Articles

Influence of the timing of bronchoscopic alveolar lavage on children with adenovirus pneumonia: a comparative study

Adenovirus pneumonia is prone to severe clinical and imaging manifestations in children. Bronchoscopic alveolar lavage (BAL) is an important adjunctive therapy for patients with severe imaging findings. The st...

Authors: Xue-hua Xu, Hui-feng Fan, Ting-Ting Shi, Di-Yuan Yang, Li Huang, Wen-hui Jiang and Gen Lu

LncRNA GAS5 participates in childhood pneumonia by inhibiting cell apoptosis and promoting SHIP-1 expression via downregulating miR-155

LncRNA GAS5 and miR-155 are reported to play opposite roles in lung inflammatory responses. Lung inflammation participates in childhood pneumonia, indicating the involvement of GAS5 and miR-155 in pneumonia. T...

Authors: Xiaoping Wang, Ping Guo, Jiahui Tian, Jie Li, Na Yan, Xin Zhao and Yue Ma

High intensity interval training versus moderate intensity continuous training for people with interstitial lung disease: protocol for a randomised controlled trial

Interstitial lung disease is a debilitating condition associated with significant dyspnoea, fatigue, and poor exercise tolerance. Pulmonary rehabilitation is an effective and key intervention in people with in...

Authors: Leona M. Dowman, Anthony K. May, Catherine J. Hill, Janet Bondarenko, Lissa Spencer, Norman R. Morris, Jennifer A. Alison, James Walsh, Nicole S. L. Goh, Tamera Corte, Ian Glaspole, Daniel C. Chambers, Christine F. McDonald and Anne E. Holland

Determinant factors for loss to follow-up in drug-resistant tuberculosis patients: the importance of psycho-social and economic aspects

Drug-resistant tuberculosis (DR-TB) is the barrier for global TB elimination efforts with a lower treatment success rate. Loss to follow-up (LTFU) in DR-TB is a serious problem, causes mortality and morbidity ...

Authors: Soedarsono Soedarsono, Ni Made Mertaniasih, Tutik Kusmiati, Ariani Permatasari, Ni Njoman Juliasih, Cholichul Hadi and Ilham Nur Alfian

Clinical analysis of the “small plateau” sign on the flow-volume curve followed by deep learning automated recognition

Small plateau (SP) on the flow-volume curve was found in parts of patients with suspected asthma or upper airway abnormalities, but it lacks clear scientific proof. Therefore, we aimed to characterize its clin...

Authors: Yimin Wang, Wenya Chen, Yicong Li, Changzheng Zhang, Lijuan Liang, Ruibo Huang, Jianling Liang, Yi Gao and Jinping Zheng

One-session bilateral sequential whole lung lavage (OSBSWLL) for the management of pulmonary alveolar proteinosis

Whole Lung Lavage (WLL) has been an important part in the management of Pulmonary Alveolar Proteinosis (PAP) since it improves radiologic and clinical parameters. Bilateral WLL is usually performed in two sess...

Authors: Javier Diaz-Mendoza, Eduardo Celis Valdiviezo, Niral M. Patel and Michael J. Simoff

Electrical impedance tomography in pediatric patients with COVID-19, the first reports

Electrical impedance tomography (EIT) is a noninvasive, radiation-free, bedside tool to monitor ventilation distribution in real time.

Authors: Milena S. Nascimento, Glasiele C. Alcala, Ana I. A. Guzman, Leticia C. Corrêa, Diana M. Baggio, Felipe S. Rossi, Linus P. Fascina, Marcelo B. P. Amato and Cristiane do Prado

Hospital admission trends due to respiratory diseases in England and Wales between 1999 and 2019: an ecologic study

Identifying trends of hospital admissions for respiratory diseases is crucial for public health and research to guide future clinical improvements for better outcomes. This study aims to define the trends of r...

Authors: Abdallah Y. Naser, Munthir M. Mansour, Abeer F. R. Alanazi, Omar Sabha, Hassan Alwafi, Zahraa Jalal, Vibhu Paudyal, Mohammad S. Dairi, Emad M. Salawati, Jaber S. Alqahtan, Shalan Alaamri and Moaath K. Mustafa Ali

Impact of high-flow oxygen therapy during exercise in idiopathic pulmonary fibrosis: a pilot crossover clinical trial

Supplemental oxygen delivered with standard oxygen therapy (SOT) improves exercise capacity in patients with idiopathic pulmonary fibrosis (IPF). Although high-flow nasal cannula oxygen therapy (HFNC) improves...

