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Table 1 Baseline characteristics of patients

From: The impact of obesity on walking and cycling performance and response to pulmonary rehabilitation in COPD

 

Normal BMI

Overweight

Obese

ANOVA

 

n = 88

n = 95

n = 78

p-value

Age, years

66.0 ± 9.4

65.7 ± 8.2

65.4 ± 8.0

NS

Sex, % of men

56

61

59

NS

Body mass index, kg/m2

22.3 ± 1.8*

27.5 ± 1.5*

35.1 ± 3.5

<0.001

Height (cm)

164 ± 9.1

165 ± 9.2

163 ± 9.8

NS

Weight (kg)

61 ± 8.6*

75 ± 9.8*

91 ± 14.6

<0.001

BODE score

3.9 ± 2.0*

3.1 ± 2.0

3.2 ± 2.4

0.002

Pulmonary function

    

   FEV1, L

1.02 ± 0.39*

1.18 ± 0.42

1.14 ± 0.38

0.002

% predicted

42 ± 15*

49 ± 15

49 ± 17

0.002

   FVC, L

2.7 ± 0.8

2.6 ± 0.8

2.5 ± 0.9

NS

% predicted

86 ± 22

83 ± 21

82 ± 23

NS

   FEV1/FVC, %

40 ± 10*

45 ± 12*

49 ± 12

0.001

   FRC, L

5.0 ± 1.6†

4.4 ± 1.5

4.1 ± 1.7

<0.001

% predicted

159 ± 42†

142 ± 41

135 ± 45

<0.001

   RV, L

4.2 ± 1.4*

3.6 ± 1.4

3.5 ± 1.5

0.002

% predicted

178 ± 60*

157 ± 58

151 ± 64

0.006

   TLC, L

6.8 ± 1.7*

6.3 ± 1.7

6.1 ± 1.8

0.01

% predicted

121 ± 22*

112 ± 21

110 ± 23

0.001

   IC, L

1.8 ± 0.6

2.0 ± 0.6

2.0 ± 0.6

NS

% predicted

73 ± 21

77 ± 20

81 ± 19

NS

   IC/TLC, %

28 ± 8*

32 ± 9

33 ± 8

<0.001

Incremental exercise test

    

   Peak V ˙ O 2 , L·min-1

0.85 ± 0.29*

1.02 ± 0.32*

1.12 ± 0.40

0.02

   Peak V ˙ O 2 , % predicted

61 ± 36*

75 ± 56*

87 ± 69

0.01

   Peak work capacity, Watt

59 ± 22

69 ± 29

65 ± 29

NS

   Peak work capacity, % predicted

57 ± 28

64 ± 41

64 ± 37

NS

Constant exercise test

    

   CET time, s

367 ± 230

324 ± 201

338 ± 203

NS

6-minute walking test

    

   6MWT, m

407 ± 75

391 ± 78

342 ± 79*

0.001

   Work-walk, m·kg

23296 ± 5902*

29590 ± 8045*

32779 ± 11078*

<0.001

Quality of life

    

   SGRQ total score

45 ± 17

45 ± 16

45 ± 18

NS

   SGRQ symptoms score

53 ± 23

51 ± 22

50 ± 24

NS

   SGRQ activity score

65 ± 20

65 ± 20

65 ± 22

NS

   SGRQ impact score

32 ± 18

32 ± 17

32 ± 19

NS

Pulmonary rehabilitation

    

   Duration of rehabilitation (weeks)

8.5 ± 1.7

8.5 ± 1.7

8.4 ± 1.7

NS

   Home based rehabilitation, n (%)

23 (26)

27 (28)

21 (27)

NS

  1. Values are mean ± SD. Definitions of abbreviations: FEV1: forced expiratory volume in 1 second; FVC: forced vital capacity; FRC: functional residual capacity; RV: residual volume; TLC: total lung capacity; IC: inspiratory capacity; V ˙ O 2 : oxygen consumption; CET: constant exercise test; 6MWT: 6-minutes walking test distance; SGRQ: St-George's respiratory questionnaire; NS: not significantly different. * = significantly different than the other two groups, p < 0.05. † = significantly different than obese group, p < 0.05.
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BMC Pulmonary Medicine

ISSN: 1471-2466

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