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  1. Aspiration pneumonia has been a growing interest in an aging population. Anaerobes are important pathogens, however, the etiology of aspiration pneumonia is not fully understood. In addition, the relationship ...

    Authors: Kentaro Akata, Kazuhiro Yatera, Kei Yamasaki, Toshinori Kawanami, Keisuke Naito, Shingo Noguchi, Kazumasa Fukuda, Hiroshi Ishimoto, Hatsumi Taniguchi and Hiroshi Mukae
    Citation: BMC Pulmonary Medicine 2016 16:79
    Content type: Research article Published on:

  3. Although the heterogeneous nature of asthma has prompted asthma phenotyping with physiological or biomarker data, these studies have been mostly cross-sectional. Longitudinal studies that assess the stability ...

    Authors: T. Zaihra, C. J. Walsh, S. Ahmed, C. Fugère, Q. A. Hamid, R. Olivenstein, J. G. Martin and A. Benedetti
    Citation: BMC Pulmonary Medicine 2016 16:74
    Content type: Research article Published on:

  4. Single nucleotide polymorphisms (SNPs) in the genes encoding the vitamin D receptor (VDR) and the vitamin D binding protein (DBP) have been reported to modify the influence of vitamin D deficiency on susceptibili...

    Authors: Kashaf Junaid, Abdul Rehman, David A. Jolliffe, Tahir Saeed, Kristie Wood and Adrian R. Martineau
    Citation: BMC Pulmonary Medicine 2016 16:73
    Content type: Research article Published on:

  5. Adult onset of Still’s disease (AOSD) is a rare systemic inflammatory disease. Cardiorespiratory complications are mainly represented by pleural and pericardial disorders and are less frequent than cutaneous a...

    Authors: L. Guilleminault, S. Laurent, A. Foucher, P. Poubeau and F. Paganin
    Citation: BMC Pulmonary Medicine 2016 16:72
    Content type: Case report Published on:

  6. Meigs’ syndrome is defined as the presence of a benign ovarian tumor with pleural effusion and ascites that resolve after removal of the tumor. The pathogenesis of the production of ascites and pleural effusio...

    Authors: Kenichi Okuda, Satoshi Noguchi, Osamu Narumoto, Masako Ikemura, Yasuhiro Yamauchi, Goh Tanaka, Daiya Takai, Masashi Fukayama and Takahide Nagase
    Citation: BMC Pulmonary Medicine 2016 16:71
    Content type: Case report Published on:

  7. Chronic Obstructive Pulmonary Disease (COPD) influences different aspects of patient’s health-related quality of life (HRQL). While disease-specific HRQL instruments focus on symptoms and functional impairment...

    Authors: Margarethe E. Wacker, Rudolf A. Jörres, Annika Karch, Sarah Wilke, Joachim Heinrich, Stefan Karrasch, Armin Koch, Holger Schulz, Henrik Watz, Reiner Leidl, Claus Vogelmeier and Rolf Holle
    Citation: BMC Pulmonary Medicine 2016 16:70
    Content type: Research article Published on:

  8. Endotoxin from Gram-negative bacteria are found in different concentrations in dust and on the ground of laboratories dealing with small animals and animal houses.

    Authors: Amanda Souza Freitas, Christian Silva Simoneti, Erica Ferraz, Ericson Bagatin, Izaira Tincani Brandão, Celio Lopes Silva, Marcos Carvalho Borges and Elcio Oliveira Vianna
    Citation: BMC Pulmonary Medicine 2016 16:69
    Content type: Research article Published on:

  10. Periostin levels are associated with airway eosinophilia and are suppressed by corticosteroid treatment in asthma. This study sought to determine the relationship between serum and sputum periostin, airway inf...

    Authors: Jodie L. Simpson, Ian A. Yang, John W. Upham, Paul N. Reynolds, Sandra Hodge, Alan L. James, Christine Jenkins, Matthew J. Peters, Guiquan Jia, Cecile T. J. Holweg and Peter G. Gibson
    Citation: BMC Pulmonary Medicine 2016 16:67
    Content type: Research article Published on:

  11. Many patients with asthma require frequent rescue medication for acute symptoms despite appropriate controller therapies. Thus, determining the most effective relief regimen is important in the management of m...