Authors: Diana Badenes-Bonet, Pilar Cejudo, Anna Rodó-Pin, Clara Martín-Ontiyuelo, Roberto Chalela, Jose Antonio Rodríguez-Portal, Rosa Vázquez-Sánchez, Joaquim Gea, Xavier Duran, Oswaldo Antonio Caguana, Diego Agustín Rodriguez-Chiaradia and Eva Balcells

Clinical outcomes of intravenous immunoglobulin therapy in COVID-19 related acute respiratory distress syndrome: a retrospective cohort study

Intravenous immunoglobulin (IVIG) has been used as an immunomodulatory therapy to counteract severe systemic inflammation in coronavirus disease 2019 (COVID-19). But its use in COVID-19 related acute respirato...

Authors: Husain S. Ali, Moustafa S. Elshafei, Mohamed O. Saad, Hassan A. Mitwally, Mohammad Al Wraidat, Asra Aroos, Nissar Shaikh, Dore C. Ananthegowda, Mohamed A. Abdelaty, Saibu George, Abdulqadir J. Nashwan, Ahmed S. Mohamed and Mohamad Y. Khatib

Lung ultrasound for the diagnosis of cystic fibrosis pulmonary exacerbation

High-resolution computed tomography (HRCT) is the gold standard for the evaluation of cystic fibrosis (CF) lung disease; however, lung ultrasound (LUS) is being increasingly used for the assessment of lung in ...

Authors: Maryam Hassanzad, Arda Kiani, Atefeh Abedini, Hoseinali Ghaffaripour, Habib Emami, Niloufar Alizadeh, Ghazal Zoghi, Saeed Hashemi and Ali Akbar Velayati

Early signs of pneumoconiosis in a dental technician in Italy: a case report

Dental technicians are at high risk of pneumoconiosis, usually driven by inhalation of mixed dusts, including metals. An etiological diagnosis is not easy to be performed, particularly in advanced stages.

Authors: Mara Maria Tiraboschi, Emma Sala, Matteo Ferroni, Andrea Tironi, Andrea Borghesi, Maria Enrica Gilberti, Paolo Ceruti, Emanuele Sansone and Giuseppe De Palma

Disturbances in branched-chain amino acid profile and poor daily functioning in mildly depressed chronic obstructive pulmonary disease patients

Depression is one of the most common and untreated comorbidities in chronic obstructive pulmonary disease (COPD), and is associated with poor health outcomes (e.g. increased hospitalization/exacerbation rates)...

Authors: Marisa R. Pinson, Nicolaas E. P. Deutz, Rajesh Harrykissoon, Anthony J. Zachria and Mariëlle P. K. J. Engelen

Drug-induced hypersensitivity syndrome caused by minodronic acid hydrate

Drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is an important adverse reaction caused by a few drugs. Reactivation of human herpesvirus 6 ...

Authors: Yutaka Muto, Naoyuki Kuse, Minoru Inomata, Nobuyasu Awano, Mari Tone, Kohei Takada, Kazushi Fujimoto, Yuan Bae, Toshio Kumasaka and Takehiro Izumo

Development of a nomogram for predicting the presence of combined pulmonary fibrosis and emphysema

In the clinical management of patients with combined pulmonary fibrosis and emphysema (CPFE), early recognition and appropriate treatment is essential. This study was designed to develop an accurate prognostic...

Authors: Xueting Yuan, Jin Jin and Xiaomao Xu

High-throughput next-generation sequencing for identifying pathogens during early-stage post-lung transplantation

High-throughput next-generation sequencing (HT-NGS) has the potential to detect a large variety of pathogens; however, the application of HT-NGS in lung transplant (LTx) recipients remains limited. We aimed to...

