Fluticasone/formoterol combination therapy is as effective as fluticasone/salmeterol in the treatment of asthma, but has a more rapid onset of action: an open-label, randomized study

Table 4 Change in lung function parameters from pre-dose baseline to 2-h post-dose at week 12 in the full analysis set

Parameter	Change from baseline, LS mean (95% CI)
	Fluticasone/formoterol	Fluticasone/salmeterol
FVC (L)	0.402 (0.296, 0.508)	0.354 (0.247, 0.461)
MEF₂₅ (%)	15.3 (10.5, 20.2)	17.3 (12.3, 22.3)
MEF₅₀ (%)	43.0 (33.1, 53.0)	51.7 (41.5, 62.0)
MEF₇₅ (%)	87.8 (71.9, 103.6)	93.5 (77.5, 109.5)

FVC, forced vital capacity; LS, least-squares; MEF₂₅; MEF₅₀; MEF₇₅, maximum expiratory flow rate at, respectively, 25%; 50%; and 75% of the volume to exhale.

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