    Authors: James F. Donohue, Robert Wise, William W. Busse, Sandra Garfinkel, Valentina B. Zubek, Mo Ghafouri, Raymond C. Manuel, Rozsa Schlenker-Herceg and Eugene R. Bleecker
    Citation: BMC Pulmonary Medicine 2016 16:65
    Content type: Research article Published on:

  12. Determining physicians’ awareness about alpha-1 antitrypsin (AAT) deficiency (AATD) may help to explain the discrepancy between the observed and expected number of patients diagnosed with this disease.

    Authors: Cristina Esquinas, Miriam Barrecheguren, Maria Sucena, Esther Rodriguez, Sandra Fernandez and Marc Miravitlles
    Citation: BMC Pulmonary Medicine 2016 16:64
    Content type: Research article Published on:

  13. Previous studies have observed that exercise-induced bronchoconstriction (EIB) is more common and more strongly related to exercise related breathing problems in female adolescents than male adolescents. Howev...

    Authors: Henrik Johansson, Katarina Norlander, Christer Janson, Andrei Malinovschi, Leif Nordang and Margareta Emtner
    Citation: BMC Pulmonary Medicine 2016 16:63
    Content type: Research article Published on:

  14. The evaluation of solitary pulmonary lesions (SPL) requires a balance between procedure-related morbidity and diagnostic yield, particularly in areas where tuberculosis (TB) is endemic. Data on ultrathin bronc...

    Authors: Daniel Franzen, Andreas H. Diacon, Lutz Freitag, Pawel T. Schubert, Colleen A. Wright and Macé M. Schuurmans
    Citation: BMC Pulmonary Medicine 2016 16:62
    Content type: Research article Published on:

  15. A national program for the treatment of severe allergic (IgE-dependent) asthma with omalizumab (OMA) was implemented in Poland in 2013. This observational study evaluated the effectiveness of the Polish OMA pr...

    Authors: Izabela Kupryś-Lipińska, Paweł Majak, Joanna Molinska and Piotr Kuna
    Citation: BMC Pulmonary Medicine 2016 16:61
    Content type: Research article Published on:

  16. Electromagnetic navigation bronchoscopy (ENB) procedures allow physicians to access peripheral lung lesions beyond the reach of conventional bronchoscopy. However, published research is primarily limited to sm...

    Authors: Erik E. Folch, Mark R. Bowling, Thomas R. Gildea, Kristin L. Hood, Septimiu D. Murgu, Eric M. Toloza, Momen M. Wahidi, Terence Williams and Sandeep J. Khandhar
    Citation: BMC Pulmonary Medicine 2016 16:60
    Content type: Study protocol Published on:

  17. In acute respiratory distress syndrome (ARDS), gas exchange and respiratory system mechanics (compliance) are severely impaired. Besides ventilatory parameters, the degree of respiratory abnormality can be inf...

    Authors: Nils Siegenthaler, Raphael Giraud, Delphine S. Courvoisier, Claes U. Wiklund and Karim Bendjelid
    Citation: BMC Pulmonary Medicine 2016 16:59
    Content type: Research article Published on:

  18. Approximately 40–60 % of patients remain sufferers of sequela of obstructive, restrictive or mixed patterns of lung disease despite treatment for pulmonary tuberculosis (PTB). The prevalence of these abnormali...

    Authors: Mohamed Manji, Grace Shayo, Simon Mamuya, Rose Mpembeni, Ahmed Jusabani and Ferdinand Mugusi
    Citation: BMC Pulmonary Medicine 2016 16:58
    Content type: Research article Published on:

  19. Burkholderia contaminans is an emerging pathogen in the cystic fibrosis (CF) setting. Included in the Burkholderia cepacia complex (Bcc), B. contaminans is a Gram negative, motile, obligate aerobe previously clas...

    Authors: Rachel F. Power, Barry Linnane, Ruth Martin, Noelle Power, Peig Harnett, Brian Casserly, Nuala H. O’Connell and Colum P. Dunne
    Citation: BMC Pulmonary Medicine 2016 16:57
    Content type: Case report Published on:

  20. Asthma is among the most common chronic diseases in adults. International guidelines have emphasized the importance of regular spirometry for asthma control evaluation. However, spirometry use in primary care ...

    Authors: Samir Gupta, Dilshad Moosa, Ana MacPherson, Christopher Allen and Itamar E. Tamari
    Citation: BMC Pulmonary Medicine 2016 16:56
    Content type: Research article Published on:

  21. Pulmonary hypertension (PH) can develop in connective tissue disease associated interstitial lung disease (CTD-ILD), and contributes to increased morbidity and mortality. However, except for systemic sclerosis...