Authors: Qiao-yan Lian, Ao Chen, Jian-heng Zhang, Wei-jie Guan, Xin Xu, Bing Wei, Dan-xia Huang, Jian-xing He and Chun-rong Ju

HB-EGF-induced IL-8 secretion from airway epithelium leads to lung fibroblast proliferation and migration

We have reported that heparin-binding epidermal growth factor (HB-EGF) is increased in patients with chronic obstructive pulmonary disease (COPD) and associated with collagen deposition, but the mechanisms rem...

Authors: Yanyu Li, Guomei Su, Yu Zhong, Zhilin Xiong, Tong Huang, Jingyun Quan, Jiewen Huang, Xiaoxia Wen, Chaole Luo, Weilin Zheng, Jinfeng Chen, Junfen Cheng, Weimin Yao and Tianwen Lai

Prognostic value of radiological findings indeterminate for UIP pattern and anterior upper lobe honeycomb-like lesion in chronic fibrosing interstitial lung disease associated with MPO-ANCA

Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) is often positive in patients with interstitial lung disease (ILD), which is also often present in patients with microscopic polyangiitis (MPA). A...

Authors: Hideaki Yamakawa, Shintaro Sato, Tomohiko Nakamura, Tomotaka Nishizawa, Rie Kawabe, Tomohiro Oba, Masanobu Horikoshi, Keiichi Akasaka, Masako Amano, Kazuyoshi Kuwano, Hiroki Sasaki and Hidekazu Matsushima

In-hospital mortality associated with community-acquired pneumonia due to methicillin-resistant Staphylococcus aureus: a matched-pair cohort study

It remains unclear whether methicillin-resistant Staphylococcus aureus (MRSA) pneumonia is associated with higher mortality compared with non-MRSA pneumonia. This study’s objective was to compare outcomes includi...

Authors: Yukiyo Sakamoto, Yasuhiro Yamauchi, Taisuke Jo, Nobuaki Michihata, Wakae Hasegawa, Hideyuki Takeshima, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga and Takahide Nagase

Spirometric reference equations for Cameroonians aged 4 to 89 years derived using lambda, mu, sigma (LMS) method

Spirometric reference values are well known in several ethnic groups but the normative spirometric values of blacks living in Africa have been less studied. The purpose of this study is to establish normative ...

Authors: Eric Walter Pefura-Yone, Adamou Dodo Balkissou, Virginie Poka-Mayap, Amadou Djenabou, Massongo Massongo, Nguetsa Arsene Ofimboudem, Catherine Fanny Mayoh-Nguemfo, Antoinette Ghislaine Tsala, Halidou Hadjara and Francine Amougou

Weighted gene co-expression network analysis to identify key modules and hub genes associated with paucigranulocytic asthma

Asthma is a heterogeneous disease that can be divided into four inflammatory phenotypes: eosinophilic asthma (EA), neutrophilic asthma (NA), mixed granulocytic asthma (MGA), and paucigranulocytic asthma (PGA)....

Authors: Min Li, Wenye Zhu, Chu Wang, Yuanyuan Zheng, Shibo Sun, Yan Fang and Zhuang Luo

Repeated bronchoscopy in health and obstructive lung disease: is the airway microbiome stable?

Little is known concerning the stability of the lower airway microbiome. We have compared the microbiota identified by repeated bronchoscopy in healthy subjects and patients with ostructive lung diseaseases (O...

Authors: Rune Nielsen, Yaxin Xue, Inge Jonassen, Ingvild Haaland, Øyvind Kommedal, Harald G. Wiker, Christine Drengenes, Per S. Bakke and Tomas M. L. Eagan

Factors associated with delirium among survivors of acute respiratory distress syndrome: a nationwide cohort study

The prevalence of delirium, its associated factors, and its impact on long-term mortality among survivors of acute respiratory distress syndrome (ARDS) is unclear.

Authors: Tak Kyu Oh, Hye Youn Park and In-Ae Song

Correction to: Clinical, radiological and functional outcomes in patients with SARS-CoV-2 pneumonia: a prospective observational study

Authors: Pietro Gianella, Elia Rigamonti, Marco Marando, Adriana Tamburello, Lorenzo Grazioli Gauthier, Gianluca Argentieri, Carla Puligheddu, Alberto Pagnamenta, Marco Pons and Tanja Fusi-Schmidhauser

The effects of inhaling hydrogen gas on macrophage polarization, fibrosis, and lung function in mice with bleomycin-induced lung injury

Acute respiratory distress syndrome, which is caused by acute lung injury, is a destructive respiratory disorder caused by a systemic inflammatory response. Persistent inflammation results in irreversible alve...

