Articles

Identifying specific needs in adult cystic fibrosis patients: a pilot study using a custom questionnaire

Adult patients with cystic fibrosis (CF) experience daily physical symptoms and disabilities that can be challenging to address for health care teams.

Authors: Sandra Dury, Jeanne-Marie Perotin, Bruno Ravoninjatovo, Catherine Llerena, Julien Ancel, Pauline Mulette, Muriel Griffon, Sophie Carré, Amélie Perrin, François Lebargy, Gaëtan Deslée and Claire Launois

Fundamental movement skill proficiency and objectively measured physical activity in children with bronchiectasis: a cross-sectional study

Bronchiectasis is a major contributor to respiratory morbidity and healthcare utilization in children. Children with bronchiectasis exhibit low levels of physical activity (PA) and poor fundamental movement sk...

Authors: Barbara Joschtel, Sjaan R. Gomersall, Sean Tweedy, Helen Petsky, Anne B. Chang and Stewart G. Trost

Randomized, placebo controlled, double blinded pilot superiority phase 2 trial to evaluate the effect of curcumin in moderate to severe asthmatics

Curcumin, a derivative of the spice turmeric, has been adopted by Eastern medicine for centuries as an adjunct to treat several medical conditions (e.g., anorexia and arthritis) because of its well-established...

Authors: Michele Quan, Abdullah Alismail, Noha Daher, Derrick Cleland, Sonia Chavan and Laren D. Tan

Prevalence and clinical consequences of atelectasis in SARS-CoV-2 pneumonia: a computed tomography retrospective cohort study

The aim of the study is to estimate the prevalence of atelectasis assessed with computer tomography (CT) in SARS-CoV-2 pneumonia and the relationship between the amount of atelectasis with oxygenation impairme...

Authors: Álvaro Mingote, Andrea Albajar, Paulino García Benedito, Jessica Garcia-Suarez, Paolo Pelosi, Lorenzo Ball and Javier García-Fernández

Effectiveness of one-on-one coaching in improving pressurized metered dose inhaler (pMDI) technique among COPD patients: a prospective clinical study

Incorrect use of inhalers among asthma and COPD patients is very prevalent. Yet, no single intervention is considered standard of care. We aimed to conduct a COPD-specific investigation of active one-on-one co...

Authors: Jin Sun Kim, Nader Hashweh, Hannah Li, Salik Choudhary, Sadashiv Santosh and Edward Charbek

A 20-year retrospective study of osteoarticular tuberculosis in a pediatric third level referral center

The objective of the present study is to describe the clinical, diagnostic, radiological and therapeutic aspects of osteoarticular tuberculosis (OATB) in patients in a tertiary pediatric hospital, to know if t...

Authors: Napoleón González Saldaña, Mercedes Macías Parra, Luis Xochihua Díaz, Martin Palavicini Rueda, Ana Jocelyn Carmona Vargas, José Iván Castillo Bejarano, Quetzalli Veloz Corona, Hugo Juárez Olguín and Juan Luis Chavez Pacheco

Deep vein thrombosis in acute respiratory distress syndrome caused by bacterial pneumonia

Acute respiratory distress syndrome (ARDS) is a clinical syndrome characterized by acute hypoxaemia, and few studies have reported the incidence of deep vein thrombosis (DVT) in direct ARDS caused by bacterial...

Authors: Na Cui, Song Mi, Chunguo Jiang, Wanlu Sun, Wenping Mao, Liming Zhang and Xiaokai Feng

Novel compound heterozygous mutations of DNAH5 identified in a pediatric patient with Kartagener syndrome: case report and literature review

Kartagener syndrome is a subtype of primary ciliary dyskinesia that may exhibit various symptoms including neonatal respiratory distress and frequent infections of the lung, sinus and middle ear because of the...

