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  1. The most common cystic fibrosis (CF) manifestation is the progressive chronic obstructive pulmonary disease caused by deficiency, dysfunction, or absence of the CFTR (Cystic Fibrosis Transmembrane Regulator) p...

    Authors: Fernando A L Marson, Carmen S Bertuzzo, Antônio F Ribeiro and José D Ribeiro
    Citation: BMC Pulmonary Medicine 2012 12:50
  2. Bronchodilator response in patients with asthma is evaluated based on post-bronchodilator increase in forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). However, the need for additiona...

    Authors: Karen S Azevedo, Ronir R Luiz, Patricia RM Rocco and Marcus B Conde
    Citation: BMC Pulmonary Medicine 2012 12:49
  3. Despite the benefits of beta-blockers in patients with established or sub-clinical coronary artery disease, their use in patients with chronic obstructive pulmonary disease (COPD) has been controversial. Curre...

    Authors: Mahyar Etminan, Siavash Jafari, Bruce Carleton and John Mark FitzGerald
    Citation: BMC Pulmonary Medicine 2012 12:48
  4. Granulomatosis with polyangitis (Wegener’s) is a vasculitic disease predominantly affecting the lungs, skin, kidneys, ears, nose and throat. Mycobacterium abscessus is an uncommon rapidly growing mycobacterium ca...

    Authors: Senyo K Tagboto and Ajay G Venkatesh
    Citation: BMC Pulmonary Medicine 2012 12:47
  5. The impact of HIV infection on the evolution of acute community-acquired pneumonia (CAP) is still controversial. The aim of this study was to investigate possible differences in the clinical presentation and i...

    Authors: Eric Walter Pefura Yone, Adamou Dodo Balkissou, André Pascal Kengne and Christopher Kuaban
    Citation: BMC Pulmonary Medicine 2012 12:46
  6. The design of new interventions to improve health care for patients with chronic obstructive pulmonary disease (COPD) requires knowledge about what patients with an acute exacerbation experience as important a...

    Authors: Ying Wang, Torbjørn Haugen, Sissel Steihaug and Anne Werner
    Citation: BMC Pulmonary Medicine 2012 12:45
  7. Neutrophils sequestered in lower respiratory tract secretions in the inflamed lung may undergo apoptosis and/or necrosis and release toxic cellular contents that can injure airways or parenchyma. This study ex...

    Authors: Francis H C Tsao, Zhuzai Xiang, Adnan Abbasi and Keith C Meyer
    Citation: BMC Pulmonary Medicine 2012 12:44
  8. Acute lung injury (ALI) is characterized by a pro-coagulant state. Heparin is an anticoagulant with anti-inflammatory properties. Unfractionated heparin has been found to be protective in experimental models o...

    Authors: Jorrit J Hofstra, Alexander P J Vlaar, David J Prins, Gavin Koh, Marcel Levi, Marcus J Schultz, Jan M Binnekade and Nicole P Juffermans
    Citation: BMC Pulmonary Medicine 2012 12:43
  9. Right-to-left shunt (RLS) may be the cause of marked hypoxemia, a respiratory insufficiency which is usually difficult to diagnose by respiratory physicians as it develops in the absence of an intrinsic lung d...

    Authors: Cristiano Carbonelli, Marialuisa Zedde, Alberto Cavazza, Nicola Facciolongo, Francesco Menzella, Lucia Spaggiari and Luigi Zucchi
    Citation: BMC Pulmonary Medicine 2012 12:42
  10. Cystic Fibrosis (CF) is a monogenic disease with complex expression because of the action of genetic and environmental factors. We investigated whether the ACE gene D/I polymorphism is associated with severity of...

    Authors: Fernando A L Marson, Carmen S Bertuzzo, Taís D R Hortencio, José D Ribeiro, Luciana C Bonadia and Antônio F Ribeiro
    Citation: BMC Pulmonary Medicine 2012 12:41
  11. Tuberculosis (TB) remains a public health issue worldwide. The lack of specific clinical symptoms to diagnose TB makes the correct decision to admit patients to respiratory isolation a difficult task for the c...