Authors: Toshiyuki Aokage, Mizuki Seya, Takahiro Hirayama, Tsuyoshi Nojima, Masumi Iketani, Michiko Ishikawa, Yasuhiro Terasaki, Akihiko Taniguchi, Nobuaki Miyahara, Atsunori Nakao, Ikuroh Ohsawa and Hiromichi Naito

Assessment of the HScore as a predictor of disease outcome in patients with COVID-19

Severe coronavirus disease 2019 (COVID-19) accompanies hypercytokinemia, similar to secondary hemophagocytic lymphohistiocytosis (sHLH). We aimed to find if HScore could predict disease severity in COVID-19. H...

Authors: Mohammadreza Bordbar, Anahita Sanaei Dashti, Ali Amanati, Eslam Shorafa, Yasaman Mansoori, Seyed Javad Dehghani and Hossein Molavi Vardanjani

Correction to: Association between plasma interleukin-33 level and acute exacerbation of chronic obstructive pulmonary disease

Authors: Hyonsoo Joo, Seoung Ju Park, Kyung Hoon Min and Chin Kook Rhee

Comparison of clinical features and prognosis in patients with cryptogenic and secondary organizing pneumonia

Organizing pneumonia (OP) can be diagnosed pathologically, and cryptogenic OP (COP) and secondary OP (SOP) have been classified by cause and particular underlying context. Because it is clinically difficult to...

Authors: Keum-Ju Choi, Eun-Hyung Yoo, Kyung Chan Kim and Eun Jin Kim

The effects of antifungal therapy on the recurrence of aspergillus infection after pulmonary aspergilloma resection: a study protocol for a single-center, prospective, non-blind, randomized, 24-month, parallel group study

In recent years, the incidence of pulmonary aspergilloma has increased. The harm of aspergilloma is life-threatening massive hemoptysis, and the conventional treatment is surgical treatment. However, whether t...

Authors: Xianqiu Chen, Yiming Zhou, Lijuan Zhang, Jinfu Xu and Shuo Liang

Patient characteristics associated with different types of prison TB: an epidemiological analysis of 921 TB cases diagnosed at an Ethiopian prison

Despite incarcerated population being at an increased risk of tuberculosis (TB) and serving as a potential source of TB transmission for the general population, prison TB remains understudied. Given its advers...

Authors: Asmah Amirkhani, Maheen Humayun, Wen Ye, Yoseph Worku and Zhenhua Yang

Management of patients with pulmonary mycobacteriosis in France: a multicenter retrospective cohort study

Recent studies report very low adherence of practitioners to ATS/IDSA recommendations for the treatment of nontuberculous mycobacteria pulmonary disease (NTM-PD), as well as a great variability of practices. T...

Authors: Pascale Bemer, Olivia Peuchant, Hélène Guet-Revillet, Julien Bador, Charlotte Balavoine, Damien Basille, Guillaume Beltramo, François-Xavier Blanc, Elodie Blanchard, Sarah Boulanger, Anne Bourgoin, David Boutoille, Emmanuelle Cambau, Frédérique Canis, Didier Caparros, Anne Carricajo…

Determination of oxygen saturation compared to a prescribed target range using continuous pulse oximetry in acutely unwell medical patients

Both inadequate and excessive administration of oxygen to acutely unwell patients results in risk of harm. Guidelines recommend titration of oxygen to achieve a target oxygen saturation (SpO₂) range. Information ...

Authors: James C. P. Harper, Ruth Semprini, Nethmi A. Kearns, Lee Hatter, Grace E. Bird, Irene Braithwaite, Allie Eathorne, Mark Weatherall and Richard Beasley

Twenty-four-hour mechanical power variation rate is associated with mortality among critically ill patients with acute respiratory failure: a retrospective cohort study

Defined as the energy applied to the respiratory system by ventilator, mechanical power (MP) of ventilation reflects the risk of ventilation-induced lung injury. This study aims to explore the relationship bet...

