Polymorphisms in ADRB2 gene can modulate the response to bronchodilators and the severity of cystic fibrosis

BMC Pulmonary Medicine

Table 3 Change in FVC, FEV _1, and FEF25-75 FEF1/FVC post-bronchodilator by ADRB2 haplotype ¹

	Arg16Gly/Gln27Glu GG haplotype group			p- value
	0 GG (n = 56)	1 GG (n = 34)	2 GG (n = 4)
Change in FVC(%)	-0.17 ± 9.86	2.29 ± 11.87	5.25 ± 4.03	0.17
Change in FEV₁(%)	2.10 ± 9.42	2.18 ± 9.57	2.75 ± 11.41	0.92
Change in FEV₁/FVC(%)	4.61 ± 10.45	0.53 ± 7.75	-2.25 ± 9.61	0.02
Change FEF25-75(%)	6.36 ± 30.75	8.62 ± 41.75	8 ± 39.45	0.79

% - Percentage; FVC - forced vital capacity; FEV - forced expiratory volume; FEF25-75% - forced expiratory flow between 27-75% of the FVC. Statistical analysis performed by linear regression. 1. Percent change calculated as 100 x (post-bronchodilator value – pre-bronchodilator value)/pre-bronchodilator value.

ISSN: 1471-2466