    Authors: Kota Takahashi, Hiroyuki Taniguchi, Masahiko Ando, Koji Sakamoto, Yasuhiro Kondoh, Naohiro Watanabe, Tomoki Kimura, Kensuke Kataoka, Atsushi Suzuki, Satoru Ito and Yoshinori Hasegawa
    Citation: BMC Pulmonary Medicine 2016 16:55
    Content type: Research article Published on:

  22. Late-onset asthma (onset > 12 years) is pathologically distinct from early-onset asthma. The mechanism of air pollution is not a classic allergic inflammation and could have differential effect on late-onset a...

    Authors: Tsung-Ju Wu, Chang-Fu Wu, Bing-Yu Chen, Yungling Leo Lee and Yue Leon Guo
    Citation: BMC Pulmonary Medicine 2016 16:54
    Content type: Research article Published on:

  23. Tracheobronchial stenosis is a known complication of endobronchial tuberculosis. Despite antituberculous and steroid therapy, the development of bronchial stenosis is usually irreversible and requires airway p...

    Authors: Mohamed Faisal, Hafaruzi Harun, Tidi M. Hassan, Andrea Y. L. Ban, Sanjay H. Chotirmall and Jamalul Azizi Abdul Rahaman
    Citation: BMC Pulmonary Medicine 2016 16:53
    Content type: Case report Published on:

  24. Pulmonary infections caused by Pneumocystis jirovecii in immunocompromised host can be associated with cysts, pneumatoceles and air leaks that can progress to pneumomediastinum and pneumothoraxes. In such case...

    Authors: Husain Shabbir Ali, Ibrahim Fawzy Hassan and Saibu George
    Citation: BMC Pulmonary Medicine 2016 16:52
    Content type: Case report Published on:

  25. CD248 or Endosialin is a transmembrane molecule expressed in stromal cells binding to extracellular matrix (ECM) components. It has been previously implicated in kidney fibrosis, rheumatoid arthritis as well a...

    Authors: Domokos Bartis, Louise E. Crowley, Vijay K. D’Souza, Lee Borthwick, Andrew J. Fisher, Adam P. Croft, Judit E. Pongrácz, Richard Thompson, Gerald Langman, Christopher D. Buckley and David R. Thickett
    Citation: BMC Pulmonary Medicine 2016 16:51
    Content type: Research article Published on:

  26. This study aims to find out whether extracellular miRNAs is implicated in recurrent childhood wheezing with asthmatic risk.

    Authors: Congshan Jiang, Hongchuan Yu, Qingzhu Sun, Wenhua Zhu, Jing Xu, Ning Gao, Rui Zhang, Li Liu, Xiaoying Wu, Xudong Yang, Liesu Meng and Shemin Lu
    Citation: BMC Pulmonary Medicine 2016 16:50
    Content type: Research article Published on:

  27. Insulinoma associated-1 (INSM1) gene is expressed exclusively in early embryonic neuroendocrine tissues, but has been found highly re-activated in most of the neuroendocrine tumors including small cell lung carci...

    Authors: Chiachen Chen, Mary B. Breslin and Michael S. Lan
    Citation: BMC Pulmonary Medicine 2016 16:49
    Content type: Research article Published on:

  28. There is very little information available on a national level as to the number of people exposed to specific asthmagens in workplaces.

    Authors: Lin Fritschi, Julie Crewe, Ellie Darcey, Alison Reid, Deborah C. Glass, Geza P. Benke, Tim Driscoll, Susan Peters, Si Si, Michael J. Abramson and Renee N. Carey
    Citation: BMC Pulmonary Medicine 2016 16:48
    Content type: Research article Published on:

  29. Objectives of this study were to evaluate the prevalence of thoracic pain in patients with chronic obstructive pulmonary disease (COPD) and its relationship with Forced Expiratory Volume in the first second (FEV1

    Authors: D. J. A. Janssen, E. F. M. Wouters, Y. Lozano Parra, K. Stakenborg and F. M. E. Franssen
    Citation: BMC Pulmonary Medicine 2016 16:47
    Content type: Research article Published on:

  30. The technique of induced sputum has allowed to subdivide asthma patients into inflammatory phenotypes according to their level of granulocyte airway infiltration. There are very few studies which looked at det...

    Authors: Sophie Demarche, Florence Schleich, Monique Henket, Virginie Paulus, Thierry Van Hees and Renaud Louis
    Citation: BMC Pulmonary Medicine 2016 16:46
    Content type: Research article Published on:

  31. Despite the progress seen in the last decade in diagnosis and treatment, lung cancer has still a bad prognosis and a substantial number of patients died within the weeks following diagnosis. The objective of t...

