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  1. YKL-40 is also called chitinase-3-like-1 (CHI3L1) protein and may be a marker for asthma. The aims of the present study were to investigate whether serum YKL-40 levels are stable or decreased in patients with ...

    Authors: Tianwen Lai, Min Chen, Zaichun Deng, Yingying Lǚ, Dong Wu, Dongming Li and Bin Wu
    Citation: BMC Pulmonary Medicine 2015 15:1
  2. This study evaluated the effects of aclidinium bromide, a long-acting muscarinic antagonist indicated for maintenance treatment of chronic obstructive pulmonary disease (COPD), on exercise endurance, dyspnea, ...

    Authors: Kai M Beeh, Henrik Watz, Luis Puente-Maestu, Luis de Teresa, Diana Jarreta, Cynthia Caracta, Esther Garcia Gil and Helgo Magnussen
    Citation: BMC Pulmonary Medicine 2014 14:209
  3. Adiposity has been linked to both higher risk of asthma and reduced lung function. The effects of adiposity on asthma may depend on both atopic status and gender, while the relationship is less clear with resp...

    Authors: Runa V Fenger, Arturo Gonzalez-Quintela, Carmen Vidal, Lise-Lotte Husemoen, Tea Skaaby, Betina H Thuesen, Mette Aadahl, Flemming Madsen and Allan Linneberg
    Citation: BMC Pulmonary Medicine 2014 14:208
  4. The association between impaired lung function and cardiovascular disease (CVD) risk factors has been shown in adults. However, there is little evidence of such an association in young adults, particularly fro...

    Authors: Vanessa Garcia-Larsen, Patricia Bustos, Hugo Amigo, James Potts and Roberto J Rona
    Citation: BMC Pulmonary Medicine 2014 14:206
  5. Epidemiological studies report high rates of depression among patients with cystic fibrosis (CF). Assuming a causal relationship between depression and the progression of CF, our hypothesis is that elevated sy...

    Authors: Astrid Fidika, Marion Herle and Lutz Goldbeck
    Citation: BMC Pulmonary Medicine 2014 14:205
  6. In a previous study, exhaled carbon monoxide (eCO) has been assessed in healthy non-smokers with a photo acoustic spectrometer Brüel&Kjær 1312. Unexpectedly, values were higher than those reported in literatur...

    Authors: Umberto Moscato, Andrea Poscia, Riccardo Gargaruti, Giovanni Capelli and Franco Cavaliere
    Citation: BMC Pulmonary Medicine 2014 14:204
  7. Community-acquired pneumonia (CAP) is a common cause of patient hospitalization and death, and its burden on the healthcare system is increasing in aging societies. Here, we develop and internally validate ris...

    Authors: Hironori Uematsu, Susumu Kunisawa, Noriko Sasaki, Hiroshi Ikai and Yuichi Imanaka
    Citation: BMC Pulmonary Medicine 2014 14:203
  8. Electronic noses are composites of nanosensor arrays. Numerous studies showed their potential to detect lung cancer from breath samples by analysing exhaled volatile compound pattern (“breathprint”). Expirator...

    Authors: Andras Bikov, Marton Hernadi, Beata Zita Korosi, Laszlo Kunos, Gabriella Zsamboki, Zoltan Sutto, Adam Domonkos Tarnoki, David Laszlo Tarnoki, Gyorgy Losonczy and Ildiko Horvath
    Citation: BMC Pulmonary Medicine 2014 14:202
  9. Tracheostomy is one of the most common surgical procedures performed in critical care patient management; more specifically, ventilation through tracheal cannula allows removal of the endotracheal tube (ETT). ...

    Authors: Pierachille Santus, Andrea Gramegna, Dejan Radovanovic, Rita Raccanelli, Vincenzo Valenti, Dimitri Rabbiosi, Michele Vitacca and Stefano Nava
    Citation: BMC Pulmonary Medicine 2014 14:201
  10. The prognosis of patients with suspected pulmonary embolism (PE) in whom PE has been ruled out (RPE) is unclear. We aimed to evaluate survival and diagnosis of new cancer in suspected PE patients at follow up.

    Authors: Fernando Javier Vazquez, María Lourdes Posadas-Martínez, Fernán González Bernaldo de Quirós and Diego Hernan Giunta
    Citation: BMC Pulmonary Medicine 2014 14:200
  11. There is no consensus regarding obesity repercussions for lung function in children and adolescents. Therefore, the aim of the study was to determine whether obesity is associated with poor physical conditioni...

