma and current asthma, and their determinants among...

    Authors: Zeina Akiki, Danielle Saadeh, Rita Farah, Souheil Hallit, Hala Sacre, Hassan Hosseini and Pascale Salameh
    Citation: BMC Pulmonary Medicine 2021 21:162
  26. Suspicion and clinical criteria continue to serve as the foundation for ventilator-associated pneumonia (VAP) diagnosis, however the criteria used to diagnose VAP vary widely. Data from head-to-head comparison...

    Authors: Farshid Rahimibashar, Andrew C. Miller, Mojtaba H. Yaghoobi and Amir Vahedian-Azimi
    Citation: BMC Pulmonary Medicine 2021 21:161
  27. To investigate the indications for high-flow nasal cannula oxygen (HFNC) therapy in patients with hypoxemia during ventilator weaning and to explore the predictors of reintubation when treatment fails.

    Authors: Taotao Liu, Qinyu Zhao and Bin Du
    Citation: BMC Pulmonary Medicine 2021 21:160

    The Correction to this article has been published in BMC Pulmonary Medicine 2021 21:194

  28. Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with a complex progression of many clinical presentations, and clinically important deterioration (CID) has been proposed in the Western ...

    Authors: Yuki Abe, Masaru Suzuki, Hironi Makita, Hirokazu Kimura, Kaoruko Shimizu, Satoshi Konno and Masaharu Nishimura
    Citation: BMC Pulmonary Medicine 2021 21:159
  29. Oscillating Positive Expiratory Pressure (OPEP) devices are important adjuncts to airway clearance therapy in patients with cystic fibrosis (CF). Current devices are typically reusable and require daily, or of...

    Authors: Kevin J. O’Sullivan, Valerie Power, Barry Linnane, Deirdre McGrath, Magdalena Mulligan, Rebecca White, Leonard W. O’Sullivan and Colum P. Dunne
    Citation: BMC Pulmonary Medicine 2021 21:158
  30. Factors that may increase the risk for delirium and the firm knowledge around mechanism for delirium in noninvasive ventilation (NIV) patients is lacking. We investigated the incidence, characteristics, and ou...

    Authors: Rui Zhang, Linfu Bai, Xiaoli Han, Shicong Huang, Lintong Zhou and Jun Duan
    Citation: BMC Pulmonary Medicine 2021 21:157
  31. The utility of bronchoscopy for patients with suspected immune checkpoint inhibitor (ICI)-related pneumonitis is currently debatable. The purpose of this study was to examine the findings of bronchoalveolar la...

    Authors: Osamu Nishiyama, Shigeki Shimizu, Koji Haratani, Kosuke Isomoto, Junko Tanizaki, Hidetoshi Hayashi, Ryo Yamazaki, Takashi Oomori, Yusaku Nishikawa, Akiko Sano, Kazuhiko Nakagawa and Yuji Tohda
    Citation: BMC Pulmonary Medicine 2021 21:155
  32. Lefamulin, a first-in-class pleuromutilin antibiotic approved for intravenous and oral use in adults with community-acquired bacterial pneumonia (CABP), was noninferior to moxifloxacin in the Lefamulin Evaluat...

    Authors: Thomas M. File Jr., Elizabeth Alexander, Lisa Goldberg, Anita F. Das, Christian Sandrock, Susanne Paukner and Gregory J. Moran
    Citation: BMC Pulmonary Medicine 2021 21:154
  33. Methacholine challenge tests (MCTs) are used to diagnose airway hyperresponsiveness (AHR) in patients with suspected asthma where previous diagnostic testing has been inconclusive. The test is time consuming a...

    Authors: Michael Peled, David Ovadya, Jennifer Cohn, Lior Seluk, Teet Pullerits, Michael J. Segel and Amir Onn
    Citation: BMC Pulmonary Medicine 2021 21:153
  34. It is important to assess the prognosis of patients with chronic obstructive pulmonary disease (COPD) and acute exacerbation of COPD (AECOPD). Recently, it was suggested that diffusing capacity of the lung for...

