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  1. Airway eosinophilia is considered a central event in the pathogenesis of asthma. The toxic components of eosinophils are thought to be important in inducing bronchial mucosal injury and dysfunction. Previous s...

    Authors: Letícia Lintomen, Gilberto Franchi, Alexandre Nowill, Antonio Condino-Neto, Gilberto de Nucci, Angelina Zanesco and Edson Antunes
    Citation: BMC Pulmonary Medicine 2008 8:13
  2. Neutrophil products like matrix metalloproteinases (MMP), involved in bacterial defence mechanisms, possibly induce lung damage and are elevated locally during hospital- acquired pneumonia (HAP). In HAP the vi...

    Authors: Bernhard Schaaf, Cornelia Liebau, Volkhard Kurowski, Daniel Droemann and Klaus Dalhoff
    Citation: BMC Pulmonary Medicine 2008 8:12
  3. There is increasing evidence that patients with low-risk community acquired pneumonia (CAP) can be effectively treated as outpatients. This study aimed to explore patients' experiences of having pneumonia and ...

    Authors: Deborah J Baldie, Vikki A Entwistle and Peter G Davey
    Citation: BMC Pulmonary Medicine 2008 8:11
  4. Several concepts of treatment in neonatal ARDS have been proposed in the last years. The present study compared the effects of open lung concept positive pressure ventilation (PPVOLC) with a conventional ventilat...

    Authors: Anne Hilgendorff, Ece Aslan, Thomas Schaible, Ludwig Gortner, Thorsten Baehner, Michael Ebsen, Jochen Kreuder, Clemens Ruppert, Andreas Guenther and Irwin Reiss
    Citation: BMC Pulmonary Medicine 2008 8:10
  5. Hypertonic saline (HTS) reduces the severity of lung injury in ischemia-reperfusion, endotoxin-induced and ventilation-induced lung injury. However, the potential for HTS to modulate the resolution of lung inj...

    Authors: Muiris T Kennedy, Brendan D Higgins, Joseph F Costello, William A Curtin and John G Laffey
    Citation: BMC Pulmonary Medicine 2008 8:9
  6. Chronic obstructive pulmonary disease (COPD) is a significant health problem worldwide. This randomised controlled trial aims at testing a new approach that involves a registered nurse working in partnership w...

    Authors: Nicholas Zwar, Oshana Hermiz, Iqbal Hasan, Elizabeth Comino, Sandy Middleton, Sanjyot Vagholkar and Guy Marks
    Citation: BMC Pulmonary Medicine 2008 8:8
  7. The surfactant proteins B (SP-B) and C (SP-C) are important for the stability and function of the alveolar surfactant film. Their involvement and down-regulation in inflammatory processes has recently been pro...

    Authors: Oliver Tafel, Philipp Latzin, Karl Paul, Tobias Winter, Markus Woischnik and Matthias Griese
    Citation: BMC Pulmonary Medicine 2008 8:6
  8. The assessment of airway inflammation for the diagnosis of asthma or COPD is still uncommon in pneumology-specialized general practices. In this respect, the measurement of exhaled nitric oxide (NO), as a fast...

    Authors: Olaf Holz, Tanja Seiler, Andreas Karmeier, Jan Fraedrich, Helmut Leiner, Helgo Magnussen, Rudolf A Jörres and Lutz Welker
    Citation: BMC Pulmonary Medicine 2008 8:5
  9. Cardiopulmonary exercise testing (CPET) has become increasingly important as a routine procedure in daily clinical work. So far, it is generally accepted that an individualized exercise protocol with exercise ...

    Authors: Sven Gläser, Sven Lodziewski, Beate Koch, Christian F Opitz, Henry Völzke and Ralf Ewert
    Citation: BMC Pulmonary Medicine 2008 8:3
  10. The reported diagnostic yield from bronchoscopies in patients with lung cancer varies greatly. The optimal combination of sampling techniques has not been finally established.

    Authors: Kjetil Roth, Jon A Hardie, Alf H Andreassen, Friedemann Leh and Tomas ML Eagan
    Citation: BMC Pulmonary Medicine 2008 8:2
  11. As supra-physiological intake of corticosteroids is a well known risk factor for the development of adrenal insufficiency, we investigated the function of the hypothalamic-pituitary-adrenal (HPA) axis during a...