    Authors: Fabio S Aguiar, Luciana L Almeida, Antonio Ruffino-Netto, Afranio Lineu Kritski, Fernanda CQ Mello and Guilherme L Werneck
    Citation: BMC Pulmonary Medicine 2012 12:40
  12. In some situations, practice guidelines do not provide firm evidence-based guidance regarding COPD treatment choices, especially when large trials have failed to identify subgroups of particularly good or poor...

    Authors: Nicolas Roche, Christos Chouaid, Bertrand Delclaux, Yan Martinat, Jean-Michel Marcos, Hervé Pégliasco and Bruno Scherrer
    Citation: BMC Pulmonary Medicine 2012 12:39
  13. Titanium dioxide (TiO2) and carbon black (CB) nanoparticles (NPs) have biological effects that could aggravate pulmonary emphysema. The aim of this study was to evaluate whether pulmonary administration of TiO2 o...

    Authors: Agnès Roulet, Lucie Armand, Maylis Dagouassat, Françoise Rogerieux, Angélique Simon-Deckers, Esther Belade, Jeanne Tran Van Nhieu, Sophie Lanone, Jean-Claude Pairon, Ghislaine Lacroix and Jorge Boczkowski
    Citation: BMC Pulmonary Medicine 2012 12:38
  14. Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are often linked to respiratory infections. However, it is unknown if COPD patients who experience frequent exacerbations have impaired hum...

    Authors: Stephanie T Yerkovich, Belinda J Hales, Melanie L Carroll, Julie G Burel, Michelle A Towers, Daniel J Smith, Wayne R Thomas and John W Upham
    Citation: BMC Pulmonary Medicine 2012 12:37
  15. Several studies suggest an increase of oxidative stress and a reduction of endothelial function in obstructive sleep apnoea syndrome (OSAS). We assessed the association between OSAS, endothelial dysfunction an...

    Authors: Maria Del Ben, Mario Fabiani, Lorenzo Loffredo, Licia Polimeni, Roberto Carnevale, Francesco Baratta, Marco Brunori, Fabiana Albanese, Teresa Augelletti, Francesco Violi and Francesco Angelico
    Citation: BMC Pulmonary Medicine 2012 12:36
  16. Therapeutic reference pricing (TRP) based on the WHO daily defined dose (DDD) is a method frequently employed for the cost-containment of pharmaceuticals. Our objective was to compare average drug use in the r...

    Authors: Zoltan Kalo, Zsolt Abonyi-Toth, Zoltan Bartfai and Zoltan Voko
    Citation: BMC Pulmonary Medicine 2012 12:35
  17. Elastin is an essential component of selected connective tissues that provides a unique physiological elasticity. Elastin may be considered a signature protein of lungs where matrix metalloprotease (MMP) -9-an...

    Authors: Helene Skjøt-Arkil, Rikke E Clausen, Quoc Hai Trieu Nguyen, Yaguo Wang, Qinlong Zheng, Fernando J Martinez, Cory M Hogaboam, Meilan Han, Lloyd B Klickstein, Martin R Larsen, Arkadiusz Nawrocki, Diana J Leeming and Morten A Karsdal
    Citation: BMC Pulmonary Medicine 2012 12:34
  18. Diagnostic and treatment approaches for sarcoidosis have changed dramatically over the past decade. Yet, the most recent reports of trends in hospitalizations of sarcoidosis patients are over ten years old. Th...

    Authors: Alicia K Gerke, Ming Yang, Fan Tang, Joseph E Cavanaugh and Philip M Polgreen
    Citation: BMC Pulmonary Medicine 2012 12:19
  19. A high-sensitivity cardiac troponin T (hs-cTnT) concentration above the 99th percentile (i.e. 14 ng/L) is common during Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) and associated with inc...