    Authors: Michel Grivaux, Didier Debieuvre, Dominique Herman, Christine Lemonnier, Jean-Michel Marcos, Jacky Crequit, Sylvie Vuillermoz-Blas, Patricia Barre, Marie Saillour and Francis Martin
    Citation: BMC Pulmonary Medicine 2016 16:45
    Content type: Research article Published on:

  33. There is a lack of studies comparing the utility of C-reactive protein (CRP) with Procalcitonin (PCT) for the management of patients with acute respiratory tract infections (ARI) in primary care. Our aim was t...

    Authors: Marc Meili, Alexander Kutz, Matthias Briel, Mirjam Christ-Crain, Heiner C. Bucher, Beat Mueller and Philipp Schuetz
    Citation: BMC Pulmonary Medicine 2016 16:43
    Content type: Research article Published on:

  34. Budesonide and formoterol (BF) Spiromax® is a dry powder inhaler designed to deliver BF with maximum ease of use for patients with asthma or chronic obstructive pulmonary disease.

    Authors: J. Christian Virchow, Roberto Rodriguez-Roisin, Alberto Papi, Tushar P. Shah and Gokul Gopalan
    Citation: BMC Pulmonary Medicine 2016 16:42
    Content type: Research article Published on:

  35. Indwelling pleural catheters (IPC) are increasingly becoming a first-line treatment in the management of malignant pleural effusions. Ambulatory management using IPC are increasingly used in this patient group...

    Authors: Charleen Chan Wah Hak, Parthipan Sivakumar and Liju Ahmed
    Citation: BMC Pulmonary Medicine 2016 16:41
    Content type: Research article Published on:

  36. Ventilator-associated respiratory infections (tracheobronchitis, pneumonia) contribute significant morbidity and mortality to adults receiving care in intensive care units (ICU). Administration of broad-spectr...

    Authors: Christopher J. Russell, Mark S. Shiroishi, Elizabeth Siantz, Brian W. Wu and Cecilia M. Patino
    Citation: BMC Pulmonary Medicine 2016 16:40
    Content type: Research article Published on:

  37. No mortality prediction rule is suited for non-elderly patients with community-acquired pneumonia. Therefore, we tried to create a mortality prediction rule that is simple and suitable for non-elderly patients...

    Authors: Masato Tashiro, Kiyohide Fushimi, Takahiro Takazono, Shintaro Kurihara, Taiga Miyazaki, Misuzu Tsukamoto, Katsunori Yanagihara, Hiroshi Mukae, Takayoshi Tashiro, Shigeru Kohno and Koichi Izumikawa
    Citation: BMC Pulmonary Medicine 2016 16:39
    Content type: Research article Published on:

  38. Nintedanib is a multi-target receptor tyrosine kinase inhibitor. In two recent randomized phase 3 trials (INPULSISâ„¢-1 and -2), it has been shown to slow the disease progression of idiopathic pulmonary fibrosis...

    Authors: Satoshi Ikeda, Akimasa Sekine, Tomohisa Baba, Hideaki Yamakawa, Masato Morita, Hideya Kitamura and Takashi Ogura
    Citation: BMC Pulmonary Medicine 2016 16:38
    Content type: Case report Published on:

  39. Obstructive sleep apnea (OSA) is severely affected by visceral adiposity (VA) that correlates to another disorder—metabolic syndrome (MetS). However, little is known concerning the relation of visceral adiposi...

    Authors: Gong-Ping Chen, Jia-Chao Qi, Bi-Ying Wang, Xin Lin, Xiao-Bin Zhang, Jian-Ming Zhao, Xiao Fang Chen, Ting Lin, Dong-Dong Chen and Qi-Chang Lin
    Citation: BMC Pulmonary Medicine 2016 16:37
    Content type: Research article Published on:

  41. Chronic Obstructive Pulmonary Disease is one of the commonest respiratory diseases in the United Kingdom, accounting for 10 % of unplanned hospital admissions each year. Nearly a third of these admitted patien...

    Authors: M. J. E. Chalder, C. L. Wright, K. J. P. Morton, P. Dixon, A. R. Daykin, S. Jenkins, J. Benger, J. Calvert, A. Shaw, C. Metcalfe, W. Hollingworth and S. Purdy
    Citation: BMC Pulmonary Medicine 2016 16:35
    Content type: Study protocol Published on:

  42. The aim of this study was to assess the association of lung function with serum fatty-acid binding protein 4 (FABP4) in apparently healthy Korean adults.

