Figure 3From: Low-dose endotoxin inhalation in healthy volunteers - a challenge model for early clinical drug development Sputum neutrophils (left) and the sum of sputum monocytes and small macrophages (right). Individual data and mean values of percent sputum leukocytes are displayed. BL: baseline, LPS 1: first LPS challenge, LPS 2: second LPS challenge at least 4 weeks after LPS 1, LPS Tx: third LPS challenge at least 4 weeks after LPS 2 and after 5 days of treatment with Roflumilast (500 μg /day). For statistical details please refer to Table 2. ** p < 0.01, *** p < 0.001 compared with baseline; # p < 0.05 compared with LPS 1.Back to article page