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  1. Research article

    Efficacy of 1, 5, and 20 mg oral sildenafil in the treatment of adults with pulmonary arterial hypertension: a randomized, double-blind study with open-label extension

    In a previous study, 6-minute walk distance (6MWD) improvement with sildenafil was not dose dependent at the 3 doses tested (20, 40, and 80 mg 3 times daily [TID]). This study assessed whether lower doses were...

    Carmine Dario Vizza, B. K. S. Sastry, Zeenat Safdar, Lutz Harnisch, Xiang Gao, Min Zhang, Manisha Lamba and Zhi-Cheng Jing

    BMC Pulmonary Medicine 2017 17:44

    Published on: 23 February 2017

  2. Research article

    Persistent asthma phenotype related with late-onset, high atopy, and low socioeconomic status in school-aged Korean children

    Treatment guidelines for asthma have been established based on asthma severity; there are limitations in the identification of underlying pathophysiology and prediction of prognosis in heterogeneous phenotypes...

    Eun Lee, Si Hyeon Lee, Ji-Won Kwon, Young-Ho Kim, Jisun Yoon, Hyun-Ju Cho, Song-I Yang, Young-Ho Jung, Hyung Young Kim, Ju-Hee Seo, Hyo Bin Kim, So Yeon Lee, Ho-Jang Kwon and Soo-Jong Hong

    BMC Pulmonary Medicine 2017 17:45

    Published on: 23 February 2017

  3. Case report

    Birt–Hogg–Dubé syndrome: a literature review and case study of a Chinese woman presenting a novel FLCN mutation

    The Birt–Hogg–Dubé (BHD) syndrome is a very rare autosomal dominant form of genodermatosis caused by germline mutations in the folliculin (FLCN) gene, which is mapped to the p11.2 region in chromosome 17. BHD com...

    Shengyu Hao, Fei Long, Fenglan Sun, Teng Liu, Daowei Li and Shujuan Jiang

    BMC Pulmonary Medicine 2017 17:43

    Published on: 21 February 2017

  4. Research article

    Characteristics and longitudinal progression of chronic obstructive pulmonary disease in GOLD B patients

    The characteristics and natural history of GOLD B COPD patients are not well described. The clinical characteristics and natural history of GOLD B patients over 1 year in a multicentre cohort of COPD patients ...

    Philip J. Lawrence, Umme Kolsum, Vandana Gupta, Gavin Donaldson, Richa Singh, Bethan Barker, Leena George, Adam Webb, Anthony J. Brookes, Christopher Brightling, Jadwiga Wedzicha and Dave Singh

    BMC Pulmonary Medicine 2017 17:42

    Published on: 20 February 2017

  5. Research article

    Cooking smoke and respiratory symptoms of restaurant workers in Thailand

    Restaurant workers are at risk from exposure to toxic compounds from burning of fuel and fumes from cooking. However, the literature is almost silent on the issue. What discussion that can be found in the lite...

    Chudchawal Juntarawijit and Yuwayong Juntarawijit

    BMC Pulmonary Medicine 2017 17:41

    Published on: 17 February 2017

  6. Case report

    Elderly-onset hereditary pulmonary alveolar proteinosis and its cytokine profile

    Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by surfactant accumulation, and is caused by disruption of granulocyte/macrophage colony-stimulating factor (GM-CSF) signaling. Abnorma...

    Masayuki Ito, Kazuyuki Nakagome, Hiromitsu Ohta, Keiichi Akasaka, Yoshitaka Uchida, Atsushi Hashimoto, Ayako Shiono, Toshinori Takada, Makoto Nagata, Jun Tohyama, Koichi Hagiwara, Minoru Kanazawa, Koh Nakata and Ryushi Tazawa

    BMC Pulmonary Medicine 2017 17:40

    Published on: 17 February 2017

  7. Research article

    Upregulation of interleukin-33 and thymic stromal lymphopoietin levels in the lungs of idiopathic pulmonary fibrosis

    Innate T helper type 2 (Th2) immune responses mediated by interleukin (IL)-33, thymic stromal lymphopoietin (TSLP), and IL-25 have been shown to play an important role in pulmonary fibrosis of animal models; h...