    Authors: Hye-Jeong Park, Se Eun Park, Cheol-Young Park, Seong Yong Lim, Won-Young Lee, Ki-Won Oh, Sung-Woo Park and Eun-Jung Rhee
    Citation: BMC Pulmonary Medicine 2016 16:34
    Content type: Research article Published on:

  43. Zambia is currently experiencing an epidemiological transition, from communicable to non-communicable diseases. The annual rate of physician-diagnosed asthma is estimated at 3 %. However, the general public’s ...

    Authors: Emilia Jumbe Marsden, Somwe Wa Somwe, Chishala Chabala, Joan B. Soriano, Cesar Picado Vallès and Julio Anchochea
    Citation: BMC Pulmonary Medicine 2016 16:33
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Pulmonary Medicine 2016 16:44

  44. In chronic obstructive pulmonary disease, the prognosis for patients who have survived an episode of acute hypercapnic respiratory failure due to an exacerbation is poor. Despite being shown to improve surviva...

    Authors: Kasper Linde Ankjærgaard, Philip Tønnesen, Lars Christian Laursen, Ejvind Frausing Hansen, Helle Frost Andreassen and Jon Torgny Wilcke
    Citation: BMC Pulmonary Medicine 2016 16:32
    Content type: Study protocol Published on:

  45. Mitochondria contain their own DNA (MtDNA) that is very sensitive to oxidative stress and as a consequence could be damaged in quantity. Oxidative stress is largely recognized to play a key role in the pathoge...

    Authors: G. E. Carpagnano, D. Lacedonia, M. Malerba, G. A. Palmiotti, G. Cotugno, M. Carone and M. P. Foschino-Barbaro
    Citation: BMC Pulmonary Medicine 2016 16:31
    Content type: Research article Published on:

  46. Paradoxical inflammations during anti-TNF-α therapy are defined as adverse effects such as psoriasiform skin lesions, uveitis and sarcoidosis-like granulomas induced by immune reactions, not by infectious agen...

    Authors: Tadahisa Numakura, Tsutomu Tamada, Masayuki Nara, Soshi Muramatsu, Koji Murakami, Toshiaki Kikuchi, Makoto Kobayashi, Miho Muroi, Tatsuma Okazaki, Sho Takagi, Yoshinobu Eishi and Masakazu Ichinose
    Citation: BMC Pulmonary Medicine 2016 16:30
    Content type: Case report Published on:

  47. Acute stroke patients suffering from aspiration may present with acute respiratory distress syndrome (ARDS). There is still a lack of convincing data about the efficacy of corticosteroids in the treatment of a...

    Authors: Jiang-nan Zhao, Yao Liu and Huai-chen Li
    Citation: BMC Pulmonary Medicine 2016 16:29
    Content type: Research article Published on:

  48. Despite inhaled medications that decrease exacerbation risk, some COPD patients experience frequent exacerbations. We determined prospective risk factors for exacerbations among subjects in the COPDGene Study ...

    Authors: Robert Busch, MeiLan K. Han, Russell P. Bowler, Mark T. Dransfield, J Michael Wells, Elizabeth A. Regan and Craig P. Hersh
    Citation: BMC Pulmonary Medicine 2016 16:28
    Content type: Research article Published on:

  49. Cigarette smoking-induced oxidative stress is known to be a key mechanism in COPD pathogenesis. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a central transcription factor that regulates the antioxida...

    Authors: Kazuhiro Yamada, Kazuhisa Asai, Fumihiro Nagayasu, Kanako Sato, Naoki Ijiri, Naoko Yoshii, Yumiko Imahashi, Tetsuya Watanabe, Yoshihiro Tochino, Hiroshi Kanazawa and Kazuto Hirata
    Citation: BMC Pulmonary Medicine 2016 16:27
    Content type: Research article Published on:

  50. Oxygen desaturation during exercise is common in people with chronic obstructive pulmonary disease (COPD). The aim of the study is to determine, in people with COPD who desaturate during exercise, whether supp...

    Authors: Jennifer A Alison, Zoe J McKeough, Sue C Jenkins, Anne E Holland, Kylie Hill, Norman R Morris, Regina WM Leung, Kathleen A Williamson, Lissa M Spencer, Catherine J Hill, Annemarie L Lee, Helen Seale, Nola Cecins and Christine F McDonald
    Citation: BMC Pulmonary Medicine 2016 16:25
    Content type: Study protocol Published on:
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BMC Pulmonary Medicine

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