    Authors: Arne Didrik Høiseth, Torbjørn Omland, Tor-Arne Hagve, Pål H Brekke and Vidar Søyseth
    Citation: BMC Pulmonary Medicine 2012 12:22
  20. Manual chest physiotherapy (MCP) techniques involving chest percussion, vibration, and shaking have long been used in the treatment of respiratory conditions. However, methodological limitations in existing re...

    Authors: Jane L Cross, Frances Elender, Gary Barton, Allan Clark, Lee Shepstone, Annie Blyth, Max O Bachmann and Ian Harvey
    Citation: BMC Pulmonary Medicine 2012 12:33
  21. This study examined associations of abdominal adiposity with lung function, asthma symptoms and current doctor-diagnosed asthma and mediation by insulin resistance (IR) and sleep disordered breathing (SDB).

    Authors: Matthew T Haren, Gary Misan, Tracey-Jayne Paterson, Richard E Ruffin, Janet F Grant, Jonathan D Buckley, Peter RC Howe, Jonathan Newbury, Anne W Taylor and Robyn A McDermott
    Citation: BMC Pulmonary Medicine 2012 12:31
  22. The evidence regarding the association between lung cancer and occupational exposure to cement is controversial. This study investigated causes of deaths from cancer of respiratory tract among cement workers.

    Authors: George Rachiotis, Spyros Drivas, Konstantinos Kostikas, Vasilios Makropoulos and Christos Hadjichristodoulou
    Citation: BMC Pulmonary Medicine 2012 12:30
  23. The objective of this study was to evaluate the comparative efficacy of indacaterol 75 μg once daily (OD), tiotropium 18 μg OD, salmeterol 50 μg twice daily (BID), formoterol 12 μg BID, and placebo for the tre...

    Authors: Shannon Cope, Jie Zhang, James Williams and Jeroen P Jansen
    Citation: BMC Pulmonary Medicine 2012 12:29
  24. Exacerbations, a leading cause of hospitalization in patients with chronic obstructive pulmonary disease (COPD), affect the quality of life and prognosis. Treatment recommendations as provided in the evidence-...

    Authors: Andrea Ban, Aniza Ismail, Roslan Harun, Azahirafairud Abdul Rahman, Saperi Sulung and Aljunid Syed Mohamed
    Citation: BMC Pulmonary Medicine 2012 12:27
  25. Treatment of chronic diseases such as chronic obstructive pulmonary disease (COPD) is complicated by the presence of comorbidities. The objective of this analysis was to estimate the prevalence of comorbidity ...

    Authors: Kerry Schnell, Carlos O Weiss, Todd Lee, Jerry A Krishnan, Bruce Leff, Jennifer L Wolff and Cynthia Boyd
    Citation: BMC Pulmonary Medicine 2012 12:26
  26. Pulmonary hypertension (PH) is a complication of chronic obstructive pulmonary disease (COPD). This study examined genetic variations in mediators of vascular remodelling and their association with PH in patie...

    Authors: Janet G Shaw, Annette G Dent, Linda H Passmore, Darryl J Burstow, Rayleen V Bowman, Paul V Zimmerman, Kwun M Fong and Ian A Yang
    Citation: BMC Pulmonary Medicine 2012 12:25
  27. Pirfenidone is a novel anti-fibrotic and anti-inflammatory agent that inhibits the progression of fibrosis in animal models and in patients with idiopathic pulmonary fibrosis (IPF). We previously showed that p...

    Authors: Keiko Hisatomi, Hiroshi Mukae, Noriho Sakamoto, Yuji Ishimatsu, Tomoyuki Kakugawa, Shintaro Hara, Hanako Fujita, Seiko Nakamichi, Hisashi Oku, Yoshishige Urata, Hiroshi Kubota, Kazuhiro Nagata and Shigeru Kohno
    Citation: BMC Pulmonary Medicine 2012 12:24
  28. Increased ventilatory response has been shown to have a high prognostic value in patients with chronic heart failure. Our aim was therefore to determine the ventilatory efficiency in pulmonary arterial hyperte...