    Authors: Philipp Schuetz, Mirjam Christ-Crain, Ursula Schild, Erika Süess, Michael Facompre, Florent Baty, Charly Nusbaumer, Martin Brutsche and Beat Müller
    Citation: BMC Pulmonary Medicine 2008 8:1
  12. Alveolar volume measured according to the American Thoracic Society-European Respiratory Society (ATS-ERS) guidelines during the single breath diffusion test can be underestimated when there is maldistribution...

    Authors: Renato Prediletto, Edo Fornai, Giosuè Catapano and Cristina Carli
    Citation: BMC Pulmonary Medicine 2007 7:18
  13. The outcome of patients with bronchiectasis during and after their stay in the intensive care unit (ICU) has seldom been reported in the literature. Managing these patients in the ICU can be challenging becaus...

    Authors: Abdulaziz H Alzeer, Mohammed Masood, Syed Jani Basha and Shaffi A Shaik
    Citation: BMC Pulmonary Medicine 2007 7:17
  14. In the management of asthma, features of care important to patients may not be fully appreciated. This study quantifies the importance of different features of asthma management from the patient perspective. T...

    Authors: John Haughney, Monica Fletcher, Stephanie Wolfe, Julie Ratcliffe, Roger Brice and Martyn R Partridge
    Citation: BMC Pulmonary Medicine 2007 7:16
  15. Cardiopulmonary exercise testing (CPET) has become an important modality for the evaluation and management of patients with a diverse array of medical problems. However, interpreting these tests is often diffi...

    Authors: Robert M Ross and David B Corry
    Citation: BMC Pulmonary Medicine 2007 7:15
  16. We previously reported that NKG2A, a key inhibitory ligand for HLA-E, is expressed on activated TH2 but not TH1 cells. Here we measured cytokine expression in human ex vivo TH2 cells upon activation with anti-CD3...

    Authors: Robert J Freishtat, Bahar Mojgani, Maryam Nazemzadeh, Kanneboyina Nagaraju and Eric P Hoffman
    Citation: BMC Pulmonary Medicine 2007 7:14
  17. There is a paucity of surrogate lung-specific biological markers that can be used to track disease progression and predict clinical outcomes in chronic obstructive pulmonary disease (COPD). The principal aim o...

    Authors: Don D Sin, Rochelle Leung, Wen Q Gan and SF Paul Man
    Citation: BMC Pulmonary Medicine 2007 7:13
  18. Respiratory tract infections are common in intensive care units (ICU), with incidences reported from 10 to 65%, and case fatality rates over 20% in pneumonia. This study was designed to identify risk factors f...

    Authors: Teresa C Cardoso, Luís M Lopes and António H Carneiro
    Citation: BMC Pulmonary Medicine 2007 7:12
  19. Several strategies and devices have been designed to protect health care providers from acquiring transmissible respiratory diseases while providing care. In modulating the physical characteristics of the resp...

    Authors: Gustavo Zayas, Juan C Valle, Mauricio Alonso, Henry Alfaro, Daniel Vega, Gloria Bonilla, Miguel Reyes and Malcolm King
    Citation: BMC Pulmonary Medicine 2007 7:11
  20. Lung volume reduction surgery is effective at improving lung function, quality of life, and mortality in carefully selected individuals with advanced emphysema. Recently, less invasive bronchoscopic approaches...

    Authors: Charlie Strange, Felix JF Herth, Kevin L Kovitz, Geoffrey McLennan, Armin Ernst, Jonathan Goldin, Marc Noppen, Gerard J Criner and Frank C Sciurba
    Citation: BMC Pulmonary Medicine 2007 7:10
  21. Cycle training intensity for patients with chronic obstructive pulmonary disease (COPD) is normally based on an incremental cycle test. Such tests are expensive and not readily available to clinicians. The six...

    Authors: Muhammad R Zainuldin, Danielle Knoke, Martin G Mackey, Nia Luxton and Jennifer A Alison
    Citation: BMC Pulmonary Medicine 2007 7:9
  22. Clinical trials show that asthma can be controlled in the majority of patients, but poorly controlled asthma still imposes a considerable burden. The level of asthma control achieved reflects the behaviour of ...