Authors: Lina Wang, Xin Zhao, Hang Liang, Li Zhang, Chunyan Li, Deli Li, Xiangfeng Meng, Fanzheng Meng and Mao Gao

The clinical and radiological characteristics of pulmonary cryptococcosis in immunocompetent and immunocompromised patients

We characterized the clinical features, radiographic characteristics, and response to treatment of immunocompetent and immunocompromised patients with pulmonary cryptococcosis (PC).

Authors: Yan Hu, Si-Ying Ren, Peng Xiao, Feng-Lei Yu and Wen-Liang Liu

Outcome and prognostic factors after lung transplantation for bronchiectasis other than cystic fibrosis

While lung transplant (LTX) can be an effective therapy to provide the survival benefit in selected populations, post-transplant outcome in LTX recipients with bronchiectasis other than cystic fibrosis (CF) ha...

Authors: Takashi Hirama, Fumiko Tomiyama, Hirotsugu Notsuda, Tatsuaki Watanabe, Yui Watanabe, Hisashi Oishi and Yoshinori Okada

Characteristics of patients meeting the new definition of pre-capillary pulmonary hypertension (Nice 2018) in a single Japanese pulmonary hypertension center

The 6th World Symposium on Pulmonary Hypertension (Nice 2018) proposed a new definition of pre-capillary pulmonary hypertension (PH) as a condition with mean pulmonary artery pressure (mPAP) > 20 mmHg, pulmona...

Authors: Keiko Yamamoto, Nobuhiro Tanabe, Yukiko Takahashi, Akira Naito, Ayumi Sekine, Rika Suda, Takayuki Jujo Sanada, Toshihiko Sugiura, Ayako Shigeta, Seiichiro Sakao and Koichiro Tatsumi

Diagnostic possibility of the combination of exhaled nitric oxide and blood eosinophil count for eosinophilic asthma

Tests to identify reversible airflow limitation are important in asthma diagnosis, but they are time-consuming and it may be difficult for patients to cooperate. We aimed to evaluate whether the combination of...

Authors: Jiang-Hua Li, Rui Han, Yu-Bo Wang, Min Cheng, Heng-Yi Chen, Wen-Hui Lei, Li Li, Chen Gao, Na-Na Zhao, Nai-Fu Nie, Zhong-Yan Li, Guo-Qing Yin, Shuai Huang and Yong He

Emergency admission parameters for predicting in-hospital mortality in patients with acute exacerbations of chronic obstructive pulmonary disease with hypercapnic respiratory failure

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a common presentation in emergency departments (ED) that can be fatal. This study aimed to develop a mortality risk assessment model for ...

Authors: Lan Chen, Lijun Chen, Han Zheng, Sunying Wu and Saibin Wang

The role of clinical characteristics and pulmonary function testing in predicting risk of pneumothorax by CT-guided percutaneous core needle biopsy of the lung

We aim to analyze the risk factors for pneumothorax associated with computed tomography (CT)-guided percutaneous core needle biopsy (PCNB) of the lung. Whether the lung function characteristics are related to ...

Authors: Chunhai Li, Dexiang Wang, Fengxia Yang, Yang Song, Xuejuan Yu, Bo Liu, Haipeng Jia and Wei Zhou

Functional respiratory imaging in relation to classical outcome measures in cystic fibrosis: a cross-sectional study

Functional Respiratory Imaging (FRI) combines HRCT scans with computational fluid dynamics to provide objective and quantitative information about lung structure and function. FRI has proven its value in pulmo...

Authors: Eline Lauwers, Annemiek Snoeckx, Kris Ides, Kim Van Hoorenbeeck, Maarten Lanclus, Wilfried De Backer, Jan De Backer and Stijn Verhulst

Living conditions and autonomy levels in COPD patients receiving non-invasive ventilation: impact on health related quality of life

Research on health-related quality of life (HRQL) has become increasingly important in recent decades. However, the impact of both living conditions and the level of autonomy impairments on HRQL in COPD patien...

