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Table 3 Sensitivity analyses*

From: Imipenem resistance of Pseudomonas in pneumonia: a systematic literature review

Subgroup

Study arm

Clinical success

Microbiologic eradication

Resistance at baseline

Emergent resistance

  

PA isolates (n)

% (range)

PA isolates (n)

% (range)

PA isolates (n)

% (range)

PA isolates (n)

% (range)

Blinding present

I

15

21.1 (0.0-42.1)

61

47.8 (25.0-70.6)

NR

 

67

56.9 (42.9-77.8)

 

C

20

78.7 (75.0-82.4)

65

52.1 (27.7-76.5)

NR

 

75

25.3 (6.3-41.7)

  

[52, 58]

 

[42, 57]

   

[55, 57, 58]

 

Comparator drug class

         

β-lactam

I

108

39.9 (0.0-72.0)

95

52.7 (0.0-70.6)

81

14.6 (4.2-24.0)

137

31.3 (5.6-52.6)

 

C

107

84.7 (0.0-100.0)

110

56.3 (0.0-100.0)

76

2.5 (0.0-7.4)

131

20.1 (4.8-56.5)

  

[39, 43, 44, 46, 48, 49, 51, 52, 54, 56]

 

[39, 40, 42, 43, 46, 48, 53, 54, 56]

 

[39, 45, 49]

 

[39, 44, 45, 49, 56, 58]

 

Fluoro-quinolone

I

47

59.7 (41.2-72.0)

95

26.5 (25.0-29.4)

NR

 

83

41.6 (5.6-77.8)

 

C

47

73.6 (64.7-85.0)

110

45.5 (27.7-58.8)

NR

 

89

20.7 (6.3-41.7)

  

[44, 46, 47]

 

[46, 47, 57]

   

[44, 47, 55, 57]

 

Nosocomial pneumonia

I

72

55.5 (41.2-72.0)

71

40.2 (25.0-50.0)

57

19.9 (4.2-24.0)

87

29.8 (5.6-52.6)

 

C

75

75.2 (64.7-85.0)

77

62.6 (50.0-76.5)

55

3.7 (0.0-7.4)

85

15.0 (6.3-35.7)

  

[39, 44, 46, 47]

 

[39, 42, 46, 47]

 

[39, 45]

 

[39, 44, 45, 47]

 

VAP subgroup

I

 

60.3 (41.2-72.0)

 

30.4 (25.0-35.7)

25

24.0 (NA)

55

30.4 (5.6-52.6)

 

C

 

78.7 (71.0-85.0)

 

57.5 (50.0-65.0)

28

0.0 (NA)

58

16.3 (6.3-35.7)

  

[39, 44, 47]

 

[39, 46]

 

[39]

 

[39, 44, 47]

 

North America only

I

36

37.7 (0.0-72.0)

78

41.7 (25.0-70.6)

NR

 

71

44.4 (5.6-77.8)

 

C

37

74.9 (64.0-85.0)

82

54.3 (27.7-76.5)

NR

 

75

25.3 (6.3-41.7)

  

[44, 46, 52]

 

[42, 46, 57]

   

[44, 55, 57]

 
  1. *Numbers in brackets represent corresponding references
  2. PA: Pseudomonas aeruginosa, I: imipenem, C: comparator, NR: not reported, NA: not applicable, VAP: ventilator-associated pneumonia