    Authors: Mariana Simões Ferreira, Roberto Teixeira Mendes, Fernando Augusto de Lima Marson, Mariana Porto Zambon, Ilma Aparecida Paschoal, Adyleia Aparecida Dalbo Contrera Toro, Silvana Dalge Severino, Maria Ângela Gonçalves de Oliveira Ribeiro and José Dirceu Ribeiro
    Citation: BMC Pulmonary Medicine 2014 14:199
  12. The classic sweat test (CST) is the golden standard for cystic fibrosis (CF) diagnosis. Then, our aim was compare the production and volume of sweat, and side effects caused by pulsed direct current (PDC) and ...

    Authors: Carla Cristina Souza Gomez, Maria de Fatima Servidoni, Fernando Augusto de Lima Marson, Paulo Jose Coelho Canavezi, Adriana Mendes Vinagre, Eduardo Tavares Costa, Antonio Fernando Ribeiro, Maria Angela Gonçalves de Oliveira Ribeiro, Adyleia Aparecida Dalbo Contrera Toro, Celia Regina Pavan, Michelle Vivine Sá dos Santos Rondon, Sonia Leticia Silva Lorena, Francisco Ubaldi Vieria Junior and Jose Dirceu Ribeiro
    Citation: BMC Pulmonary Medicine 2014 14:198
  13. Late prognosis of Community-Acquired Pneumonia (CAP) patients is related to cardiovascular events. Persistence of inflammation-related markers, defined by high circulatory levels of interleukin 6 and 10 (IL-6/...

    Authors: Olga Rajas, Mara Ortega-Gómez, José María Galván Román, José Curbelo, Guillermo Fernández Jiménez, Lorena Vega Piris, Francisco Rodríguez Salvanes, Belén Arnalich, Sergio Luquero Bueno, Ana Díaz López, Hortensia de la Fuente, Carmen Suárez, Julio Ancochea and Javier Aspa
    Citation: BMC Pulmonary Medicine 2014 14:197
  14. Surfactant proteins SP-A and SP-D are useful biomarkers in diagnosis, monitoring, and prognosis of idiopathic pulmonary fibrosis (IPF). Despite their high structural homology, their serum concentrations often ...

    Authors: Hirotaka Nishikiori, Hirofumi Chiba, Shigeru Ariki, Koji Kuronuma, Mitsuo Otsuka, Masanori Shiratori, Kimiyuki Ikeda, Atsushi Watanabe, Yoshio Kuroki and Hiroki Takahashi
    Citation: BMC Pulmonary Medicine 2014 14:196
  15. Evidence suggests that there is an association between chronic obstructive pulmonary disease (COPD) and coronary heart disease (CHD). An important etiological link between COPD and CHD may be an underlying sys...

    Authors: Donna R Parker, Jonathan Liu, Mary B Roberts and Charles B Eaton
    Citation: BMC Pulmonary Medicine 2014 14:195
  16. To evaluate noninvasive ventilation (NIV) in diffuse interstitial lung diseases (DILD) patients with acute respiratory failure (ARF) according to baseline radiological patterns and the etiology of ARF.

    Authors: Stefano Aliberti, Grazia Messinesi, Silvia Gamberini, Sveva Maggiolini, Dina Visca, Vanni Galavotti, Fabio Giuliani, Roberto Cosentini, Anna Maria Brambilla, Francesco Blasi, Raffaele Scala, Mauro Carone, Francesca Luisi, Sergio Harari, Antonio Voza, Antonio Esquinas…
    Citation: BMC Pulmonary Medicine 2014 14:194
  17. The COPD Assessment Test (CAT™) is a new questionnaire that has been developed recently for measuring the COPD patient’s health status. It is known to have a good correlation with disease specific health statu...

    Authors: Chaicharn Pothirat, Sumalee Kiatboonsri and Charoen Chuchottaworn
    Citation: BMC Pulmonary Medicine 2014 14:193
  18. Non-small cell lung cancer (NSCLC) imposes a substantial burden on patients, health care systems and society due to increasing incidence and poor survival rates. In recent years, advances in the treatment of m...

    Authors: Ansgar Lange, Anne Prenzler, Martin Frank, Heiko Golpon, Tobias Welte and J-Matthias von der Schulenburg
    Citation: BMC Pulmonary Medicine 2014 14:192
  19. A subset of severe asthma patients has fixed airways obstruction, which is characterized by incomplete reversibility to bronchodilator challenge. We aimed to elucidate the factors associated with fixed airways...

    Authors: Anthony Chau Ang Yii, Gan Liang Tan, Keng Leong Tan, Therese Sophie Lapperre and Mariko Siyue Koh
    Citation: BMC Pulmonary Medicine 2014 14:191
  20. An innovative approach to lung volume reduction (LVR) for emphysema is introduced in the design of the Sequential Segmental Treatment of Emphysema with Upper Lobe Predominance (STEP-UP) trial where vapour abla...