Authors: Sarah Bettina Schwarz, Tim Mathes, Daniel Sebastian Majorski, Maximilian Wollsching-Strobel, Doreen Kroppen, Friederike Sophie Magnet and Wolfram Windisch

An uncommon etiological factor for aspiration pneumonitis caused by spontaneous sphenoid sinus meningoencephalocele with cerebrospinal fluid rhinorrhea: a case report

Aspiration pneumonitis is an inflammatory disease of the lungs which is difficult to diagnose accurately. Large-volume aspiration of oropharyngeal or gastric contents is essential for the development of aspira...

Authors: Jiayu Cao, Wei Liu, Li Wang, Yujuan Yang, Yu Zhang and Xicheng Song

Time-to-first exacerbation, adherence, and medical costs among US patients receiving umeclidinium/vilanterol or tiotropium as initial maintenance therapy for chronic obstructive pulmonary disease: a retrospective cohort study

Adherence to chronic obstructive pulmonary disease (COPD) maintenance medication is important for managing symptoms and exacerbation risk, and is associated with reduced mortality, hospitalizations, and costs....

Authors: David Slade, Riju Ray, Chad Moretz, Guillaume Germain, François Laliberté, Qin Shen, Mei Sheng Duh, Malena Mahendran and Beth Hahn

Emodin inhibits viability, proliferation and promotes apoptosis of hypoxic human pulmonary artery smooth muscle cells via targeting miR-244-5p/DEGS1 axis

This study aimed to determine the effects of emodin on the viability, proliferation and apoptosis of human pulmonary artery smooth muscle cells (PASMCs) under hypoxia and to explore the underling molecular mec...

Authors: Li Yi, JunFang Liu, Ming Deng, Huihua Zuo and Mingyan Li

Pulmonary hypertension in systemic sclerosis: diagnosis by systematic screening and prognosis after three years follow-up

Systemic sclerosis (SSc) is a rare disease, and the presence of pulmonary hypertension can be a determining factor in prognosis. The aim of this study was to evaluate the diagnosis, profile, and prognosis of s...

Authors: Verônica Silva Vilela, Marcio Macri Dias, Ângelo Antunes Salgado, Bruno Rangel Antunes da Silva, Agnaldo José Lopes, Elizabeth Jauhar Cardoso Bessa, Leonardo Palermo Bruno, Cláudia Henrique da Costa, Roger Abramino Levy and Rogério Rufino

Rationale and design of REGULATE: an observational study protocol for relationship between plasma metabolome and the efficacy of systemic glucocorticoid in acute exacerbation of chronic obstructive pulmonary disease

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) significantly increases the mortality of patients with COPD. Guidelines have recommended systemic glucocorticoid as a regular treatment. Rec...

Authors: Qiu-Yu Li, Zhuo-Yu An, Zi-Han Pan and Rui-Ying Qi

Cyclophosphamide for interstitial lung disease-associated acute respiratory failure: mortality, clinical response and radiological characteristics

Treatment for interstitial lung disease (ILD) patients with acute respiratory failure (ARF) is challenging, and literature to guide such treatment is scarce. The reported in-hospital mortality rates of ILD pat...

Authors: Johanna P. van Gemert, Inge A. H. van den Berk, Esther J. Nossent, Leo M. A. Heunks, Rene E. Jonkers, Alexander P. Vlaar and Peter I. Bonta

Correction to: A multicenter randomized trial to assess the efficacy of CONvalescent plasma therapy in patients with Invasive COVID-19 and acute respiratory failure treated with mechanical ventilation: the CONFIDENT trial protocol

Authors: Benoît Misset, Eric Hoste, Anne Françoise Donneau, David Grimaldi, Geert Meyfroidt, Michel Moutschen, Veerle Compernolle, André Gothot, Daniel Desmecht, Mutien Garigliany, Tome Najdovski and Pierre François Laterre

Silencing of long non-coding RNA KCNQ1OT1 alleviates LPS-induced lung injury by regulating the miR-370-3p/FOXM1 axis in childhood pneumonia

Long non-coding RNAs (lncRNAs) play important roles in the development of pneumonia. We aimed to explore the role of the lncRNA KCNQ1OT1 in pneumonia and its underlying mechanisms.