    Jong-Uk Lee, Hun Soo Chang, Hyeon Ju Lee, Chang An Jung, Da Jeong Bae, Hyun Ji Song, Jong Sook Park, Soo-Taek Uh, Young Hoon Kim, Ki-Hyun Seo and Choon-Sik Park

    BMC Pulmonary Medicine 2017 17:39

    Published on: 15 February 2017

  8. Case report

    Extracorporeal membrane oxygenation for avian influenza A (H7N9) patient with acute respiratory distress syndrome: a case report and short literature review

    Extracorporeal membrane oxygenation (ECMO) is performed as an acceptable life-saving bridging procedure in patients with severe acute respiratory distress syndrome (ARDS).To patients with avian influenza A (H7...

    Qi Nie, Ding-yu Zhang, Wen-juan Wu, Chao-lin Huang and Zheng-yi Ni

    BMC Pulmonary Medicine 2017 17:38

    Published on: 14 February 2017

  9. Research article

    Observation management of pulmonary embolism and agreement with claims-based and clinical risk stratification criteria in United States patients: a retrospective analysis

    Guidelines suggest observation stays are appropriate for pulmonary embolism (PE) patients at low-risk for early mortality. We sought to assess agreement between United States (US) observation management of PE ...

    Elaine Nguyen, Craig I. Coleman, W. Frank Peacock, Philip S. Wells, Erin R. Weeda, Veronica Ashton, Concetta Crivera, Peter Wildgoose, Jeff R. Schein, Thomas J. Bunz and Gregory J. Fermann

    BMC Pulmonary Medicine 2017 17:37

    Published on: 13 February 2017

  10. Study protocol

    Early detection of COPD patients in GOLD 0 population: an observational non-interventional cohort study - MARKO study

    Main risk factor for the development of chronic obstructive pulmonary disease (COPD) is smoking, although only less than 1/3 of smokers develop clinically manifest COPD. COPD’s progressive nature with high dis...

    Žarko Vrbica, Marina Labor, Ivan Gudelj, Slavica Labor, Iva Jurić and Davor Plavec

    BMC Pulmonary Medicine 2017 17:36

    Published on: 10 February 2017

  11. Research article

    Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome

    Clinical trials have, so far, failed to establish clear beneficial outcomes of recruitment maneuvers (RMs) on patient mortality in acute respiratory distress syndrome (ARDS), and the effects of RMs on the card...

    Anup Das, Mainul Haque, Marc Chikhani, Oana Cole, Wenfei Wang, Jonathan G. Hardman and Declan G. Bates

    BMC Pulmonary Medicine 2017 17:34

    Published on: 8 February 2017

  12. Research article

    IL-8 predicts early mortality in patients with acute hypercapnic respiratory failure treated with noninvasive positive pressure ventilation

    Patients with Acute Hypercapnic Respiratory Failure (AHRF) who are unresponsive to appropriate medical treatment, are often treated with Noninvasive Positive Pressure Ventilation (NPPV). Clinical predictors of...

    Brynja Jónsdóttir, Åsa Jaworowski, Carmen San Miguel and Olle Melander

    BMC Pulmonary Medicine 2017 17:35

    Published on: 8 February 2017

  13. Case report

    First time identification of Pandoraea sputorum from a patient with cystic fibrosis in Argentina: a case report

    Pandoraea species are considered emerging pathogens in the context of cystic fibrosis (CF) and are difficult to identify by conventional biochemical methods. These multidrug resistant ...