    Authors: Arschang Valipour, Felix JF Herth, Ralf Eberhardt, Pallav L Shah, Avina Gupta, Robert Barry, Erik Henne, Sourish Bandyopadhyay and Greg Snell
    Citation: BMC Pulmonary Medicine 2014 14:190
  21. The use of computerized clinical decision support systems may improve the diagnosis and ongoing management of chronic diseases, which requires recurrent visits to multiple health professionals, disease and med...

    Authors: Mariam Fathima, David Peiris, Pradnya Naik-Panvelkar, Bandana Saini and Carol Lyn Armour
    Citation: BMC Pulmonary Medicine 2014 14:189
  22. To evaluate the compliance, benefits and side effects associated with continuous positive airway pressure (CPAP) therapy among Pakistani patients treated for obstructive sleep apnea (OSA) in private sector.

    Authors: Syed Fayyaz Hussain, Muhammad Irfan, Zeeshan Waheed, Naveen Alam, Saba Mansoor and Muhammad Islam
    Citation: BMC Pulmonary Medicine 2014 14:188
  23. Increased small airway resistance and decreased lung elasticity contribute to the airflow limitation in chronic obstructive pulmonary disease (COPD). The lesion that corresponds to loss of lung elasticity is e...

    Authors: Sergey Stepaniants, I-Ming Wang, Yves Boie, James Mortimer, Brian Kennedy, Mark Elliott, Shizu Hayashi, Honglin Luo, Jerry Wong, Leanna Loy, Silvija Coulter, Christopher J Roberts, James C Hogg, Don D Sin, Gary O’Neill, Michael Crackower…
    Citation: BMC Pulmonary Medicine 2014 14:187
  24. Depression is a common comorbidity among patients with Chronic Obstructive Pulmonary Disease (COPD) and has a significant impact on the course of the disease. The aim of this study is to determine association ...

    Authors: José Laerte R Silva Júnior, Marcus Barreto Conde, Krislainy de Sousa Corrêa, Christina da Silva, Leonardo da Silva Prestes and Marcelo Fouad Rabahi
    Citation: BMC Pulmonary Medicine 2014 14:186
  25. Toxoplasmosis is one of the most common human zoonosis, and is generally benign in most of the individuals. Pulmonary involvement is common in immunocompromised subjects, but very rare in immunocompetents and ...

    Authors: Karina de Souza Giassi, Andre Nathan Costa, Andre Apanavicius, Fernando Bin Teixeira, Caio Julio Cesar Fernandes, Alfredo Salim Helito and Ronaldo Adib Kairalla
    Citation: BMC Pulmonary Medicine 2014 14:185
  26. This paper reviews evidence and quality of Systematic Reviews (SRs) on the effects of breathing control exercises (BCEs) and respiratory muscle training (RMT) on breathlessness/dyspnea and other symptoms, and ...

    Authors: Christine Råheim Borge, Kåre Birger Hagen, Anne Marit Mengshoel, Ernst Omenaas, Torbjørn Moum and Astrid Klopstad Wahl
    Citation: BMC Pulmonary Medicine 2014 14:184
  27. The safety and efficiency of gene therapies for cystic fibrosis (CF) need to be assessed in pre-clinical models. Using the normal ferret, this study sought to determine whether ferret airway epithelia could be...

    Authors: Patricia Cmielewski, Nigel Farrow, Martin Donnelley, Chantelle McIntyre, Jahan Penny-Dimri, Tim Kuchel and David Parsons
    Citation: BMC Pulmonary Medicine 2014 14:183
  28. Concurrent infection may be found in Pneumocystis jirovecii pneumonia (PJP) of non-acquired immunodeficiency syndrome (AIDS) patients, however, its impact on immune dysregulation of PJP in non-AIDS patients remai...

    Authors: Chung-Wei Chou, Fang-Chi Lin, Han-Chen Tsai and Shi-Chuan Chang
    Citation: BMC Pulmonary Medicine 2014 14:182
  29. Authors: Victoria M Lord, Victoria J Hume, Julia L Kelly, Phoene Cave, Judith Silver, Maya Waldman, Chris White, Cayley Smith, Rebecca Tanner, Melissa Sanchez, William D-C Man, Michael I Polkey and Nicholas S Hopkinson
    Citation: BMC Pulmonary Medicine 2014 14:181

    The original article was published in BMC Pulmonary Medicine 2012 12:69

  30. The study aimed to determine the short and long-term effects of exercise training on exercise capacity and health-related quality of life (HRQoL) compared to usual care in people with dust-related pleural and ...