Authors: Ping Wang, Haitao Zhang, Weiqing Zhao and Nini Dai

Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study

Observational studies show an association between reduced lung function and impaired cognition. Cognitive dysfunction influences important health outcomes and is a precursor to dementia, but treatments options...

Authors: Daniel H. Higbee, Raquel Granell, Gibran Hemani, George Davey Smith and James W. Dodd

Handgrip strength during admission for COPD exacerbation: impact on further exacerbation risk

Low handgrip strength (HGS) is independently associated with a higher exacerbation risk in stable chronic obstructive pulmonary disease (COPD); however, the relationship between HGS while being admitted for CO...

Authors: Chi-Tai Lee and Ping-Huai Wang

Exposure–safety analyses of nintedanib in patients with chronic fibrosing interstitial lung disease

Nintedanib reduces the rate of decline in forced vital capacity in patients with idiopathic pulmonary fibrosis (IPF), other chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype and ...

Authors: Ulrike Schmid, Benjamin Weber, Celine Sarr and Matthias Freiwald

Efficacy of treatment with corticosteroids for fibrotic hypersensitivity pneumonitis: a propensity score-matched cohort analysis

Fibrotic hypersensitivity pneumonitis (HP) is a chronic interstitial lung disease caused by allergic responses to repeated exposures to a causative antigen. Therapeutic evidence of the use of corticosteroids t...

Authors: Masaru Ejima, Tsukasa Okamoto, Takafumi Suzuki, Tatsuhiko Anzai, Kunihiko Takahashi and Yasunari Miyazaki

LINC01089 suppresses lung adenocarcinoma cell proliferation and migration via miR-301b-3p/STARD13 axis

Lung adenocarcinoma (LUAD) is one of the most common cancers with high morbidity and mortality worldwide. Long non-coding RNAs (lncRNAs) serve as tumor promoters or suppressors in the development of various hu...

Authors: Ye Qian, Yan Zhang, Haoming Ji, Yucheng Shen, Liangfeng Zheng, Shouliang Cheng and Xiaomin Lu

Residual respiratory impairment after COVID-19 pneumonia

The novel coronavirus SARS-Cov-2 can infect the respiratory tract causing a spectrum of disease varying from mild to fatal pneumonia, and known as COVID-19. Ongoing clinical research is assessing the potential...

Authors: Francesco Lombardi, Angelo Calabrese, Bruno Iovene, Chiara Pierandrei, Marialessia Lerede, Francesco Varone, Luca Richeldi and Giacomo Sgalla

Anesthesia considerations to reduce motion and atelectasis during advanced guided bronchoscopy

Partnership between anesthesia providers and proceduralists is essential to ensure patient safety and optimize outcomes. A renewed importance of this axiom has emerged in advanced bronchoscopy and intervention...

Authors: Michael A. Pritchett, Kelvin Lau, Scott Skibo, Karen A. Phillips and Krish Bhadra

Outcomes for hospitalized patients with idiopathic pulmonary fibrosis treated with antifibrotic medications

Idiopathic Pulmonary Fibrosis is a chronic, progressive interstitial lung disease for which there is no cure. However, lung function decline, hospitalizations, and mortality may be reduced with the use of the ...

Authors: Bryan T. Kelly, Viengneesee Thao, Timothy M. Dempsey, Lindsey R. Sangaralingham, Stephanie R. Payne, Taylor T. Teague, Teng Moua, Nilay D. Shah and Andrew H. Limper

Pain in Veterans with COPD: relationship with physical activity and exercise capacity

Pain is a common but underappreciated symptom experienced by people with Chronic Obstructive Pulmonary Disease (COPD). The relationships between pain and physical activity (PA) and exercise capacity are poorly...