    Authors: Rob Horne, David Price, Jen Cleland, Rui Costa, Donna Covey, Kevin Gruffydd-Jones, John Haughney, Svein Hoegh Henrichsen, Alan Kaplan, Arnulf Langhammer, Anders Østrem, Mike Thomas, Thys van der Molen, J Christian Virchow and Siân Williams
    Citation: BMC Pulmonary Medicine 2007 7:8
  23. Pulmonary rehabilitation programs have been shown to increase functional exercise capacity and quality of life in COPD patients. However, following the completion of pulmonary rehabilitation the benefits begin...

    Authors: Lissa M Spencer, Jennifer A Alison and Zoe J McKeough
    Citation: BMC Pulmonary Medicine 2007 7:7
  24. Surfactant proteins (SP) are important for the innate host defence and essential for a physiological lung function. Several linkage and association studies have investigated the genes coding for different surf...

    Authors: Beena Puthothu, Johannes Forster, Jessica Heinze, Andrea Heinzmann and Marcus Krueger
    Citation: BMC Pulmonary Medicine 2007 7:6
  25. Endothelin-1 (EDN1) has been involved in the development of airway obstruction and inflammation in asthma. Several polymorphisms have been identified among the genes encoding for preproET1, an inactive precurs...

    Authors: Camille Taillé, Armelle Guénégou, Abdelhamid Almolki, Marie Piperaud, Bénédicte Leynaert, Sandrine Vuillaumier, Françoise Neukirch, Jorge Boczkowski, Michel Aubier, Joëlle Benessiano and Bruno Crestani
    Citation: BMC Pulmonary Medicine 2007 7:5
  26. Despite effective treatments, asthma outcomes remain suboptimal. Interest exists in complementary therapies, particularly in herbal remedies for asthma treatment, currently with inconclusive evidence of effica...

    Authors: Michael Thomas, Jane Sheran, Natalie Smith, Sofia Fonseca and Amanda J Lee
    Citation: BMC Pulmonary Medicine 2007 7:4
  27. Benchmarking is the comparison of a process to the work or results of others. We conducted a national benchmarking exercise to determine how UK pulmonologists manage common clinical scenarios in diffuse parenc...

    Authors: Patricia Macedo, Robina K Coker and Martyn R Partridge
    Citation: BMC Pulmonary Medicine 2007 7:3
  28. Current systemic therapy for nontuberculous mycobacterial pulmonary infection is limited by poor clinical response rates, drug toxicities and side effects. The addition of aerosolized amikacin to standard oral...

    Authors: Kala K Davis, Peter N Kao, Susan S Jacobs and Stephen J Ruoss
    Citation: BMC Pulmonary Medicine 2007 7:2
  29. Individuals with severe Z α1-antitrypsin (AAT) deficiency have a considerably increased risk of developing chronic obstructive lung disease (COPD). It has been hypothesized that compensatory increases in level...

    Authors: Camilla Hollander, Ulla Westin, Anders Wallmark, Eeva Piitulainen, Tomas Sveger and Sabina M Janciauskiene
    Citation: BMC Pulmonary Medicine 2007 7:1
  30. Severe acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) is a common reason for emergency room (ER) visit about which little has been documented from India.

    Authors: Alladi Mohan, Raya Premanand, Lebaka Narayana Reddy, Mangu H Rao, Surendra K Sharma, Ranjit Kamity and Srinivas Bollineni
    Citation: BMC Pulmonary Medicine 2006 6:27
  31. Sarcoidosis is rarely associated with a distinct disease. One disease infrequently associated with sarcoidosis is psoriasis.

    Authors: Melita Nikolopoulou, Stamatis Katsenos, Kostas Psathakis, Efstathios Rallis, Dimitrios Sampaziotis, Panagiotis Panagou, Kostas Tsintiris and Demosthenes Bouros
    Citation: BMC Pulmonary Medicine 2006 6:26
  32. Allergic rhinitis (AR) and asthma are inflammatory conditions of the airways that often occur concomitantly. This global survey was undertaken to understand patient perspectives regarding symptoms, treatments,...

    Authors: Erkka Valovirta and Ruby Pawankar
    Citation: BMC Pulmonary Medicine 2006 6(Suppl 1):S3

    This article is part of a Supplement: Volume 6 Supplement 1

  33. An understanding of the needs and behaviors of asthma patients is important in developing an asthma-related healthcare policy. The primary goal of the present review was to assess patient perspectives on key i...