    Authors: Martin Schwaiblmair, Christian Faul, Wolfgang von Scheidt and Thomas M Berghaus
    Citation: BMC Pulmonary Medicine 2012 12:23
  29. Length of hospital stay (LOS) in patients with community-acquired pneumonia (CAP) is variable and directly related to medical costs. Accurate estimation of LOS on admission and during follow-up may result in e...

    Authors: Isabelle Suter-Widmer, Mirjam Christ-Crain, Werner Zimmerli, Werner Albrich, Beat Mueller and Philipp Schuetz
    Citation: BMC Pulmonary Medicine 2012 12:21
  30. Health status provides valuable information, complementary to spirometry and improvement of health status has become an important treatment goal in COPD management. We compared the usefulness and validity of t...

    Authors: Ioanna G Tsiligianni, Thys van der Molen, Despoina Moraitaki, Ilaine Lopez, Janwillem WH Kocks, Konstantinos Karagiannis, Nikolaos Siafakas and Nikolaos Tzanakis
    Citation: BMC Pulmonary Medicine 2012 12:20
  31. Quantification of lung tissue via analysis of computed tomography (CT) scans is increasingly common for monitoring disease progression and for planning of therapeutic interventions. The current study evaluates...

    Authors: Erik Henne, Joseph C Anderson, Norma Lowe and Steven Kesten
    Citation: BMC Pulmonary Medicine 2012 12:18
  32. While it is suggested that the prevalence of asthma in developed countries may have stabilized, this is not clear in currently developing countries. Current available information for both adults and children s...

    Authors: Rodolfo J Dennis, Luis Caraballo, Elizabeth García, María X Rojas, Martín A Rondon, Adriana Pérez, Gustavo Aristizabal, Augusto Peñaranda, Ana M Barragan, Velky Ahumada and Silvia Jimenez
    Citation: BMC Pulmonary Medicine 2012 12:17
  33. Surfactant protein C (SP-C) is important for the function of pulmonary surfactant. Heterozygous mutations in SFTPC, the gene encoding SP-C, cause sporadic and familial interstitial lung disease (ILD) in children ...

    Authors: Ralf Zarbock, Markus Woischnik, Christiane Sparr, Tobias Thurm, Sunčana Kern, Eva Kaltenborn, Andreas Hector, Dominik Hartl, Gerhard Liebisch, Gerd Schmitz and Matthias Griese
    Citation: BMC Pulmonary Medicine 2012 12:15
  34. The aim of this study was to assess the responsiveness of the asthma control test (ACT) to detect changes at the initiation of therapy and its utilization in the initiation of asthma treatment.

    Authors: Mohamed S Al Moamary, Ahmed G Al-Kordi, Mohammed O Al Ghobain and Hani M Tamim
    Citation: BMC Pulmonary Medicine 2012 12:14
  35. Early wheezing and asthma are relevant health problems in the tropics. Mite sensitization is an important risk factor, but the roles of others, inherent in poverty, are unknown. We designed a birth-cohort stud...

    Authors: Nathalie Acevedo, Jorge Sánchez, Josefina Zakzuk, Adriana Bornacelly, Carlos Quiróz, Álvaro Alvarez, Marta Puello, Ketty Mendoza, Dalgys Martínez, Dilia Mercado, Silvia Jiménez and Luis Caraballo
    Citation: BMC Pulmonary Medicine 2012 12:13
  36. Current COPD guidelines advocate a fixed < 0.70 FEV1/FVC cutpoint to define airflow obstruction. We compared rate of lung function decline in respiratory symptomatic 40+ subjects who were 'obstructive' or 'non...