Authors: Rebecca A. Raphaely, Maria A. Mongiardo, Rebekah L. Goldstein, Stephanie A. Robinson, Emily S. Wan and Marilyn L. Moy

Risk assessment in interstitial lung disease: the incremental prognostic value of cardiopulmonary ultrasound

The mortality risk of chronic interstitial lung disease (ILD) is currently assessed using the ILD-GAP score. The present study evaluates whether the addition of cardiopulmonary ultrasound parameters to the ILD...

Authors: Wei-wei Zhu, Hong Li, Yi-dan Li, Lanlan Sun, Lingyun Kong, Xiaoguang Ye, Qizhe Cai and Xiu-zhang Lv

Long non-coding RNA OIP5-AS1 aggravates acute lung injury by promoting inflammation and cell apoptosis via regulating the miR-26a-5p/TLR4 axis

Acute lung injury (ALI) is a pulmonary disorder that leads to acute respiration failure and thereby results in a high mortality worldwide. Increasing studies have indicated that toll-like receptor 4 (TLR4) is ...

Authors: Qingsong Sun, Man Luo, Zhiwei Gao, Xiang Han, Weiqin Wu and Hongmei Zhao

Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors

Secondary polycythemia is associated with cigarette smoking and chronic obstructive pulmonary disease (COPD). However, the prevalence of polycythemia in COPD and the contributing risk factors for polycythemia ...

Authors: Jingzhou Zhang, Dawn L. DeMeo, Edwin K. Silverman, Barry J. Make, R. Chad Wade, J. Michael Wells, Michael H. Cho and Brian D. Hobbs

LncRNA PCGEM1 induces proliferation and migration in non-small cell lung cancer cells through modulating the miR-590-3p/SOX11 axis

Non-small cell lung cancer (NSCLC) is one of the most prevalent cancers. As reported, long non-coding RNAs (lncRNAs) induce various biological behaviors in cancers. LncRNA PCGEM1 prostate-specific transcript (...

Authors: Huanshun Wen, Hongxiang Feng, Qianli Ma and Chaoyang Liang

Longitudinal trajectories of pneumonia lesions and lymphocyte counts associated with disease severity among convalescent COVID-19 patients: a group-based multi-trajectory analysis

To explore the long-term trajectories considering pneumonia volumes and lymphocyte counts with individual data in COVID-19.

Authors: Nannan Shi, Chao Huang, Qi Zhang, Chunzi Shi, Fengjun Liu, Fengxiang Song, Qinguo Hou, Jie Shen, Fei Shan, Xiaoming Su, Cheng Liu, Zhiyong Zhang, Lei Shi and Yuxin Shi

The need for race-specific reference equations for pulmonary diffusing capacity for nitric oxide

Few reference equations exist for healthy adults of various races for pulmonary diffusing capacity for nitric oxide (DLNO). The purpose of this study was to collect pilot data to demonstrate that race-specific...

Authors: Gerald Stanley Zavorsky, Ahmad Saleh Almamary, Mobarak Khalid Alqahtani, Shi Huh Samuel Shan and Douglas Shawn Gardenhire

Association between dual use of e-cigarette and cigarette and chronic obstructive pulmonary disease: an analysis of a nationwide representative sample from 2013 to 2018

The association between the dual use of electronic cigarette (e-cigarette) and conventional cigarettes (c-cigarette) and spirometry-defined chronic obstructive pulmonary disease (COPD) has not been studied tho...

Authors: Taeyun Kim and Jihun Kang

Massive haemorrhagic complications of ruptured pulmonary arteriovenous malformations: outcomes from a 12 years’ retrospective study

The life-threatening haemorrhagic complications of pulmonary arteriovenous malformations (PAVMs) are extremely rare, and only described in isolated cases. This study was designed to comprehensively investigate...

Authors: Xu Ma, Bing Jie, Dong Yu, Ling-Ling Li and Sen Jiang

A novel ferroptosis-related genes model for prognosis prediction of lung adenocarcinoma

Ferroptosis is a newly discovered form of cell death characterized by iron-dependent lipid peroxidation. This study aims to investigate the potential correlation between ferroptosis and the prognosis of lung a...