    Authors: Stephen T Holgate, David Price and Erkka Valovirta
    Citation: BMC Pulmonary Medicine 2006 6(Suppl 1):S2

    This article is part of a Supplement: Volume 6 Supplement 1

    The Erratum to this article has been published in Primary Care Respiratory Journal 1998 6:pcrj199815

  34. Primary ciliary dyskinesia (PCD) is a chronic respiratory disease for which there is little psycho-social research and no qualitative studies of individuals living with the condition. A questionnaire-based sur...

    Authors: Simon Whalley and IC McManus
    Citation: BMC Pulmonary Medicine 2006 6:25
  35. Asthma and allergic diseases are becoming increasingly frequent in children in urban centres of Latin America although the prevalence of allergic disease is still low in rural areas. Understanding better why t...

    Authors: Philip J Cooper, Martha E Chico, Maritza G Vaca, Alejandro Rodriguez, Neuza M Alcântara-Neves, Bernd Genser, Lain Pontes de Carvalho, Renato T Stein, Alvaro A Cruz, Laura C Rodrigues and Mauricio L Barreto
    Citation: BMC Pulmonary Medicine 2006 6:24
  36. Several studies investigated the association of anemia with health related quality of life (HRQL) in patients with chronic disease. However, there is little evidence regarding the association of anemia with HR...

    Authors: Gokul Krishnan, Brydon J Grant, Paola C Muti, Archana Mishra, Heather M Ochs-Balcom, Jo L Freudenheim, Maurizio Trevisan and Holger J Schünemann
    Citation: BMC Pulmonary Medicine 2006 6:23
  37. To evaluate the diagnostic accuracy of the integrated Practical Approach to Lung Health in South Africa (PALSA) guideline in identifying patients requiring bacteriological screening for tuberculosis (TB), and ...

    Authors: René G English, Max O Bachmann, Eric D Bateman, Merrick F Zwarenstein, Lara R Fairall, Angeni Bheekie, Bosielo P Majara, Carl Lombard, Robert Scherpbier and Salah Eddine Ottomani
    Citation: BMC Pulmonary Medicine 2006 6:22
  38. A design concept of low-cost, simple, fully mechanical model of a mechanically ventilated, passively breathing lung is developed. An example model is built to simulate a patient under mechanical ventilation wi...

    Authors: J Geoffrey Chase, Toshinori Yuta, Kerry J Mulligan, Geoffrey M Shaw and Beverley Horn
    Citation: BMC Pulmonary Medicine 2006 6:21
  39. In ventilated newborns the use of multiple breath washout (MBW) techniques for measuring both lung volume and ventilation inhomogeneity (VI) is hampered by the comparatively high dead space fraction. We studie...

    Authors: G Schmalisch, H Proquitté, CC Roehr and RR Wauer
    Citation: BMC Pulmonary Medicine 2006 6:20
  40. Anemic syndrome is a frequent problem in intensive care units. The most probable etiology is the suppression of the erythropoietin response due to the direct effects of cytokines, as well as frequent blood sam...

    Authors: David Yepes, Bladimir Gil, Olga Hernandez, Rodrigo Murillo, Marco Gonzalez and Juan Pablo Velasquez
    Citation: BMC Pulmonary Medicine 2006 6:18
  41. The inhalation of normal or hypertonic saline during sputum induction (SI) may act as an indirect bronchoconstrictive stimulus leading to dyspnea and lung function deterioration. Our aim was to assess dyspnea ...

    Authors: Demosthenes Makris, Nikolaos Tzanakis, Joanna Moschandreas and Nikolaos M Siafakas
    Citation: BMC Pulmonary Medicine 2006 6:17
  42. Detecting serum antibody against inhaled antigens is an important diagnostic adjunct for hypersensitivity pneumonitis (HP). We sought to validate a quantitative fluorimetric assay testing serum from bird fanci...

    Authors: Charles McSharry, George M Dye, Tengku Ismail, Kenneth Anderson, Elizabeth M Spiers and Gavin Boyd
    Citation: BMC Pulmonary Medicine 2006 6:16

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