    Authors: Marita T Dale, Zoe J McKeough, Phillip A Munoz, Peter Corte, Peter T P Bye and Jennifer A Alison
    Citation: BMC Pulmonary Medicine 2014 14:180
  31. The Global Initiative defines COPD for chronic obstructive lung disease as an entirely preventable and treatable disease characterized by sputum production, bacterial colonisation, neutrophilic bronchial airwa...

    Authors: Dachang Wu, Chenxia Hou, Yanxia Li, Zinan Zhao, Jianjun Liu, Xin Lu, Xueqi Shang and Yi Xin
    Citation: BMC Pulmonary Medicine 2014 14:179
  32. Aclidinium/formoterol is a twice-daily (BID) fixed-dose combination (FDC) in development for chronic obstructive pulmonary disease (COPD). The efficacy and safety of aclidinium/formoterol versus monotherapy an...

    Authors: Dave Singh, Paul W Jones, Eric D Bateman, Stephanie Korn, Cristina Serra, Eduard Molins, Cynthia Caracta, Esther Garcia Gil and Anne Leselbaum
    Citation: BMC Pulmonary Medicine 2014 14:178
  33. We have previously shown that diabetic rats are more susceptible to sepsis, but that the Acute lung injury (ALI) secondary to sepsis is less intense than in non-diabetics. In the present study, we further inve...

    Authors: Luciano Ribeiro Filgueiras, Vera L Capelozzi, Joilson O Martins and Sonia Jancar
    Citation: BMC Pulmonary Medicine 2014 14:177
  34. Long-acting β2-adrenergic agonists (LABAs) are recommended in combination with inhaled corticosteroids (ICSs) for asthma management. Abediterol is a novel, selective, potent, once-daily LABA in development for tr...

    Authors: Dave Singh, Helena Pujol, Anna Ribera, Beatriz Seoane, Eric Massana, Carol Astbury, Sandrine Ruiz and Gonzalo de Miquel
    Citation: BMC Pulmonary Medicine 2014 14:176
  35. Studies have shown that nonspecific interstitial pneumonitis (NSIP), even when initially diagnosed as an idiopathic form of the disease, might be associated with an autoimmune background that later reveals its...

    Authors: WenBin Xu, Yi Xiao, HongRui Liu, MingWei Qin, WenJie Zheng and JuHong Shi
    Citation: BMC Pulmonary Medicine 2014 14:175
  36. Epithelial-mesenchymal transition (EMT) has been believed to be related with chemotherapy resistance in non-small cell lung cancer (NSCLC). Recent studies have suggested eIF5A-2 may function as a proliferation...

    Authors: Guodong Xu, Hui Yu, Xinbao Shi, Lebo Sun, Qingyun Zhou, Dawei Zheng, Huoshun Shi, Ni Li, Xianning Zhang and Guofeng Shao
    Citation: BMC Pulmonary Medicine 2014 14:174
  37. Genetic factors play a role in the development and severity of chronic obstructive pulmonary disease (COPD). The pathogenesis of COPD is a multifactorial process including an inflammatory cell profile. Recent ...

    Authors: Xinyan Wang, Wan Li, Kun Huang, Xiaowen Kang, Zhaoguo Li, Chengcheng Yang, Xiaomei Wu and Lina Chen
    Citation: BMC Pulmonary Medicine 2014 14:173
  38. Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare lung disease caused by the autoantibody against granulocyte-macrophage colony stimulating factor (GM-CSF). The clinical course of aPAP is variable; in...

    Authors: Yuhei Kinehara, Hiroshi Kida, Yoshikazu Inoue, Masaki Hirose, Akihiko Nakabayashi, Yoshiko Takeuchi, Yoshitomo Hayama, Kiyoharu Fukushima, Haruhiko Hirata, Koji Inoue, Toshiyuki Minami, Izumi Nagatomo, Yoshito Takeda, Toshiki Funakoshi, Takashi Kijima and Atsushi Kumanogoh
    Citation: BMC Pulmonary Medicine 2014 14:172
  39. Due to the small amount of alveolar tissue in transbronchial biopsy (TBB) by forceps, the diagnosis of diffuse, parenchymal lung diseases (DPLD) is inherently problematic, with an overall low yield. The use of...

    Authors: Sergej Griff, Nicolas Schönfeld, Wilhelm Ammenwerth, Torsten-Gerriet Blum, Christian Grah, Torsten T Bauer, Wolfram Grüning, Thomas Mairinger and Henrik Wurps
    Citation: BMC Pulmonary Medicine 2014 14:171
  40. Activins are members of the TGF-ß superfamily of growth factors. First, we identified by expression array screening that activin-B and follistatin are upregulated in human idiopathic pulmonary fibrosis (IPF). ...