Authors: Fei Li, Dongcen Ge and Shu-lan Sun

Role of respiratory intermediate care units during the SARS-CoV-2 pandemic

The SARS-CoV2 pandemic increased exponentially the need for both Intensive (ICU) and Intermediate Care Units (RICU). The latter are of particular importance because they can play a dual role in critical and po...

Authors: Mónica Matute-Villacís, Jorge Moisés, Cristina Embid, Judith Armas, Isabel Fernández, Montserrat Medina, Miquel Ferrer, Oriol Sibila and Joan Ramón Badia

Internet search results correlate with seasonal variation of sarcoidosis

The etiology and pathophysiology of sarcoidosis remains unclear, with epidemiologic studies limited by its relatively low prevalence. The internet has prompted patients to seek information about medical diagno...

Authors: Amanda Stanton and Steven J. Katz

An update of the long-term outcome of patients with nonspecific pleurisy at medical thoracoscopy

Medical thoracoscopy (MT) is recommended in patients with undiagnosed exudative pleural effusion and offers a degree of diagnostic sensitivity for pleural malignancy. However, not all patients who undergo MT r...

Authors: Yan-Xia Yu, Yuan Yang, Yan-Bing Wu, Xiao-Juan Wang, Li-Li Xu, Zhen Wang, Feng Wang, Zhao-Hui Tong and Huan-Zhong Shi

Rheological effects of hypertonic saline and sodium bicarbonate solutions on cystic fibrosis sputum in vitro

Cystic fibrosis (CF) is a life-threatening multiorgan genetic disease, particularly affecting the lungs, where recurrent infections are the main cause of reduced life expectancy. In CF, mutations in the gene e...

Authors: Mária Budai-Szűcs, Szilvia Berkó, Anita Kovács, Pongsiri Jaikumpun, Rita Ambrus, Adrien Halász, Piroska Szabó-Révész, Erzsébet Csányi and Ákos Zsembery

Contrast-enhanced ultrasound guided pleural biopsy improves diagnostic confidence for pleural based lesions: a 3-year prospective study

To evaluate the accuracy and safety of contrast-enhanced ultrasound (CEUS) guided biopsy in the diagnosis of radiologically determined pleural based lesions.

Authors: Wenwen Sun, Yiming Zhou, Cong Yang, Zhengwei Dong, ZheMin Zhang, Yin Wang and Lin Fan

A rare case of ciliated muconodular papillary tumor accompanied with adenocarcinoma in situ

Ciliated muconodular papillary tumor (CMPT) is an incredibly rare pulmonary tumor. Currently, little is known about CMPT, and it has not yet been classified by the World Health Organization. The clinical manif...

Authors: Lei Zhao, Conner M. Willson, Nathan T. Givens, Ziwen Zhu, Mark R. Wakefield, Yongsheng Wang, Wanchun Yang and Yujiang Fang

Cerebral arterial air embolism after endobronchial electrocautery: a case report and review of the literature

Endobronchial electrocautery is a common and safe therapeutic endoscopic treatment for malignant airway obstruction. Cerebral arterial air embolism (CAAE) is a rare but potentially fatal complication of endobr...

Authors: Yu-Ping He, Yuan-Ling Liu, Xing-Lin Gao and Li-Hua Wang

Switching antifibrotics in patients with idiopathic pulmonary fibrosis: a multi-center retrospective cohort study

Currently, there are two antifibrotics used to treat idiopathic pulmonary fibrosis (IPF): pirfenidone and nintedanib. Antifibrotics slow disease progression by reducing the annual decline of forced vital capac...

Authors: Yuzo Suzuki, Kazutaka Mori, Yuya Aono, Masato Kono, Hirotsugu Hasegawa, Koshi Yokomura, Hyogo Naoi, Hironao Hozumi, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Hidenori Nakamura and Takafumi Suda