    Pablo F. Martina, Mónica Martínez, Guillermo Frada, Florencia Alvarez, Lorena Leguizamón, Claudia Prieto, Carolina Barrias, Marisa Bettiol, Antonio Lagares, Alejandra Bosch, Julián Ferreras and Martha Von Specht

    BMC Pulmonary Medicine 2017 17:33

    Published on: 7 February 2017

  14. Research article

    Combined cumulative sum (CUSUM) and chronological environmental analysis as a tool to improve the learning environment for linear-probe endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) trainees: a pilot study

    Cumulative sum (CUSUM) analysis can be used to continuously monitor the performance of an individual or process and detect deviations from a preset or standard level of achievement. However, no previous study ...

    Yasuhiro Norisue, Yasuharu Tokuda, Mayrol Juarez, Ryo Uchimido, Shigeki Fujitani and David A. Stoeckel

    BMC Pulmonary Medicine 2017 17:32

    Published on: 7 February 2017

  15. Research article

    Effect of inhaled corticosteroid particle size on asthma efficacy and safety outcomes: a systematic literature review and meta-analysis

    Inhaled corticosteroids (ICS) are the primary treatment for persistent asthma. Currently available ICS have differing particle size due to both formulation and propellant, and it has been postulated that this ...

    Céline El Baou, Rachael L. Di Santostefano, Rafael Alfonso-Cristancho, Elizabeth A Suarez, David Stempel, Mark L Everard and Neil Barnes

    BMC Pulmonary Medicine 2017 17:31

    Published on: 7 February 2017

  16. Research article

    Hemosiderin-laden macrophages are an independent factor correlated with pulmonary vascular resistance in idiopathic pulmonary fibrosis: a case control study

    Increases in hemosiderin-laden macrophages (HLM) are reported to be observed in idiopathic pulmonary fibrosis (IPF). According to a recent study, significant correlation between hemosiderin deposition in the l...

    Jun Fukihara, Hiroyuki Taniguchi, Masahiko Ando, Yasuhiro Kondoh, Tomoki Kimura, Kensuke Kataoka, Taiki Furukawa, Takeshi Johkoh, Junya Fukuoka, Koji Sakamoto and Yoshinori Hasegawa

    BMC Pulmonary Medicine 2017 17:30

    Published on: 6 February 2017

  17. Research article

    Early exposure to hyperoxia and mortality in critically ill patients with severe traumatic injuries

    Hyperoxia is common early in the course of resuscitation of critically ill patients. It has been associated with mortality in some, but not all, studies of cardiac arrest patients and other critically ill coho...

    Derek W. Russell, David R. Janz, William L. Emerson, Addison K. May, Gordon R. Bernard, Zhiguo Zhao, Tatsuki Koyama and Lorraine B. Ware

    BMC Pulmonary Medicine 2017 17:29

    Published on: 3 February 2017

  18. Research article

    Development of a respiratory severity score for hospitalized adults in a high HIV-prevalence setting—South Africa, 2010–2011

    Acute lower respiratory tract infections (LRTI) are a frequent cause of hospitalization and mortality in South Africa; however, existing respiratory severity scores may underestimate mortality risk in HIV-infe...

    Alexander J. Millman, Adena Greenbaum, Sibongile Walaza, Adam L. Cohen, Michelle J. Groome, Carrie Reed, Meredith McMorrow, Stefano Tempia, Marietjie Venter, Florette K. Treurnicht, Shabir A. Madhi, Cheryl Cohen and Ebrahim Variava

    BMC Pulmonary Medicine 2017 17:28

    Published on: 2 February 2017

  19. Research article

    Airway wall thickness on HRCT scans decreases with age and increases with smoking

    To investigate if age, gender and smoking are associated with airway wall thickness (AWT) measured by high resolution computed tomography (HRCT) and if higher AWT is associated with lower levels of pulmonary f...