    Authors: Marjukka Myllärniemi, Jussi Tikkanen, Juha J Hulmi, Arja Pasternack, Eva Sutinen, Mikko Rönty, Outi Leppäranta, Hongqiang Ma, Olli Ritvos and Katri Koli
    Citation: BMC Pulmonary Medicine 2014 14:170
  41. Little is known about whether or how supplemental oxygen affects patients with pulmonary fibrosis.

    Authors: Amanda Belkin, Kaitlin Fier, Karen Albright, Susan Baird, Brenda Crowe, Linda Eres, Marjorie Korn, Leslie Maginn, Mark McCormick, Elisabeth D Root, Thomas Vierzba, Frederick S Wamboldt and Jeffrey J Swigris
    Citation: BMC Pulmonary Medicine 2014 14:169
  42. Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown causes. Three proteins (mammalian target of rapamycin, mTOR; zinc finger E-box-binding homeobox 1, ZEB1; Rho-associated, coiled-coil conta...

    Authors: Jong Sun Park, Hyo Jin Park, Young Sik Park, Sang-Min Lee, Jae-Joon Yim, Chul-Gyu Yoo, Sung Koo Han and Young Whan Kim
    Citation: BMC Pulmonary Medicine 2014 14:168
  43. The 6-Minute Walk Test (6MWT) is representative of daily-life activities and reflects the functional capacity of patients. The change of oxygen uptake (VO2) in the initial phase of low-intensity exercise (VO2 kin...

    Authors: Lukas Kern, Sophie Condrau, Florent Baty, Jan Wiegand, Arno JR van Gestel, Andrea Azzola, Michael Tamm and Martin Brutsche
    Citation: BMC Pulmonary Medicine 2014 14:167
  44. Inhaled allergen challenge is a standard method to study airway responses to inflammatory provocation and evaluate the therapeutic potential of novel anti-inflammatory compounds in asthma. MEM 1414 is a novel ...

    Authors: Brian R Leaker, Dave Singh, Ferhana Y Ali, Peter J Barnes and Brian O’Connor
    Citation: BMC Pulmonary Medicine 2014 14:166
  45. Cystic Fibrosis (CF) is a genetic disease with equal prevalence across sexes. However, women present worse lung function with faster function decline, earlier onset of bacterial colonization, more frequent pul...

    Authors: Adelaida Lamas, Luis Máiz, Marta Ruiz de Valbuena, José Manuel González-Casbas and Lucrecia Suárez
    Citation: BMC Pulmonary Medicine 2014 14:165
  46. Chronic obstructive pulmonary disease (COPD) has been classically divided into blue bloaters and pink puffers. The utility of these clinical subtypes is unclear. However, the broader distinction between airway...

    Authors: Craig P Hersh, Barry J Make, David A Lynch, R Graham Barr, Russell P Bowler, Peter MA Calverley, Peter J Castaldi, Michael H Cho, Harvey O Coxson, Dawn L DeMeo, Marilyn G Foreman, MeiLan K Han, Benjamin J Harshfield, John E Hokanson, Sharon Lutz, Joe W Ramsdell…
    Citation: BMC Pulmonary Medicine 2014 14:164
  47. The 2013 GOLD classification system for COPD distinguishes four stages: A (low symptoms, low exacerbation risk), B (high symptoms, low risk), C (low symptoms, high risk) and D (high symptoms, high risk). Asses...

    Authors: Lucas M A Goossens, Inge Leimer, Norbert Metzdorf, Karin Becker and Maureen P M H Rutten-van Mölken
    Citation: BMC Pulmonary Medicine 2014 14:163
  48. Wheezing during early life is a very common disorder, but the reasons underlying the different wheezing phenotypes are still unclear. The aims of this study were to analyse the potential correlations between t...

    Authors: Susanna Esposito, Valentina Ierardi, Cristina Daleno, Alessia Scala, Leonardo Terranova, Claudia Tagliabue, Walter Peves Rios, Claudio Pelucchi and Nicola Principi
    Citation: BMC Pulmonary Medicine 2014 14:162
  49. In epidemiological studies of asthma, questionnaires to differentiate asthmatics from non-asthmatics have proven to be cost-effective and convenient. The aim of this study was to analyze the association betwee...

    Authors: So Yeon Lim, Young Joo Jo and Eun Mi Chun
    Citation: BMC Pulmonary Medicine 2014 14:161

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