    Authors: Reinier P Akkermans, Marvin A Berrevoets, Ivo J Smeele, Annelies E Lucas, Bart P Thoonen, Joke G Grootens-Stekelenburg, Yvonne F Heijdra, Chris van Weel and Tjard R Schermer
    Citation: BMC Pulmonary Medicine 2012 12:12
  37. The Influenza A H1N1 virus can be transmitted via direct, indirect, and airborne route to non-infected subjects when an infected patient coughs, which expels a number of different sized droplets to the surroun...

    Authors: Gustavo Zayas, Ming C Chiang, Eric Wong, Fred MacDonald, Carlos F Lange, Ambikaipakan Senthilselvan and Malcolm King
    Citation: BMC Pulmonary Medicine 2012 12:11
  38. Tobacco smoking is an important public health concern worldwide leading to both chronic disease and early death. In Latin America, smoking prevalence is estimated at approximately 30% and prior studies suggest...

    Authors: Paul Logan Weygandt, Elisa Vidal-Cardenas, Robert H Gilman, Erika Avila-Tang, Lilia Cabrera and William Checkley
    Citation: BMC Pulmonary Medicine 2012 12:9
  39. Spirometry is regarded as the gold standard for the diagnosis of COPD, yet the condition is widely underdiagnosed. Therefore, additional screening methods that are easy to perform and to interpret are needed. ...

    Authors: Katrin Morenz, Heike Biller, Frank Wolfram, Steffen Leonhadt, Dirk Rüter, Thomas Glaab, Stefan Uhlig and Jens M Hohlfeld
    Citation: BMC Pulmonary Medicine 2012 12:8
  40. The aim of our study was to investigate the predictive value of the biomarkers interleukin 6 (IL-6), interleukin 10 (IL-10) and lipopolysaccharide-binding protein (LBP) compared with clinical CRB and CRB-65 se...

    Authors: Katrin Zobel, Peter Martus, Mathias W Pletz, Santiago Ewig, Michael Prediger, Tobias Welte and Frank Bühling
    Citation: BMC Pulmonary Medicine 2012 12:6
  41. The tissue factor (TF)-dependent extrinsic pathway has been suggested to be a central mechanism by which the coagulation cascade is locally activated in the lungs of patients with acute lung injury and acute r...

    Authors: Peter E Morris, Jay S Steingrub, Bee Y Huang, Shamay Tang, Patrick M Liu, Peter R Rhode and Hing C Wong
    Citation: BMC Pulmonary Medicine 2012 12:5
  42. No population study has explored the population distribution of adult asthma in the United Arab Emirates (UAE). The objective is to estimate asthma prevalence in general population in UAE.

    Authors: Bassam H Mahboub, Suleiman Al-Hammadi, Mohamed Rafique, Nabil Sulaiman, Ruby Pawankar, Abdulla I Al Redha and Atul C Mehta
    Citation: BMC Pulmonary Medicine 2012 12:4
  43. In cystic fibrosis (CF) patients, it has been suggested that systemic inflammation may be an important risk factor for poor health outcomes. The relationship of plasma inflammatory biomarkers to lung function ...

    Authors: David A Ngan, Pearce G Wilcox, May Aldaabil, Yuexin Li, Jonathon A Leipsic, Don D Sin and SF Paul Man
    Citation: BMC Pulmonary Medicine 2012 12:3
  44. Detection of risk factors for an air embolism in the left atrium, left ventricle, or systemic circulation (systemic air embolism, SAE) during a percutaneous core needle biopsy (PCNB) of the thorax.

    Authors: Martin C Freund, Johannes Petersen, Katharina C Goder, Tillmann Bunse, Franz Wiedermann and Bernhard Glodny
    Citation: BMC Pulmonary Medicine 2012 12:2
  45. The poor recognition and related underdiagnosis of COPD contributes to an underestimation of mortality in subjects with COPD. Data derived from population studies can advance our understanding of the true burd...

    Authors: Anne Lindberg, Lars-Gunnar Larsson, Hana Muellerova, Eva Rönmark and Bo Lundbäck
    Citation: BMC Pulmonary Medicine 2012 12:1

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