    Eef D. Telenga, Matthijs Oudkerk, Peter M. A. van Ooijen, Rozemarijn Vliegenthart, Nick H. T. ten Hacken, Dirkje S. Postma and Maarten van den Berge

    BMC Pulmonary Medicine 2017 17:27

    Published on: 1 February 2017

  20. Research article

    Immediate salbutamol responsiveness does not predict long-term benefits of indacaterol in patients with chronic obstructive pulmonary disease

    The purpose of this study was to evaluate the correlation between immediate responsiveness with the short-acting β2-agonist salbutamol and effects of treatment with the ultra-long-acting β2-agonist indacaterol in...

    Pierre-Régis Burgel, Vincent Le Gros, Laurent Decuypère, Isabelle Bourdeix, Thierry Perez and Gaëtan Deslée

    BMC Pulmonary Medicine 2017 17:25

    Published on: 31 January 2017

  21. Research article

    Epigenetic modifying enzyme expression in asthmatic airway epithelial cells and fibroblasts

    Recognition of the airway epithelium as a central mediator in the pathogenesis of asthma has necessitated greater understanding of the aberrant cellular mechanisms of the epithelium in asthma. The architecture...

    Dorota Stefanowicz, Jari Ullah, Kevin Lee, Furquan Shaheen, Ekiomoado Olumese, Nick Fishbane, Hyun-Kyoung Koo, Teal S. Hallstrand, Darryl A. Knight and Tillie-Louise Hackett

    BMC Pulmonary Medicine 2017 17:24

    Published on: 31 January 2017

  22. Research article

    Pulmonary oxygen uptake and muscle deoxygenation kinetics during heavy intensity cycling exercise in patients with emphysema and idiopathic pulmonary fibrosis

    Little is known about the mechanistic basis for the exercise intolerance characteristic of patients with respiratory disease; a lack of clearly defined, distinct patient groups limits interpretation of many st...

    Melitta A. McNarry, Nicholas K. Harrison, Tom Withers, Narendra Chinnappa and Michael J. Lewis

    BMC Pulmonary Medicine 2017 17:26

    Published on: 31 January 2017

  23. Study protocol

    Effects of periodontal treatment on exacerbation frequency and lung function in patients with chronic periodontitis: study protocol of a 1-year randomized controlled trial

    Chronic obstructive pulmonary disease (COPD) has been associated with periodontal disease (PD), and periodontal treatment (PT) has been connected to reduction of lung disease exacerbations. Bronchiectasis has ...

    Sergio Romero Santos, Erika Horácio Pinto, Priscila Larcher Longo, Simone Dal Corso, Fernanda Cordoba Lanza, Rafael Stelmach, Samia Zahi Rached, Adriana Lino-dos-Santos-Franco, Marcia Pinto Alves Mayer, Sandra Kalil Bussadori, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari and Anna Carolina Ratto Tempestini Horliana

    BMC Pulmonary Medicine 2017 17:23

    Published on: 23 January 2017

  24. Study protocol

    A prospective pilot study of home monitoring in adults with cystic fibrosis (HOME-CF): protocol for a randomised controlled trial

    Home monitoring has the potential to detect early pulmonary exacerbations in people with cystic fibrosis (CF), with consequent improvements in health outcomes and healthcare associated costs. This study aims t...

    Jocelyn Choyce, Karen L. Shaw, Alice J. Sitch, Hema Mistry, Joanna L. Whitehouse and Edward F. Nash

    BMC Pulmonary Medicine 2017 17:22

    Published on: 23 January 2017

  25. Research article

    Can healthcare utilization data reliably capture cases of chronic respiratory diseases? a cross-sectional investigation in Italy

    Healthcare utilization data are increasingly used for chronic disease surveillance. Nevertheless, no standard criteria for estimating prevalence of high-impact diseases, such as chronic obstructive pulmonary d...

    A Biffi, R Comoretto, A Arfè, L Scotti, L Merlino, A Vaghi, A Pesci, R de Marco and G Corrao

    BMC Pulmonary Medicine 2017 17:20

    Published on: 19 January 2017

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