Authors: Yi Chi, Qing Zhang, Siyi Yuan, Zhanqi Zhao, Yun Long and Huaiwu He

Structural and functional stability of the sulfur-free surfactant protein B peptide mimic B-YL in synthetic surfactant lipids

Optimal functionality of synthetic lung surfactant for treatment of respiratory distress syndrome in preterm infants largely depends on the quality and quantity of the surfactant protein B (SP-B) peptide mimic...

Authors: Frans J. Walther, Shantanu Sharma, Larry M. Gordon and Alan J. Waring

Prediction of gold stage in patients hospitalized with COPD exacerbations using blood neutrophils and demographic parameters as risk factors

Patients hospitalized with chronic obstructive pulmonary disease (COPD) exacerbations are unable to complete the pulmonary function test reliably due to their poor health conditions. Creating an easy-to-use in...

Authors: Jing Chen, Zhao Yang, Qun Yuan, Li-quan Guo and Da-xi Xiong

Interventricular septal curvature as an additional echocardiographic parameter for evaluating chronic thromboembolic pulmonary hypertension: a single-center retrospective study

Noninvasive estimation of the actual systolic pulmonary artery pressure measured via right-sided heart catheterization (sPAP_RHC) is vital for the management of pulmonary hypertension, including chronic thromboemb...

Authors: Akane Matsumura, Ayako Shigeta, Hajime Kasai, Hajime Yokota, Jiro Terada, Keiko Yamamoto, Toshihiko Sugiura, Takuma Matsumura, Seiichiro Sakao, Nobuhiro Tanabe and Koichiro Tatsumi

Cone beam CT augmented fluoroscopy allows safe and efficient diagnosis of a difficult lung nodule

Detection of small peripheral lung nodules is constantly increasing with the development of low dose computed tomography lung cancer screening programs. A tissue diagnosis is often required to confirm malignit...

Authors: Roberto Piro, Matteo Fontana, Eleonora Casalini, Sofia Taddei, Marco Bertolini, Mauro Iori and Nicola Facciolongo

An initial evaluation of the safety of a disposable oscillating positive expiratory pressure device in patients with chronic obstructive pulmonary disease: a short-term pilot study

Handheld oscillating positive expiratory pressure (OPEP) devices have been a mainstay of treatment for patients with hypersecretory conditions such as cystic fibrosis (CF) and chronic obstructive pulmonary dis...

Authors: Kevin J. O’Sullivan, Valerie Power, Barry Linnane, Deirdre McGrath, Hilda Fogarty, Martina Ryan, Rebecca White, Conor Noonan, Eithne Mulloy, Leonard W. O’Sullivan and Colum P. Dunne

Circular RNA NEK6 contributes to the development of non-small-cell lung cancer by competitively binding with miR-382-5p to elevate BCAS2 expression at post-transcriptional level

Non-small-cell lung cancer (NSCLC) is the commonest type of lung cancer, which is one of most deadly cancers that possess high morbidity and mortality all over the world. The function of circular RNA NIMA rela...

Authors: Fei Cao, Xiaoxia Wu, Yongfeng Shan, Binbin Zhang, Haonan Wang, Hui Liu and Hao Yu

Cardiopulmonary exercise testing and pulmonary function testing for predicting the severity of CTEPH

Cardiopulmonary exercise testing (CPET) and pulmonary function testing (PFT) are noninvasive methods to evaluate the respiratory and circulatory systems. This research aims to evaluate and monitor chronic thro...

Authors: Hanqing Zhu, Xingxing Sun, Yuan Cao, Bigyan Pudasaini, Wenlan Yang, Jinming Liu and Jian Guo

Association of the location and initial degree of malignant central airway stenosis with the risk of severe restenosis after interventional bronchoscopy

Therapeutic bronchoscopy is one of the effective methods in the treatment and management of malignant central airway stenosis (MCAS). However, restenosis after therapeutic bronchoscopy frequently occurs and se...

