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Table 2 NPS concentration-response curve analysis on NPSR1-A or -B overexpressing HEK-293 cells.

From: The asthma candidate gene NPSR1 mediates isoform specific downstream signalling

pEC50 values

NPSR1-A

NPSR1-B

NR4A2

8.10 ± 0.06

7.08 ± 0.27

EGR1

7.14 ± 0.27

n.d.

FOS

7.27 ± 0.21

n.d.

CGA

7.34 ± 0.05

7.00 ± 0.06

AREG

6.63 ± 0.31

6.77 ± 0.83

NTS

7.06 ± 0.23

n.d.

IL8

7.35 ± 0.14

n.d.

SERPINB2

7.62 ± 2.93

6.90 ± 0.61

CCL20

6.79 ± 1.67

7.00 ± 0.08

CD69

n.d.

n.d.

PCK1

6.79 ± 0.07

7.05 ± 0.15

cAMP

8.35 ± 0.17

8.41 ± 0.28

  1. The EC50 value (the agonist concentration that induces half-maximum effect) is presented as -log10 (pEC50). Data are expressed as mean ± SEM. When a concentration-response curve not fitted to the Hill equation the pEC50 was not determined (n.d.).
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BMC Pulmonary Medicine

ISSN: 1471-2466

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