    Authors: Juwhan Choi, Jae Kyeom Sim, Jee Youn Oh, Young Seok Lee, Gyu Young Hur, Sung Yong Lee, Jae Jeong Shim, Chin Kook Rhee and Kyung Hoon Min
    Citation: BMC Pulmonary Medicine 2021 21:152
  35. It is difficult to assess the impact of multiple comorbidities on clinical outcomes in chronic obstructive pulmonary disease (COPD). In this study, we aimed to investigate exacerbation-associated comorbidities...

    Authors: Youngmee Kim, Ye-Jee Kim, Yu Mi Kang and Won-Kyung Cho
    Citation: BMC Pulmonary Medicine 2021 21:151
  36. Acute exacerbation (AE) is a devastating phenomenon and reported to be complicated with systemic autoimmune disease-associated interstitial lung disease (ILD). The aim of this study was to investigate the inci...

    Authors: Hiroyuki Kamiya and Ogee Mer Panlaqui
    Citation: BMC Pulmonary Medicine 2021 21:150
  37. Several studies demonstrate that endoplasmic reticulum (ER) stress-mediated epithelial-mesenchymal transition (EMT) is involved in the process of bleomycin (BLM)-induced pulmonary fibrosis. Tauroursodeoxycholi...

    Authors: Bin Tong, Lin Fu, Biao Hu, Zhi-Cheng Zhang, Zhu-Xia Tan, Se-Ruo Li, Yuan-Hua Chen, Cheng Zhang, Hua Wang, De-Xiang Xu and Hui Zhao
    Citation: BMC Pulmonary Medicine 2021 21:149
  38. There is limited data available on the use of CPET as a predictive tool for disease outcomes in the setting of IPF. We investigated the feasibility of undertaking CPET and the relationship between CPET and qua...

    Authors: R. Davis, C. Dixon, A. B. Millar, N. A. Maskell and S. L. Barratt
    Citation: BMC Pulmonary Medicine 2021 21:147
  39. Transbronchial lung biopsy (TBLB) in the diagnosis of lymphangioleiomyomatosis (LAM) is not a common approach, although TBLB is often performed in diffuse lung diseases. We aimed to examine the diagnostic valu...

    Authors: Wenshuai Xu, Han Cui, Hongrui Liu, Ruie Feng, Xinlun Tian, Yanli Yang and Kai-Feng Xu
    Citation: BMC Pulmonary Medicine 2021 21:146
  40. Pirfenidone is an anti-fibrotic agent shown to slow the progression of idiopathic pulmonary fibrosis (IPF). However, its effectiveness in association with serological autoimmune features in IPF remains unclear.

    Authors: Myung Jin Song, Sang Hoon Lee, Ji Ye Jung, Young Ae Kang, Moo Suk Park, Young Sam Kim, Joon Chang and Song Yee Kim
    Citation: BMC Pulmonary Medicine 2021 21:145
  41. Pulmonary diseases affect health-related quality of life (HRQoL), but there are few data on patients’ adaptation to a serious illness. This study assessed resilience and its associations with HRQoL, life satis...

    Authors: Siiri Isokääntä, Kirsi Honkalampi, Hannu Kokki, Harri Sintonen and Merja Kokki
    Citation: BMC Pulmonary Medicine 2021 21:144
  42. Acute kidney injury (AKI) is a frequent complication of community acquired pneumonia (CAP). However, the impact of AKI on in-hospital outcomes of patients with CAP in the Chinese population remains unclear.

    Authors: Dawei Chen, Hongbo Yuan, Changchun Cao, Zhihe Liu, Linglin Jiang, Yan Tan, Ji Ding, Mengqing Ma, Wenjuan Huang and Xin Wan
    Citation: BMC Pulmonary Medicine 2021 21:143
  43. In nonneutropenic patients with underlying respiratory diseases (URD), invasive pulmonary aspergillosis (IPA) is a life-threatening disease. Yet establishing early diagnosis in those patients remains quite a c...

    Authors: Fei Chen, Yonghong Zhong, Na Li, Huijie Wang, Yanbin Tan, Hao Zhang, Wen Hua, Yanxiong Mao and Huaqiong Huang
    Citation: BMC Pulmonary Medicine 2021 21:142

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