Authors: Saibin Wang, Renzhi Zhou, Siyao Zhu and Dan Yan

Shape-sensing robotic-assisted bronchoscopy for pulmonary nodules: initial multicenter experience using the Ion™ Endoluminal System

Traditional bronchoscopy provides limited approach to peripheral nodules. Shape-sensing robotic-assisted bronchoscopy (SSRAB, Ion™ Endoluminal System) is a new tool for minimally invasive peripheral nodule bio...

Authors: Michael J. Simoff, Michael A. Pritchett, Janani S. Reisenauer, David E. Ost, Adnan Majid, Colleen Keyes, Roberto F. Casal, Mihir S. Parikh, Javier Diaz-Mendoza, Sebastian Fernandez-Bussy and Erik E. Folch

Multi-channel lung sounds intelligent diagnosis of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease that seriously threatens people’s health, with high morbidity and mortality worldwide. At present, the clinical diagnosis methods o...

Authors: Hui Yu, Jing Zhao, Dongyi Liu, Zhen Chen, Jinglai Sun and Xiaoyun Zhao

Prediction of readmission in patients with acute exacerbation of chronic obstructive pulmonary disease within one year after treatment and discharge

To investigate the risk factors and construct a logistic model and an extreme gradient boosting (XGBoost) model to compare the predictive performances for readmission in acute exacerbation of chronic obstructi...

Authors: Lili Chen and Shiping Chen

Underdiagnosis of obstructive lung disease: findings from the French CONSTANCES cohort

The burden of undiagnosed obstructive lung disease (OLD) (mainly asthma and chronic obstructive pulmonary disease) is not fully established, and targets for corrective action are yet to be identified. We asses...

Authors: Marie-Christine Delmas, Laetitia Bénézet, Céline Ribet, Yuriko Iwatsubo, Marie Zins, Rachel Nadif, Nicolas Roche and Bénédicte Leynaert

Innate lymphoid cells exhibited IL-17-expressing phenotype in active tuberculosis disease

Innate lymphoid cells (ILCs), as an important group of innate immunity, could respond rapidly to Mycobacterium tuberculosis (Mtb) infection. In this research, we studied the phenotypic changes of circulatory ILCs...

Authors: Linyue Pan, Xiaoli Chen, Xuanqi Liu, Wenjia Qiu, Yunhuan Liu, Weiping Jiang, Yang Zheng, Yan Mou, Wei Xu, Xiangyang Li, Haiyan Ge and Huili Zhu

Effect of counselling during pulmonary rehabilitation on self-determined motivation to be physically active for people with chronic obstructive pulmonary disease: a pragmatic RCT

Counselling is considered to be a promising approach to increasing physical activity (PA) in people with chronic obstructive pulmonary disease (COPD). The aim of the current study was to investigate whether a ...

Authors: Anne-Kathrin Rausch Osthoff, Swantje Beyer, David Gisi, Spencer Rezek, Ariane Schwank, André Meichtry, Noriane A. Sievi, Thomas Hess and Markus Wirz

Differences in genetics and microenvironment of lung adenocarcinoma patients with or without TP53 mutation

Differences in genetics and microenvironment of LUAD patients with or without TP53 mutation were analyzed to illustrate the role of TP53 mutation within the carcinogenesis of LUAD, which will provide new concepts...

Authors: Dejun Zeng, Zhengyang Hu, Yanjun Yi, Besskaya Valeria, Guangyao Shan, Zhencong Chen, Cheng Zhan, Miao Lin, Zongwu Lin and Qun Wang

Validation of the Arabic Severe Respiratory Insufficiency Questionnaire

Assessment of Health-Related Quality of Life (HRQL) in patients with chronic respiratory insufficiency requiring Home Mechanical Ventilation (HMV) requires a valid measurement tool. The Severe Respiratory Insu...

Authors: Marwan F. Alawieh, Rania N. Bzeih, Mohamad F. El-Khatib, Abla M. Sibai, Lilian A. Ghandour and Salah M. Zeineldine

Phrenic nerve stimulation prevents diaphragm atrophy in patients with respiratory failure on mechanical ventilation

Diaphragm atrophy and dysfunction is a major problem among critically ill patients on mechanical ventilation. Ventilator-induced diaphragmatic dysfunction is thought to play a major role, resulting in a failur...

Authors: Michal Soták, Karel Roubík, Tomáš Henlín and Tomáš Tyll